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2015 Conference Publication The adaptor protein ASC controls transplantation outcomes independently of the inflammasomeCheong, Melody, Gartlan, Kate, Tey, Siok-Keen, Kuns, Rachel, Lor, Mary, Lineburg, Katie, Tea, Bianca, Shi, Wei, Raju, Jyothy, Zhang, Ping, Varelias, Antiopi, Leveque-El Mouttie, Lucie, Olver, Stuart, Bunting, Mark, Lane, Steven, Boyle, Glen, Ting, Jenny, Schroder, Kate, Engwerda, Christian, Khanna, Kum Kum, Smyth, Mark, MacDonald, Kelli, Koyama, Motoko and Hill, Geoffrey (2015). The adaptor protein ASC controls transplantation outcomes independently of the inflammasome. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS. |
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2015 Journal Article Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafishJeffery, Jessie, Neyt, Christine, Moore, Wade, Paterson, Scott, Bower, Neil I., Chenevix-Trench, Georgia, Verkade, Heather, Hogan, Benjamin M. and Khanna, Kum Kum (2015). Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. The FASEB Journal, 29 (5), 1999-2009. doi: 10.1096/fj.14-265090 |
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2015 Journal Article Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesisJeffery, J., Sinha, D., Srihari, S., Kalimutho, M. and Khanna, K. K. (2015). Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene, 35 (6), 683-690. doi: 10.1038/onc.2015.128 |
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2015 Journal Article The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to ChromatinKalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G. and Soutoglou, Evi (2015). The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin. Cell Reports, 11 (1), 149-163. doi: 10.1016/j.celrep.2015.03.005 |
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2015 Journal Article The Integrator complex controls the termination of transcription at diverse classes of gene targetsSkaar, Jeffrey R., Ferris, Andrea L., Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P., Hughes, Stephen H. and Pagano, Michele (2015). The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Research, 25 (3), 288-305. doi: 10.1038/cr.2015.19 |
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2015 Journal Article Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsPandita, Raj K., Chow, Tracy T., Udayakumar, Durga, Bain, Amanda L., Cubeddu, Liza, Hunt, Clayton R., Shi, Wei, Horikoshi, Nobuo, Zhao, Yong, Wright, Woodring E., Khanna, Kum Kum, Shay, Jerry W. and Pandita, Tej K. (2015). Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research, 75 (5), 858-869. doi: 10.1158/0008-5472.CAN-14-2289 |
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2015 Journal Article Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell linesMomeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846 |
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2015 Conference Publication Genomic and transcriptomic landscapes of human brain metastasesSaunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3 |
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2015 Journal Article ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754 |
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2014 Journal Article Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanomade Andrade, Lucas Ferrari, Ngiow, Shin F., Stannard, Kimberly, Rusakiewicz, Sylvie, Kalimutho, Murugan, Khanna, Kum Kum, Tey, Siok-Keen, Takeda, Kazyuoshi, Zitvogel, Laurence, Martinet, Ludovic and Smyth, Mark J. (2014). Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Research, 74 (24), 7298-7308. doi: 10.1158/0008-5472.CAN-14-1339 |
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2014 Journal Article Complex-based analysis of dysregulated cellular processes in cancerSrihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014). Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 (Supplement 4) S1. doi: 10.1186/1752-0509-8-S4-S1 |
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2014 Journal Article SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replicationJohansson, Pegah, Jeffery, Jessie, Al-Ejeh, Fares, Schulz, Renèe B., Callen, David F., Kumar, Raman and Khanna, Kum Kum (2014). SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication. Journal of Biological Chemistry, 289 (26), 18514-18525. doi: 10.1074/jbc.M114.559930 |
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2014 Journal Article Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinomaAl-Ejeh, Fares, Pajic, Marina, Shi, Wei, Kalimutho, Murugan, Miranda, Mariska, Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Grimmond, Sean M., Brown, Michael P. and Khanna, Kum Kum (2014). Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma. Clinical Cancer Research, 20 (12), 3187-3197. doi: 10.1158/1078-0432.CCR-14-0048 |
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2014 Journal Article Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forksBolderson, Emma, Petermann, Eva, Croft, Laura, Suraweera, Amila, Pandita, Raj K., Pandita, Tej K., Helleday, Thomas, Khanna, Kum Kum and Richard, Derek J. (2014). Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42 (10), 6326-6336. doi: 10.1093/nar/gku276 |
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2014 Journal Article A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapyLiu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014). A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 (10), 6106-6127. doi: 10.1093/nar/gku284 |
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2014 Journal Article Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancerAl-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014). Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (4) e100, 1-12. doi: 10.1038/oncsis.2014.14 |
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2014 Journal Article Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancerAl-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014). Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 (10), 3145-3158. doi: 10.18632/oncotarget.1865 |
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2014 Journal Article Rad51 supports triple negative breast cancer metastasisWiegmans, Adrian P., Al-Ejeh, Fares, Chee, Nicole, Yap, Pei-Yi, Gorski, Julia J., Da Silva, Leonard, Bolderson, Emma, Chenevix-Trench, Georgia, Anderson, Robin, Simpson, Peter T., Lakhani, Sunil R. and Khanna, Kum Kum (2014). Rad51 supports triple negative breast cancer metastasis. Oncotarget, 5 (10), 3261-3272. doi: 10.18632/oncotarget.1923 |
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2014 Journal Article Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choiceTomimatsu, Nozomi, Mukherjee, Bipasha, Catherine Hardebeck, Molly, Ilcheva, Mariya, Vanessa Camacho, Cristel, Louise Harris, Janelle, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum K.um and Burma, Sandeep (2014). Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nature communications, 5 3561. doi: 10.1038/ncomms4561 |
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2014 Journal Article Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cellsSpeckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001 |
