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2011 Conference Publication Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemiasSykes, S. M., Lane, S. W., Bullinger, L., Demetrios, K., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K. M., Acharya, S., Scholl, C., Tothova, Z., Attar, E., Froehling, S., DePinho, R. A., Gilliland, D. G., Armstrong, S. A. and Sca, D. T. (2011). Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias. ISEH 40th Annual Scientific Meeting, -, 25 - 28 August 2011. Philadelphia, PA, United States: Elsevier. |
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2011 Conference Publication Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signalingFaber, Katrin, Bullinger, Lars, Garding, Angela, Mertens, Daniel, Martin, Daniela, Walcher, Daniel, Doehner, Konstanze, Doehner, Hartmut, Sykes, Stephen M., Claus, Rainer, Plass, Christoph, Lane, Steven W., Scholl, Claudia and Froehling, Stefan (2011). Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signaling. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesisKalaitzidis, Demetrios, Sykes, Stephen M., Punt, Natalie, Tang, Yuefeng, Lane, Steven W., Clish, Clary, Gilliland, D. Gary, Scadden, David T., Guertin, David and Armstrong, Scott A. (2011). Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPNMullally, Ann, Poveromo, Luke, Brumme, Kristina, Al-Shahrour, Fatima, Lane, Steven W., Shih, Alan H., Aifantis, Iannis, Levine, Ross L. and Ebert, Benjamin L. (2011). Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeletonDorrance, Adrienne M., Kosoff', Rachelle, McGuinness, Meaghan, Harris, Chad, De Vita, Serena, Mathieu, Ronald, Lane, Steven W., Milsom, Michael D., Chernoff, Jonathan and Williams, David A. (2011). Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2010 Journal Article Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemiaKharas, Michael G., Lengner, Christopher J., Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W., Scholl, Claudia, Froehling, Stefan, Fleming, Mark, Ebert, Benjamin L., Gilliland, D. Gary, Jaenisch, Rudolf and Daley, George Q. (2010). Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nature Medicine, 16 (8), 903-908. doi: 10.1038/nm.2187 |
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2010 Journal Article CNS Relapse in Acute Promyeloctyic LeukemiaHousman, Elizabeth, Chang, Priscilla, Lane, Steven W., Blinder, Russell, Galinsky, Ilene, Kesari, Santosh, Ho, Vincent T., Stone, Richard M. and Mullally, Ann (2010). CNS Relapse in Acute Promyeloctyic Leukemia. Journal of Clinical Oncology, 28 (24), E409-E411. doi: 10.1200/JCO.2009.27.1577 |
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2010 Journal Article Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cellsMullally, Ann, Lane, Steven W., Ball, Brian, Megerdichian, Christine, Okabe, Rachel, Al-Shahrour, Fatima, Paktinat, Mahnaz, Haydu, J. Erika, Housman, Elizabeth, Lord, Allegra M., Wernig, Gerlinde, Kharas, Michael G., Mercher, Thomas, Kutok, Jeffery L., Gilliland, D. Gary and Ebert, Benjamin L. (2010). Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cells. Cancer Cell, 17 (6), 584-596. doi: 10.1016/j.ccr.2010.05.015 |
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2010 Journal Article The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDSLane, Steven W., Sykes, Stephen M., Al-Shahrour, Fatima, Shterental, Sebastian, Paktinat, Mahnaz, Lo Celso, Cristina, Jesneck, Jonathan L., Ebert, Benjamin L., Williams, David A. and Gilliland, D. Gary (2010). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood, 115 (17), 3489-3497. doi: 10.1182/blood-2009-11-251728 |
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2010 Journal Article Leukemia stem cellsLane, Steven W. and Gilliland, D. Gary (2010). Leukemia stem cells. Seminars in Cancer Biology, 20 (2), 71-76. doi: 10.1016/j.semcancer.2009.12.001 |
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2010 Conference Publication Characterizing the disease-initiating cell population in a murine model of Jak2V617F+ myeloproliferative neoplasmMullally, Ann, Lane, Steven W., Poveromo, Luke, Al-Shahrour, Fatima, Kutok, Jeffery and Ebert, Benjamin L. (2010). Characterizing the disease-initiating cell population in a murine model of Jak2V617F+ myeloproliferative neoplasm. 52nd Annual Meeting of the American Society of Hematology (ASH), Orlando, FL, United States, 4-7 Dec 2010. Washington, DC, United States: American Society of Hematology. |
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2010 Conference Publication Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cellsLane, S. W., Sykes, S. M., Ferraro, F., Lin, C. P., Gilliland, D. G., Williams, D. A., Scadden, D. T. and Lo Celso, C. (2010). Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells. 39th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Melbourne Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2010.07.008 |
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2009 Journal Article Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropeniaLane, S. W., Hassell, P., Kennedy, G. A., Fung, Y. L. and Williams, B. A. (2009). Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia. International Journal of Laboratory Hematology, 31 (5), 567-571. doi: 10.1111/j.1751-553X.2008.01084.x |
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2009 Journal Article The leukemic stem cell niche: Current concepts and therapeutic opportunitiesLane, Steven W., Scadden, David T. and Gilliland, D. Gary (2009). The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood, 114 (6), 1150-1157. doi: 10.1182/blood-2009-01-202606 |
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2009 Conference Publication WT1 Expression Levels at Diagnosis and as a Marker of Minimal Residual Disease (MRD) in Patients with Acute Myeloid Leukaernia (AML)Gray, J. X., McMillen, L., Saal, R., Lane, S., Mollee, P., Bird, R., Gill, D. and Marlton, P. (2009). WT1 Expression Levels at Diagnosis and as a Marker of Minimal Residual Disease (MRD) in Patients with Acute Myeloid Leukaernia (AML). 51st Annual Meeting of the American Society of Hematology, New Orleans, LA, United States, 5-8 December 2009. Washington, DC, United States: American Society of Hematology. |
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2009 Conference Publication Leukemia stem cells are resistant to in vivo, cell non-autonomous Wnt inhibition.Lane, Steven W., Lo Celso, Cristina, Sykes, Stephen M., Shterental, Sebastian, Paktinat, Mahnaz, Lin, Charles P., Williams, David A., Scadden, David T. and Gilliland, D. Gary (2009). Leukemia stem cells are resistant to in vivo, cell non-autonomous Wnt inhibition.. 51st Annual Meeting of the American Society of Hematology, New Orleans, LA, United States, 5-8 Dec 2009. Washington, DC, United States: American Society of Hematology. |
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2008 Journal Article Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patientsGill, Saar, Lane, Steven, Crawford, Julie, Cull, Gavin, Joske, David, Joske, David, Marlton, Paula, Mollee, Peter, Prince, Miles and Seymour, John (2008). Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients. Annals of Hematology, 87 (9), 727-734. doi: 10.1007/s00277-008-0488-6 |
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2008 Journal Article A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapseLane, Steven, Saal, Russell, Mollee, Peter, Jones, Mark, Grigg, Andrew, Taylor, Kerry, Seymour, John, Kennedy, Glen, Williams, Bronwyn, Grimmett, Karen, Griffiths, Vanessa, Gill, Devinder, Hourigan, Matthew and Marlton, Paula (2008). A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapse. Leukemia & Lymphoma, 49 (3), 517-523. doi: 10.1080/10428190701817266 |
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2007 Journal Article Palifermin-induced Acanthosis NigricansLane, S. W., Manoharan, S. and Mollee, P. N. (2007). Palifermin-induced Acanthosis Nigricans. Internal Medicine Journal, 37 (6), 417-418. doi: 10.1111/j.1445-5994.2007.01340.x |
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2006 Journal Article Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor)Lane, Steven W., Marlton, Paula and Mollee, Peter N. (2006). Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor). Blood, 108 (12), 3950-3951. doi: 10.1182/blood-2006-06-032680 |
