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2022 Journal Article Paving the way to improve therapy for Myeloproliferative NeoplasmsBywater, Megan and Lane, Steven W. (2022). Paving the way to improve therapy for Myeloproliferative Neoplasms. Nature Communications, 13 (1) 5025. doi: 10.1038/s41467-022-32694-2 |
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2022 Journal Article Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AMLSalmon, Jessica M., Todorovski, Izabela, Stanley, Kym L., Bruedigam, Claudia, Kearney, Conor J., Martelotto, Luciano G., Rossello, Fernando, Semple, Timothy, Arnau, Gisela Mir, Zethoven, Magnus, Bots, Michael, Bjelosevic, Stefan, Cluse, Leonie A., Fraser, Peter J., Litalien, Veronique, Vidacs, Eva, McArthur, Kate, Matthews, Antony Y., Gressier, Elise, De Weerd, Nicole A., Lichte, Jens, Kelly, Madison J., Hogg, Simon J., Hertzog, Paul J., Kats, Lev M., Vervoort, Stephin J., De Carvalho, Daniel D., Scheu, Stefanie, Bedoui, Sammy ... Johnstone, Ricky W. (2022). Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12 (6), 1560-1579. doi: 10.1158/2159-8290.CD-20-1145 |
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2022 Journal Article Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statementEnjeti, Anoop K., Agarwal, Rishu, Blombery, Piers, Chee, Lynette, Chua, Chong Chyn, Grigg, Andrew, Hamad, Nada, Iland, Harry, Lane, Steven, Perkins, Andrew, Singhal, Deepak, Tate, Courtney, Tiong, Ing Soo and Ross, David M. (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54 (4), 389-398. doi: 10.1016/j.pathol.2022.03.002 |
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2022 Journal Article Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patientsSubramanian, Sreedhar, Rhodes, Jonathan M., Taylor, Joseph M., Milan, Anna M., Lane, Steven, Hewison, Martin, Chun, Rene F., Jorgensen, Andrea, Richardson, Paul, Nitchingham, Darshan, Aslan, Joseph, Shah, Maya, Chandrasekar, Coonoor R., Wood, Amanda, Beadsworth, Mike and Pirmohamed, Munir (2022). Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients. American Journal of Clinical Nutrition, 115 (5), 1367-1377. doi: 10.1093/ajcn/nqac027 |
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2022 Journal Article Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantationTey, Siok-Keen and Lane, Steven W (2022). Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation. Blood Advances, 6 (5), 1619-1622. doi: 10.1182/bloodadvances.2021004829 |
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2022 Journal Article PLCG1 is required for AML1-ETO leukemia stem cell self-renewalSchnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A, Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei ... Heidel, Florian (2022). PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood, 139 (7), 1080-1097. doi: 10.1182/blood.2021012778 |
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2022 Journal Article Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsisAlsabani, Mohmad, Abrams, Simon T., Cheng, Zhenxing, Morton, Ben, Lane, Steven, Alosaimi, Samar, Yu, Weiping, Wang, Guozheng and Toh, Cheng-Hock (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128 (2), 283-293. doi: 10.1016/j.bja.2021.10.039 |
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2021 Conference Publication Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid LeukemiaLing, Victoria Y., Jacquelin, Sebastien, Straube, Jasmin, Haldar, Rohit, Janardhanan, Yashaswini, Cooper, Leanne T., Bruedigam, Claudia, Cooper, Emily, Godfrey, William, Tey, Siok-Keen, Bullinger, Lars, Herold, Marco J., Baell, Jonathan, Bywater, Megan and Lane, Steven W. (2021). Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia. 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. AMSTERDAM: ELSEVIER. doi: 10.1182/blood-2021-148379 |
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2021 Conference Publication A Phase- Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT<sub>3</sub>-ITD and CBL-Mutant Acute Myeloid Leukemia (PON-AZA study)Kipp, David, Loo, Sun, Perkins, Andrew Charles, Lane, Steven W., Blyth, Emily, Ejeti, Anoop Kumar, Bajel, Ashish, Reynolds, John and Wei, Andrew H. (2021). A Phase- Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3-ITD and CBL-Mutant Acute Myeloid Leukemia (PON-AZA study). 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood-2021-154247 |
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2021 Conference Publication A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)Palandri, Francesca, Vianelli, Nicola, Ross, David M., Cochrane, Tara, Lane, Steven W., Larsen, Stephen R., Gerds, Aaron T., Halpern, Anna B., Shortt, Jake, Rossetti, James M., Pettit, Kristen M., Jones, Amber, Peppe, Jennifer, Natsoulis, Georges, Navarro, Willis, Hong, Wan-Jen, Stevenson, William S., Harrison, Claire N., Talpaz, Moshe and Rienhoff, Hugh Young (2021). A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET). 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. AMSTERDAM: ELSEVIER. doi: 10.1182/blood-2021-148210 |
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2021 Journal Article Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: a cross-sectional study from PakistanHusain, Muhammad Omair, Chaudhry, Imran B., Blakemore, Amy, Shakoor, Suleman, Husain, Muhammad Ali, Lane, Steven, Kiran, Tayyeba, Jafri, Farhat, Memon, Rakhshi, Panagioti, Maria and Husain, Nusrat (2021). Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: a cross-sectional study from Pakistan. Sage Open Medicine, 9. doi: 10.1177/20503121211032813 |
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2021 Journal Article Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromesStraube, Jasmin, Lane, Steven W. and Vu, Therese (2021). Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes. BioEssays, 43 (10) 2100125, 1-14. doi: 10.1002/bies.202100125 |
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2021 Journal Article Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activityWeerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M. and Lepletier, Ailin (2021). Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9) e1334, e1334. doi: 10.1002/cti2.1334 |
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2021 Journal Article Circulating histones play a central role in COVID-19-associated coagulopathy and mortalityShaw, Rebecca J., Abrams, Simon T., Austin, James, Taylor, Joseph M., Lane, Steven, Dutt, Tina, Downey, Colin, Du, Min, Turtle, Lance, Baillie, J. Kenneth, Openshaw, Peter J. M., Wang, Guozheng, Semple, Malcolm G. and Toh, Cheng-Hock (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. Haematologica, 106 (9), 2493-2498. doi: 10.3324/haematol.2021.278492 |
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2021 Journal Article Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemiasThijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167 |
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2021 Journal Article IFN-λ therapy prevents severe gastrointestinal graft-versus-host diseaseHenden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375 |
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2021 Journal Article Myeloid somatic mutation panel testing in myeloproliferative neoplasmsRoss, David M., Thomson, Candice, Hamad, Nada, Lane, Steven W., Manos, Kate, Grigg, Andrew P., Guo, Belinda, Erber, Wendy N., Scott, Ashleigh, Viiala, Nick, Chee, Lynette, Latimer, Maya, Tate, Courtney, Grove, Carolyn, Perkins, Andrew C. and Blombery, Piers (2021). Myeloid somatic mutation panel testing in myeloproliferative neoplasms. Pathology, 53 (3), 339-348. doi: 10.1016/j.pathol.2021.01.003 |
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2021 Journal Article Real-world experience with caplacizumab in the management of acute TTPDutt, Tina, Shaw, Rebecca J., Stubbs, Matthew, Yong, Jun, Bailiff, Benjamin, Cranfield, Tanya, Crowley, Maeve P., Desborough, Michael, Eyre, Toby A., Gooding, Richard, Grainger, John, Hanley, John, Haughton, Joanna, Hermans, Joannes, Hill, Quentin, Humphrey, Louise, Lowe, Gillian, Lyall, Hamish, Mohsin, Muhammad, Nicolson, Phillip L. R., Priddee, Nicole, Rampotas, Alexandros, Rayment, Rachel, Rhodes, Susan, Taylor, Alice, Thomas, William, Tomkins, Oliver, Van Veen, Joost J., Lane, Steven ... Scully, Marie (2021). Real-world experience with caplacizumab in the management of acute TTP. Blood, 137 (13), 1731-1740. doi: 10.1182/blood.2020007599 |
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2021 Journal Article A knockout combination for MPN stem cellsBywater, Megan and Lane, Steven W. (2021). A knockout combination for MPN stem cells. Journal of Experimental Medicine, 218 (2) e20201884. doi: 10.1084/JEM.20201884 |
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2021 Journal Article Intravascular large B-cell lymphoma presenting with extensive pulmonary embolismWong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182 |
