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2021

Journal Article

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

Shaw, Rebecca J., Abrams, Simon T., Austin, James, Taylor, Joseph M., Lane, Steven, Dutt, Tina, Downey, Colin, Du, Min, Turtle, Lance, Baillie, J. Kenneth, Openshaw, Peter J. M., Wang, Guozheng, Semple, Malcolm G. and Toh, Cheng-Hock (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. Haematologica, 106 (9), 2493-2498. doi: 10.3324/haematol.2021.278492

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

2021

Journal Article

Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic

Mayland, Catriona R., Hughes, Rosemary, Lane, Steven, McGlinchey, Tamsin, Donnellan, Warren, Bennett, Kate, Hanna, Jeffrey, Rapa, Elizabeth, Dalton, Louise and Mason, Stephen R. (2021). Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic. Palliative Medicine, 35 (8), 1480-1491. doi: 10.1177/02692163211019885

Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic

2021

Journal Article

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

2021

Journal Article

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

2021

Journal Article

Myeloid somatic mutation panel testing in myeloproliferative neoplasms

Ross, David M., Thomson, Candice, Hamad, Nada, Lane, Steven W., Manos, Kate, Grigg, Andrew P., Guo, Belinda, Erber, Wendy N., Scott, Ashleigh, Viiala, Nick, Chee, Lynette, Latimer, Maya, Tate, Courtney, Grove, Carolyn, Perkins, Andrew C. and Blombery, Piers (2021). Myeloid somatic mutation panel testing in myeloproliferative neoplasms. Pathology, 53 (3), 339-348. doi: 10.1016/j.pathol.2021.01.003

Myeloid somatic mutation panel testing in myeloproliferative neoplasms

2021

Journal Article

Real-world experience with caplacizumab in the management of acute TTP

Dutt, Tina, Shaw, Rebecca J., Stubbs, Matthew, Yong, Jun, Bailiff, Benjamin, Cranfield, Tanya, Crowley, Maeve P., Desborough, Michael, Eyre, Toby A., Gooding, Richard, Grainger, John, Hanley, John, Haughton, Joanna, Hermans, Joannes, Hill, Quentin, Humphrey, Louise, Lowe, Gillian, Lyall, Hamish, Mohsin, Muhammad, Nicolson, Phillip L. R., Priddee, Nicole, Rampotas, Alexandros, Rayment, Rachel, Rhodes, Susan, Taylor, Alice, Thomas, William, Tomkins, Oliver, Van Veen, Joost J., Lane, Steven ... Scully, Marie (2021). Real-world experience with caplacizumab in the management of acute TTP. Blood, 137 (13), 1731-1740. doi: 10.1182/blood.2020007599

Real-world experience with caplacizumab in the management of acute TTP

2021

Journal Article

A knockout combination for MPN stem cells

Bywater, Megan and Lane, Steven W. (2021). A knockout combination for MPN stem cells. Journal of Experimental Medicine, 218 (2) e20201884. doi: 10.1084/JEM.20201884

A knockout combination for MPN stem cells

2021

Journal Article

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

2021

Conference Publication

PREDICTORS OF AND TIME FRAME FOR READMISSION FOLLOWING HOSPITALISATION WITH COMMUNITY ACQUIRED PNEUMONIA

Chakrabarti, B., Lane, S., Jenks, T., Higgins, J., Kanwar, E., Allen, M. and Wootton, D. G. (2021). PREDICTORS OF AND TIME FRAME FOR READMISSION FOLLOWING HOSPITALISATION WITH COMMUNITY ACQUIRED PNEUMONIA. Winter Meeting of the British-Thoracic-Society (BTS), Electr Network, Feb 17-19, 2021. LONDON: BMJ PUBLISHING GROUP. doi: 10.1136/thorax-2020-BTSabstracts.106

PREDICTORS OF AND TIME FRAME FOR READMISSION FOLLOWING HOSPITALISATION WITH COMMUNITY ACQUIRED PNEUMONIA

2020

Journal Article

Anti-FXa Activity with Intermediate-Dose Thromboprophylaxis in COVID-19 Reply

Dutt, Tina, Simcox, David, Downey, Colin, McLenaghan, Daniella, King, Charlotte, Gautam, Manish, Lane, Steven and Burhan, Hassan (2020). Anti-FXa Activity with Intermediate-Dose Thromboprophylaxis in COVID-19 Reply. American Journal of Respiratory and Critical Care Medicine, 202 (12), 1733-1734. doi: 10.1164/rccm.202007-2913LE

Anti-FXa Activity with Intermediate-Dose Thromboprophylaxis in COVID-19 Reply

2020

Journal Article

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R. ... Heidel, Florian H. (2020). Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature, 588 (7836), 157-163. doi: 10.1038/s41586-020-2968-3

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

2020

Journal Article

Do not get burnt by damn statistics

Li, Chen, Lane, Steven and McKeever, Stephen (2020). Do not get burnt by damn statistics. Journal of Child Health Care, 24 (4), 499-501. doi: 10.1177/1367493520966682

Do not get burnt by damn statistics

2020

Journal Article

Murine models of myelofibrosis

Jacquelin, Sebastien, Kramer, Frederike, Mullally, Ann and Lane, Steven W. (2020). Murine models of myelofibrosis. Cancers, 12 (9) 2381, 1-22. doi: 10.3390/cancers12092381

Murine models of myelofibrosis

2020

Journal Article

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

Grabek, Julian, Straube, Jasmin, Bywater, Megan and Lane, Steven W. (2020). MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment. Cells, 9 (8) 1912, 1901. doi: 10.3390/cells9081901

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

2020

Journal Article

Parasite histories are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Moxon, Christopher A., Alhamdi, Yasir, Storm, Janet, Toh, Julien M. H., McGuinness, Dagmara, Ko, Joo Yeon, Murphy, George, Lane, Steven, Taylor, Terrie E., Seydel, Karl B., Kampondeni, Sam, Potchen, Michael, O'Donnell, James S., O'Regan, Niamh, Wang, Guozheng, Garcia-Cardena, Guillermo, Molyneux, Malcolm, Craig, Alister G., Abrams, Simon T. and Toh, Cheng-Hock (2020). Parasite histories are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4 (13), 2851-2864. doi: 10.1182/bloodadvances.2019001258

Parasite histories are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

2020

Journal Article

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, Mallm, Jan-Philipp, Fröhling, Stefan, Scholl, Claudia and Lane, Steven W. (2020). Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. Nature Communications, 11 (1) 3021, 3021. doi: 10.1038/s41467-020-16840-2

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

2020

Journal Article

Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

Weinkove, Robert, McQuilten, Zoe K, Adler, Jonathan, Agar, Meera R, Blyth, Emily, Cheng, Allen C, Conyers, Rachel, Haeusler, Gabrielle M, Hardie, Claire, Jackson, Christopher, Lane, Steven W, Middlemiss, Tom, Mollee, Peter, Mulligan, Stephen P, Ritchie, David, Ruka, Myra, Solomon, Benjamin, Szer, Jeffrey, Thursky, Karin A, Wood, Erica M, Worth, Leon J, Yong, Michelle K, Slavin, Monica A and Teh, Benjamin W (2020). Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Medical Journal of Australia, 212 (10) mja2.50607, 481-489. doi: 10.5694/mja2.50607

Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

2020

Journal Article

Being 'at-home' on outpatient parenteral antimicrobial therapy (OPAT): a qualitative study of parents' experiences of paediatric OPAT

Carter, Bernie, Fisher-Smith, Debra, Porter, David, Lane, Steven, Peak, Matthew, Taylor-Robinson, David, Bracken, Louise and Carrol, Enitan (2020). Being 'at-home' on outpatient parenteral antimicrobial therapy (OPAT): a qualitative study of parents' experiences of paediatric OPAT. Archives of Disease in Childhood, 105 (3), 276-281. doi: 10.1136/archdischild-2019-317629

Being 'at-home' on outpatient parenteral antimicrobial therapy (OPAT): a qualitative study of parents' experiences of paediatric OPAT

2020

Journal Article

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

2020

Journal Article

Mapping functional susceptibilities in AML

Lane, Steven and Henden, Andrea (2020). Mapping functional susceptibilities in AML. The Hematologist, 17 (1). doi: 10.1182/hem.v17.1.10162

Mapping functional susceptibilities in AML