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2025

Journal Article

Assessing the performance of paediatric early warning scores to predict critical deterioration events in hospitalised children (the DETECT study): a retrospective matched case-control study

Bracken, Abbey, Lane, Steven, Siner, Sarah, Jones, Dawn, Lambert, Caroline, Mehta, Fulya, Eyton-Chong, Chin-Kien, Davis, Peter, Fitzsimons, John, Lim, Emma, Clerihew, Linda, Carter, Bernie, Sefton, Gerri and Carrol, Enitan D. (2025). Assessing the performance of paediatric early warning scores to predict critical deterioration events in hospitalised children (the DETECT study): a retrospective matched case-control study. BMC Pediatrics, 25 (1) 520. doi: 10.1186/s12887-025-05754-x

Assessing the performance of paediatric early warning scores to predict critical deterioration events in hospitalised children (the DETECT study): a retrospective matched case-control study

2025

Journal Article

Clinical prediction models for febrile neutropenia and its outcomes: a systematic review

Sheehy, Joshua, Gallanagh, Marianne, Sullivan, Clair and Lane, Steven (2025). Clinical prediction models for febrile neutropenia and its outcomes: a systematic review. Supportive Care in Cancer, 33 (7) 537, 537. doi: 10.1007/s00520-025-09562-y

Clinical prediction models for febrile neutropenia and its outcomes: a systematic review

2025

Journal Article

Prevention, diagnosis and management of myeloproliferative neoplasms: an introduction to a review series

Yuan, Yin and Lane, Steven W. (2025). Prevention, diagnosis and management of myeloproliferative neoplasms: an introduction to a review series. Haematologica, 110 (4), 825-827. doi: 10.3324/haematol.2024.285414

Prevention, diagnosis and management of myeloproliferative neoplasms: an introduction to a review series

2025

Journal Article

ALLG APML5: Bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL

Iland, Harry J, Reynolds, John, Boddy, Alan, Schultz, Hayley B, Khoo, Liane, Fleming, Shaun A, Lane, Steven W, Weber, Nicholas, Gasiorowski, Robin, Armytage, Tasman, Harrup, Rosemary Anne, Watson, Anne-Marie, Tan, Peter, Filshie, Robin, Kwok, Fiona, Stevenson, William S., Yuen, Sam L.S., Ng, Ashley Peng Chee, Rowley, Leesa, Marlton, Paula and Wei, Andrew H (2025). ALLG APML5: Bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL. Blood Advances, 9 (6), 1476-1484. doi: 10.1182/bloodadvances.2024015397

ALLG APML5: Bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL

2024

Conference Publication

Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1c-Flt3ITD Acute Myeloid Leukemia

Tavakoli, Paniz, Bywater, Megan, Straube, Jasmin, Ling, Victoria, Cooper, Emily, Haldar, Rohit, Janardhanan, Yashaswini, Cooper, Leanne, Bruedigam, Claudia, Grove, Carolyn S. and Lane, Steven W. (2024). Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1c-Flt3ITD Acute Myeloid Leukemia. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-201250

Dnmt3a Mutation Promotes Expansion of a Quiescent Myeloid Progenitor Population in Npm1c-Flt3ITD Acute Myeloid Leukemia

2024

Conference Publication

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

Lim, Kelly, Kutyna, Monika, Kan, Winnie, Lopez, Angel F., Brown, Anna, Yong, Agnes S. M., Lane, Steven W., Fong, Chun Yew, Hughes, Timothy P., Yeung, David T., Ross, David M., Hiwase, Devendra and Thomas, Daniel (2024). CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202682

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

2024

Conference Publication

Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments

Straube, Jasmin, Grabek, Julian, Cooper, Leanne, Haldar, Rohit, McNamara, Caroline, Ross, David M., Perkins, Andrew, Bywater, Megan and Lane, Steven W. (2024). Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-199841

Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments

2024

Conference Publication

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

Hiwase, Devendra, Ross, David M., Yeung, David T., Yong, Agnes S. M., Lane, Steven W., Brown, Anna, Fong, Chun Yew, Hughes, Timothy P., Reynolds, John and Thomas, Daniel (2024). Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202867

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

2024

Conference Publication

High Dose Ascorbate Reduces Interleukin-1 Beta Secretion in TET2 Mutant Monocytes and Demonstrates Excellent Safety and Tolerability in CMML Patients in Combination with Azacitidine

Kamel, Maha M., Robinson, Nirmal, Kutyna, Monika, Lim, Kelly, Thompson-Peach, Chloe, Lane, Steven W., Yeung, David T., Yong, Agnes S. M., Ross, David M., Hiwase, Devendra and Thomas, Daniel (2024). High Dose Ascorbate Reduces Interleukin-1 Beta Secretion in TET2 Mutant Monocytes and Demonstrates Excellent Safety and Tolerability in CMML Patients in Combination with Azacitidine. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-204177

High Dose Ascorbate Reduces Interleukin-1 Beta Secretion in TET2 Mutant Monocytes and Demonstrates Excellent Safety and Tolerability in CMML Patients in Combination with Azacitidine

2024

Conference Publication

Update of the Ascend-CML Study of Frontline Asciminib: High Rate of Optimal Response and Resistance Due to Mutations Is Rare

Yeung, David T., Shanmuganathan, Naranie, Yong, Agnes S. M., Shortt, Jake, Chee, Lynette C.Y., Vialla, Nicholas, Cunningham, Ilona, Ross, David M., D'Souza, Alwyn, Wright, Matthew P.F., Harrup, Rosemary, Forsyth, Cecily, Filshie, Robin, Lane, Steven W., Browett, Peter J., Grove, Carolyn S., Walia, Mannu, Branford, Susan, Reynolds, John, Grigg, Andrew P. and Hughes, Timothy P. (2024). Update of the Ascend-CML Study of Frontline Asciminib: High Rate of Optimal Response and Resistance Due to Mutations Is Rare. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-201218

Update of the Ascend-CML Study of Frontline Asciminib: High Rate of Optimal Response and Resistance Due to Mutations Is Rare

2024

Conference Publication

Overcoming Ven/Aza Resistance through Imetelstat-Mediated Lipophagy in Acute Myeloid Leukemia

Bruedigam, Claudia, Dulatre, Eunice Anne, Lee, Carol, Porter, Amy H., Lim, Elisa L.S.P., Shi, Alexander Z., Hodson, Mark P., Heidel, Florian H. and Lane, Steven W. (2024). Overcoming Ven/Aza Resistance through Imetelstat-Mediated Lipophagy in Acute Myeloid Leukemia. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-206473

Overcoming Ven/Aza Resistance through Imetelstat-Mediated Lipophagy in Acute Myeloid Leukemia

2024

Journal Article

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Lim, Kelly, Kan, Winnie L., Nair, Pramod C., Kutyna, Monika, Lopez, Angel F., Hercus, Timothy, Ross, David M., Lane, Steven, Fong, Chun Yew, Brown, Anna, Yong, Agnes, Yeung, David, Hughes, Timothy, Hiwase, Devendra and Thomas, Daniel (2024). CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting. PLoS One, 19 (9 September) e0310641, 1-19. doi: 10.1371/journal.pone.0310641

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

2024

Journal Article

Identifying disease-modifying potential in myelofibrosis clinical trials

Ross, David M, Lane, Steven W and Harrison, Claire N. (2024). Identifying disease-modifying potential in myelofibrosis clinical trials. Blood Journal, 144 (16), 1679-1688. doi: 10.1182/blood.2024024220

Identifying disease-modifying potential in myelofibrosis clinical trials

2024

Journal Article

Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND Study

Yeung, David T., Shanmuganathan, Naranie, Reynolds, John, Branford, Susan, Walia, Mannu, Yong, Agnes S.M., Shortt, Jake, Chee, Lynette, Viiala, Nicholas, Cunningham, Ilona, Ross, David M., D'Souza, Alwyn Bernard, Wright, Matthew, Harrup, Rosemary Anne, Forsyth, Cecily Jane, Filshie, Robin, Lane, Steven W., Browett, Peter J., Grove, Carolyn S., Grigg, Andrew A. and Hughes, Timothy P. (2024). Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND Study. Blood Journal, 144 (19), 1993-2001. doi: 10.1182/blood.2024024657

Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND Study

2024

Conference Publication

3035 – INTERFERON ALPHA THERAPY ATTENUATES LEUKAEMIC TRANSFORMATION IN JAK2V617F-DRIVEN MPN WITH TRP53-LOSS

Bywater, Megan, Zhang, Ranran, Grabek, Julian, Halder, Rohit, Janardhanan, Yashaswini, Cooper, Leanne, Cooper, Emily, Ross, David, Straube, Jasmin and Lane, Steven (2024). 3035 – INTERFERON ALPHA THERAPY ATTENUATES LEUKAEMIC TRANSFORMATION IN JAK2V617F-DRIVEN MPN WITH TRP53-LOSS. EXPHEM 2024, Philadelphia, PA, United States: Elsevier BV. doi: 10.1016/j.exphem.2024.104357

3035 – INTERFERON ALPHA THERAPY ATTENUATES LEUKAEMIC TRANSFORMATION IN JAK2V617F-DRIVEN MPN WITH TRP53-LOSS

2024

Conference Publication

Performance of eight different severity scores to predict critical care admission in paediatric inpatients treated for sepsis: a retrospective cohort study

Deef, Minnah, Bracken, Abbey, Lane, Steven, Gittings, Robert, Curran, Rachel, Foreman, Rachael, Gawne, Andrew, Carter, Bernie, Saron, Holly, Eyton-Chong, Chin-Kien, Mehta, Fulya, Siner, Sarah, Lambert, Caroline, Sefton, Gerri and Carrol, Enitan D (2024). Performance of eight different severity scores to predict critical care admission in paediatric inpatients treated for sepsis: a retrospective cohort study. Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Birmingham, United Kingdom, 25 - 27 March 2024. London, United Kingdom: BMJ Group. doi: 10.1136/archdischild-2024-rcpch.491

Performance of eight different severity scores to predict critical care admission in paediatric inpatients treated for sepsis: a retrospective cohort study

2024

Journal Article

Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality

Scho, Jeremy, Abrams, Simon T., Jenkins, Rosalind, Lane, Steven, Wang, Guozheng and Toh, Cheng-Hock (2024). Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality. Blood Advances, 8 (10), 2499-2508. doi: 10.1182/bloodadvances.2023012473

Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality

2024

Journal Article

Survival for the fittest: guadecitabine in rel/ref AML

Sheehy, Joshua and Lane, Steven W. (2024). Survival for the fittest: guadecitabine in rel/ref AML. Blood Advances, 8 (8), 2018-2019. doi: 10.1182/bloodadvances.2024012569

Survival for the fittest: guadecitabine in rel/ref AML

2024

Journal Article

Autophagy prevents graft failure during murine Graft versus Host Disease

Lineburg, Katie E., Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laeitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W., Hill, Geoffrey R., Levesque, Jean-Pierre and MacDonald, Kelli P.A. (2024). Autophagy prevents graft failure during murine Graft versus Host Disease. Blood Advances, 8 (8), 2032-2043. doi: 10.1182/bloodadvances.2023010972

Autophagy prevents graft failure during murine Graft versus Host Disease

2024

Journal Article

Low iodine nutrition knowledge in Chinese breastfeeding women despite adequate iodine status

Liu, Shuchang, Sharp, Andrew, Lane, Steven, Villanueva, Elmer V., Lu, Zhiliang and Ma, Zheng Feei (2024). Low iodine nutrition knowledge in Chinese breastfeeding women despite adequate iodine status. Nutrients, 16 (4) 491, 1-14. doi: 10.3390/nu16040491

Low iodine nutrition knowledge in Chinese breastfeeding women despite adequate iodine status