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2021

Journal Article

Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

Straube, Jasmin, Lane, Steven W. and Vu, Therese (2021). Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes. BioEssays, 43 (10) 2100125, 1-14. doi: 10.1002/bies.202100125

Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

2021

Journal Article

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Weerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M. and Lepletier, Ailin (2021). Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9) e1334, e1334. doi: 10.1002/cti2.1334

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

2021

Journal Article

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

2021

Journal Article

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

2021

Journal Article

Myeloid somatic mutation panel testing in myeloproliferative neoplasms

Ross, David M., Thomson, Candice, Hamad, Nada, Lane, Steven W., Manos, Kate, Grigg, Andrew P., Guo, Belinda, Erber, Wendy N., Scott, Ashleigh, Viiala, Nick, Chee, Lynette, Latimer, Maya, Tate, Courtney, Grove, Carolyn, Perkins, Andrew C. and Blombery, Piers (2021). Myeloid somatic mutation panel testing in myeloproliferative neoplasms. Pathology, 53 (3), 339-348. doi: 10.1016/j.pathol.2021.01.003

Myeloid somatic mutation panel testing in myeloproliferative neoplasms

2021

Journal Article

A knockout combination for MPN stem cells

Bywater, Megan and Lane, Steven W. (2021). A knockout combination for MPN stem cells. Journal of Experimental Medicine, 218 (2) e20201884. doi: 10.1084/JEM.20201884

A knockout combination for MPN stem cells

2021

Journal Article

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

2020

Journal Article

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R. ... Heidel, Florian H. (2020). Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature, 588 (7836), 157-163. doi: 10.1038/s41586-020-2968-3

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

2020

Journal Article

Murine models of myelofibrosis

Jacquelin, Sebastien, Kramer, Frederike, Mullally, Ann and Lane, Steven W. (2020). Murine models of myelofibrosis. Cancers, 12 (9) 2381, 1-22. doi: 10.3390/cancers12092381

Murine models of myelofibrosis

2020

Journal Article

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

Grabek, Julian, Straube, Jasmin, Bywater, Megan and Lane, Steven W. (2020). MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment. Cells, 9 (8) 1912, 1901. doi: 10.3390/cells9081901

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

2020

Journal Article

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, Mallm, Jan-Philipp, Fröhling, Stefan, Scholl, Claudia and Lane, Steven W. (2020). Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. Nature Communications, 11 (1) 3021, 3021. doi: 10.1038/s41467-020-16840-2

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

2020

Journal Article

Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

Weinkove, Robert, McQuilten, Zoe K, Adler, Jonathan, Agar, Meera R, Blyth, Emily, Cheng, Allen C, Conyers, Rachel, Haeusler, Gabrielle M, Hardie, Claire, Jackson, Christopher, Lane, Steven W, Middlemiss, Tom, Mollee, Peter, Mulligan, Stephen P, Ritchie, David, Ruka, Myra, Solomon, Benjamin, Szer, Jeffrey, Thursky, Karin A, Wood, Erica M, Worth, Leon J, Yong, Michelle K, Slavin, Monica A and Teh, Benjamin W (2020). Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Medical Journal of Australia, 212 (10) mja2.50607, 481-489. doi: 10.5694/mja2.50607

Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

2020

Journal Article

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

2020

Journal Article

Mapping functional susceptibilities in AML

Lane, Steven and Henden, Andrea (2020). Mapping functional susceptibilities in AML. The Hematologist, 17 (1). doi: 10.1182/hem.v17.1.10162

Mapping functional susceptibilities in AML

2020

Journal Article

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

Soon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

2019

Journal Article

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Austin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

2019

Journal Article

Inflammation in del(20q): a MST opportunity?

Lane, Steven W. (2019). Inflammation in del(20q): a MST opportunity?. Blood, 134 (20), 1685-1686. doi: 10.1182/blood.2019003028

Inflammation in del(20q): a MST opportunity?

2019

Journal Article

Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology

Yuan, Yin, Mediwake, Heshani, Bokhari, Syed W., Holley, Anthony and Lane, Steven W. (2019). Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology. British Journal of Haematology, 186 (5), 649-649. doi: 10.1111/bjh.16016

Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology

2019

Journal Article

Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms

Forsyth, Cecily J., Chan, Wai-Hoong, Grigg, Andrew P., Cook, Nathalie C., Lane, Steven W., Burbury, Kate L., Perkins, Andrew C. and Ross, David M. (2019). Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms. Internal Medicine Journal, 49 (8), 948-954. doi: 10.1111/imj.14154

Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms

2019

Journal Article

Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome

Ling, Victoria Y., Saw, Jesslyn, Tremblay, Cedric S., Sonderegger, Stefan E., Toulmin, Emma, Boyle, Jacqueline, Chiu, Sung Kai, Lane, Steven W., Ting, Stephen B. and Curtis, David J. (2019). Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome. HemaSphere, 3 (4) e277, e277. doi: 10.1097/HS9.0000000000000277

Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome