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Dr Andrew Kassianos
Dr

Andrew Kassianos

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Overview

Background

Dr Kassianos is a Senior Scientist at the Conjoint Internal Medical Laboratory, Queensland Health. Dr Kassianos has made significant contributions to understanding the cell-cell communication between discrete kidney cell and immune cell populations and the therapeutic potential of targeting this cross-talk in chronic kidney disease (CKD). Dr Kassianos has been integral in the development of innovative tools for CKD analytics: (i) in situ/ex vivo profiling for integrating CKD molecular profiles with histopathology; and (ii) preclinical models for screening novel CKD therapeutics. His research is internationally recognised in the field of CKD pathobiology.

Dr Kassianos has contributed to the fields of nephrology and immunology with 41 publications, >2000 career citations (~48 citations/paper) and invited international keynote lectures. Dr Kassianos has a continued record of success in attracting competitive research funding (>$2M as CI), including an NHMRC Dora Lush Scholarship (2007-2010), an RBWH Foundation Fellowship (2012-2014) and two NHMRC Project Grants as CIA (2016-2019; 2019-2022). Dr Kassianos has publications in high-ranking specialist (nephrology, immunology) and generalist journals, including five editorial commentaries in publication issues. These include 21 publications (~50% of his papers) as first or senior author/co-author – of which, 19 (90%) are in top field-weighted journals (Q1, top 10%), including Kidney Int, J Am Soc Nephrol, Cell Death Dis and J Extracell Vesicles. During this time, Dr Kassianos has supervised 5 Early Career Researchers, 5 PhD students (3 to completion) and 2 Masters students (both to completion). Dr Kassianos is also an Editor at Frontiers in Physiology and has contributed to 3 NHMRC grant review panels (2019-2021).

Availability

Dr Andrew Kassianos is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Andrew Kassianos’s works on UQ eSpace

46 works between 2005 and 2024

21 - 40 of 46 works

2019

Journal Article

Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease

Owens, Evan P., Vesey, David A., Kassianos, Andrew J., Healy, Helen, Hoy, Wendy E. and Gobe, Glenda C. (2019). Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease. Translational Andrology and Urology, 8 (S2), S175-S183. doi: 10.21037/tau.2018.11.03

Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease

2019

Journal Article

Pigment nephropathy: novel insights into inflammasome-mediated pathogenesis

Giuliani, Kurt T. K., Kassianos, Andrew J., Healy, Helen and Gois, Pedro H. F. (2019). Pigment nephropathy: novel insights into inflammasome-mediated pathogenesis. International Journal of Molecular Sciences, 20 (8) 1997, 1997. doi: 10.3390/ijms20081997

Pigment nephropathy: novel insights into inflammasome-mediated pathogenesis

2019

Journal Article

Natural killer cells in kidney health and disease

Turner, Jan-Eric, Rickassel, Constantin, Healy, Helen and Kassianos, Andrew J. (2019). Natural killer cells in kidney health and disease. Frontiers in Immunology, 10 (March) 587. doi: 10.3389/fimmu.2019.00587

Natural killer cells in kidney health and disease

2018

Journal Article

The role of oxidative stress and inflammation in acute oxalate nephropathy associated with ethylene glycol intoxication

Wilson, Gregory J., Gois, Pedro H.F., Zhang, Alice, Wang, Xiangju, Law, Becker M.P., Kassianos, Andrew J. and Healy, Helen G. (2018). The role of oxidative stress and inflammation in acute oxalate nephropathy associated with ethylene glycol intoxication. Kidney International Reports, 3 (5), 1217-1221. doi: 10.1016/j.ekir.2018.05.005

The role of oxidative stress and inflammation in acute oxalate nephropathy associated with ethylene glycol intoxication

2018

Journal Article

Identification and quantitation of leukocyte populations in human kidney tissue by multi-parameter flow cytometry

Kildey, Katrina, Law, Becker M. P., Muczynski, Kimberly A., Wilkinson, Ray, Healy, Helen and Kassianos, Andrew J. (2018). Identification and quantitation of leukocyte populations in human kidney tissue by multi-parameter flow cytometry. Bio-Protocol, 8 (16) ARTN e2980, e2980. doi: 10.21769/BioProtoc.2980

Identification and quantitation of leukocyte populations in human kidney tissue by multi-parameter flow cytometry

2018

Journal Article

Effector γδ T cells in human renal fibrosis and chronic kidney disease

Law, Becker Meng-Po, Wilkinson, Ray, Wang, Xiangju, Kildey, Katrina, Lindner, Mae, Beagley, Kenneth, Healy, Helen and Kassianos, Andrew J. (2018). Effector γδ T cells in human renal fibrosis and chronic kidney disease. Nephrology, Dialysis, Transplantation, 34 (1), 40-48. doi: 10.1093/ndt/gfy098

Effector γδ T cells in human renal fibrosis and chronic kidney disease

2017

Journal Article

Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression

Law, Becker M. P., Wilkinson, Ray, Wang, Xiangju, Kildey, Katrina, Lindner, Mae, Rist, Melissa J., Beagley, Kenneth, Healy, Helen and Kassianos, Andrew J. (2017). Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression. Kidney International, 92 (1), 79-88. doi: 10.1016/j.kint.2017.02.006

Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression

2017

Journal Article

Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Potriquet, Jeremy, Mulvenna, Jason, Lobb, Richard J., Moller, Andreas, Cloonan, Nicole, Mukhopadhyay, Pamela, Kassianos, Andrew J. and Healy, Helen (2017). Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions. Journal of Extracellular Vesicles, 6 (1) 1314073, 1314073-1314073. doi: 10.1080/20013078.2017.1314073

Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

2015

Journal Article

Human proximal tubule epithelial cells modulate autologous B-cell function

Sampangi, Sandeep, Wang, Xiangju, Beagley, Kenneth W., Klein, Travis, Afrin, Sadia, Healy, Helen, Wilkinson, Ray and Kassianos, Andrew J. (2015). Human proximal tubule epithelial cells modulate autologous B-cell function. Nephrology Dialysis Transplantation, 30 (10), 1674-1683. doi: 10.1093/ndt/gfv242

Human proximal tubule epithelial cells modulate autologous B-cell function

2015

Journal Article

The mechanisms of human renal epithelial cell modulation of autologous dendritic cell phenotype and function

Sampangi, Sandeep, Kassianos, Andrew J., Wang, Xiangju, Beagley, Kenneth W., Klein, Travis, Afrin, Sadia, Healy, Helen and Wilkinson, Ray (2015). The mechanisms of human renal epithelial cell modulation of autologous dendritic cell phenotype and function. PLoS One, 10 (7) e0134688, e0134688. doi: 10.1371/journal.pone.0134688

The mechanisms of human renal epithelial cell modulation of autologous dendritic cell phenotype and function

2015

Journal Article

Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells

Kassianos, Andrew J., Wang, Xiangju, Sampang, Sandeep, Afrin, Sadia, Wilkinson, Ray and Healy, Helen (2015). Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells. Kidney International, 87 (6), 1153-1163. doi: 10.1038/ki.2014.407

Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells

2015

Journal Article

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets

Chiang, Meng-Chieh, Tullett, Kirsteen M., Lee, Yoke Seng, Idris, Adi, Ding, Yitian, McDonald, Kylie J., Kassianos, Andrew, Leal Rojas, Ingrid M., Jeet, Varinder, Lahoud, Mireille H. and Radford, Kristen J. (2015). Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets. European Journal of Immunology, 46 (2), 329-339. doi: 10.1002/eji.201546023

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets

2014

Journal Article

Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease

Wilkinson, Ray, Wang, Xiangju, Kassianos, Andrew J., Zuryn, Steven, Roper, Kathrein E., Osborne, Andrew, Sampangi, Sandeep, Francis, Leo, Raghunath, Vishwas and Healy, Helen (2014). Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease. PLoS One, 9 (1) e87345, e87345.1-e87345.10. doi: 10.1371/journal.pone.0087345

Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease

2013

Journal Article

Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease

Kassianos, Andrew J., Wang, Xiangju, Sampangi, Sandeep, Muczynski, Kimberly, Healy, Helen and Wilkinson, Ray (2013). Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease. American Journal of Physiology - Renal Physiology, 305 (10), F1391-F1401. doi: 10.1152/ajprenal.00318.2013

Increased tubulointerstitial recruitment of human CD141hi CLEC9A+ and CD1c+ myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease

2013

Journal Article

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

2013

Journal Article

Human proximal tubule epithelial cells modulate autologous dendritic cell function

Kassianos, Andrew J., Sampangi, Sandeep, Wang, Xiangju, Roper, Kathrein E., Beagley, Ken, Healy, Helen and Wilkinson, Ray (2013). Human proximal tubule epithelial cells modulate autologous dendritic cell function. Nephrology Dialysis Transplantation, 28 (2), 303-312. doi: 10.1093/ndt/gfs136

Human proximal tubule epithelial cells modulate autologous dendritic cell function

2012

Journal Article

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli

Kassianos, Andrew J., Hardy, Melinda Y., Ju, Xinsheng, Vijayan, Dipti, Ding, Yitian, Vulink, Annelie J. E., McDonald, Kylie J., Jongbloed, Sarah L., Wadley, Robert B., Wells, Christine, Hart, Derek N. J. and Radford, Kristen J. (2012). Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli. European Journal of Immunology, 42 (6), 1512-1522. doi: 10.1002/eji.201142098

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli

2011

Journal Article

New approaches to immunotherapy for HPV associated cancer

Bergot, Anne-Sophie, Kassianos, Andrew, Frazer, Ian H. and Mittal, Deepak (2011). New approaches to immunotherapy for HPV associated cancer. Cancers, 3 (3), 3461-3495. doi: 10.3390/cancers3033461

New approaches to immunotherapy for HPV associated cancer

2011

Journal Article

CD34+ cord blood DC-induced antitumor lymphoid cells have efficacy in a murine xenograft model of human ALL

Cullup, Hannah, Hsu, Andy K. W., Kassianos, Andrew J., McDonald, Kylie, Radford, Kristen J. and Rice, Alison M. (2011). CD34+ cord blood DC-induced antitumor lymphoid cells have efficacy in a murine xenograft model of human ALL. Journal of Immunotherapy, 34 (4), 362-371. doi: 10.1097/CJI.0b013e31821b7230

CD34+ cord blood DC-induced antitumor lymphoid cells have efficacy in a murine xenograft model of human ALL

2010

Journal Article

Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Jongbloed, Sarah L., Kassianos, Andrew J., McDonald, Kylie J., Clark, Georgina J., Ju, Xinsheng, Angel, Catherine E., Chen, Chun-Jen J., Dunbar, P. Rod, Wadley, obert B., Jeet, Varinder, Vulink, Annelie J.E., Hart, Derek N.J. and Radford, Kristen J. (2010). Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. Journal of Experimental Medicine, 207 (6), 1247-1260. doi: 10.1084/jem.20092140

Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Funding

Past funding

  • 2020 - 2021
    Applying Spatial Transcriptomics to Discover Kidney Disease Pathways and Optimize Clinical Kidney Biopsy Assessment
    Metro North Hospital and Health Service
    Open grant

Supervision

Availability

Dr Andrew Kassianos is:
Available for supervision

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Available projects

  • Targeting the ‘wave of death’ check-points of chronic kidney disease (CKD)

    Principal Advisor: Dr Andrew Kassianos

    Email: Andrew.Kassianos@health.qld.gov.au

    Organisational unit: QIMR Berghofer and Royal Brisbane Clinical Unit

    Chronic kidney disease (CKD) is a worldwide public health burden, defined as decreased kidney function for >3months. In Australia alone, 1 in 3 adults (6 million people) are at risk of developing CKD, with the annual financial cost of CKD >$5 billion. Furthermore, there is no cure for CKD. Understanding the pathological mechanisms of CKD progression will fast-track the development of urgently needed clinical therapeutics.

    Our team have established specialised epithelial cells of the kidney proximal tubule (PTEC) as central players in CKD. Under the pathological conditions of CKD, we show that human PTEC:

    1. Undergo primary cell death;
    2. Release small extracellular vesicles (exosomes) from their (polarised) apical membrane that directly induce secondary cell death in adjacent healthy PTEC; and
    3. Produce danger signals (including exosomes) from their (polarised) basolateral membrane that activate local immune cells and indirectly induce secondary cell death in adjacent PTEC.

    This project will explore the therapeutic potential of targeting these ‘wave of death’ check-points in established pre-clinical human models of CKD. Outcomes of this proposal will have a major health impact in providing the rationale for innovative, evidence-based therapies for CKD. A PhD scholarship is available for this project.

Supervision history

Current supervision

  • Doctor Philosophy

    Familial hypercholesterolaemia: towards diagnosis in newborns

    Principal Advisor

  • Doctor Philosophy

    Therapeutic targeting of wave of death signalling in human kidney disease

    Associate Advisor

Completed supervision

Media

Enquiries

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