
Overview
Background
Dr Kassianos is a Senior Scientist at the Conjoint Internal Medical Laboratory, Queensland Health. Dr Kassianos has made significant contributions to understanding the cell-cell communication between discrete kidney cell and immune cell populations and the therapeutic potential of targeting this cross-talk in chronic kidney disease (CKD). Dr Kassianos has been integral in the development of innovative tools for CKD analytics: (i) in situ/ex vivo profiling for integrating CKD molecular profiles with histopathology; and (ii) preclinical models for screening novel CKD therapeutics. His research is internationally recognised in the field of CKD pathobiology.
Dr Kassianos has contributed to the fields of nephrology and immunology with 41 publications, >2000 career citations (~48 citations/paper) and invited international keynote lectures. Dr Kassianos has a continued record of success in attracting competitive research funding (>$2M as CI), including an NHMRC Dora Lush Scholarship (2007-2010), an RBWH Foundation Fellowship (2012-2014) and two NHMRC Project Grants as CIA (2016-2019; 2019-2022). Dr Kassianos has publications in high-ranking specialist (nephrology, immunology) and generalist journals, including five editorial commentaries in publication issues. These include 21 publications (~50% of his papers) as first or senior author/co-author – of which, 19 (90%) are in top field-weighted journals (Q1, top 10%), including Kidney Int, J Am Soc Nephrol, Cell Death Dis and J Extracell Vesicles. During this time, Dr Kassianos has supervised 5 Early Career Researchers, 5 PhD students (3 to completion) and 2 Masters students (both to completion). Dr Kassianos is also an Editor at Frontiers in Physiology and has contributed to 3 NHMRC grant review panels (2019-2021).
Availability
- Dr Andrew Kassianos is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Andrew Kassianos’s works on UQ eSpace
2021
Journal Article
Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions
Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Ungerer, Jacobus P. J., Hill, Michelle M., Shah, Alok K., Mohamed, Ahmed, Dutt, Mriga, Molendijk, Jeffrey, Healy, Helen and Kassianos, Andrew J. (2021). Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions. Journal of Extracellular Vesicles, 10 (4) e12064, e12064. doi: 10.1002/jev2.12064
2020
Journal Article
Oxidative stress and inflammasome activation in human rhabdomyolysis-induced acute kidney injury
Grivei, Anca, Giuliani, Kurt T.K., Wang, Xiangju, Ungerer, Jacobus, Francis, Leo, Hepburn, Kirsten, John, George T., Gois, Pedro F.H., Kassianos, Andrew J. and Healy, Helen (2020). Oxidative stress and inflammasome activation in human rhabdomyolysis-induced acute kidney injury. Free Radical Biology and Medicine, 160, 690-695. doi: 10.1016/j.freeradbiomed.2020.09.011
2020
Conference Publication
Spatial Transcriptomics (ST): Integrating Molecular Profiles with Histomorphology in Kidney Tissue Sections
Raghubar, Arti M., Pham, Duy T., Tan, Xiao, Grice, Laura F., Lam, Pui Yeng, Crawford, Joanna, Andersen, Stacey, Yoon, Sohye, Holland, Samuel E., Francis, Leo, Combes, Alexander N., Kassianos, Andrew J., Healy, Helen G., Nguyen, Quan and Mallett, Andrew J. (2020). Spatial Transcriptomics (ST): Integrating Molecular Profiles with Histomorphology in Kidney Tissue Sections. Kidney Week, Online, 19-25 October 2020. Washington, DC United States: American Society of Nephrology. doi: 10.1681/asn.20203110s112b
2020
Journal Article
The emerging role of renal tubular epithelial cells in the immunological pathophysiology of lupus nephritis
Hong, Seokchan, Healy, Helen and Kassianos, Andrew J. (2020). The emerging role of renal tubular epithelial cells in the immunological pathophysiology of lupus nephritis. Frontiers in Immunology, 11 578952, 578952. doi: 10.3389/fimmu.2020.578952
2020
Journal Article
The role of inflammation and inflammasome activation in human bile cast nephropathy
Giuliani, Kurt T. K., Kassianos, Andrew J., Kildey, Katrina, Grivei, Anca, Wang, Xiangju, Ungerer, Jacobus, Francis, Leo, Healy, Helen and Gois, Pedro F. H. (2020). The role of inflammation and inflammasome activation in human bile cast nephropathy. Nephrology, 25 (6) nep.13696, 502-506. doi: 10.1111/nep.13696
2020
Journal Article
Underlying histopathology determines response to oxidative stress in cultured human primary proximal tubular epithelial cells
Khan, Muhammad Ali, Wang, Xiangju, Giuliani, Kurt T. K., Nag, Purba, Grivei, Anca, Ungerer, Jacobus, Hoy, Wendy, Healy, Helen, Gobe, Glenda and Kassianos, Andrew J. (2020). Underlying histopathology determines response to oxidative stress in cultured human primary proximal tubular epithelial cells. International Journal of Molecular Sciences, 21 (2) 560, 1-15. doi: 10.3390/ijms21020560
2019
Journal Article
Specialized roles of human natural killer cell subsets in kidney transplant rejection
Kildey, Katrina, Francis, Ross S., Hultin, Sebastian, Harfield, Michelle, Giuliani, Kurt, Law, Becker M. P., Wang, Xiangju, See, Emily J., John, George, Ungerer, Jacobus, Wilkinson, Ray, Kassianos, Andrew J. and Healy, Helen (2019). Specialized roles of human natural killer cell subsets in kidney transplant rejection. Frontiers in Immunology, 10 (AUG) Article 1877, 1877. doi: 10.3389/fimmu.2019.01877
2019
Journal Article
Human tissue-resident mucosal-associated invariant T (MAIT) cells in renal fibrosis and CKD
Law, Becker M. P., Wilkinson, Ray, Wang, Xiangju, Kildey, Katrina, Giuliani, Kurt, Beagley, Kenneth W., Ungerer, Jacobus, Healy, Helen and Kassianos, Andrew J. (2019). Human tissue-resident mucosal-associated invariant T (MAIT) cells in renal fibrosis and CKD. Journal of the American Society of Nephrology, 30 (7), 1322-1335. doi: 10.1681/asn.2018101064
2019
Journal Article
Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease
Owens, Evan P., Vesey, David A., Kassianos, Andrew J., Healy, Helen, Hoy, Wendy E. and Gobe, Glenda C. (2019). Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease. Translational Andrology and Urology, 8 (S2), S175-S183. doi: 10.21037/tau.2018.11.03
2019
Journal Article
Pigment nephropathy: novel insights into inflammasome-mediated pathogenesis
Giuliani, Kurt T. K., Kassianos, Andrew J., Healy, Helen and Gois, Pedro H. F. (2019). Pigment nephropathy: novel insights into inflammasome-mediated pathogenesis. International Journal of Molecular Sciences, 20 (8) 1997, 1997. doi: 10.3390/ijms20081997
2019
Journal Article
Natural killer cells in kidney health and disease
Turner, Jan-Eric, Rickassel, Constantin, Healy, Helen and Kassianos, Andrew J. (2019). Natural killer cells in kidney health and disease. Frontiers in Immunology, 10 (March) 587. doi: 10.3389/fimmu.2019.00587
2018
Journal Article
The role of oxidative stress and inflammation in acute oxalate nephropathy associated with ethylene glycol intoxication
Wilson, Gregory J., Gois, Pedro H.F., Zhang, Alice, Wang, Xiangju, Law, Becker M.P., Kassianos, Andrew J. and Healy, Helen G. (2018). The role of oxidative stress and inflammation in acute oxalate nephropathy associated with ethylene glycol intoxication. Kidney International Reports, 3 (5), 1217-1221. doi: 10.1016/j.ekir.2018.05.005
2018
Journal Article
Identification and quantitation of leukocyte populations in human kidney tissue by multi-parameter flow cytometry
Kildey, Katrina, Law, Becker M. P., Muczynski, Kimberly A., Wilkinson, Ray, Healy, Helen and Kassianos, Andrew J. (2018). Identification and quantitation of leukocyte populations in human kidney tissue by multi-parameter flow cytometry. Bio-Protocol, 8 (16) e2980, e2980. doi: 10.21769/BioProtoc.2980
2018
Journal Article
Effector γδ T cells in human renal fibrosis and chronic kidney disease
Law, Becker Meng-Po, Wilkinson, Ray, Wang, Xiangju, Kildey, Katrina, Lindner, Mae, Beagley, Kenneth, Healy, Helen and Kassianos, Andrew J. (2018). Effector γδ T cells in human renal fibrosis and chronic kidney disease. Nephrology, Dialysis, Transplantation, 34 (1), 40-48. doi: 10.1093/ndt/gfy098
2017
Journal Article
Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression
Law, Becker M. P., Wilkinson, Ray, Wang, Xiangju, Kildey, Katrina, Lindner, Mae, Rist, Melissa J., Beagley, Kenneth, Healy, Helen and Kassianos, Andrew J. (2017). Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression. Kidney International, 92 (1), 79-88. doi: 10.1016/j.kint.2017.02.006
2017
Journal Article
Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions
Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Potriquet, Jeremy, Mulvenna, Jason, Lobb, Richard J., Moller, Andreas, Cloonan, Nicole, Mukhopadhyay, Pamela, Kassianos, Andrew J. and Healy, Helen (2017). Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions. Journal of Extracellular Vesicles, 6 (1) 1314073, 1314073-1314073. doi: 10.1080/20013078.2017.1314073
2015
Journal Article
Human proximal tubule epithelial cells modulate autologous B-cell function
Sampangi, Sandeep, Wang, Xiangju, Beagley, Kenneth W., Klein, Travis, Afrin, Sadia, Healy, Helen, Wilkinson, Ray and Kassianos, Andrew J. (2015). Human proximal tubule epithelial cells modulate autologous B-cell function. Nephrology Dialysis Transplantation, 30 (10), 1674-1683. doi: 10.1093/ndt/gfv242
2015
Journal Article
The mechanisms of human renal epithelial cell modulation of autologous dendritic cell phenotype and function
Sampangi, Sandeep, Kassianos, Andrew J., Wang, Xiangju, Beagley, Kenneth W., Klein, Travis, Afrin, Sadia, Healy, Helen and Wilkinson, Ray (2015). The mechanisms of human renal epithelial cell modulation of autologous dendritic cell phenotype and function. PLoS One, 10 (7) e0134688, e0134688. doi: 10.1371/journal.pone.0134688
2015
Journal Article
Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells
Kassianos, Andrew J., Wang, Xiangju, Sampang, Sandeep, Afrin, Sadia, Wilkinson, Ray and Healy, Helen (2015). Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells. Kidney International, 87 (6), 1153-1163. doi: 10.1038/ki.2014.407
2015
Journal Article
Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets
Chiang, Meng-Chieh, Tullett, Kirsteen M., Lee, Yoke Seng, Idris, Adi, Ding, Yitian, McDonald, Kylie J., Kassianos, Andrew, Leal Rojas, Ingrid M., Jeet, Varinder, Lahoud, Mireille H. and Radford, Kristen J. (2015). Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets. European Journal of Immunology, 46 (2), 329-339. doi: 10.1002/eji.201546023
Funding
Past funding
Supervision
Availability
- Dr Andrew Kassianos is:
- Available for supervision
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Available projects
-
Targeting the ‘wave of death’ check-points of chronic kidney disease (CKD)
Principal Advisor: Dr Andrew Kassianos
Email: Andrew.Kassianos@health.qld.gov.au
Organisational unit: QIMR Berghofer and Royal Brisbane Clinical Unit
Chronic kidney disease (CKD) is a worldwide public health burden, defined as decreased kidney function for >3months. In Australia alone, 1 in 3 adults (6 million people) are at risk of developing CKD, with the annual financial cost of CKD >$5 billion. Furthermore, there is no cure for CKD. Understanding the pathological mechanisms of CKD progression will fast-track the development of urgently needed clinical therapeutics.
Our team have established specialised epithelial cells of the kidney proximal tubule (PTEC) as central players in CKD. Under the pathological conditions of CKD, we show that human PTEC:
- Undergo primary cell death;
- Release small extracellular vesicles (exosomes) from their (polarised) apical membrane that directly induce secondary cell death in adjacent healthy PTEC; and
- Produce danger signals (including exosomes) from their (polarised) basolateral membrane that activate local immune cells and indirectly induce secondary cell death in adjacent PTEC.
This project will explore the therapeutic potential of targeting these ‘wave of death’ check-points in established pre-clinical human models of CKD. Outcomes of this proposal will have a major health impact in providing the rationale for innovative, evidence-based therapies for CKD. A PhD scholarship is available for this project.
Supervision history
Current supervision
-
Doctor Philosophy
Familial hypercholesterolaemia: towards diagnosis in newborns
Principal Advisor
-
Doctor Philosophy
Therapeutic targeting of wave of death signalling in human kidney disease
Associate Advisor
-
Doctor Philosophy
Leveraging complex cellular models and extracellular vesicles to reveal novel druggable targets in polycystic kidney disease
Associate Advisor
Completed supervision
-
2023
Doctor Philosophy
Defining the cellular milieu within the clear cell renal cell carcinoma microenvironment
Associate Advisor
Other advisors: Dr Quan Nguyen, Dr Andrew Mallett
-
2023
Doctor Philosophy
Kidneys on fire: The role of inflammasome signalling in human chronic kidney disease
Associate Advisor
Other advisors: Honorary Professor Josephine Forbes
-
2022
Doctor Philosophy
Use of Bioactive Compounds of Plants for the Treatment of Chronic Kidney Disease
Associate Advisor
Media
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