Associate Professor Anne Lagendijk
Associate Professor

Anne Lagendijk

Email: 
Phone: 
+61 7 334 62105

Availability

Associate Professor Anne Lagendijk is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Utrecht University

Research interests

  • Cellular mechanisms to maintain a healthy vasculature

    Our vascular system transports approximately 7500 liters of blood each day. Arteries deliver oxygen and nutrients throughout the body after which the venous system returns the deoxygenated blood back to the heart. Architecturally, these blood vessels are extremely heterogeneous. The Lagendijk group investigates the development and maintenance of a functional blood vessel network in zebrafish and bioengineered human microvessels. The cells that make up our blood vessels continuously adapt their size, adhesiveness and compliance order to ensure the right balance between vessel integrity and permeability in a context dependent manner. Mechanical cues play a major role in the functional adaptation of blood vessels. Despite ongoing research unraveling the structural components of mechanical hubs in the cells, it is essential to assess the magnitude of forces that are transduced at these sites and the biological consequences for vessel function. Dr. Lagendijk has previously developed a VE-cadherin tension biosensor line in zebrafish. This line provides the first vertebrate model that reports intra-molecular tension and was utilised to identify changes in junctional organisation and VE-cadherin tension that occur as arteries mature and revealed molecular pathways that allow for this maturation to happen. In addition, the lab has established disease models for vascular malformations that are known to lead to neurological deficits and stroke. Modelling in zebrafish allows analyses of the initiating mechanisms of these vascular pathologies at unprecedented cellular and subcellular resolution.

Search Professor Anne Lagendijk’s works on UQ eSpace

51 works between 2006 and 2024
All (51) Journal Article (45) Book Chapter (1) Conference Publication (3) Other Outputs (2)

21 - 40 of 51 works

2019

Journal Article

Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling

Ando, Koji, Wang, Weili, Peng, Di, Chiba, Ayano, Lagendijk, Anne K., Barske, Lindsey, Crump, J. Gage, Stainier, Didier Y. R., Lendahl, Urban, Koltowska, Katarzyna, Hogan, Benjamin M., Fukuhara, Shigetomo, Mochizuki, Naoki and Betsholtz, Christer (2019). Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling. Development, 146 (2) dev165589, dev165589. doi: 10.1242/dev.165589

Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling

2018

Journal Article

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction

Paatero, Ilkka, Sauteur, Loïc, Lee, Minkyoung, Lagendijk, Anne K., Heutschi, Daniel, Wiesner, Cora, Guzmán, Camilo, Bieli, Dimitri, Hogan, Benjamin M., Affolter, Markus and Belting, Heinz-Georg (2018). Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction. Nature Communications, 9 (1) 3545, 3545. doi: 10.1038/s41467-018-05851-9

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction

2018

Journal Article

Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume

Grassini, Daniela R., Lagendijk, Anne K., De Angelis, Jessica E., Da Silva, Jason, Jeanes, Angela, Zettler, Nicole, Bower, Neil I., Hogan, Benjamin M. and Smith, Kelly A. (2018). Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume. Development, 145 (12) dev160739, dev160739. doi: 10.1242/dev.160739

Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume

2018

Journal Article

Notching a new pathway in vascular flow sensing

Lagendijk, Anne K., Yap, Alpha S. and Hogan, Benjamin M. (2018). Notching a new pathway in vascular flow sensing. Trends in Cell Biology, 28 (3), 173-175. doi: 10.1016/j.tcb.2017.12.003

Notching a new pathway in vascular flow sensing

2017

Journal Article

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

Lagendijk, Anne Karine, Gomez, Guillermo A, Baek, Sungmin, Hesselson, Daniel, Hughes, William E, Paterson, Scott, Conway, Daniel E, Belting, Heinz-Georg, Affolter, Markus, Smith, Kelly A, Schwartz, Martin A, Yap, Alpha S and Hogan, Benjamin M (2017). Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish. Nature communications, 8 (1) 1402, 1-12. doi: 10.1038/s41467-017-01325-6

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

2017

Journal Article

Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (vol 144, pg 2629, 2017)

Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Fossat, Nicolas, Radziewic, Tania, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Tam, Patrick P. L., Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin M., Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (vol 144, pg 2629, 2017). Development, 144 (20), 3847-3848. doi: 10.1242/dev.159715

Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (vol 144, pg 2629, 2017)

2017

Journal Article

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin, Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144 (14), 2629-2639. doi: 10.1242/dev.146241

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

2017

Journal Article

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

Bower, Neil I., Koltowska, Katarzyna, Pichol-Thievend, Cathy, Virshup, Isaac, Paterson, Scott, Lagendijk, Anne K., Wang, Weili, Lindsey, Benjamin W., Bent, Stephen J., Baek, Sungmin, Rondon-Galeano, Maria, Hurley, Daniel G., Mochizuki, Naoki, Simons, Cas, Francois, Mathias, Wells, Christine A., Kaslin, Jan and Hogan, Benjamin M. (2017). Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience, 20 (6), 774-783. doi: 10.1038/nn.4558

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

2017

Journal Article

Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136)

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005

Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136)

2017

Journal Article

Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017

Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover

2017

Conference Publication

Lymphatic and facial defects 1 regulates expansion of the lymphatic endothelial cell lineage upon its emergence from the cardinal vein

Koltowska, Kaska, Paterson, Scott, Lagendijk, Anne Karine, Chen, Huijun, Baillie, Gregory, Leshchiner, Ignat, Geossling, Wolfram, Smith, Kelly, Simons, Cas, Schulte-Merker, Stefan and Hogan, Ben (2017). Lymphatic and facial defects 1 regulates expansion of the lymphatic endothelial cell lineage upon its emergence from the cardinal vein. 18th International Congress of Developmental Biology, Singapore, Singapore, 18 - 22 June 2017. Shannon, Clare Ireland: Elsevier. doi: 10.1016/j.mod.2017.04.447

Lymphatic and facial defects 1 regulates expansion of the lymphatic endothelial cell lineage upon its emergence from the cardinal vein

2016

Journal Article

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

San, Bilge, Chrispijn, Naomi D., Wittkopp, Nadine, Van Heeringen, Simon J., Lagendijk, Anne K., Aben, Marco, Bakkers, Jeroen, Ketting, Rene F. and Kamminga, Leonie M. (2016). Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports, 6 (1) 24658. doi: 10.1038/srep24658

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

2015

Journal Article

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish

Koltowska, Katarzyna, Paterson, Scott, Bower, Neil I., Baillie, Gregory J., Lagendijk, Anne K., Astin, Jonathan W., Chen, Huijun, Francois, Mathias, Crosier, Philip S., Taft, Ryan J., Simons, Cas, Smith, Kelly A. and Hogan, Benjamin M. (2015). mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes and Development, 29 (15), 1618-1630. doi: 10.1101/gad.263210.115

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish

2015

Journal Article

Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish

Koltowska, Katarzyna, Lagendijk, Anne K., Pichol-Thievend, Cathy, Fischer, Johanna C., Francois, Mathias, Ober, Elke A., Yap, Alpha S. and Hogan, Benjamin M. (2015). Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish. Cell Reports, 13 (9), 1828-1841. doi: 10.1016/j.celrep.2015.10.055

Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish

2015

Journal Article

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

Wu, Selwin K., Lagendijk, Anne K., Hogan, Benjamin M., Gomez, Guillermo A. and Yap, Alpha S. (2015). Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer. Cell Cycle, 14 (3), 315-322. doi: 10.4161/15384101.2014.989127

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

2015

Book Chapter

VE-cadherin in Vascular Development: A Coordinator of Cell Signaling and Tissue Morphogenesis

Lagendijk, Anne Karine and Hogan, Benjamin M. (2015). VE-cadherin in Vascular Development: A Coordinator of Cell Signaling and Tissue Morphogenesis. Cellular Adhesion in Development and Disease. (pp. 325-352) edited by Alpha S. Yap. Maryland Heights, MO United States: Academic Press. doi: 10.1016/bs.ctdb.2014.11.024

VE-cadherin in Vascular Development: A Coordinator of Cell Signaling and Tissue Morphogenesis

2014

Conference Publication

A large-scale phenotype-to-genotype screen identifies regulators of cardiac development and function

Smith, K., Paterson, S., Capon, S., De Angelis, J., Grassini, D., Lagendijk, A., Bailey, G., Simons, C., Taft, R. and Hogan, B. (2014). A large-scale phenotype-to-genotype screen identifies regulators of cardiac development and function. International Clinical Cardiovascular Genetics Conference, Brisbane, Australia, 6-9 August 2014. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2014.07.045

A large-scale phenotype-to-genotype screen identifies regulators of cardiac development and function

2014

Journal Article

Endothelial cell-cell adhesion during zebrafish vascular development

Lagendijk, Anne Karine, Yap, Alpha S. and Hogan, Benjamin M. (2014). Endothelial cell-cell adhesion during zebrafish vascular development. Cell Adhesion and Migration, 8 (2), 136-145. doi: 10.4161/cam.28229

Endothelial cell-cell adhesion during zebrafish vascular development

2013

Journal Article

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

Goudarzi, Mehdi, Strate, Ina, Paksa, Azadeh, Lagendijk, Anne-Karine, Bakkers, Jeroen and Raz, Erez (2013). On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nature Genetics, 45 (11), 1264-1265. doi: 10.1038/ng.2793

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

2013

Journal Article

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Lagendijk, Anne Karine, Szabó, András, Merks, Roeland M. H. and Bakkers, Jeroen (2013). Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation. Trends in Cardiovascular Medicine, 23 (5), 135-142. doi: 10.1016/j.tcm.2012.10.002

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Current funding

  • 2024 - 2027
    Discovering therapeutic vulnerabilities of circulating melanoma clusters
    United States Congressionally Directed Medical Research Programs - Melanoma Research Program
    Open grant
  • 2024 - 2027
    The impact of Hyaluronic Acid on growth factor signalling and angiogenesis (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2027
    Validating new druggable pathways for cerebral cavernous malformations
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    Identifying genetic and lifestyle determinants of abdominal aortic calcification that predispose to cardiovascular disease (MRFF Cardiovascular Health Mission Grant administered by Edith Cowan Uni)
    Edith Cowan University
    Open grant
  • 2023 - 2026
    Adrenomedullin: a specific regulator of venous vessel integrity
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Integrating innovative models of the brain microenvironment to identify new treatment strategies for medulloblastoma
    The Cure Starts Now Australia
    Open grant
  • 2022 - 2025
    Epithelial mechanics and the fate of cancer
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2025
    Blood Brain Barrier Program (Carrie Bickmore's Beanies 4 Brain Cancer Limited grant administered by The Walter and Eliza Hall Institute of Medical Research)
    Walter & Eliza Hall Institute of Medical Research (WEHI)
    Open grant

Past funding

  • 2023 - 2024
    Integrating innovative models of the brain microenvironment to identify new treatment strategies for medulloblastoma
    The Cure Starts Now Foundation
    Open grant
  • 2023
    IMB Stroke research led by Dr Anne Lagendijk
    Research Donation Generic
    Open grant
  • 2023
    Improving the accuracy of CCM modelling
    Be Brave for Life Foundation
    Open grant
  • 2020 - 2024
    Integrating innovative models of the brain microenvironment to identify new treatment strategies for medulloblastoma
    Brainchild Foundation
    Open grant
  • 2020
    Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation (NHMRC Project Grant administered by The University of Melbourne)
    University of Melbourne
    Open grant
  • 2020 - 2023
    Defining mechanisms behind the formation of hierarchical vascular networks
    ARC Discovery Projects
    Open grant
  • 2017 - 2020
    Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    The contribution of cell-cell forces to vascular morphogenesis
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Associate Professor Anne Lagendijk is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • How to make and maintain a healthy vasculature

    Our group aims to understand how our blood vessel network is established during embryonic development and how its function is maintained during life. The development of an aberrant vessel network contributes to a range of cardio-vascular diseases. For example leaky vessels in the brain can cause stroke. In the lab we employ the zebrafish as a model organism since zebrafish embryos are viable ex utero and can be imaged at extremely high resolution which gives us a unique, live, view of vascular development. We make use of existing and novel biosensors in zebrafish to reveal dynamics of adhesion complexes at the cell-cell and cell-matrix interface whilst also examining distribution of tension at these mechanical hubs. By combining these high-end imaging approaches with detailed, innovative molecular genetics approaches, like CRISPR mutagenesis, we explore the fundamental importance of cell-matrix adhesion in vascular biology. We complement this in vivo modelling with analysis of bioengineered human micro-vessels. This adaptable system allows us to detail the impact of physical cues by the environment and by blood flow.

    PhD projects include:

    - The role of neuropeptides in establishing and maintaining blood vessels in zebrafish and 3D bioengineered human vessels.

    - Using CRISPR mutagenesis to uncover novel players that drive a vascular disease that can cause stroke.

    - Modelling how the brain vasculature impacts on brain tumors growth and cancer treatment using zebrafish models.

    - Profiling changes in tension across wild-type and mutant forms of the adhesion protein VE-cadherin using in vivo live imaging.

    - The impact of cell-matrix interactions on vascular growth in zebrafish mutant models.

Supervision history

Current supervision

  • Doctor Philosophy

    Characterisation of a molecular pathway controlling cell-cell adhesion in veins but not arteries

    Principal Advisor

    Other advisors: Professor Alpha Yap

  • Doctor Philosophy

    Investigating the role of the blood vasculature in Medulloblastoma progression using zebrafish models

    Principal Advisor

    Other advisors: Dr Laura Genovesi, Dr Emma Gordon

  • Doctor Philosophy

    Uncovering dynamic changes in tumour associated vasculature using zebrafish models

    Principal Advisor

    Other advisors: Dr Laura Genovesi, Dr Emma Gordon

  • Doctor Philosophy

    Uncovering why CCM vascular malformations are restricted to the brain.

    Principal Advisor

    Other advisors: Professor Robert Parton

  • Doctor Philosophy

    Targetting blood vessel dysfunction in disease

    Principal Advisor

    Other advisors: Dr Samantha Stehbens, Dr Emma Gordon

  • Doctor Philosophy

    Investigating the mechanosensory properties of blood vessels

    Principal Advisor

    Other advisors: Dr Samantha Stehbens, Dr Emma Gordon

  • Doctor Philosophy

    Targetting blood vessel dysfunction in disease

    Principal Advisor

    Other advisors: Dr Samantha Stehbens, Dr Emma Gordon

  • Doctor Philosophy

    Investigating the role of the blood vasculature in Medulloblastoma progression using zebrafish models

    Principal Advisor

    Other advisors: Dr Laura Genovesi, Dr Emma Gordon

  • Doctor Philosophy

    Characterisation of a molecular pathway controlling cell-cell adhesion in veins but not arteries

    Principal Advisor

    Other advisors: Professor Alpha Yap

  • Doctor Philosophy

    Characterisation of a molecular pathway controlling cell-cell adhesion in veins but not arteries

    Principal Advisor

    Other advisors: Professor Alpha Yap

  • Doctor Philosophy

    The role of c-Src in facilitating endothelial dysfunction in aortic disease

    Associate Advisor

    Other advisors: Dr Emma Gordon, Dr Lilian Schimmel

  • Doctor Philosophy

    The role of c-Src in facilitating endothelial dysfunction in aortic disease

    Associate Advisor

    Other advisors: Dr Emma Gordon, Dr Lilian Schimmel

  • Doctor Philosophy

    The role of c-Src in facilitating endothelial dysfunction in aortic disease

    Associate Advisor

    Other advisors: Dr Emma Gordon, Dr Lilian Schimmel

  • Doctor Philosophy

    How the interaction between blood flow forces and ECM controls vessel assembly and function during development

    Associate Advisor

    Other advisors: Dr Mel White

Completed supervision

Enquiries

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