![Dr Samantha Stehbens](/sites/default/files/profiles/17029.jpeg)
Overview
Background
Dr Stehbens is a cell biologist with a long-standing interest in understanding the fundamental mechanisms that regulate cell adhesion and the cytoskeleton. She has made key contributions to the fields of quantitative microscopy, cell motility, adhesion and the cytoskeleton with publications spanning multiple fields from ion channels in brain cancer, to growth factor signalling and autophagy. Her research group (joint between AIBN and IMB) aims to understand the fundamental principles of how cells integrate secreted and biomechanical signals from their local microenvironment to facilitate movement and survival. They have uncovered an entirely novel role for the microtubule cytoskeleton in protecting cells from cortical and nuclear rupture during cell migration in 3D cell migration and invasion. Using patient-derived tumour cells, coupled to genetic alteration and substrate microfabrication, they use state-of-the-art microscopy to understand the mechanisms of cell migratory behaviour required for cancer cells to traverse the body during metastasis.
Her graduate work in the laboratory of Alpha Yap (IMB IQ) discovered how the microtubule cytoskeleton regulates cell-cell adhesion. After which she relocated to The University of California San Francisco (UCSF) to work with Prof Wittmann, a microtubule biologist who is an expert in live-cell spinning disc microscopy. Here she worked at the cutting edge of biology imaging advancements as the greater bay area research community combines several of the top-laboratories for imaging technologies. Supported by a competitive American Heart Fellowship Post-Doctoral fellowship, she identified how microtubules coordinate protease secretion during migration to mediate cell-matrix adhesion disassembly. In 2013, she returned to Australia to expand her imaging-based skill set to focus on models of cancer cell biology. Working with Prof. Pamela Pollock (QUT) she uncovered how activating FGFR2 mutations resulted in a loss of cell polarity potentiating migration and invasion in endometrial cancer. Following this, she worked with Prof. Nikolas Haass (UQDI) a melanoma expert, investigating the role of microtubule +TIP proteins in 3D models of metastatic invasion before starting her lab at the Institute for Molecular Bioscience as an ARC Future Fellow.
Lab Overview
Cells in living organisms navigate highly crowded three-dimensional environments, where their coordinated migration provides the driving force behind developmental and homeostatic tissue maintenance. Our research aims to understand the fundamental principles underpinning how cells integrate secreted and biomechanical signals from their local microenvironment to facilitate cell movement and survival. We apply these findings to understand how cancer cells exploit this to metastasise or spread to distal tissues. We hypothesise that targeting the crosstalk between the cytoskeleton and the mechanical micro-environment, can be developed as an anti-metastatic approach.
Cancer cells spread aggressively through tissues by adapting their cell shape to fit the environment in addition to altering their environment so they can squeeze through tight tissue spaces. Cancer cells sense and become more invasive following changes in the biophysical properties their microenvironment including increases in stromal stiffness and interstitial fluid pressures. These changes make cancer cells mechanically compliant and adaptive to fluctuations in their surrounding environment allowing them to alter their shape to fit matrix physical attributes. As such, cells need mechanisms in place to 1) detect these physical limits, 2) deform their cortex whilst producing mechanical force for forward locomotion and 3) orient themselves to move through tissues. We focus on understanding- at the molecular level- how the microtubule cytoskeleton and microtubule associated proteins called +TIPs, regulate how cells move through physically challenging environments. To do this we utilize cutting-edge methodology including microchannel fabrication, novel light sheet microscopy, quantitative imaging methods in combination with patient-derived cell and 3D hydrogel models to recapitulate the 3D microenvironment.
Our research areas include:
- Cytoskeleton
- Cell adhesion
- Cell migration
- Cell mechanics
- Cancer cell biology
Areas of Expertise
Microtubules and Cell-Cell Adhesion
My early research, in the laboratory of Professor Alpha Yap, focused on understanding how the microtubule cytoskeleton regulates E-cadherin-based cell-cell adhesion. This work was the first to discover that it was the dynamacity, not simply the tethering, of the microtubule cytoskeleton that was critical for E-cadherin accumulation and junctional reinforcement. This was in addition to defining a previously unappreciated role for the cytokinetic machinery (Ect2) in regulating cell-cell adhesion
- Stehbens, S.J., …,and Yap, A. S. (2006). Dynamic Microtubules Regulate the Local Concentration of E-cadherin at Cell-Cell Contacts. Journal of Cell Science 119: 1801-1811
- Ratheesh, A., … Stehbens, S.J., and Yap, A.S. (2012). Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nature Cell Biology 14(8): 818-28
Microtubules and Cell-Matrix Adhesion
Following my PhD, I relocated to the University of California San Francisco to work with Professor Torsten Wittmann, an expert in live-cell spinning disc microscopy and microtubule functions during cell motility. This work was dogma changing and established how the microtubule interacting protein, CLASP, facilitates targeted protease secretion at focal adhesions during epithelial sheet migration to mediate cell-matrix adhesion disassembly, from the inside-out. It includes the first observation of live, directed exocytosis of the matrix protease MT1MMP at focal adhesions. Our work pioneered the combined application of quantitative live-cell protein dynamics and the application of the novel super resolution imaging technique, SAIM (Scanning Angle Interference Microscopy). During my time at UCSF I learnt how to custom design live-cell microscopes with these live-cell imaging platforms now commercially distributed as the Spectral Diskovery and Andor Dragonfly.
- Stehbens, S.J., … and Wittmann., T (2014). CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nature Cell Biology 16(6): 558-570
- Stehbens, S.J., and Witmann, T. (2014) Analysis of focal adhesion turnover: a quantitative live-cell imaging example. Methods in Cell Biology 123: 335-46
- Stehbens, S.J., and Witmann, T. (2012) Targeting and transport: how microtubules control focal adhesion dynamics. Journal of Cell Biology 20, 198(4): 481-9
Cell Morphology and Cancer Biology
In 2013 I returned to Australia, joining the lab of Pamela Pollock with focus on applying my skill set to have translational impact. Here I described the impact of activating FGFR2b-mutations on endometrial cancer progession. These findings uncovered collective cell polarity and invasion as common targets of disease-associated FGFR2 mutations that lead to shorter survival in endometrial cancer patients.
Stehbens, S.J, Ju, R.J and Pollock P.M. (2018) FGFR2b activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer. Journal of Cell Science, 131(15)
Microtubules in Metastatic Plasticity
In 2017, I joined the Experimental Melanoma Group at UQDI, where I work together with Professor Nikolas Haass in applying innovative live-cell spinning disc confocal imaging and biosensor approaches to understand cell-cell and cell-matrix interactions of melanoma with its microenvironment. Our work explores the adaptive role that the microtubule cytoskeleton plays in facilitating cell shape plasticity, matrix remodelling and resistance to compression during migration in complex 3D matrix models of metastatic melanoma invasion. We are fundamentally interested in understanding the reciprocal biophysical relationship between the microtubule cytoskeleton and the microenvironment during melanoma invasion, with the aim to expand our findings to other metastatic cancers.
Ju, Robert J., Stehbens, Samantha J., Haass, Nikolas K. 2018, ‘The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis’, Frontiers in Medicine, vol. 5
Availability
- Dr Samantha Stehbens is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Microtubules, motility and mechanics
Innovative imaging and cell biology approaches have recently uncovered novel biology that is unique to cells navigating confined 3Dimensional spaces vs 2D, underlining the significance of understanding cell migration and invasion in mechanically relevant cell culture models. As a cell navigates its local environment, the adaptive migration strategies they deploy are greatly influenced by the physical parameters of the microenvironment. As such, the mechanical interrelationship between the cell cytoskeleton, adhesion, and the matrix is an exciting emergent research theme. My lab's current work focuses on understanding the fundamental mechanisms governing the bi-directional relationship between cells and extracellular matrix during 3D invasion with a focus on the contribution of the microtubule cytoskeleton in a metastatic cancer setting. Metastatic success requires cells to navigate complex cellular environments, adapting either their shape to navigate between matrix fibres or adapting their environment to facilitate movement between tight spaces. We are interested in: Microtubule-dependent positioning of organelles, implications for cell migration Understanding the role of microtubules in protecting cells from mechanical stress Regulation of protease secretion in 3D environments by biophysical cues; can cells "digest on demand"? How do cells cluster in low adhesion environments and how does this promote survival in fluid environments like the lymph or vasculature?
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Microtubules in Metastatic Melanoma Invasion
We explore the adaptive role that the microtubule cytoskeleton plays in facilitating cell shape plasticity, matrix remodelling and resistance to compression during migration in complex 3D matrix models of metastatic melanoma invasion. We aim to understand the role of the mechano-environment in metastatic disease and therapy resistance. To do this we apply innovative live-cell imaging technologies, microfluidics and biosensor approaches to understand cell-cell and cell-matrix interactions of melanoma with its microenvironment.
Research impacts
Our research aims to
- facilitate the development of advanced imaging techniques and technology, by bridging the gap between optical physicists and fundamental biologists to facilitate the transition of these technologies into research institutes both within Australia and around the world.
- Understanding metastasis to open new therapeutics opportunities. As tumours proliferate uncontrollably, the focus of clinical therapies for cancer have concentrated on the development of effective cytotoxic drugs. This era of tumour biology has defined the key response criteria for therapeutic agents targeting solid cancers as a reduction in tumour size. However, with the gain of an invasive phenotype being necessary for a tumour to metastasise, and the association of morbidity with metastatic disease, there is a strong precedent to refocus our efforts to understand metastasis. Thus, to bring about revolutionary improvements our understanding of cancer biology we need to not only study proliferation but focus towards the microenvironment and understanding how tumour cells adapt to move. Our work will open this new frontier by bringing key mechanistic insights of metastasis with the potential to reveal new therapeutical leads.
Works
Search Professor Samantha Stehbens’s works on UQ eSpace
2024
Journal Article
Adaptive microtubule reinforcement enables cell migration through 3D environments
Ju, Robert J. and Stehbens, Samantha J. (2024). Adaptive microtubule reinforcement enables cell migration through 3D environments. Nature Cell Biology. doi: 10.1038/s41556-024-01477-w
2024
Journal Article
Compression-dependent microtubule reinforcement enables cells to navigate confined environments
Ju, Robert J., Falconer, Alistair D., Schmidt, Christanny J., Martinez, Marco A. Enriquez, Dean, Kevin M., Fiolka, Reto P., Sester, David P., Nobis, Max, Timpson, Paul, Lomakin, Alexis J., Danuser, Gaudenz, White, Melanie D., Haass, Nikolas K., Oelz, Dietmar B. and Stehbens, Samantha J. (2024). Compression-dependent microtubule reinforcement enables cells to navigate confined environments. Nature Cell Biology. doi: 10.1038/s41556-024-01476-x
2024
Journal Article
c-Src induced vascular malformations require localised matrix degradation at focal adhesions
Essebier, Patricia, Keyser, Mikaela, Yordanov, Teodor, Hill, Brittany, Yu, Alexander, Noordstra, Ivar, Yap, Alpha S., Stehbens, Samantha J., Lagendijk, Anne K., Schimmel, Lilian and Gordon, Emma J. (2024). c-Src induced vascular malformations require localised matrix degradation at focal adhesions. Journal of Cell Science, 137 (13) jcs262101. doi: 10.1242/jcs.262101
2024
Journal Article
Perspectives in collective cell migration – moving forward
Stehbens, Samantha J., Scarpa, Elena and White, Melanie D. (2024). Perspectives in collective cell migration – moving forward. Journal of Cell Science, 137 (12) jcs261549. doi: 10.1242/jcs.261549
2024
Conference Publication
Uncovering Microtubule-driven Mechanisms of Melanoma Invasion
Ju, R. J., Falconer, A. D., Dean, K. M., Fiolka, R. P., Sester, D. P., Nobis, M., Timpson, P., Lomakin, A. J., Danuser, G., White, M. D., Oelz, D. B., Haass, N. K. and Stehbens, S. J. (2024). Uncovering Microtubule-driven Mechanisms of Melanoma Invasion. 50th Annual Meeting of the Dermatological Research Working Group (ADF), Dusseldorf, Germany, 6-9 March 2024. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
2024
Journal Article
Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
Yordanov, Teodor E., Keyser, Mikaela S., Enriquez Martinez, Marco A., Esposito, Tyron, Tefft, Juliann B., Morris, Elysse K., Labzin, Larisa I., Stehbens, Samantha J., Rowan, Alan E., Hogan, Benjamin M., Chen, Christopher S., Lauko, Jan and Lagendijk, Anne K. (2024). Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioengineering, 8 (1) 016108, 016108. doi: 10.1063/5.0159330
2024
Journal Article
Microtubule control of migration: Coordination in confinement
Schmidt, Christanny J. and Stehbens, Samantha J. (2024). Microtubule control of migration: Coordination in confinement. Current Opinion in Cell Biology, 86 102289, 102289. doi: 10.1016/j.ceb.2023.102289
2024
Journal Article
Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration
Jin, Wanli, Stehbens, Samantha J., Barnard, Ross T., Blaskovich, Mark A. T. and Ziora, Zyta M. (2024). Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration. Journal of Pharmacy and Pharmacology, 76 (1), 13-22. doi: 10.1093/jpp/rgad107
2023
Conference Publication
Uncovering Dynamic Changes In Medulloblastoma Associated Vasculature In Zebrafish
Morris, Elysse, Daignault-Mill, Sheena, Ju, Robert J., da Silva, Jason, Gordon, Emma, Wainwright, Brandon, Stehbens, Samantha, Genovesi, Laura and Lagendijk, Anne (2023). Uncovering Dynamic Changes In Medulloblastoma Associated Vasculature In Zebrafish. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad073.274
2023
Journal Article
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
2023
Conference Publication
MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma
Spoerri, L., Tonnessen-Murray, C. A., Beaumont, K. A., Hill, D. S., Jurek, R. J., Gunasingh, G., Vanwalleghem, G., Daignault, S., Fane, M. E., Schaider, H., Smith, A., Stehbens, S. J., Weninger, W., Scott, E. E., Gabrielli, B. and Haass, N. (2023). MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma. Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, 11-14 March 2020. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
2023
Conference Publication
Uncovering biomechanically regulated cellular processes of melanoma cell invasion and survival in confined environments
Ju, R. J., Chhabra, Y., Stehbens, S. J. and Haass, N. (2023). Uncovering biomechanically regulated cellular processes of melanoma cell invasion and survival in confined environments. Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, 11-14 March 2020. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
2023
Conference Publication
Bortezomib induces immunogenic cell death in melanoma and enhances immune response in vivo
Daignault, S., Ju, R. J., Spoerri, L., Stehbens, S. J., Hill, D. S., Dolcetti, R. and Haass, N. (2023). Bortezomib induces immunogenic cell death in melanoma and enhances immune response in vivo. Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, 11-14 March 2020. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
2023
Journal Article
Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models
Morris, Elysse K., Daignault-Mill, Sheena, Stehbens, Samantha J., Genovesi, Laura A. and Lagendijk, Anne K. (2023). Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models. Frontiers in Oncology, 13 1101522, 1-9. doi: 10.3389/fonc.2023.1101522
2022
Journal Article
Editorial: Forces in biology - Cell and developmental mechanobiology and its implications in disease - Volume II
Wu, Selwin K., Gomez, Guillermo A., Stehbens, Samantha, Acharya, Bipul R., Ratheesh, Aparna, Priya, Rashmi, Lagendijk, Anne and Bershadsky, Alexander (2022). Editorial: Forces in biology - Cell and developmental mechanobiology and its implications in disease - Volume II. Frontiers in Cell and Developmental Biology, 10 1082857, 1082857. doi: 10.3389/fcell.2022.1082857
2022
Journal Article
Persister state-directed transitioning and vulnerability in melanoma
Chauvistré, Heike, Shannan, Batool, Daignault-Mill, Sheena M., Ju, Robert J., Picard, Daniel, Egetemaier, Stefanie, Váraljai, Renáta, Gibhardt, Christine S., Sechi, Antonio, Kaschani, Farnusch, Keminer, Oliver, Stehbens, Samantha J., Liu, Qin, Yin, Xiangfan, Jeyakumar, Kirujan, Vogel, Felix C. E., Krepler, Clemens, Rebecca, Vito W., Kubat, Linda, Lueong, Smiths S., Forster, Jan, Horn, Susanne, Remke, Marc, Ehrmann, Michael, Paschen, Annette, Becker, Jürgen C., Helfrich, Iris, Rauh, Daniel, Kaiser, Markus ... Roesch, Alexander (2022). Persister state-directed transitioning and vulnerability in melanoma. Nature Communications, 13 (1) 3055, 3055. doi: 10.1038/s41467-022-30641-9
2022
Journal Article
The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis—A structural, molecular, and biochemical analysis
Fan, Xiwei, Wu, Xiaoxin, Trevisan Franca De Lima, Lucas, Stehbens, Samantha, Punyadeera, Chamindie, Webb, Richard, Hamilton, Brett, Ayyapann, Vijay, McLauchlan, Connor, Crawford, Ross, Zheng, Minghao, Xiao, Yin and Prasadam, Indira (2022). The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis—A structural, molecular, and biochemical analysis. FASEB Journal, 36 (2) e22142, 1-18. doi: 10.1096/fj.202101449R
2021
Journal Article
Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation
Katsuno-Kambe, Hiroko, Teo, Jessica L., Ju, Robert J., Hudson, James, Stehbens, Samantha J. and Yap, Alpha S. (2021). Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation. eLife, 10 e67915. doi: 10.7554/elife.67915
2020
Journal Article
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics
Sapoznik, Etai, Chang, Bo-Jui, Huh, Jaewon, Ju, Robert J., Azarova, Evgenia, Pohlkamp, Theresa, Welf, Erik S., Broadbent, David, Carisey, Alexandre F., Stehbens, Samantha J., Lee, Kyung-Min, Marin, Arnaldo, Hanker, Ariella B., Schmidt, Jens C., Arteaga, Carlos L., Bin Yang, , Kobayashi, Yoshihiko, Tata, Purushothama Rao, Kruithoff, Rory, Doubrovinski, Konstantin, Shepherd, Douglas P., Millett-Sikking, Alfred, York, Andrew G., Dean, Kevin M. and Fiolka, Reto P. (2020). A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. eLife, 9 e57681, 1-39. doi: 10.7554/elife.57681
2020
Journal Article
Editorial: Forces in biology-cell and developmental mechanobiology and its implications in disease
Wu, Selwin K., Gomez, Guillermo A., Stehbens, Samantha J. and Smutny, Michael (2020). Editorial: Forces in biology-cell and developmental mechanobiology and its implications in disease. Frontiers in Cell and Developmental Biology, 8 598179, 598179. doi: 10.3389/fcell.2020.598179
Funding
Current funding
Past funding
Supervision
Availability
- Dr Samantha Stehbens is:
- Available for supervision
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Available projects
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The Role of Microenvironment Mechanics in Melanoma Brain Metastasis
Extracerebral brain metastases account for 90% of all brain malignancies, outnumbering primary brain cancers. Melanoma originates in collagen rich skin, yet exhibits trophisim to the brain which exhibits unique mechanical properties due to the brain ECM being heavily composed of glycosaminoglycans (GAGs) including hyaluronic acid (HA) and tenascin. Mechanical stiffness of the microenvironement plays key roles in cell survivial, response to therapies and metastatic ability of cancer. The mechanical role of the brain microenvironment remains poorly explored for melanoma.
As such, we are aiming to establish mechanically relevant three-dimensional cell culture models of MBM (melanoma brain metastases) from patient-derived cell lines. Investigate MBM motility, proliferation and survival in extra-cerebral (collagen I) and brain (HA) matrices using a combination of high-resolution live-cell microscopy, cutting-edge bio-reporters, immunofluorescence and 3D cell culture.
We aim to understand the contribution of the mechanical microenvironment and the bi-directional role of the cytoskeleton and cell-matrix adhesions.
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Microtubules, mechanics and cell motility
Innovative imaging and cell biology approaches have recently uncovered novel biology that is unique to cells navigating confined 3Dimensional spaces vs 2D, underlining the significance of understanding cell migration and invasion in mechanically relevant cell culture models. As a cells navigates its local environment, the adaptive migration strategies they deploy are greatly influenced by the physical parameters of the microenvironment. As such, the mechanical interrelationship between the cell cytoskeleton, adhesion, matrix density, porosity, curvature and stiffness is an exciting emergent research theme. My lab's current work focuses on understanding the fundamental mechanisms governing the bi-directional relationship between cells and extracellular matrix during 3D invasion with a focus on the contribution of the microtuble cytoskeleon in a metastatic cancer setting.Metastatic success requires cells to navigate complex cellular environments, adapting either their shape to navigate between matrix fibres or adapting their environment to facilitate movement between tight spaces.
See: Compression-dependent microtubule reinforcement enables cells to navigate confined environments Ju Robert J. Ju, Alistair D. Falconer, Christanny J. Schmidt, Marco A. Enriquez Martinez, Kevin M. Dean, Reto P. Fiolka, David P. Sester, Max Nobis, Paul Timpson, Alexis J. Lomakin, Gaudenz Danuser, Melanie D. White, Nikolas K. Haass Dietmar B. Oelz and Samantha J. Stehbens. Nature Cell Biology In press
We have multiple projects including:
- Microtubule-dependent positioning of organelles, implications for cell migration
- Understanding the role of microtubules in protecting cells from mechanical stress
- The role of the mechano-environment in metastatic disease and therapy resistance
- Regulation of protease secretion in 3D environments; can cells "digest on demand"
Supervision history
Current supervision
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Doctor Philosophy
Understanding the role of microtubules in mitochondrial positioning and function during cell migration
Principal Advisor
Other advisors: Dr Julia Pagan
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Doctor Philosophy
Understanding Cytoskeletal-Golgi cross talk in cellular pathfinding in crowded tissue environments
Principal Advisor
Other advisors: Professor Robert Parton, Dr Mel White
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Doctor Philosophy
Investigating the molecular mechanism of cellular recognition by bacterial ABC toxins.
Associate Advisor
Other advisors: Associate Professor Michael Landsberg
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Doctor Philosophy
Targetting blood vessel dysfunction in disease
Associate Advisor
Other advisors: Dr Emma Gordon, Dr Anne Lagendijk
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Doctor Philosophy
Modelling and simulation of cellular contractility and mechano-transduction in epithelial tissue.
Associate Advisor
Other advisors: Dr Zoltan Neufeld, Dr Dietmar Oelz
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Completed supervision
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2022
Doctor Philosophy
Regulation of Microtubules in 3D by CLASPs
Principal Advisor
Other advisors: Professor Nikolas Haass
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2024
Doctor Philosophy
Defining the function of SCF-FBXO16 ubiquitin ligase at centrosomes and microtubules
Associate Advisor
Other advisors: Associate Professor Dominic Ng, Dr Julia Pagan
Media
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