Associate Professor Dominic Ng
Associate Professor

Dominic Ng

Email: 
Phone: 
+61 7 336 53077

Background

Dr Dominic Ng graduated with a BSc (Hons) and gained his PhD from the University of Western Australia. His doctoral studies, conducted in the laboratory of Assoc. Prof. Marie Bogoyevitch, were focused on cardiomyocyte signalling mechanisms regulating pathological tissue growth (ie cardiac hypertrophy). He continued his research training in Singapore as a post-doctoral research fellow based at the Institute of Molecular and Cell Biology, the flagship institute of Singapore’s science agency (A*STAR) located at the world renowned Biopolis research precinct. During this time, his research interests turned to the complex regulation of the cytoskeleton and their functions in development and disease.

He returned to the Australian medical research community on an NHMRC Peter Doherty Fellowship (2006-2010) followed by a Faculty Trust Roper Fellowship (2011-2012). In this time, Dominic established an independent research program focused on complex signalling regulation of microtubule organization. In 2013, Dominic was appointed as a Senior Research Fellow, supported by an ARC Future Fellowship (2013-2016) at the Department of Biochemistry within the Bio21 Institute, University of Melbourne. In 2015, Dominic relocated his research group to the School of Biomedical Science, University of Queensland and is currently appointed as an ARC Future Fellow and Senior Lecturer.

Availability

Associate Professor Dominic Ng is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cardiovascular medicine and haematology Cardiovascular medicine and haematology not elsewhere classified Cell development, proliferation and death Neurosciences Oncology and carcinogenesis Signal transduction

Qualifications

  • Bachelor of Science, University of Western Australia
  • Doctor of Philosophy, University of Western Australia

Research interests

  • Cell Signalling

    Protein phosphorylation, protein interactions, kinases, STAT transcription factors, microtubule-associated proteins.

  • Molecular Cardiology

    Cardiomyocyte growth, cardiac hypertrophy, cardiac injury, cardioprotection

  • Neural Development

    Neural stem cells, microcephaly genes, neural migration, neural proliferation, neuronal cell death

Search Professor Dominic Ng’s works on UQ eSpace

69 works between 2000 and 2024
All (69) Journal Article (68) Book Chapter (1)

1 - 20 of 69 works

Featured

2024

Journal Article

Stress pathway outputs are encoded by pH-dependent clustering of kinase components

Didan, Yuliia, Ghomlaghi, Milad, Nguyen, Lan K. and Ng, Dominic C. H. (2024). Stress pathway outputs are encoded by pH-dependent clustering of kinase components. Nature Communications, 15 (1) 6614, 1-16. doi: 10.1038/s41467-024-50638-w

Stress pathway outputs are encoded by pH-dependent clustering of kinase components

Featured

2021

Journal Article

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

Rashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J., Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C., Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H. and Khanna, Kum Kum (2021). Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis. PLoS Genetics, 17 (10) e1009334, 1-31. doi: 10.1371/journal.pgen.1009334

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

Featured

2020

Journal Article

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y., Parton, Robert G., Millard, Sean S., Xu, Zhiheng, Piper, Michael and Ng, Dominic C. H. (2020). The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics, 29 (2), 248-263. doi: 10.1093/hmg/ddz281

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

2024

Journal Article

Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation

Yan, Yu, Sankar, Baradwaj Simha, Mirza, Bilal, Ng, Dominic C. M., Pelletier, Alexander R., Huang, Sarah D., Wang, Wei, Watson, Karol, Wang, Ding and Ping, Peipei (2024). Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation. Journal of Proteome Research, 23 (9), 4151-4162. doi: 10.1021/acs.jproteome.4c00263

Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation

2024

Journal Article

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

2024

Journal Article

Tissue usage preference and intrinsically disordered region remodeling of alternative splicing derived proteoforms in the heart

Pandi, Boomathi, Brenman, Stella, Black, Alexander, Ng, Dominic C. M., Lau, Edward and Lam, Maggie P. Y. (2024). Tissue usage preference and intrinsically disordered region remodeling of alternative splicing derived proteoforms in the heart. Journal of Proteome Research, 23 (8), 3161-3173. doi: 10.1021/acs.jproteome.3c00789

Tissue usage preference and intrinsically disordered region remodeling of alternative splicing derived proteoforms in the heart

2023

Journal Article

Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S

Yan, Yu, Wang, Dean, Xin, Ruiqi, Soriano, Raine A., Ng, Dominic C. M., Wang, Wei and Ping, Peipei (2023). Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S. Star Protocols, 4 (4) 102682, 1-10. doi: 10.1016/j.xpro.2023.102682

Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S

2023

Journal Article

MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases

Yan, Yu, Jiang, Jyun-Yu, Fu, Mingzhou, Wang, Ding, Pelletier, Alexander R., Sigdel, Dibaka, Ng, Dominic C. M., Wang, Wei and Ping, Peipei (2023). MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases. Cell Reports Methods, 3 (3) 100430, 1-19. doi: 10.1016/j.crmeth.2023.100430

MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases

2022

Journal Article

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

2021

Journal Article

Cilia, centrosomes and skeletal muscle

Ng, Dominic C. H., Ho, Uda Y. and Grounds, Miranda D. (2021). Cilia, centrosomes and skeletal muscle. International Journal of Molecular Sciences, 22 (17) 9605, 9605. doi: 10.3390/ijms22179605

Cilia, centrosomes and skeletal muscle

2021

Journal Article

TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells

Ding, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601

TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells

2021

Journal Article

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Ho, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

2021

Journal Article

Pathophysiological significance of WDR62 and JNK signaling in human diseases

Zhi, Yiqiang, Zhou, Xiaokun, Yu, Jurui, Yuan, Ling, Zhang, Hongsheng, Ng, Dominic C. H., Xu, Zhiheng and Xu, Dan (2021). Pathophysiological significance of WDR62 and JNK signaling in human diseases. Frontiers in Cell and Developmental Biology, 9 640753, 640753. doi: 10.3389/fcell.2021.640753

Pathophysiological significance of WDR62 and JNK signaling in human diseases

2020

Journal Article

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

2020

Journal Article

The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus

Shohayeb, Belal, Ho, Uda Y., Hassan, Halah, Piper, Michael and Ng, Dominic C. H. (2020). The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus. Frontiers in Cell and Developmental Biology, 8 549353, 549353. doi: 10.3389/fcell.2020.549353

The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus

2020

Journal Article

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC

Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M. and Ng, Dominic C.H. (2020). Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. Biochimica et Biophysica Acta - Molecular Cell Research, 1867 (7) 118713, 118713. doi: 10.1016/j.bbamcr.2020.118713

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC

2019

Journal Article

Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association. Biochemical and Biophysical Research Communications, 513 (3), 540-545. doi: 10.1016/j.bbrc.2019.04.005

Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association

2019

Journal Article

Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments. Biochimica et Biophysica Acta - Molecular Cell Research, 1866 (4), 638-649. doi: 10.1016/j.bbamcr.2019.01.003

Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments

2019

Journal Article

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Hoque, Ashfaqul, Williamson, Nicholas A., Ameen, S. Sadia, Ciccotosto, Giuseppe D., Hossain, M. Iqbal, Oakhill, Jonathan S., Ng, Dominic C. H., Ang, Ching-Seng and Cheng, Heung-Chin (2019). Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death and Disease, 10 (3) 213, 213. doi: 10.1038/s41419-019-1445-0

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

2018

Journal Article

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

Xu, Dan, Yao, Minghui, Wang, Yaqing, Yuan, Ling, Hoeck, Joerg D., Yu, Jingwen, Liu, Liang, Yeap, Yvonne Y. C., Zhang, Weiya, Zhang, Feng, Feng, Yinghang, Ma, Tiantian, Wang, Yujie, Ng, Dominic C. H., Niu, Xiaoyin, Su, Bing, Behrens, Axel and Xu, Zhiheng (2018). MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology, 16 (12) e2006613, e2006613. doi: 10.1371/journal.pbio.2006613

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

Current funding

  • 2025 - 2026
    Striking a sour note: Revealing ageing-related intracellular acidification as a trigger for ALS pathomechanisms
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2025
    Understanding how the ALS risk factor, GGNBP2, contributes to autophagy
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    How defects in centrosome to microtubule attachment cause microcephaly
    NHMRC Project Grant
    Open grant
  • 2019 - 2023
    Identifying conserved alternative splicing mechanisms in vivo
    NHMRC Project Grant
    Open grant
  • 2017 - 2021
    Trophoblast cell-cell fusion in preeclampsia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Mitotic spindle regulation by novel Aurora A control mechanisms [The Robert Baillie Research Grant]
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Interrogating a novel protein scaffold that coordinates signal transduction and molecular motor function
    ARC Future Fellowships
    Open grant
  • 2015 - 2016
    New insights into mechanisms that coordinate kinase signalling and molecular motors in mitosis: A novel role for the protein scaffold WD-repeat protein 62 (WDR62)
    NHMRC Project Grant
    Open grant

Availability

Associate Professor Dominic Ng is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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