Dr Julia Pagan
Dr

Julia Pagan

Email: 
Phone: 
+61 7 336 54484

Background

Dr Julia Pagan heads the Targeted Protein Degradation lab.

Availability

Dr Julia Pagan is:
Available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Julia Pagan’s works on UQ eSpace

23 works between 2001 and 2024
All (23) Journal Article (21) Book Chapter (1) Conference Publication (1)

1 - 20 of 23 works

2024

Journal Article

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

2024

Journal Article

FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy

Kulkarni, Prajakta, Nguyen-Dien, Giang Thanh, Kozul, Keri-Lyn and Pagan, Julia K. (2024). FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy. Autophagy, 20 (6), 1-3. doi: 10.1080/15548627.2024.2318077

FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy

2023

Journal Article

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Niemi, Natalie M., Serrano, Lia R., Muehlbauer, Laura K., Balnis, Catherine E., Wei, Lianjie, Smith, Andrew J., Kozul, Keri-Lyn, Forny, Merima, Connor, Olivia M., Rashan, Edrees H., Shishkova, Evgenia, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Friedman, Jonathan R., Pagan, Julia K., Coon, Joshua J. and Pagliarini, David J. (2023). PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. Nature Communications, 14 (1) 6431, 1-17. doi: 10.1038/s41467-023-42069-w

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

2023

Journal Article

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

2020

Journal Article

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

2018

Journal Article

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

Rona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K., Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli and Pagano, Michele (2018). PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. eLife, 7 e38771. doi: 10.7554/eLife.38771.001

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

2017

Journal Article

PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth

Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo and Pagano, Michele (2017). PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth. Nature, 546 (7659), 554-558. doi: 10.1038/nature22965

PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth

2015

Journal Article

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

2014

Journal Article

SCF ubiquitin ligase-targeted therapies

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2014). SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery, 13 (12), 889-903. doi: 10.1038/nrd4432

SCF ubiquitin ligase-targeted therapies

2013

Journal Article

Mechanisms and function of substrate recruitment by F-box proteins

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2013). Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology, 14 (6), 369-381. doi: 10.1038/nrm3582

Mechanisms and function of substrate recruitment by F-box proteins

2013

Journal Article

Role of the ubiquitin proteasome system in the heart

Pagan, Julia, Seto, Tiffany, Pagano, Michele and Cittadini, Antonio (2013). Role of the ubiquitin proteasome system in the heart. Circulation Research, 112 (7), 1046-1058. doi: 10.1161/CIRCRESAHA.112.300521

Role of the ubiquitin proteasome system in the heart

2012

Journal Article

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

Duan, Shanshan, Cermak, Lukas, Pagan, Julia K., Rossi, Mario, Martinengo, Cinzia, di Celle, Paola Francia, Chapuy, Bjoern, Shipp, Margaret, Chiarle, Roberto and Pagano, Michele (2012). FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature, 481 (7379), 90-94. doi: 10.1038/nature10688

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

2011

Journal Article

FBXW5 controls centrosome number

Pagan, Julia and Pagano, Michele (2011). FBXW5 controls centrosome number. Nature Cell Biology, 13 (8), 888-890. doi: 10.1038/ncb2312

FBXW5 controls centrosome number

2010

Journal Article

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

Bashir, Tarig, Pagan, Julia K., Busino, Luca and Pagano, Michele (2010). Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle, 9 (5), 971-974. doi: 10.4161/cc.9.5.10914

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

2009

Journal Article

SnapShot: F Box Proteins II

Skaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins II. Cell, 137 (7), 1358-U100. doi: 10.1016/j.cell.2009.05.040

SnapShot: F Box Proteins II

2009

Journal Article

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair

Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair

2009

Journal Article

SnapShot: F Box Proteins I

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins I. Cell, 137 (6), 1358-U100. doi: 10.1016/j.cell.2009.05.039

SnapShot: F Box Proteins I

2009

Book Chapter

Chromatin modifications involved in the DNA damage response to double strand breaks

Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6

Chromatin modifications involved in the DNA damage response to double strand breaks

2007

Journal Article

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

2006

Journal Article

Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup

Kay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200

Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup

Current funding

  • 2023 - 2025
    Tuning mitophagy in mitochondrial diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2023 - 2024
    Restoring mitochondrial function in FBXL4-associated MTDPS13
    Australian Functional Genomics Network
    Open grant
  • 2022 - 2023
    Inhibiting autophagy in FBXL4-associated mitochondrial DNA depletion syndrome
    Mito Foundation Incubator Grants
    Open grant
  • 2020 - 2022
    Inhibition of mitophagy by ubiquitin-mediated proteolysis
    NHMRC IDEAS Grants
    Open grant
  • 2020
    Mechanisms to augment mitophagy in Parkinson's disease
    Brain Foundation Research Gift
    Open grant
  • 2019 - 2023
    Regulation of cell proliferation and survival by the ubiquitin system
    ARC Future Fellowships
    Open grant

Availability

Dr Julia Pagan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Mechanisms of mitochondrial quality control

    Principal Advisor

    Other advisors: Associate Professor Sean Millard

  • Doctor Philosophy

    Understanding the role of microtubules in mitochondrial positioning and function during cell migration

    Associate Advisor

    Other advisors: Dr Samantha Stehbens

Completed supervision

Enquiries

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