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2024 Journal Article PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y |
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2024 Journal Article FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagyKulkarni, Prajakta, Nguyen-Dien, Giang Thanh, Kozul, Keri-Lyn and Pagan, Julia K. (2024). FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy. Autophagy, 20 (6), 1-3. doi: 10.1080/15548627.2024.2318077 |
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2023 Journal Article PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagyNiemi, Natalie M., Serrano, Lia R., Muehlbauer, Laura K., Balnis, Catherine E., Wei, Lianjie, Smith, Andrew J., Kozul, Keri-Lyn, Forny, Merima, Connor, Olivia M., Rashan, Edrees H., Shishkova, Evgenia, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Friedman, Jonathan R., Pagan, Julia K., Coon, Joshua J. and Pagliarini, David J. (2023). PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. Nature Communications, 14 (1) 6431, 1-17. doi: 10.1038/s41467-023-42069-w |
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2023 Journal Article FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptorsNguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767 |
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2020 Journal Article Centrosome reduction promotes terminal differentiation of human cardiomyocytesNg, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007 |
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2018 Journal Article PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loadingRona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K., Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli and Pagano, Michele (2018). PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. eLife, 7 e38771. doi: 10.7554/eLife.38771.001 |
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2017 Journal Article PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growthKuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo and Pagano, Michele (2017). PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth. Nature, 546 (7659), 554-558. doi: 10.1038/nature22965 |
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2015 Journal Article Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensingPagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076 |
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2014 Journal Article SCF ubiquitin ligase-targeted therapiesSkaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2014). SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery, 13 (12), 889-903. doi: 10.1038/nrd4432 |
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2013 Journal Article Mechanisms and function of substrate recruitment by F-box proteinsSkaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2013). Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology, 14 (6), 369-381. doi: 10.1038/nrm3582 |
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2013 Journal Article Role of the ubiquitin proteasome system in the heartPagan, Julia, Seto, Tiffany, Pagano, Michele and Cittadini, Antonio (2013). Role of the ubiquitin proteasome system in the heart. Circulation Research, 112 (7), 1046-1058. doi: 10.1161/CIRCRESAHA.112.300521 |
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2012 Journal Article FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomasDuan, Shanshan, Cermak, Lukas, Pagan, Julia K., Rossi, Mario, Martinengo, Cinzia, di Celle, Paola Francia, Chapuy, Bjoern, Shipp, Margaret, Chiarle, Roberto and Pagano, Michele (2012). FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature, 481 (7379), 90-94. doi: 10.1038/nature10688 |
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2011 Journal Article FBXW5 controls centrosome numberPagan, Julia and Pagano, Michele (2011). FBXW5 controls centrosome number. Nature Cell Biology, 13 (8), 888-890. doi: 10.1038/ncb2312 |
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2010 Journal Article Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localizationBashir, Tarig, Pagan, Julia K., Busino, Luca and Pagano, Michele (2010). Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle, 9 (5), 971-974. doi: 10.4161/cc.9.5.10914 |
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2009 Journal Article SnapShot: F Box Proteins IISkaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins II. Cell, 137 (7), 1358-U100. doi: 10.1016/j.cell.2009.05.040 |
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2009 Journal Article Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repairArun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947 |
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2009 Journal Article SnapShot: F Box Proteins ISkaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins I. Cell, 137 (6), 1358-U100. doi: 10.1016/j.cell.2009.05.039 |
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2009 Book Chapter Chromatin modifications involved in the DNA damage response to double strand breaksPagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6 |
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2007 Journal Article A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBPPagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200 |
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2006 Journal Article Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cupKay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200 |
