Dr Mathew Jones
Dr

Mathew Jones

Email: 
Phone: 
+61 7 336 54878

Availability

Dr Mathew Jones is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mathew Jones’s works on UQ eSpace

23 works between 2007 and 2024
All (23) Journal Article (21) Book Chapter (2)

1 - 20 of 23 works

2024

Journal Article

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

2023

Journal Article

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

2022

Journal Article

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death

Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death

2021

Journal Article

Targeting BRF2 in cancer using repurposed drugs

Rashidieh, Behnam, Molakarimi, Maryam, Mohseni, Ammar, Tria, Simon Manuel, Truong, Hein, Srihari, Sriganesh, Adams, Rachael C., Jones, Mathew, Duijf, Pascal H. G., Kalimutho, Murugan and Khanna, Kum Kum (2021). Targeting BRF2 in cancer using repurposed drugs. Cancers, 13 (15) 3778, 1-28. doi: 10.3390/cancers13153778

Targeting BRF2 in cancer using repurposed drugs

2021

Journal Article

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

Jones, Mathew J. K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A, Santos, Ruth E, Olsen, Jesper V, McCarroll, Steven A, Frattini, Mark G, Takahashi, Tatsuro S and Jallepalli, Prasad V (2021). Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell, 81 (3), 426-441.e8. doi: 10.1016/j.molcel.2021.01.004

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

2019

Journal Article

Everything in moderation: lessons learned by exploiting moderate replication stress in cancer

Nazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320

Everything in moderation: lessons learned by exploiting moderate replication stress in cancer

2017

Journal Article

SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function

Coleman, Kate E., Békés, Miklós, Chapman, Jessica R., Crist, Sarah B., Jones, Mathew J.K., Ueberheide, Beatrix M. and Huang, Tony T. (2017). SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function. eLife, 6 e24325. doi: 10.7554/eLife.24325

SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function

2017

Journal Article

Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation

Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D. and Jallepalli, Prasad V. (2017). Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2), 143-156.e6. doi: 10.1016/j.devcel.2017.03.025

Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation

2016

Book Chapter

Engineering and functional analysis of mitotic kinases through chemical genetics

Jones, Mathew J. K. and Jallepalli, Prasad V. (2016). Engineering and functional analysis of mitotic kinases through chemical genetics. The Mitotic Spindle. (pp. 349-363) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3542-0_22

Engineering and functional analysis of mitotic kinases through chemical genetics

2015

Journal Article

Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells

Rahman, Sadia, Jones, Mathew J.K. and Jallepalli, Prasad V. (2015). Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (36), 11270-11275. doi: 10.1073/pnas.1505323112

Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells

2015

Journal Article

T cell help controls the speed of the cell cycle in germinal center B cells

Gitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J. K., Koren, Amnon and Nussenzweig, Michel C. (2015). T cell help controls the speed of the cell cycle in germinal center B cells. Science, 349 (6248), 643-646. doi: 10.1126/science.aac4919

T cell help controls the speed of the cell cycle in germinal center B cells

2015

Journal Article

ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress

Chen, Yu-Hung, Jones, Mathew J.K., Yin, Yandong, Crist, Sarah B., Colnaghi, Luca, Sims, Robert J., Rothenberg, Eli, Jallepalli, Prasad V. and Huang, Tony T. (2015). ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress. Molecular Cell, 58 (2), 323-338. doi: 10.1016/j.molcel.2015.02.031

ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress

2015

Journal Article

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

2014

Journal Article

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

Grabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew J.K., Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, HaoHsuan and Bar-Sagi, Dafna (2014). Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell, 25 (2), 243-256. doi: 10.1016/j.ccr.2014.01.005

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

2013

Journal Article

DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells

Békés, Miklós, Okamoto, Keiji, Crist, Sarah B., Jones, Mathew J., Chapman, Jessica R., Brasher, Bradley B., Melandri, Francesco D., Ueberheide, Beatrix M., LazzeriniDenchi, Eros and Huang, Tony T. (2013). DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Reports, 5 (3), 826-838. doi: 10.1016/j.celrep.2013.10.008

DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells

2012

Journal Article

The Fanconi anemia pathway in replication stress and DNA crosslink repair

Jones, Mathew J. K. and Huang, Tony T. (2012). The Fanconi anemia pathway in replication stress and DNA crosslink repair. Cellular and Molecular Life Sciences, 69 (23), 3963-3974. doi: 10.1007/s00018-012-1051-0

The Fanconi anemia pathway in replication stress and DNA crosslink repair

2012

Journal Article

Chromothripsis: chromosomes in crisis

Jones, Mathew J.K. and Jallepalli, Prasad V. (2012). Chromothripsis: chromosomes in crisis. Developmental Cell, 23 (5), 908-917. doi: 10.1016/j.devcel.2012.10.010

Chromothripsis: chromosomes in crisis

2012

Journal Article

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

Jones, Mathew J. K., Colnaghi, Luca and Huang, Tony T. (2012). Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. The EMBO Journal, 31 (4), 908-918. doi: 10.1038/emboj.2011.457

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

2011

Journal Article

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

Cotto-Rios, Xiomaris M., Jones, Mathew J.K. and Huang, Tony T. (2011). Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle, 10 (23), 4009-4016. doi: 10.4161/cc.10.23.18501

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

2011

Journal Article

APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele and Huang, Tony T. (2011). APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. Journal of Cell Biology, 194 (2), 177-186. doi: 10.1083/jcb.201101062

APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

Current funding

  • 2023 - 2025
    Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)
    Schrodinger Inc.
    Open grant

Past funding

  • 2023 - 2024
    Functional analysis of STAG2 variants
    Australian Functional Genomics Network
    Open grant
  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2022
    Validation of Cdc7 inhibitors
    Schrodinger Inc.
    Open grant
  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant

Availability

Dr Mathew Jones is:
Available for supervision

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Available projects

  • Targeting replication stress in cancer

    DNA replication is the fundamental mechanism of genetic inheritance and an essential process for all cellular life. In cancer cells, replication is corrupted and replication forks frequently stall and collapse causing DNA damage and copying errors that drive tumorigenesis. As a result, cancer cells are heavily dependent on the pathways that protect and repair stalled replication forks. Disrupting these mechanisms can be selectively toxic to cancer cells. A key player in the regulation of DNA replication and repair is DDK (Dbf4-dependent kinase also known as Cdc7). DDK is frequently overexpressed in cancer, but its role during DNA replication and the repair of stalled replication forks has not been well characterised. Our research uses chemical genetic approaches to selectively target DDK and gain valuable insights into its requirements and molecular targets.

    This project aims to understand how DDK coordinates DNA replication and repair to help develop new therapeutic strategies to target these processes in cancer cells. This project is suitable for a PhD student and provides an excellent opportunity to learn molecular and cell biology techniques and gain experience with long-read genome sequencing tools and genome engineering methods (CRISPR/Cas9).

Supervision history

Current supervision

Completed supervision

Enquiries

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