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2025 Journal Article FTO suppresses DNA repair by inhibiting PARP1Zhu, Tianyi, Tan, Jing Zhi Anson, Zhang, Lingrui, Huang, He, Das, Sooraj S., Cheng, Flora, Padmanabhan, Pranesh, Jones, Mathew J. K., Lee, Mihwa, Lee, Albert, Widagdo, Jocelyn and Anggono, Victor (2025). FTO suppresses DNA repair by inhibiting PARP1. Nature Communications, 16 (1) 2925. doi: 10.1038/s41467-025-58309-0 |
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2025 Journal Article Roles for the 3D genome in the cell cycle, DNA replication, and double strand break repairGiles, Katherine A., Taberlay, Phillippa C., Cesare, Anthony J. and Jones, Mathew J. K. (2025). Roles for the 3D genome in the cell cycle, DNA replication, and double strand break repair. Frontiers in Cell and Developmental Biology, 13 1548946, 13. doi: 10.3389/fcell.2025.1548946 |
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2025 Journal Article DNA replication dynamics are associated with genome composition in <i>Plasmodium</i> speciesTotañes, Francis Isidore Garcia, Chapman, Sarah E, Rai, Subash Kumar, Jones, Mathew J K, Boemo, Michael A and Merrick, Catherine J (2025). DNA replication dynamics are associated with genome composition in Plasmodium species. Nucleic Acids Research, 53 (4) gkaf111. doi: 10.1093/nar/gkaf111 |
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2025 Journal Article Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cellsVora, Shivam, Chatterjee, Saptarshi, Andrew, Ariel, Kumar, Ramyashree Prasanna, Proctor, Martina, Zeng, Zhen, Bhatt, Rituparna, Nazareth, Deborah, Fernando, Madushan, Jones, Mathew J. K., He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Saeh, Jamal, Travers, Jon, Cimini, Daniela, Chen, Jing and Gabrielli, Brian (2025). Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells. Cell Death & Disease, 16 (1) 7, 7-1. doi: 10.1038/s41419-024-07329-7 |
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2024 Journal Article Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibitionVora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew J. K. and Gabrielli, Brian (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death & Disease, 15 (11) 810, 810. doi: 10.1038/s41419-024-07204-5 |
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2024 Journal Article PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y |
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2023 Journal Article FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptorsNguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767 |
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2022 Journal Article Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell deathBonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316 |
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2021 Journal Article Targeting BRF2 in cancer using repurposed drugsRashidieh, Behnam, Molakarimi, Maryam, Mohseni, Ammar, Tria, Simon Manuel, Truong, Hein, Srihari, Sriganesh, Adams, Rachael C., Jones, Mathew, Duijf, Pascal H. G., Kalimutho, Murugan and Khanna, Kum Kum (2021). Targeting BRF2 in cancer using repurposed drugs. Cancers, 13 (15) 3778, 1-28. doi: 10.3390/cancers13153778 |
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2021 Journal Article Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replicationJones, Mathew J. K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A, Santos, Ruth E, Olsen, Jesper V, McCarroll, Steven A, Frattini, Mark G, Takahashi, Tatsuro S and Jallepalli, Prasad V (2021). Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell, 81 (3), 426-441.e8. doi: 10.1016/j.molcel.2021.01.004 |
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2019 Journal Article Everything in moderation: lessons learned by exploiting moderate replication stress in cancerNazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320 |
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2017 Journal Article SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase functionColeman, Kate E., Békés, Miklós, Chapman, Jessica R., Crist, Sarah B., Jones, Mathew J.K., Ueberheide, Beatrix M. and Huang, Tony T. (2017). SENP8 limits aberrant neddylation of nedd8 pathway components to promote cullin-RING ubiquitin ligase function. eLife, 6 e24325. doi: 10.7554/eLife.24325 |
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2017 Journal Article Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregationMaciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D. and Jallepalli, Prasad V. (2017). Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2), 143-156.e6. doi: 10.1016/j.devcel.2017.03.025 |
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2016 Book Chapter Engineering and functional analysis of mitotic kinases through chemical geneticsJones, Mathew J. K. and Jallepalli, Prasad V. (2016). Engineering and functional analysis of mitotic kinases through chemical genetics. The Mitotic Spindle. (pp. 349-363) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3542-0_22 |
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2015 Journal Article Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cellsRahman, Sadia, Jones, Mathew J.K. and Jallepalli, Prasad V. (2015). Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (36), 11270-11275. doi: 10.1073/pnas.1505323112 |
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2015 Journal Article T cell help controls the speed of the cell cycle in germinal center B cellsGitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J. K., Koren, Amnon and Nussenzweig, Michel C. (2015). T cell help controls the speed of the cell cycle in germinal center B cells. Science, 349 (6248), 643-646. doi: 10.1126/science.aac4919 |
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2015 Journal Article ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stressChen, Yu-Hung, Jones, Mathew J.K., Yin, Yandong, Crist, Sarah B., Colnaghi, Luca, Sims, Robert J., Rothenberg, Eli, Jallepalli, Prasad V. and Huang, Tony T. (2015). ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress. Molecular Cell, 58 (2), 323-338. doi: 10.1016/j.molcel.2015.02.031 |
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2015 Journal Article Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensingPagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076 |
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2014 Journal Article Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage responseGrabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew J.K., Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, HaoHsuan and Bar-Sagi, Dafna (2014). Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell, 25 (2), 243-256. doi: 10.1016/j.ccr.2014.01.005 |
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2013 Journal Article DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cellsBékés, Miklós, Okamoto, Keiji, Crist, Sarah B., Jones, Mathew J., Chapman, Jessica R., Brasher, Bradley B., Melandri, Francesco D., Ueberheide, Beatrix M., LazzeriniDenchi, Eros and Huang, Tony T. (2013). DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Reports, 5 (3), 826-838. doi: 10.1016/j.celrep.2013.10.008 |
