Dr Mathew Jones
Dr

Mathew Jones

Email: 
Phone: 
+61 7 336 54878

Availability

Dr Mathew Jones is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mathew Jones’s works on UQ eSpace

28 works between 2007 and 2025
All (28) Journal Article (26) Book Chapter (2)

21 - 28 of 28 works

2012

Journal Article

The Fanconi anemia pathway in replication stress and DNA crosslink repair

Jones, Mathew J. K. and Huang, Tony T. (2012). The Fanconi anemia pathway in replication stress and DNA crosslink repair. Cellular and Molecular Life Sciences, 69 (23), 3963-3974. doi: 10.1007/s00018-012-1051-0

The Fanconi anemia pathway in replication stress and DNA crosslink repair

2012

Journal Article

Chromothripsis: chromosomes in crisis

Jones, Mathew J.K. and Jallepalli, Prasad V. (2012). Chromothripsis: chromosomes in crisis. Developmental Cell, 23 (5), 908-917. doi: 10.1016/j.devcel.2012.10.010

Chromothripsis: chromosomes in crisis

2012

Journal Article

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

Jones, Mathew J. K., Colnaghi, Luca and Huang, Tony T. (2012). Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. The EMBO Journal, 31 (4), 908-918. doi: 10.1038/emboj.2011.457

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

2011

Journal Article

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

Cotto-Rios, Xiomaris M., Jones, Mathew J.K. and Huang, Tony T. (2011). Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle, 10 (23), 4009-4016. doi: 10.4161/cc.10.23.18501

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

2011

Journal Article

APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele and Huang, Tony T. (2011). APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. Journal of Cell Biology, 194 (2), 177-186. doi: 10.1083/jcb.201101062

APC/C Cdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

2011

Journal Article

Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

Colnaghi, Luca, Jones, Mathew J. K., Cotto-Rios, Xiomaris M., Schindler, Detlev, Hanenberg, Helmut and Huang, Tony T. (2011). Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. Blood, 117 (7), 2247-2256. doi: 10.1182/blood-2010-07-295758

Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

2009

Book Chapter

Chromatin modifications involved in the DNA damage response to double strand breaks

Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6

Chromatin modifications involved in the DNA damage response to double strand breaks

2007

Journal Article

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Current funding

  • 2023 - 2025
    Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)
    Schrodinger Inc.
    Open grant

Past funding

  • 2023 - 2024
    Functional analysis of STAG2 variants
    Australian Functional Genomics Network
    Open grant
  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2022
    Validation of Cdc7 inhibitors
    Schrodinger Inc.
    Open grant
  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant

Availability

Dr Mathew Jones is:
Available for supervision

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Available projects

  • Targeting replication stress in cancer

    DNA replication is the fundamental mechanism of genetic inheritance and an essential process for all cellular life. In cancer cells, replication is corrupted and replication forks frequently stall and collapse causing DNA damage and copying errors that drive tumorigenesis. As a result, cancer cells are heavily dependent on the pathways that protect and repair stalled replication forks. Disrupting these mechanisms can be selectively toxic to cancer cells. A key player in the regulation of DNA replication and repair is DDK (Dbf4-dependent kinase also known as Cdc7). DDK is frequently overexpressed in cancer, but its role during DNA replication and the repair of stalled replication forks has not been well characterised. Our research uses chemical genetic approaches to selectively target DDK and gain valuable insights into its requirements and molecular targets.

    This project aims to understand how DDK coordinates DNA replication and repair to help develop new therapeutic strategies to target these processes in cancer cells. This project is suitable for a PhD student and provides an excellent opportunity to learn molecular and cell biology techniques and gain experience with long-read genome sequencing tools and genome engineering methods (CRISPR/Cas9).

Supervision history

Current supervision

Completed supervision

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