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Professor Paul Clarke
Professor

Paul Clarke

Email: 

Overview

Background

Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.

Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.

Availability

Professor Paul Clarke is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Biochemistry, University of Bristol
  • Doctor of Philosophy of Biochemistry, University of Dundee

Research interests

  • Cell division

  • Cell death

  • Cancer chemotherapy

Works

Search Professor Paul Clarke’s works on UQ eSpace

94 works between 1989 and 2021

1 - 20 of 94 works

2021

Journal Article

Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis

Clarke, Paul R. (2021). Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis. Molecular Cell, 81 (6), 1128-1129. doi: 10.1016/j.molcel.2021.02.026

Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis

2019

Journal Article

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

Guo, Li, Mohd, Khamsah Suryati, Ren, He, Xin, Guangwei, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2019). Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly. Journal of Cell Science, 132 (18) jcs232314, jcs232314. doi: 10.1242/jcs.232314

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly

2018

Journal Article

Timed degradation of Mcl-1 controls mitotic cell death

Clarke, Paul R., Allan, Lindsey A. and Skowyra, Agnieszka (2018). Timed degradation of Mcl-1 controls mitotic cell death. Molecular & Cellular Oncology, 5 (6) e1516450, e1516450. doi: 10.1080/23723556.2018.1516450

Timed degradation of Mcl-1 controls mitotic cell death

2018

Journal Article

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, Lindsey A., Skowyra, Agnieszka, Rogers, Katie I., Zeller, Désirée and Clarke, Paul R. (2018). Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest. The EMBO Journal, 37 (17) e96831, e96831. doi: 10.15252/embj.201796831

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

2018

Journal Article

USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability

Skowyra, Agnieszka, Allan, Lindsey A., Saurin, Adrian T. and Clarke, Paul R. (2018). USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability. Cell Reports, 23 (3), 852-865. doi: 10.1016/j.celrep.2018.03.100

USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability

2017

Journal Article

Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death

Hou, Ying, Allan, Lindsey A. and Clarke, Paul R. (2017). Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death. Journal of Cell Science, 130 (2), 502-511. doi: 10.1242/jcs.192310

Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death

2016

Journal Article

Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

Hain, Karolina O., Colin, Didier J., Rastogi, Shubhra, Allan, Lindsey A. and Clarke, Paul R. (2016). Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival. Scientific Reports, 6 (1) 26766, 26766 .1-26766 .11. doi: 10.1038/srep26766

Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

2016

Conference Publication

The assembly and function of the Annulate Lamellae pore complexes in Xenopus Egg extract and cultured mammalian cells

Lu, L. Q., Ren, H., Guo, L., Jiang, Q., Clarke, P. R. and Zhang, C. (2016). The assembly and function of the Annulate Lamellae pore complexes in Xenopus Egg extract and cultured mammalian cells. Annual Meeting of the American-Society-for-Cell-Biology (ASCB), San Francisco, United States, Dec 03-07, 2016. BETHESDA: AMER SOC CELL BIOLOGY.

The assembly and function of the Annulate Lamellae pore complexes in Xenopus Egg extract and cultured mammalian cells

2015

Journal Article

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins

Colin, Didier J., Hain, Karolina O., Allan, Lindsey A. and Clarke, Paul R. (2015). Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biology, 5 (3) 140156, 140156-140156. doi: 10.1098/rsob.140156

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins

2013

Journal Article

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

Wu, Zhige, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2013). Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly. Journal of Cell Science, 126 (15), 3417-3428. doi: 10.1242/jcs.126854

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly

2012

Journal Article

Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β

Lu, Quanlong, Lu, Zhigang, Liu, Qinying, Guo, Li, Ren, He, Fu, Jingyan, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2012). Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 22 (11), 1562-1575. doi: 10.1038/cr.2012.113

Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β

2010

Journal Article

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

Fu, Wenxiang, Tao, Wei, Zheng, Puwei, Fu, Jingyan, Bian, Minglei, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2010). Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of Cell Science, 123 (21), 3645-3651. doi: 10.1242/jcs.075911

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

2010

Journal Article

Destruction's our delight Controlling apoptosis during mitotic arrest

Clarke, Paul R. and Allan, Lindsey A. (2010). Destruction's our delight Controlling apoptosis during mitotic arrest. Cell Cycle, 9 (20), 4035-4036. doi: 10.4161/cc.9.20.13522

Destruction's our delight Controlling apoptosis during mitotic arrest

2010

Journal Article

Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

Harley, Margaret E., Allan, Lindsey A., Sanderson, Helen S. and Clarke, Paul R. (2010). Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. Embo Journal, 29 (14), 2407-2420. doi: 10.1038/emboj.2010.112

Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

2010

Journal Article

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

Hitakomate, Ekarat, Hood, Fiona E., Sanderson, Helen S. and Clarke, Paul R. (2010). The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells. Bmc Cell Biology, 11 (1) 43. doi: 10.1186/1471-2121-11-43

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

2010

Journal Article

Microtubule assembly by the Apc protein is regulated by importin-β-RanGTP

Dikovskaya, Dina, Li, Zhuoyu, Newton, Ian P., Davidson, Iain, Hutchins, James R. A., Kalab, Petr, Clarke, Paul R. and Naethke, Inke S. (2010). Microtubule assembly by the Apc protein is regulated by importin-β-RanGTP. Journal of Cell Science, 123 (5), 736-746. doi: 10.1242/jcs.060806

Microtubule assembly by the Apc protein is regulated by importin-β-RanGTP

2009

Journal Article

p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

Seifert, Anne and Clarke, Paul R. (2009). p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress. Cellular Signalling, 21 (11), 1626-1633. doi: 10.1016/j.cellsig.2009.06.009

p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

2009

Journal Article

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation

Allan, Lindsey A. and Clarke, Paul R. (2009). Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. Febs Journal, 276 (21), 6063-6073. doi: 10.1111/j.1742-4658.2009.07330.x

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation

2009

Journal Article

Control of apoptosis and autophagy by cellular signalling pathways

Clarke, Paul (2009). Control of apoptosis and autophagy by cellular signalling pathways. FEBS Journal, 276 (21), 6049-6049. doi: 10.1111/j.1742-4658.2009.07328.x

Control of apoptosis and autophagy by cellular signalling pathways

2009

Journal Article

Dynamic localisation of Ran GTPase during the cell cycle

Hutchins, James R. A., Moore, William J. and Clarke, Paul R. (2009). Dynamic localisation of Ran GTPase during the cell cycle. Bmc Cell Biology, 10 (1) 1471. doi: 10.1186/1471-2121-10-66

Dynamic localisation of Ran GTPase during the cell cycle

Funding

Current funding

  • 2014 - 2026
    Dr Jian Zhou Memorial Scholarship
    Research Donation Generic
    Open grant

Past funding

  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant
  • 2019
    A Gas Chromatography-High Resolution Accurate Mass Spectrometry Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Supervision

Availability

Professor Paul Clarke is:
Available for supervision

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Available projects

  • Control of mitotic cell death in health and disease

  • Control of chromosome instability by tumour suppressors

Supervision history

Current supervision

  • Doctor Philosophy

    Control of mitotic cell death in response to chemotherapy

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Regulation of Mitosis by Oncogenes and Tumor Suppressors

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Understanding the role of FBXW7 in mitosis and chromosomal stability

    Associate Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Decoding the spatiotemporal control of DNA replication and repair

    Associate Advisor

    Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones

Completed supervision

Media

Enquiries

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communications@uq.edu.au