Overview
Background
Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.
Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.
Availability
- Professor Paul Clarke is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Biochemistry, University of Bristol
- Doctor of Philosophy of Biochemistry, University of Dundee
Research interests
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Cell division
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Cell death
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Cancer chemotherapy
Works
Search Professor Paul Clarke’s works on UQ eSpace
2021
Journal Article
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis
Clarke, Paul R. (2021). Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis. Molecular Cell, 81 (6), 1128-1129. doi: 10.1016/j.molcel.2021.02.026
2019
Journal Article
Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly
Guo, Li, Mohd, Khamsah Suryati, Ren, He, Xin, Guangwei, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2019). Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly. Journal of Cell Science, 132 (18) jcs232314, jcs232314. doi: 10.1242/jcs.232314
2018
Journal Article
Timed degradation of Mcl-1 controls mitotic cell death
Clarke, Paul R., Allan, Lindsey A. and Skowyra, Agnieszka (2018). Timed degradation of Mcl-1 controls mitotic cell death. Molecular & Cellular Oncology, 5 (6) e1516450, e1516450. doi: 10.1080/23723556.2018.1516450
2018
Journal Article
Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest
Allan, Lindsey A., Skowyra, Agnieszka, Rogers, Katie I., Zeller, Désirée and Clarke, Paul R. (2018). Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest. The EMBO Journal, 37 (17) e96831, e96831. doi: 10.15252/embj.201796831
2018
Journal Article
USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability
Skowyra, Agnieszka, Allan, Lindsey A., Saurin, Adrian T. and Clarke, Paul R. (2018). USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability. Cell Reports, 23 (3), 852-865. doi: 10.1016/j.celrep.2018.03.100
2017
Journal Article
Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death
Hou, Ying, Allan, Lindsey A. and Clarke, Paul R. (2017). Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death. Journal of Cell Science, 130 (2), 502-511. doi: 10.1242/jcs.192310
2016
Journal Article
Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival
Hain, Karolina O., Colin, Didier J., Rastogi, Shubhra, Allan, Lindsey A. and Clarke, Paul R. (2016). Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival. Scientific Reports, 6 (1) 26766, 26766 .1-26766 .11. doi: 10.1038/srep26766
2016
Conference Publication
The assembly and function of the Annulate Lamellae pore complexes in Xenopus Egg extract and cultured mammalian cells
Lu, L. Q., Ren, H., Guo, L., Jiang, Q., Clarke, P. R. and Zhang, C. (2016). The assembly and function of the Annulate Lamellae pore complexes in Xenopus Egg extract and cultured mammalian cells. Annual Meeting of the American-Society-for-Cell-Biology (ASCB), San Francisco, United States, Dec 03-07, 2016. BETHESDA: AMER SOC CELL BIOLOGY.
2015
Journal Article
Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins
Colin, Didier J., Hain, Karolina O., Allan, Lindsey A. and Clarke, Paul R. (2015). Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biology, 5 (3) 140156, 140156-140156. doi: 10.1098/rsob.140156
2013
Journal Article
Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly
Wu, Zhige, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2013). Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly. Journal of Cell Science, 126 (15), 3417-3428. doi: 10.1242/jcs.126854
2012
Journal Article
Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β
Lu, Quanlong, Lu, Zhigang, Liu, Qinying, Guo, Li, Ren, He, Fu, Jingyan, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2012). Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 22 (11), 1562-1575. doi: 10.1038/cr.2012.113
2010
Journal Article
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment
Fu, Wenxiang, Tao, Wei, Zheng, Puwei, Fu, Jingyan, Bian, Minglei, Jiang, Qing, Clarke, Paul R. and Zhang, Chuanmao (2010). Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of Cell Science, 123 (21), 3645-3651. doi: 10.1242/jcs.075911
2010
Journal Article
Destruction's our delight Controlling apoptosis during mitotic arrest
Clarke, Paul R. and Allan, Lindsey A. (2010). Destruction's our delight Controlling apoptosis during mitotic arrest. Cell Cycle, 9 (20), 4035-4036. doi: 10.4161/cc.9.20.13522
2010
Journal Article
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
Harley, Margaret E., Allan, Lindsey A., Sanderson, Helen S. and Clarke, Paul R. (2010). Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. Embo Journal, 29 (14), 2407-2420. doi: 10.1038/emboj.2010.112
2010
Journal Article
The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells
Hitakomate, Ekarat, Hood, Fiona E., Sanderson, Helen S. and Clarke, Paul R. (2010). The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells. Bmc Cell Biology, 11 (1) 43. doi: 10.1186/1471-2121-11-43
2010
Journal Article
Microtubule assembly by the Apc protein is regulated by importin-β-RanGTP
Dikovskaya, Dina, Li, Zhuoyu, Newton, Ian P., Davidson, Iain, Hutchins, James R. A., Kalab, Petr, Clarke, Paul R. and Naethke, Inke S. (2010). Microtubule assembly by the Apc protein is regulated by importin-β-RanGTP. Journal of Cell Science, 123 (5), 736-746. doi: 10.1242/jcs.060806
2009
Journal Article
Control of apoptosis and autophagy by cellular signalling pathways
Clarke, Paul (2009). Control of apoptosis and autophagy by cellular signalling pathways. FEBS Journal, 276 (21), 6049-6049. doi: 10.1111/j.1742-4658.2009.07328.x
2009
Journal Article
p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress
Seifert, Anne and Clarke, Paul R. (2009). p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress. Cellular Signalling, 21 (11), 1626-1633. doi: 10.1016/j.cellsig.2009.06.009
2009
Journal Article
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation
Allan, Lindsey A. and Clarke, Paul R. (2009). Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. Febs Journal, 276 (21), 6063-6073. doi: 10.1111/j.1742-4658.2009.07330.x
2009
Journal Article
Dynamic localisation of Ran GTPase during the cell cycle
Hutchins, James R. A., Moore, William J. and Clarke, Paul R. (2009). Dynamic localisation of Ran GTPase during the cell cycle. Bmc Cell Biology, 10 (1) 1471. doi: 10.1186/1471-2121-10-66
Supervision
Availability
- Professor Paul Clarke is:
- Available for supervision
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Available projects
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Control of mitotic cell death in health and disease
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Control of chromosome instability by tumour suppressors
Supervision history
Current supervision
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Doctor Philosophy
Control of mitotic cell death in response to chemotherapy
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Regulation of Mitosis by Oncogenes and Tumor Suppressors
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Decoding the spatiotemporal control of DNA replication and repair
Associate Advisor
Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones
Completed supervision
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2023
Doctor Philosophy
Defining the role of cGAS in mitotic cell death
Principal Advisor
Other advisors: Dr Mathew Jones
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2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Principal Advisor
Other advisors: Professor Nikolas Haass
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2024
Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
Media
Enquiries
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