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Professor Paul Clarke
Professor

Paul Clarke

Email: 

Overview

Background

Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.

Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.

Availability

Professor Paul Clarke is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Biochemistry, University of Bristol
  • Doctor of Philosophy of Biochemistry, University of Dundee

Research interests

  • Cell division

  • Cell death

  • Cancer chemotherapy

Works

Search Professor Paul Clarke’s works on UQ eSpace

94 works between 1989 and 2021

21 - 40 of 94 works

2009

Journal Article

hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks

Berglund, Fredfk M. and Clarke, Paul R. (2009). hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks. Biochemical and Biophysical Research Communications, 381 (1), 59-64. doi: 10.1016/j.bbrc.2009.02.019

hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks

2009

Journal Article

Cell-cycle control in the face of damage - a matter of life or death

Clarke, Paul R. and Allan, Lindsey A. (2009). Cell-cycle control in the face of damage - a matter of life or death. Trends in Cell Biology, 19 (3), 89-98. doi: 10.1016/j.tcb.2008.12.003

Cell-cycle control in the face of damage - a matter of life or death

2008

Journal Article

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

Seifert, Anne, Allan, Lindsey A. and Clarke, Paul R. (2008). DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. Febs Journal, 275 (24), 6268-6280. doi: 10.1111/j.1742-4658.2008.06751.x

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

2008

Journal Article

Spatial and temporal coordination of mitosis by Ran GTPase

Clarke, Paul R. and Zhang, Chuanmao (2008). Spatial and temporal coordination of mitosis by Ran GTPase. Nature Reviews Molecular Cell Biology, 9 (6), 464-477. doi: 10.1038/nrm2410

Spatial and temporal coordination of mitosis by Ran GTPase

2008

Journal Article

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1

Bennett, Lara N., Larkin, Conor, Gillespie, David A. and Clarke, Paul R. (2008). Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. Biochemical and Biophysical Research Communications, 369 (3), 973-976. doi: 10.1016/j.bbrc.2008.02.154

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1

2008

Conference Publication

To the centre of the volcano. Workshop on the Mechanisms of Nucleocytoplasmic Transport

Fornerod, Maarten and Clarke, Paul R. (2008). To the centre of the volcano. Workshop on the Mechanisms of Nucleocytoplasmic Transport. NATURE PUBLISHING GROUP. doi: 10.1038/embor.2008.51

To the centre of the volcano. Workshop on the Mechanisms of Nucleocytoplasmic Transport

2008

Journal Article

Signaling to nuclear transport.

Clarke, Paul R. (2008). Signaling to nuclear transport.. Developmental Cell, 14 (3), 316-318. doi: 10.1016/j.devcel.2008.02.005

Signaling to nuclear transport.

2008

Journal Article

The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125

Martin, Morag C., Allan, Lindsey A., Mancini, Erika J. and Clarke, Paul R. (2008). The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125. Journal of Biological Chemistry, 283 (7), 3854-3865. doi: 10.1074/jbc.M705647200

The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125

2008

Journal Article

Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis

Chen, Qiang, Zhang, Xiaoyan, Jiang, Qing, Clarke, Paul R. and Zhang, Chuamnao (2008). Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Research, 18 (2), 268-280. doi: 10.1038/cr.2008.11

Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis

2008

Journal Article

A mechanism coupling cell division and the control of apoptosis

Allan, Lindsey A and Clarke, Paul R (2008). A mechanism coupling cell division and the control of apoptosis. SEB experimental biology series, 59, 257-265.

A mechanism coupling cell division and the control of apoptosis

2007

Journal Article

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation

Hood, Fiona E. and Clarke, Paul R. (2007). RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation. Journal of Cell Science, 120 (19), 3436-3445. doi: 10.1242/jcs.009092

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation

2007

Journal Article

Mitosis: Ran scales the alps of spindle formation

Clarke, Paul R. and Sazer, Shelley (2007). Mitosis: Ran scales the alps of spindle formation. Current Biology, 17 (16), R643-R645. doi: 10.1016/j.cub.2007.06.023

Mitosis: Ran scales the alps of spindle formation

2007

Journal Article

Anchoring RCC1 by the tail

Clarke, Paul R. (2007). Anchoring RCC1 by the tail. Nature Cell Biology, 9 (5), 485-487. doi: 10.1038/ncb0507-485

Anchoring RCC1 by the tail

2007

Journal Article

Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis

Allan, Lindsey A. and Clarke, Paul R. (2007). Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis. Molecular Cell, 26 (2), 301-310. doi: 10.1016/j.molcel.2007.03.019

Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis

2006

Journal Article

A mitotic role for BRCA1/BARD1 in tumor suppression?

Clarke, Paul R. and Sanderson, Helen S. (2006). A mitotic role for BRCA1/BARD1 in tumor suppression?. Cell, 127 (3), 453-455. doi: 10.1016/j.cell.2006.10.020

A mitotic role for BRCA1/BARD1 in tumor suppression?

2006

Journal Article

Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation

Bennett, Lara N. and Clarke, Paul R. (2006). Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. Febs Letters, 580 (17), 4176-4181. doi: 10.1016/j.febslet.2006.06.071

Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation

2006

Journal Article

Cell biology: Ran, mitosis and the cancer Lconnection

Sanderson, HS and Clarke, PR (2006). Cell biology: Ran, mitosis and the cancer Lconnection. Current Biology, 16 (12), R466-R468. doi: 10.1016/j.cub.2006.05.032

Cell biology: Ran, mitosis and the cancer Lconnection

2005

Journal Article

Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress

Brady, S. C., Allan, L. A. and Clarke, P. R. (2005). Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress. Molecular and Cellular Biology, 25 (23), 10543-10555. doi: 10.1128/MCB.25.23.10543-10555.2005

Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress

2005

Journal Article

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

Clarke, Catriona A. L., Bennett, Lara N. and Clarke, Paul R. (2005). Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. Journal of Biological Chemistry, 280 (42), 35337-35345. doi: 10.1074/jbc.M506460200

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

2005

Journal Article

A gradient signal orchestrates the mitotic spindle

Clarke, PR (2005). A gradient signal orchestrates the mitotic spindle. Science, 309 (5739), 1334-1335. doi: 10.1126/science.1117842

A gradient signal orchestrates the mitotic spindle

Funding

Current funding

  • 2014 - 2026
    Dr Jian Zhou Memorial Scholarship
    Research Donation Generic
    Open grant

Past funding

  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant
  • 2019
    A Gas Chromatography-High Resolution Accurate Mass Spectrometry Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Supervision

Availability

Professor Paul Clarke is:
Available for supervision

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Available projects

  • Control of mitotic cell death in health and disease

  • Control of chromosome instability by tumour suppressors

Supervision history

Current supervision

  • Doctor Philosophy

    Control of mitotic cell death in response to chemotherapy

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Regulation of Mitosis by Oncogenes and Tumor Suppressors

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Understanding the role of FBXW7 in mitosis and chromosomal stability

    Associate Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Decoding the spatiotemporal control of DNA replication and repair

    Associate Advisor

    Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones

Completed supervision

Media

Enquiries

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communications@uq.edu.au