
Overview
Background
Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.
Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.
Availability
- Professor Paul Clarke is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Biochemistry, University of Bristol
- Doctor of Philosophy of Biochemistry, University of Dundee
Research interests
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Cell division
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Cell death
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Cancer chemotherapy
Works
Search Professor Paul Clarke’s works on UQ eSpace
2009
Journal Article
hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks
Berglund, Fredfk M. and Clarke, Paul R. (2009). hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks. Biochemical and Biophysical Research Communications, 381 (1), 59-64. doi: 10.1016/j.bbrc.2009.02.019
2009
Journal Article
Cell-cycle control in the face of damage - a matter of life or death
Clarke, Paul R. and Allan, Lindsey A. (2009). Cell-cycle control in the face of damage - a matter of life or death. Trends in Cell Biology, 19 (3), 89-98. doi: 10.1016/j.tcb.2008.12.003
2008
Journal Article
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
Seifert, Anne, Allan, Lindsey A. and Clarke, Paul R. (2008). DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. Febs Journal, 275 (24), 6268-6280. doi: 10.1111/j.1742-4658.2008.06751.x
2008
Journal Article
Spatial and temporal coordination of mitosis by Ran GTPase
Clarke, Paul R. and Zhang, Chuanmao (2008). Spatial and temporal coordination of mitosis by Ran GTPase. Nature Reviews Molecular Cell Biology, 9 (6), 464-477. doi: 10.1038/nrm2410
2008
Journal Article
Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1
Bennett, Lara N., Larkin, Conor, Gillespie, David A. and Clarke, Paul R. (2008). Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. Biochemical and Biophysical Research Communications, 369 (3), 973-976. doi: 10.1016/j.bbrc.2008.02.154
2008
Conference Publication
To the centre of the volcano. Workshop on the Mechanisms of Nucleocytoplasmic Transport
Fornerod, Maarten and Clarke, Paul R. (2008). To the centre of the volcano. Workshop on the Mechanisms of Nucleocytoplasmic Transport. NATURE PUBLISHING GROUP. doi: 10.1038/embor.2008.51
2008
Journal Article
Signaling to nuclear transport.
Clarke, Paul R. (2008). Signaling to nuclear transport.. Developmental Cell, 14 (3), 316-318. doi: 10.1016/j.devcel.2008.02.005
2008
Journal Article
The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125
Martin, Morag C., Allan, Lindsey A., Mancini, Erika J. and Clarke, Paul R. (2008). The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125. Journal of Biological Chemistry, 283 (7), 3854-3865. doi: 10.1074/jbc.M705647200
2008
Journal Article
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis
Chen, Qiang, Zhang, Xiaoyan, Jiang, Qing, Clarke, Paul R. and Zhang, Chuamnao (2008). Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Research, 18 (2), 268-280. doi: 10.1038/cr.2008.11
2008
Journal Article
A mechanism coupling cell division and the control of apoptosis
Allan, Lindsey A and Clarke, Paul R (2008). A mechanism coupling cell division and the control of apoptosis. SEB experimental biology series, 59, 257-265.
2007
Journal Article
RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation
Hood, Fiona E. and Clarke, Paul R. (2007). RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation. Journal of Cell Science, 120 (19), 3436-3445. doi: 10.1242/jcs.009092
2007
Journal Article
Mitosis: Ran scales the alps of spindle formation
Clarke, Paul R. and Sazer, Shelley (2007). Mitosis: Ran scales the alps of spindle formation. Current Biology, 17 (16), R643-R645. doi: 10.1016/j.cub.2007.06.023
2007
Journal Article
Anchoring RCC1 by the tail
Clarke, Paul R. (2007). Anchoring RCC1 by the tail. Nature Cell Biology, 9 (5), 485-487. doi: 10.1038/ncb0507-485
2007
Journal Article
Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis
Allan, Lindsey A. and Clarke, Paul R. (2007). Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis. Molecular Cell, 26 (2), 301-310. doi: 10.1016/j.molcel.2007.03.019
2006
Journal Article
A mitotic role for BRCA1/BARD1 in tumor suppression?
Clarke, Paul R. and Sanderson, Helen S. (2006). A mitotic role for BRCA1/BARD1 in tumor suppression?. Cell, 127 (3), 453-455. doi: 10.1016/j.cell.2006.10.020
2006
Journal Article
Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation
Bennett, Lara N. and Clarke, Paul R. (2006). Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. Febs Letters, 580 (17), 4176-4181. doi: 10.1016/j.febslet.2006.06.071
2006
Journal Article
Cell biology: Ran, mitosis and the cancer Lconnection
Sanderson, HS and Clarke, PR (2006). Cell biology: Ran, mitosis and the cancer Lconnection. Current Biology, 16 (12), R466-R468. doi: 10.1016/j.cub.2006.05.032
2005
Journal Article
Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress
Brady, S. C., Allan, L. A. and Clarke, P. R. (2005). Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress. Molecular and Cellular Biology, 25 (23), 10543-10555. doi: 10.1128/MCB.25.23.10543-10555.2005
2005
Journal Article
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway
Clarke, Catriona A. L., Bennett, Lara N. and Clarke, Paul R. (2005). Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. Journal of Biological Chemistry, 280 (42), 35337-35345. doi: 10.1074/jbc.M506460200
2005
Journal Article
A gradient signal orchestrates the mitotic spindle
Clarke, PR (2005). A gradient signal orchestrates the mitotic spindle. Science, 309 (5739), 1334-1335. doi: 10.1126/science.1117842
Supervision
Availability
- Professor Paul Clarke is:
- Available for supervision
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Available projects
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Control of mitotic cell death in health and disease
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Control of chromosome instability by tumour suppressors
Supervision history
Current supervision
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Doctor Philosophy
Control of mitotic cell death in response to chemotherapy
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Regulation of Mitosis by Oncogenes and Tumor Suppressors
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Decoding the spatiotemporal control of DNA replication and repair
Associate Advisor
Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones
Completed supervision
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2023
Doctor Philosophy
Defining the role of cGAS in mitotic cell death
Principal Advisor
Other advisors: Dr Mathew Jones
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2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Principal Advisor
Other advisors: Professor Nikolas Haass
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2024
Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
Media
Enquiries
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