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Professor Paul Clarke
Professor

Paul Clarke

Email: 

Overview

Background

Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.

Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.

Availability

Professor Paul Clarke is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Biochemistry, University of Bristol
  • Doctor of Philosophy of Biochemistry, University of Dundee

Research interests

  • Cell division

  • Cell death

  • Cancer chemotherapy

Works

Search Professor Paul Clarke’s works on UQ eSpace

94 works between 1989 and 2021

61 - 80 of 94 works

2000

Journal Article

Ran alters nuclear pore complex conformation

Goldberg, MW, Rutherford, SA, Hughes, M, Cotter, LA, Bagley, S, Kiseleva, E, Allen, TD and Clarke, PR (2000). Ran alters nuclear pore complex conformation. Journal of Molecular Biology, 300 (3), 519-529. doi: 10.1006/jmbi.2000.3891

Ran alters nuclear pore complex conformation

2000

Journal Article

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

Zhang, CM and Clarke, PR (2000). Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science, 288 (5470), 1429-1432. doi: 10.1126/science.288.5470.1429

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

2000

Journal Article

Substrate specificity determinants of the checkpoint protein kinase Chk1

Hutchins, JRA, Hughes, M and Clarke, PR (2000). Substrate specificity determinants of the checkpoint protein kinase Chk1. Febs Letters, 466 (1), 91-95. doi: 10.1016/S0014-5793(99)01763-9

Substrate specificity determinants of the checkpoint protein kinase Chk1

1999

Conference Publication

Structural effects of Ran on the nuclear pore complex

Goldberg, MW, Rutherford, S, Cotter, L, Kiseleva, E, Allen, TD and Clarke, PR (1999). Structural effects of Ran on the nuclear pore complex. AMER SOC CELL BIOLOGY.

Structural effects of Ran on the nuclear pore complex

1999

Journal Article

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

Zhang, CM, Hughes, M and Clarke, PR (1999). Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 112 (14), 2453-2461.

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

1999

Journal Article

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

Swanton, Eileithyia, Savory, Peter, Cosulich, Sabina, Clarke, Paul and Woodman, Philip (1999). Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene, 18 (10), 1781-1787. doi: 10.1038/sj.onc.1202490

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

1999

Journal Article

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, SC, Savory, PJ and Clarke, PR (1999). Bcl-2 regulates amplification of caspase activation by cytochrome c. Current Biology, 9 (3), 147-150. doi: 10.1016/S0960-9822(99)80068-2

Bcl-2 regulates amplification of caspase activation by cytochrome c

1998

Journal Article

The role of the Ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants

Hughes, M, Zhang, CM, Avis, JM, Hutchison, CJ and Clarke, PR (1998). The role of the Ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants. Journal of Cell Science, 111, 3017-3026.

The role of the Ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants

1997

Journal Article

Regulation of apoptosis by BH3 domains in a cell-free system

Cosulich, SC, Worrall, V, Hedge, PJ, Green, S and Clarke, PR (1997). Regulation of apoptosis by BH3 domains in a cell-free system. Current Biology, 7 (12), 913-920. doi: 10.1016/S0960-9822(06)00410-6

Regulation of apoptosis by BH3 domains in a cell-free system

1997

Journal Article

Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts

Nicolas, FJ, Zhang, CM, Hughes, M, Goldberg, MW, Watton, SJ and Clarke, PR (1997). Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 110 (24), 3019-3030.

Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts

1997

Journal Article

Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis

Cosulich, SC, Horiuchi, H, Zerial, M, Clarke, PR and Woodman, PG (1997). Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis. Embo Journal, 16 (20), 6182-6191. doi: 10.1093/emboj/16.20.6182

Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis

1996

Journal Article

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

LeRomancer, M, Cosulich, SC, Jackson, SP and Clarke, PR (1996). Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. Journal of Cell Science, 109 (13), 3121-3127.

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

1996

Journal Article

Ran, a GTPase involved in nuclear processes: Its regulators and effectors

Avis, JM and Clarke, PR (1996). Ran, a GTPase involved in nuclear processes: Its regulators and effectors. Journal of Cell Science, 109 (10), 2423-2427.

Ran, a GTPase involved in nuclear processes: Its regulators and effectors

1996

Journal Article

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

Cosulich, SC, Green, S and Clarke, PR (1996). Bcl-2 regulates activation of apoptotic proteases in a cell-free system. Current Biology, 6 (8), 997-1005. doi: 10.1016/S0960-9822(02)00644-9

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

1996

Journal Article

Apoptosis: Does stress kill?

Cosulich, Sabina and Clarke, Paul (1996). Apoptosis: Does stress kill?. Current Biology, 6 (12), 1586-1588. doi: 10.1016/S0960-9822(02)70779-3

Apoptosis: Does stress kill?

1995

Journal Article

Regulation of Cdc2 Cyclin-B Activation by Ran, a Ras-Related Gtpase

Clarke, PR, Klebe, C, Wittinghofer, A and Karsenti, E (1995). Regulation of Cdc2 Cyclin-B Activation by Ran, a Ras-Related Gtpase. Journal of Cell Science, 108 (3), 1217-1225.

Regulation of Cdc2 Cyclin-B Activation by Ran, a Ras-Related Gtpase

1995

Journal Article

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

Hoffmann, Ingrid, Clarke, Paul R. and Draetta, Giulio (1995). The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle. Advances in Molecular and Cell Biology, 13 (C), 151-164. doi: 10.1016/S1569-2558(08)60010-7

The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle

1995

Journal Article

Cyclin-Dependent Kinases: CAK-handed kinase activation

Clarke, PR (1995). Cyclin-Dependent Kinases: CAK-handed kinase activation. Current Biology, 5 (1), 40-42. doi: 10.1016/S0960-9822(95)00013-3

Cyclin-Dependent Kinases: CAK-handed kinase activation

1994

Journal Article

Signal Transduction: Switching off MAP kinases

Clarke, P.R. (1994). Signal Transduction: Switching off MAP kinases. Current Biology, 4 (7), 647-650. doi: 10.1016/S0960-9822(00)00144-5

Signal Transduction: Switching off MAP kinases

1993

Journal Article

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

Clarke, PR, Siddhanti, SR, Cohen, P and Blackshear, PJ (1993). Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate. Febs Letters, 336 (1), 37-42. doi: 10.1016/0014-5793(93)81604-X

Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate

Funding

Current funding

  • 2014 - 2026
    Dr Jian Zhou Memorial Scholarship
    Research Donation Generic
    Open grant

Past funding

  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant
  • 2019
    A Gas Chromatography-High Resolution Accurate Mass Spectrometry Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Supervision

Availability

Professor Paul Clarke is:
Available for supervision

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Available projects

  • Control of mitotic cell death in health and disease

  • Control of chromosome instability by tumour suppressors

Supervision history

Current supervision

  • Doctor Philosophy

    Control of mitotic cell death in response to chemotherapy

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Regulation of Mitosis by Oncogenes and Tumor Suppressors

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Understanding the role of FBXW7 in mitosis and chromosomal stability

    Associate Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Decoding the spatiotemporal control of DNA replication and repair

    Associate Advisor

    Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones

Completed supervision

Media

Enquiries

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