
Overview
Background
Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.
Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.
Availability
- Professor Paul Clarke is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Biochemistry, University of Bristol
- Doctor of Philosophy of Biochemistry, University of Dundee
Research interests
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Cell division
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Cell death
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Cancer chemotherapy
Works
Search Professor Paul Clarke’s works on UQ eSpace
2000
Journal Article
Ran alters nuclear pore complex conformation
Goldberg, MW, Rutherford, SA, Hughes, M, Cotter, LA, Bagley, S, Kiseleva, E, Allen, TD and Clarke, PR (2000). Ran alters nuclear pore complex conformation. Journal of Molecular Biology, 300 (3), 519-529. doi: 10.1006/jmbi.2000.3891
2000
Journal Article
Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
Zhang, CM and Clarke, PR (2000). Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science, 288 (5470), 1429-1432. doi: 10.1126/science.288.5470.1429
2000
Journal Article
Substrate specificity determinants of the checkpoint protein kinase Chk1
Hutchins, JRA, Hughes, M and Clarke, PR (2000). Substrate specificity determinants of the checkpoint protein kinase Chk1. Febs Letters, 466 (1), 91-95. doi: 10.1016/S0014-5793(99)01763-9
1999
Conference Publication
Structural effects of Ran on the nuclear pore complex
Goldberg, MW, Rutherford, S, Cotter, L, Kiseleva, E, Allen, TD and Clarke, PR (1999). Structural effects of Ran on the nuclear pore complex. AMER SOC CELL BIOLOGY.
1999
Journal Article
Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
Zhang, CM, Hughes, M and Clarke, PR (1999). Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 112 (14), 2453-2461.
1999
Journal Article
Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts
Swanton, Eileithyia, Savory, Peter, Cosulich, Sabina, Clarke, Paul and Woodman, Philip (1999). Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene, 18 (10), 1781-1787. doi: 10.1038/sj.onc.1202490
1999
Journal Article
Bcl-2 regulates amplification of caspase activation by cytochrome c
Cosulich, SC, Savory, PJ and Clarke, PR (1999). Bcl-2 regulates amplification of caspase activation by cytochrome c. Current Biology, 9 (3), 147-150. doi: 10.1016/S0960-9822(99)80068-2
1998
Journal Article
The role of the Ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants
Hughes, M, Zhang, CM, Avis, JM, Hutchison, CJ and Clarke, PR (1998). The role of the Ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants. Journal of Cell Science, 111, 3017-3026.
1997
Journal Article
Regulation of apoptosis by BH3 domains in a cell-free system
Cosulich, SC, Worrall, V, Hedge, PJ, Green, S and Clarke, PR (1997). Regulation of apoptosis by BH3 domains in a cell-free system. Current Biology, 7 (12), 913-920. doi: 10.1016/S0960-9822(06)00410-6
1997
Journal Article
Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts
Nicolas, FJ, Zhang, CM, Hughes, M, Goldberg, MW, Watton, SJ and Clarke, PR (1997). Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 110 (24), 3019-3030.
1997
Journal Article
Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis
Cosulich, SC, Horiuchi, H, Zerial, M, Clarke, PR and Woodman, PG (1997). Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis. Embo Journal, 16 (20), 6182-6191. doi: 10.1093/emboj/16.20.6182
1996
Journal Article
Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts
LeRomancer, M, Cosulich, SC, Jackson, SP and Clarke, PR (1996). Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. Journal of Cell Science, 109 (13), 3121-3127.
1996
Journal Article
Ran, a GTPase involved in nuclear processes: Its regulators and effectors
Avis, JM and Clarke, PR (1996). Ran, a GTPase involved in nuclear processes: Its regulators and effectors. Journal of Cell Science, 109 (10), 2423-2427.
1996
Journal Article
Bcl-2 regulates activation of apoptotic proteases in a cell-free system
Cosulich, SC, Green, S and Clarke, PR (1996). Bcl-2 regulates activation of apoptotic proteases in a cell-free system. Current Biology, 6 (8), 997-1005. doi: 10.1016/S0960-9822(02)00644-9
1996
Journal Article
Apoptosis: Does stress kill?
Cosulich, Sabina and Clarke, Paul (1996). Apoptosis: Does stress kill?. Current Biology, 6 (12), 1586-1588. doi: 10.1016/S0960-9822(02)70779-3
1995
Journal Article
Regulation of Cdc2 Cyclin-B Activation by Ran, a Ras-Related Gtpase
Clarke, PR, Klebe, C, Wittinghofer, A and Karsenti, E (1995). Regulation of Cdc2 Cyclin-B Activation by Ran, a Ras-Related Gtpase. Journal of Cell Science, 108 (3), 1217-1225.
1995
Journal Article
The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle
Hoffmann, Ingrid, Clarke, Paul R. and Draetta, Giulio (1995). The cdc25 Phosphatase: Biochemistry and Regulation in the Eukaryotic Cell Cycle. Advances in Molecular and Cell Biology, 13 (C), 151-164. doi: 10.1016/S1569-2558(08)60010-7
1995
Journal Article
Cyclin-Dependent Kinases: CAK-handed kinase activation
Clarke, PR (1995). Cyclin-Dependent Kinases: CAK-handed kinase activation. Current Biology, 5 (1), 40-42. doi: 10.1016/S0960-9822(95)00013-3
1994
Journal Article
Signal Transduction: Switching off MAP kinases
Clarke, P.R. (1994). Signal Transduction: Switching off MAP kinases. Current Biology, 4 (7), 647-650. doi: 10.1016/S0960-9822(00)00144-5
1993
Journal Article
Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate
Clarke, PR, Siddhanti, SR, Cohen, P and Blackshear, PJ (1993). Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate. Febs Letters, 336 (1), 37-42. doi: 10.1016/0014-5793(93)81604-X
Supervision
Availability
- Professor Paul Clarke is:
- Available for supervision
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Available projects
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Control of mitotic cell death in health and disease
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Control of chromosome instability by tumour suppressors
Supervision history
Current supervision
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Doctor Philosophy
Control of mitotic cell death in response to chemotherapy
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Regulation of Mitosis by Oncogenes and Tumor Suppressors
Principal Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
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Doctor Philosophy
Decoding the spatiotemporal control of DNA replication and repair
Associate Advisor
Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones
Completed supervision
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2023
Doctor Philosophy
Defining the role of cGAS in mitotic cell death
Principal Advisor
Other advisors: Dr Mathew Jones
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2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Principal Advisor
Other advisors: Professor Nikolas Haass
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2024
Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
Media
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