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Professor Paul Clarke
Professor

Paul Clarke

Email: 

Overview

Background

Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.

Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.

Availability

Professor Paul Clarke is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Biochemistry, University of Bristol
  • Doctor of Philosophy of Biochemistry, University of Dundee

Research interests

  • Cell division

  • Cell death

  • Cancer chemotherapy

Works

Search Professor Paul Clarke’s works on UQ eSpace

94 works between 1989 and 2021

81 - 94 of 94 works

1993

Journal Article

Dephosphorylation of Cdc25-C by a Type-2A Protein Phosphatase - Specific Regulation During the Cell-Cycle in Xenopus Egg Extracts

Clarke, PR, Hoffmann, I, Draetta, G and Karsenti, E (1993). Dephosphorylation of Cdc25-C by a Type-2A Protein Phosphatase - Specific Regulation During the Cell-Cycle in Xenopus Egg Extracts. Molecular Biology of the Cell, 4 (4), 397-411. doi: 10.1091/mbc.4.4.397

Dephosphorylation of Cdc25-C by a Type-2A Protein Phosphatase - Specific Regulation During the Cell-Cycle in Xenopus Egg Extracts

1993

Journal Article

Phosphorylation and Activation of Human Cdc25-C by Cdc2 Cyclin-B and its Involvement in the Self-Amplification of Mpf At Mitosis

Hoffmann, I, Clarke, PR, Marcote, MJ, Karsenti, E and Draetta, G (1993). Phosphorylation and Activation of Human Cdc25-C by Cdc2 Cyclin-B and its Involvement in the Self-Amplification of Mpf At Mitosis. Embo Journal, 12 (1), 53-63. doi: 10.1002/j.1460-2075.1993.tb05631.x

Phosphorylation and Activation of Human Cdc25-C by Cdc2 Cyclin-B and its Involvement in the Self-Amplification of Mpf At Mitosis

1992

Journal Article

Cyclin A-Dependent and Cyclin B-Dependent Protein-Kinases Are Regulated by Different Mechanisms in Xenopus Egg Extracts

Clarke, PR, Leiss, D, Pagano, M and Karsenti, E (1992). Cyclin A-Dependent and Cyclin B-Dependent Protein-Kinases Are Regulated by Different Mechanisms in Xenopus Egg Extracts. Embo Journal, 11 (5), 1751-1761. doi: 10.1002/j.1460-2075.1992.tb05227.x

Cyclin A-Dependent and Cyclin B-Dependent Protein-Kinases Are Regulated by Different Mechanisms in Xenopus Egg Extracts

1992

Journal Article

Inhibition of Membrane-Fusion Invitro Via Cyclin-B But Not Cyclin-a

Thomas, L, Clarke, PR, Pagano, M and Gruenberg, J (1992). Inhibition of Membrane-Fusion Invitro Via Cyclin-B But Not Cyclin-a. Journal of Biological Chemistry, 267 (9), 6183-6187.

Inhibition of Membrane-Fusion Invitro Via Cyclin-B But Not Cyclin-a

1992

Journal Article

Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))

Thomas, L., Clarke, P. R., Pagano, M. and Gruenberg, J. (1992). Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187)). Journal of Biological Chemistry, 267 (19).

Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))

1992

Journal Article

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

Mackintosh, RW, Davies, SP, Clarke, PR, Weekes, J, Gillespie, JG, Gibb, BJ and Hardie, DG (1992). Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase. European Journal of Biochemistry, 209 (3), 923-931. doi: 10.1111/j.1432-1033.1992.tb17364.x

Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase

1992

Journal Article

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

Hoffmann, Ingrid, Clarke, Paul, Karsenti, Eric and Draetta, Giulio (1992). cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS. Biology of the Cell, 76 (2), 213-213. doi: 10.1016/0248-4900(92)90225-P

cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS

1991

Journal Article

Regulation of P34Cdc2 Protein-Kinase - New Insights Into Protein-Phosphorylation and the Cell-Cycle

Clarke, PR and Karsenti, E (1991). Regulation of P34Cdc2 Protein-Kinase - New Insights Into Protein-Phosphorylation and the Cell-Cycle. Journal of Cell Science, 100, 409-414.

Regulation of P34Cdc2 Protein-Kinase - New Insights Into Protein-Phosphorylation and the Cell-Cycle

1991

Journal Article

Adenosine Monophosphate-Activated Protein-Kinase - Hydroxymethylglutaryl-Coa Reductase Kinase

Carling, D, Clarke, PR and Hardie, DG (1991). Adenosine Monophosphate-Activated Protein-Kinase - Hydroxymethylglutaryl-Coa Reductase Kinase. Methods in Enzymology, 200 (C), 362-371. doi: 10.1016/0076-6879(91)00153-N

Adenosine Monophosphate-Activated Protein-Kinase - Hydroxymethylglutaryl-Coa Reductase Kinase

1991

Journal Article

REGULATION OF PROTEIN-KINASES ASSOCIATED WITH CYCLIN-A AND CYCLIN-B AND THEIR EFFECT ON MICROTUBULE DYNAMICS AND NUCLEATION IN XENOPUS EGG EXTRACTS

BUENDIA, B, CLARKE, PR, FELIX, MA, KARSENTI, E, LEISS, D and VERDE, F (1991). REGULATION OF PROTEIN-KINASES ASSOCIATED WITH CYCLIN-A AND CYCLIN-B AND THEIR EFFECT ON MICROTUBULE DYNAMICS AND NUCLEATION IN XENOPUS EGG EXTRACTS. Cold Spring Harbor Symposia On Quantitative Biology, 56, 523-532.

REGULATION OF PROTEIN-KINASES ASSOCIATED WITH CYCLIN-A AND CYCLIN-B AND THEIR EFFECT ON MICROTUBULE DYNAMICS AND NUCLEATION IN XENOPUS EGG EXTRACTS

1991

Conference Publication

Regulation of Protein-Kinases Associated with Cyclin-A and Cyclin-B and Their Effect On Microtubule Dynamics and Nucleation in Xenopus Egg Extracts

Buendia, B, Clarke, PR, Felix, MA, Karsenti, E, Leiss, D and Verde, F (1991). Regulation of Protein-Kinases Associated with Cyclin-A and Cyclin-B and Their Effect On Microtubule Dynamics and Nucleation in Xenopus Egg Extracts. 56Th Cold Spring Harbor Symp On the Cell Cycle, Cold Spring Harbor Ny, 1991. PLAINVIEW: COLD SPRING HARBOR LABORATORY PRESS. doi: 10.1101/SQB.1991.056.01.059

Regulation of Protein-Kinases Associated with Cyclin-A and Cyclin-B and Their Effect On Microtubule Dynamics and Nucleation in Xenopus Egg Extracts

1990

Journal Article

Regulation of Hmg-Coa Reductase - Identification of the Site Phosphorylated by the Amp-Activated Protein-Kinase Invitro and in Intact Rat-Liver

Clarke, PR and Hardie, DG (1990). Regulation of Hmg-Coa Reductase - Identification of the Site Phosphorylated by the Amp-Activated Protein-Kinase Invitro and in Intact Rat-Liver. Embo Journal, 9 (8), 2439-2446. doi: 10.1002/j.1460-2075.1990.tb07420.x

Regulation of Hmg-Coa Reductase - Identification of the Site Phosphorylated by the Amp-Activated Protein-Kinase Invitro and in Intact Rat-Liver

1990

Journal Article

Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase

Clarke, PR and Hardie, DG (1990). Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase. Febs Letters, 269 (1), 213-217. doi: 10.1016/0014-5793(90)81157-J

Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase

1989

Journal Article

Purification and characterization of the AMP‐activated protein kinase: Copurification of acetyl‐CoA carboxylase kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA reductase kinase activities

Carling, D, Clarke, PR, Zammit, VA and Hardie, DG (1989). Purification and characterization of the AMP‐activated protein kinase: Copurification of acetyl‐CoA carboxylase kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA reductase kinase activities. European Journal of Biochemistry, 186 (1-2), 129-136. doi: 10.1111/j.1432-1033.1989.tb15186.x

Purification and characterization of the AMP‐activated protein kinase: Copurification of acetyl‐CoA carboxylase kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA reductase kinase activities

Funding

Current funding

  • 2014 - 2026
    Dr Jian Zhou Memorial Scholarship
    Research Donation Generic
    Open grant

Past funding

  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant
  • 2019
    A Gas Chromatography-High Resolution Accurate Mass Spectrometry Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Supervision

Availability

Professor Paul Clarke is:
Available for supervision

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Available projects

  • Control of mitotic cell death in health and disease

  • Control of chromosome instability by tumour suppressors

Supervision history

Current supervision

  • Doctor Philosophy

    Control of mitotic cell death in response to chemotherapy

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Regulation of Mitosis by Oncogenes and Tumor Suppressors

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Understanding the role of FBXW7 in mitosis and chromosomal stability

    Associate Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Decoding the spatiotemporal control of DNA replication and repair

    Associate Advisor

    Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones

Completed supervision

Media

Enquiries

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