
Overview
Background
Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.
Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.
Availability
- Professor Paul Clarke is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Biochemistry, University of Bristol
- Doctor of Philosophy of Biochemistry, University of Dundee
Research interests
-
Cell division
-
Cell death
-
Cancer chemotherapy
Works
Search Professor Paul Clarke’s works on UQ eSpace
1993
Journal Article
Dephosphorylation of Cdc25-C by a Type-2A Protein Phosphatase - Specific Regulation During the Cell-Cycle in Xenopus Egg Extracts
Clarke, PR, Hoffmann, I, Draetta, G and Karsenti, E (1993). Dephosphorylation of Cdc25-C by a Type-2A Protein Phosphatase - Specific Regulation During the Cell-Cycle in Xenopus Egg Extracts. Molecular Biology of the Cell, 4 (4), 397-411. doi: 10.1091/mbc.4.4.397
1993
Journal Article
Phosphorylation and Activation of Human Cdc25-C by Cdc2 Cyclin-B and its Involvement in the Self-Amplification of Mpf At Mitosis
Hoffmann, I, Clarke, PR, Marcote, MJ, Karsenti, E and Draetta, G (1993). Phosphorylation and Activation of Human Cdc25-C by Cdc2 Cyclin-B and its Involvement in the Self-Amplification of Mpf At Mitosis. Embo Journal, 12 (1), 53-63. doi: 10.1002/j.1460-2075.1993.tb05631.x
1992
Journal Article
Cyclin A-Dependent and Cyclin B-Dependent Protein-Kinases Are Regulated by Different Mechanisms in Xenopus Egg Extracts
Clarke, PR, Leiss, D, Pagano, M and Karsenti, E (1992). Cyclin A-Dependent and Cyclin B-Dependent Protein-Kinases Are Regulated by Different Mechanisms in Xenopus Egg Extracts. Embo Journal, 11 (5), 1751-1761. doi: 10.1002/j.1460-2075.1992.tb05227.x
1992
Journal Article
Inhibition of Membrane-Fusion Invitro Via Cyclin-B But Not Cyclin-a
Thomas, L, Clarke, PR, Pagano, M and Gruenberg, J (1992). Inhibition of Membrane-Fusion Invitro Via Cyclin-B But Not Cyclin-a. Journal of Biological Chemistry, 267 (9), 6183-6187.
1992
Journal Article
Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187))
Thomas, L., Clarke, P. R., Pagano, M. and Gruenberg, J. (1992). Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187)). Journal of Biological Chemistry, 267 (19).
1992
Journal Article
Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase
Mackintosh, RW, Davies, SP, Clarke, PR, Weekes, J, Gillespie, JG, Gibb, BJ and Hardie, DG (1992). Evidence for a protein kinase cascade in higher plants: 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase kinase. European Journal of Biochemistry, 209 (3), 923-931. doi: 10.1111/j.1432-1033.1992.tb17364.x
1992
Journal Article
cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS
Hoffmann, Ingrid, Clarke, Paul, Karsenti, Eric and Draetta, Giulio (1992). cdc25‐C is ACTIVATED BY PHOSPHORYLATION AT MITOSIS. Biology of the Cell, 76 (2), 213-213. doi: 10.1016/0248-4900(92)90225-P
1991
Journal Article
Regulation of P34Cdc2 Protein-Kinase - New Insights Into Protein-Phosphorylation and the Cell-Cycle
Clarke, PR and Karsenti, E (1991). Regulation of P34Cdc2 Protein-Kinase - New Insights Into Protein-Phosphorylation and the Cell-Cycle. Journal of Cell Science, 100, 409-414.
1991
Journal Article
Adenosine Monophosphate-Activated Protein-Kinase - Hydroxymethylglutaryl-Coa Reductase Kinase
Carling, D, Clarke, PR and Hardie, DG (1991). Adenosine Monophosphate-Activated Protein-Kinase - Hydroxymethylglutaryl-Coa Reductase Kinase. Methods in Enzymology, 200 (C), 362-371. doi: 10.1016/0076-6879(91)00153-N
1991
Journal Article
REGULATION OF PROTEIN-KINASES ASSOCIATED WITH CYCLIN-A AND CYCLIN-B AND THEIR EFFECT ON MICROTUBULE DYNAMICS AND NUCLEATION IN XENOPUS EGG EXTRACTS
BUENDIA, B, CLARKE, PR, FELIX, MA, KARSENTI, E, LEISS, D and VERDE, F (1991). REGULATION OF PROTEIN-KINASES ASSOCIATED WITH CYCLIN-A AND CYCLIN-B AND THEIR EFFECT ON MICROTUBULE DYNAMICS AND NUCLEATION IN XENOPUS EGG EXTRACTS. Cold Spring Harbor Symposia On Quantitative Biology, 56, 523-532.
1991
Conference Publication
Regulation of Protein-Kinases Associated with Cyclin-A and Cyclin-B and Their Effect On Microtubule Dynamics and Nucleation in Xenopus Egg Extracts
Buendia, B, Clarke, PR, Felix, MA, Karsenti, E, Leiss, D and Verde, F (1991). Regulation of Protein-Kinases Associated with Cyclin-A and Cyclin-B and Their Effect On Microtubule Dynamics and Nucleation in Xenopus Egg Extracts. 56Th Cold Spring Harbor Symp On the Cell Cycle, Cold Spring Harbor Ny, 1991. PLAINVIEW: COLD SPRING HARBOR LABORATORY PRESS. doi: 10.1101/SQB.1991.056.01.059
1990
Journal Article
Regulation of Hmg-Coa Reductase - Identification of the Site Phosphorylated by the Amp-Activated Protein-Kinase Invitro and in Intact Rat-Liver
Clarke, PR and Hardie, DG (1990). Regulation of Hmg-Coa Reductase - Identification of the Site Phosphorylated by the Amp-Activated Protein-Kinase Invitro and in Intact Rat-Liver. Embo Journal, 9 (8), 2439-2446. doi: 10.1002/j.1460-2075.1990.tb07420.x
1990
Journal Article
Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase
Clarke, PR and Hardie, DG (1990). Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase. Febs Letters, 269 (1), 213-217. doi: 10.1016/0014-5793(90)81157-J
1989
Journal Article
Purification and characterization of the AMP‐activated protein kinase: Copurification of acetyl‐CoA carboxylase kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA reductase kinase activities
Carling, D, Clarke, PR, Zammit, VA and Hardie, DG (1989). Purification and characterization of the AMP‐activated protein kinase: Copurification of acetyl‐CoA carboxylase kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA reductase kinase activities. European Journal of Biochemistry, 186 (1-2), 129-136. doi: 10.1111/j.1432-1033.1989.tb15186.x
Supervision
Availability
- Professor Paul Clarke is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Control of mitotic cell death in health and disease
-
Control of chromosome instability by tumour suppressors
Supervision history
Current supervision
-
Doctor Philosophy
Control of mitotic cell death in response to chemotherapy
Principal Advisor
Other advisors: Dr Mathew Jones
-
Doctor Philosophy
Regulation of Mitosis by Oncogenes and Tumor Suppressors
Principal Advisor
Other advisors: Dr Mathew Jones
-
Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
-
Doctor Philosophy
Decoding the spatiotemporal control of DNA replication and repair
Associate Advisor
Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones
Completed supervision
-
2023
Doctor Philosophy
Defining the role of cGAS in mitotic cell death
Principal Advisor
Other advisors: Dr Mathew Jones
-
2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Principal Advisor
Other advisors: Professor Nikolas Haass
-
2024
Doctor Philosophy
Understanding the role of FBXW7 in mitosis and chromosomal stability
Associate Advisor
Other advisors: Dr Mathew Jones
Media
Enquiries
For media enquiries about Professor Paul Clarke's areas of expertise, story ideas and help finding experts, contact our Media team: