Professor Paul Clarke
Professor

Paul Clarke

Email: 

Background

Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the University of Dundee in Scotland, Senior Research Fellow at the University of Manchester in England, and Research Fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Professor Clarke studied Biochemistry at the University of Bristol and undertook research for his PhD at the University of Dundee.

Frazer Institute, formerly UQ Diamantina Institute, is named in honour of its Founding Director, Emeritus Professor Ian Frazer, co-discoverer of the Gardasil HPV cervical cancer vaccine. Frazer Institute is part of The University of Queensland Faculty of Medicine and is a key partner in the Translational Research Institute, a $360 million research facility at the Princess Alexandra Hospital precinct in Woolloongabba. Scientists and clinical researchers at Frazer Institute develop new methods for the prevention, detection and treatment of human diseases.

Availability

Professor Paul Clarke is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cell development, proliferation and death Oncology and carcinogenesis

Qualifications

  • Bachelor (Honours) of Biochemistry, University of Bristol
  • Doctor of Philosophy of Biochemistry, University of Dundee

Research interests

  • Cell division

  • Cell death

  • Cancer chemotherapy

Search Professor Paul Clarke’s works on UQ eSpace

94 works between 1989 and 2021
All (94) Journal Article (89) Conference Publication (5)

41 - 60 of 94 works

2005

Journal Article

The Crm de la crème of mitosis

Clarke, PR (2005). The Crm de la crème of mitosis. Nature Cell Biology, 7 (6), 551-552. doi: 10.1038/ncb0605-551

The Crm de la crème of mitosis

2005

Journal Article

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, CAL and Clarke, PR (2005). DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochemical Journal, 388 (2), 705-712. doi: 10.1042/BJ20041966

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

2005

Journal Article

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c

Martin, MC, Allan, LA, Lickrish, M, Sampson, C, Morrice, N and Clarke, PR (2005). Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c. Journal of Biological Chemistry, 280 (15), 15449-15455. doi: 10.1074/jbc.M414325200

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c

2005

Journal Article

Regulation of Cdc2/cyclin B activation in xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca2+/calmodulin-dependent protein kinase II. (vol 14, pg 4003, 2003)

Hutchins, JRA, Dikovskaya, D and Clarke, PR (2005). Regulation of Cdc2/cyclin B activation in xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca2+/calmodulin-dependent protein kinase II. (vol 14, pg 4003, 2003). Molecular Biology of the Cell, 16 (3), 1568-1568.

Regulation of Cdc2/cyclin B activation in xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca2+/calmodulin-dependent protein kinase II. (vol 14, pg 4003, 2003)

2004

Journal Article

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

Hutchins, JRA, Moore, WJ, Hood, FE, Wilson, JSJ, Andrews, PD, Swedlow, JR and Clarke, PR (2004). Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis. Current Biology, 14 (12), 1099-1104. doi: 10.1016/j.cub.2004.05.021

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

2004

Journal Article

Many fingers on the mitotic trigger - Post-translational regulation of the Cdc25C phosphatase

Hutchins, JRA and Clarke, PR (2004). Many fingers on the mitotic trigger - Post-translational regulation of the Cdc25C phosphatase. Cell Cycle, 3 (1), 41-45.

Many fingers on the mitotic trigger - Post-translational regulation of the Cdc25C phosphatase

2004

Journal Article

Spatial and temporal control of nuclear envelope assembly by Ran GTPase

Clarke, Paul R and Zhang, Chuanmao (2004). Spatial and temporal control of nuclear envelope assembly by Ran GTPase. Symposia of the Society for Experimental Biology (56), 193-204.

Spatial and temporal control of nuclear envelope assembly by Ran GTPase

2003

Journal Article

Nuclear pores: Sowing the seeds of assembly on the chromatin landscape

Wozniak, R and Clarke, PR (2003). Nuclear pores: Sowing the seeds of assembly on the chromatin landscape. Current Biology, 13 (24), R970-R972. doi: 10.1016/j.cub.2003.11.046

Nuclear pores: Sowing the seeds of assembly on the chromatin landscape

2003

Journal Article

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25c phosphatase by Ca 2+/calmodium-dependent kinase II

Hutchins, James R. A., Dikovskaya, D. and Clarke, P. R. (2003). Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25c phosphatase by Ca 2+/calmodium-dependent kinase II. Molecular Biology of the Cell, 14 (10), 4003-4014. doi: 10.1091/mbc.E03-02-0061

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25c phosphatase by Ca 2+/calmodium-dependent kinase II

2003

Journal Article

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

Allan, LA, Morrice, N, Brady, S, Magee, G, Pathak, S and Clarke, PR (2003). Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nature Cell Biology, 5 (7), 647-654. doi: 10.1038/ncb1005

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

2002

Journal Article

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

Zhang, Chuanmao, Goldberg, Martin W., Moore, William J., Allen, Terence D. and Clarke, Paul R. (2002). Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. European Journal of Cell Biology, 81 (11), 623-633. doi: 10.1078/0171-9335-00288

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

2002

Journal Article

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

Hutchins, JRA, Dikovskaya, D and Clarke, PR (2002). Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding. Febs Letters, 528 (1-3), 267-271. doi: 10.1016/S0014-5793(02)03327-6

Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding

2002

Journal Article

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

Moore, WJ, Zhang, CM and Clarke, PR (2002). Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells. Current Biology, 12 (16), 1442-1447. doi: 10.1016/S0960-9822(02)01076-X

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

2002

Journal Article

The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope

Timinszky, G, Tirian, L, Nagy, FT, Toth, G, Perczel, A, Kiss-Laszlo, Z, Boros, I, Clarke, PR and Szabad, J (2002). The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope. Journal of Cell Science, 115 (8), 1675-1687.

The importin-beta P446L dominant-negative mutant protein loses RanGTP binding ability and blocks the formation of intact nuclear envelope

2002

Journal Article

Role of importin-β in the control of nuclear envelope assembly by Ran

Zhang, CM, Hutchins, JRA, Muhlhausser, P, Kutay, U and Clarke, PR (2002). Role of importin-β in the control of nuclear envelope assembly by Ran. Current Biology, 12 (6), 498-502. doi: 10.1016/S0960-9822(02)00714-5

Role of importin-β in the control of nuclear envelope assembly by Ran

2001

Journal Article

Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Clarke, PR and Zhang, CM (2001). Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?. Trends in Cell Biology, 11 (9), 366-371. doi: 10.1016/S0962-8924(01)02071-2

Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

2001

Journal Article

XMog1, a nuclear Ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe Mog1p that co-operates with RanBP1 to control generation of Ran-GTP

Nicolas, FJ, Moore, WJ, Zhang, CM and Clarke, PR (2001). XMog1, a nuclear Ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe Mog1p that co-operates with RanBP1 to control generation of Ran-GTP. Journal of Cell Science, 114 (16), 3013-3023.

XMog1, a nuclear Ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe Mog1p that co-operates with RanBP1 to control generation of Ran-GTP

2001

Journal Article

Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

Zhang, CM and Clarke, PR (2001). Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. Current Biology, 11 (3), 208-212. doi: 10.1016/S0960-9822(01)00053-7

Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

2001

Journal Article

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Curman, D, Cinel, B, Williams, DE, Rundle, N, Block, WD, Goodarzi, AA, Hutchins, JR, Clarke, PR, Zhou, BB, Lees-Miller, SP, Andersen, RJ and Roberge, M (2001). Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine. Journal of Biological Chemistry, 276 (21), 17914-17919. doi: 10.1074/jbc.M100728200

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

2000

Conference Publication

Structural modifications of nuclear pure complexes associated with transport.

Allen, TD, Kiseleva, E, Rutherford, SA, Bagley, S, Clarke, PR and Goldberg, MW (2000). Structural modifications of nuclear pure complexes associated with transport.. AMER SOC CELL BIOLOGY.

Structural modifications of nuclear pure complexes associated with transport.

Current funding

  • 2014 - 2026
    Dr Jian Zhou Memorial Scholarship
    Research Donation Generic
    Open grant

Past funding

  • 2021 - 2023
    Decoding the spatiotemporal control of DNA replication and repair
    ARC Discovery Projects
    Open grant
  • 2019
    A Gas Chromatography-High Resolution Accurate Mass Spectrometry Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Availability

Professor Paul Clarke is:
Available for supervision

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Available projects

  • Control of mitotic cell death in health and disease

  • Control of chromosome instability by tumour suppressors

Supervision history

Current supervision

  • Doctor Philosophy

    Control of mitotic cell death in response to chemotherapy

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Regulation of Mitosis by Oncogenes and Tumor Suppressors

    Principal Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Understanding the role of FBXW7 in mitosis and chromosomal stability

    Associate Advisor

    Other advisors: Dr Mathew Jones

  • Doctor Philosophy

    Decoding the spatiotemporal control of DNA replication and repair

    Associate Advisor

    Other advisors: Dr Alexis de Sa Ribeiro Do Bonfim Melo, Dr Mathew Jones

Completed supervision

Enquiries

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