Regulation of cell proliferation and survival by the ubiquitin system (2019-2023)
Abstract
The overarching aim of this research is to systematically elucidate the biochemical mechanisms by which protein degradation enzymes (known as ubiquitin ligases) regulate cellular homeostasis. To date, the biological function of most ubiquitin ligases remains elusive as most have not been paired with substrates. Using interdisciplinary approaches incorporating proteomics, biochemistry, and molecular cell biology, this proposal seeks to delineate the components of signalling pathways implicated in the degradation of proteins implicated in cell division and cell death. Expected outcomes of this project include an increased understanding of how proteins are specifically selected for degradation.
