How pH alters cell responses to kinase signalling. (2026-2030)
Abstract
This project aims to determine how animal cells are able to sense their environment and interpret signals from a cacophony of stimuli to respond specifically. Protein networks inside cells are organized into biological circuits that communicate biochemical signals to enact a specific response such as to grow, divide or undergo cell death. In a new approach, we will use light to manipulate signal circuits inside living cells in order to unravel how proton dynamics influence how these circuits specify distinct cell functions. This quantum leap in our understanding of the internal mechanisms that control cell behaviour will lead to the development of better drugs, designer cells or synthetic design of artificial biological systems.
