Overview
Background
I am an Associate Professor in the School of Biomedical Sciences (SBMS) at The University of Queensland, where I teach physiology and lead research that explores how cells respond to stress, injury and disease. My work aims to better understand the molecular and cellular processes that influence health and disease, with a particular focus on areas relevant to cancer, heart disease, neurological conditions and emerging cell-based therapies.
I completed my doctorate at the University of Western Australia in Biochemistry and Cell Biology, where I studied how heart cells respond to signals that can drive abnormal tissue growth. I then undertook postdoctoral training in Singapore at the Institute of Molecular and Cell Biology, part of A*STAR, where my research expanded into understanding how the cytoskeleton, internal structures of cells, help control development and disease.
After returning to Australia, I was supported by national fellowships from the NHMRC and ARC, which enabled me to establish an internationally connected research program. My research brings together cell biology, imaging, computational approaches and emerging technologies to uncover how cells make critical decisions, including whether to survive or die under stress.
Alongside my research and teaching, I contribute to leadership within SBMS as Director of Research and support major research infrastructure initiatives across the Faculty of Health, Medicine and Behavioural Sciences (HMBS) as Academic Director of Research Infrastructure. I also serve on steering committees for UQ’s Viral Vector Core (VVC) and the Centre for Cardiovascular Health and Research (CCVHR), helping to strengthen the platforms and partnerships that support biomedical discovery and translation.
Availability
- Associate Professor Dominic Ng is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, University of Western Australia
- Doctor of Philosophy, University of Western Australia
Research interests
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Cell Signalling
Protein phosphorylation, protein interactions, kinases, STAT transcription factors, microtubule-associated proteins.
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Molecular Cardiology
Cardiomyocyte growth, cardiac hypertrophy, cardiac injury, cardioprotection
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Neural Development
Neural stem cells, microcephaly genes, neural migration, neural proliferation, neuronal cell death
Research impacts
My research contributes to society by improving understanding of how cells respond to stress, injury and disease, generating knowledge that can inform new approaches to diagnosis, prevention and treatment. By uncovering the molecular mechanisms that influence cell survival, tissue growth and disease progression, my work supports advances in areas of major health burden, including cancer, cardiovascular disease and neurological conditions. Beyond academic discovery, this research helps strengthen Australia’s biomedical innovation pipeline by supporting translational partnerships, enabling platform technologies such as viral vectors and advanced imaging, and training the next generation of researchers with skills relevant to the health, biotechnology and medical research sectors.
Works
Search Professor Dominic Ng’s works on UQ eSpace
2018
Journal Article
MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis
Xu, Dan, Yao, Minghui, Wang, Yaqing, Yuan, Ling, Hoeck, Joerg D., Yu, Jingwen, Liu, Liang, Yeap, Yvonne Y. C., Zhang, Weiya, Zhang, Feng, Feng, Yinghang, Ma, Tiantian, Wang, Yujie, Ng, Dominic C. H., Niu, Xiaoyin, Su, Bing, Behrens, Axel and Xu, Zhiheng (2018). MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology, 16 (12) e2006613, e2006613. doi: 10.1371/journal.pbio.2006613
2018
Journal Article
Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases
Woodman, Owen L., Chin, Kai Yee, Thomas, Colleen J., Ng, Dominic C. H. and May, Clive N. (2018). Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases. Current Medicinal Chemistry, 25 (34), 4402-4415. doi: 10.2174/0929867325666180326161730
2018
Journal Article
Factors that influence adult neurogenesis as potential therapy
Shohayeb, Belal, Diab, Mohamed, Ahmed, Mazen and Ng, Dominic Chi Hiung (2018). Factors that influence adult neurogenesis as potential therapy. Translational Neurodegeneration, 7 (1) 4, 1-19. doi: 10.1186/s40035-018-0109-9
2018
Journal Article
Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2
Chin, Kai Yee, Silva, Lokugan S., Darby, Ian A., Ng, Dominic C. H. and Woodman, Owen L. (2018). Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2. International Journal of Cardiology, 254, 265-271. doi: 10.1016/j.ijcard.2017.11.101
2017
Journal Article
The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development
Shohayeb, Belal, Lim, Nicholas Rui, Ho, Uda, Xu, Zhiheng, Dottori, Mirella, Quinn, Leonie and Ng, Dominic Chi Hiung (2017). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Molecular Neurobiology, 55 (7), 5409-5424. doi: 10.1007/s12035-017-0778-x
2017
Journal Article
Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus
Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2017). Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. Scientific Reports, 7 (1) 5245, 5245. doi: 10.1038/s41598-017-05340-x
2017
Journal Article
Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth
Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C. H. and Quinn, Leonie M. (2017). Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth. Stem Cell Reports, 9 (1), 32-41. doi: 10.1016/j.stemcr.2017.05.015
2017
Journal Article
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration
Fife, C. M., Sagnella, S. M., Teo, W. S., Po'Uha, S. T., Byrne, F. L., Yeap, Y. Y. C., Ng, D. C. H., Davis, T. P., McCarroll, J. A. and Kavallaris, M. (2017). Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Intensive Care Medicine, 36 (4), 501-511. doi: 10.1038/onc.2016.220
2017
Journal Article
WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells
Alshawaf, Abdulah J., Antonic, Ana, Skafidas, Efstratios, Ng, Dominic Chi-Hung and Dottori, Mirella (2017). WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells. Stem Cells International, 2017 7848932, 7848932-9. doi: 10.1155/2017/7848932
2016
Journal Article
A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
Hoque, Ashfaqul, Hossain, M. Iqbal, Ameen, S. Sadia, Ang, Ching-Seng, Williamson, Nicholas, Ng, Dominic C. H., Chueh, Anderly C., Roulston, Carli and Cheng, Heung-Chin (2016). A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies. Pharmacology and Therapeutics, 160, 159-179. doi: 10.1016/j.pharmthera.2016.02.009
2016
Journal Article
A large dataset of protein dynamics in the mammalian heart proteome
Lau, Edward, Cao, Quan, Ng, Dominic C. M., Bleakley, Brian J., Dincer, T. Umut, Bot, Brian M., Wang, Ding, Liem, David A., Lam, Maggie P. Y., Ge, Junbo and Ping, Peipei (2016). A large dataset of protein dynamics in the mammalian heart proteome. Scientific Data, 3 (1) 160015. doi: 10.1038/sdata.2016.15
2016
Journal Article
Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation
Lim, Nicholas R., Yeap, Yvonne Y. C., Ang, Ching-Seng, Williamson, Nicholas A., Bogoyevitch, Marie A., Quinn, Leonie M. and Ng, Dominic C. H. (2016). Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation. Cell Cycle, 15 (3), 413-424. doi: 10.1080/15384101.2015.1127472
2015
Journal Article
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol
Thomas, Colleen J., Lim, Nicholas R., Kedikaetswe, Alphious, Yeap, Yvonne Y., Woodman, Owen L., Ng, Dominic C. H. and May, Clive N. (2015). Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol. European Journal of Pharmacology, 758, 53-59. doi: 10.1016/j.ejphar.2015.03.054
2015
Journal Article
Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma
Birnie, Kimberly A., Yip, Yan Y., Ng, Dominic C. H., Kirschner, Michaela B., Reid, Glen, Prele, Cecilia M., Musk, Arthur W. (Bill), Lee, Y. C. Gary, Thompson, Philip J., Mutsaers, Steven E. and Badrian, Bahareh (2015). Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma. Molecular Cancer Research, 13 (7), 1106-1118. doi: 10.1158/1541-7786.MCR-14-0442
2015
Journal Article
Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart
Bell, James R., Raaijmakers, Antonia J. A., Curl, Claire L., Reichelt, Melissa E., Harding, TristanW., Bei, Aier, Ng, Dominic C. H., Erickson, Jeffrey R., Petroff, Martin Vila, Harrap, Stephen B. and Delbridge, Lea M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159
2015
Journal Article
Dual role of Src kinase in governing neuronal survival
Hossaina, M. Iqbal, Hoquel, Ashfaqul, Lessene, Guillaume, Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Ivan H. W., Irtegun, Sevgi, Ng, Dominic C. H., Bogoyevitch, Marie A., Burgess, Antony W., Hill, Andrew F. and Cheng, Heung-Chin (2015). Dual role of Src kinase in governing neuronal survival. Brain Research, 1594, 1-14. doi: 10.1016/j.brainres.2014.10.040
2015
Journal Article
Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules
Lim, Nicholas R., Yeap, Yvonne Y. C., Zhao, Teresa T., Yip, Yan Y., Wong, Shu C., Xu, Dan, Ang, Ching-Seng, Williamson, Nicholas A., Xu, Zhiheng, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2015). Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules. Journal of Cell Science, 128 (3), 527-540. doi: 10.1242/jcs.157537
2014
Journal Article
Lysine ubiquitination and acetylation of human cardiac 20S proteasomes
Zong, Nobel, Ping, Peipei, Lau, Edward, Choi, Howard J. H., Ng, Dominic C. M., Meyer, David, Fang, Caiyun, Li, Haomin, Wang, Ding, Zelaya, Ivette M., Yates, John R. and Lam, Maggie P. Y. (2014). Lysine ubiquitination and acetylation of human cardiac 20S proteasomes. Proteomics Clinical Applications, 8 (7-8), 590-594. doi: 10.1002/prca.201400029
2014
Journal Article
Characterization of human plasma proteome dynamics using deuterium oxide
Wang, Ding, Liem, David A., Lau, Edward, Ng, Dominic C. M., Bleakley, Brian J., Cadeiras, Martin, Deng, Mario C., Lam, Maggie P. Y. and Ping, Peipei (2014). Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clinical Applications, 8 (7-8), 610-619. doi: 10.1002/prca.201400038
2014
Journal Article
Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members
Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members. Biochemical and Biophysical Research Communications, 446 (1), 248-254. doi: 10.1016/j.bbrc.2014.02.101
Funding
Current funding
Supervision
Availability
- Associate Professor Dominic Ng is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.
Associate Advisor
Other advisors: Professor Wally Thomas, Dr Melissa Reichelt
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Doctor Philosophy
Tuning mitophagy in mitochondrial disease
Associate Advisor
Other advisors: Associate Professor Julia Pagan
Completed supervision
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2026
Doctor Philosophy
A novel role for the microcephaly protein WDR62 in protein folding and purine metabolism
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2024
Doctor Philosophy
Optogenetic control of cell signalling dynamics and stress responses
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2020
Doctor Philosophy
Characterization of the microcephaly gene wd40-repeat protein 62 (wdr62) in brain growth and development
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2024
Doctor Philosophy
Characterising the role of Dscam2 in synaptic vesicle recycling and memory formation in Drosophila.
Associate Advisor
Other advisors: Associate Professor Sean Millard
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2024
Doctor Philosophy
Defining the function of SCF-FBXO16 ubiquitin ligase at centrosomes and microtubules
Associate Advisor
Other advisors: Associate Professor Samantha Stehbens, Associate Professor Julia Pagan
Media
Enquiries
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