Associate Professor Dominic Ng
Associate Professor

Dominic Ng

Email: 
Phone: 
+61 7 336 53077

Background

Dr Dominic Ng graduated with a BSc (Hons) and gained his PhD from the University of Western Australia. His doctoral studies, conducted in the laboratory of Assoc. Prof. Marie Bogoyevitch, were focused on cardiomyocyte signalling mechanisms regulating pathological tissue growth (ie cardiac hypertrophy). He continued his research training in Singapore as a post-doctoral research fellow based at the Institute of Molecular and Cell Biology, the flagship institute of Singapore’s science agency (A*STAR) located at the world renowned Biopolis research precinct. During this time, his research interests turned to the complex regulation of the cytoskeleton and their functions in development and disease.

He returned to the Australian medical research community on an NHMRC Peter Doherty Fellowship (2006-2010) followed by a Faculty Trust Roper Fellowship (2011-2012). In this time, Dominic established an independent research program focused on complex signalling regulation of microtubule organization. In 2013, Dominic was appointed as a Senior Research Fellow, supported by an ARC Future Fellowship (2013-2016) at the Department of Biochemistry within the Bio21 Institute, University of Melbourne. In 2015, Dominic relocated his research group to the School of Biomedical Science, University of Queensland and is currently appointed as an ARC Future Fellow and Senior Lecturer.

Availability

Associate Professor Dominic Ng is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cardiovascular medicine and haematology Cardiovascular medicine and haematology not elsewhere classified Cell development, proliferation and death Neurosciences Oncology and carcinogenesis Signal transduction

Qualifications

  • Bachelor of Science, University of Western Australia
  • Doctor of Philosophy, University of Western Australia

Research interests

  • Cell Signalling

    Protein phosphorylation, protein interactions, kinases, STAT transcription factors, microtubule-associated proteins.

  • Molecular Cardiology

    Cardiomyocyte growth, cardiac hypertrophy, cardiac injury, cardioprotection

  • Neural Development

    Neural stem cells, microcephaly genes, neural migration, neural proliferation, neuronal cell death

Search Professor Dominic Ng’s works on UQ eSpace

69 works between 2000 and 2024
All (69) Journal Article (68) Book Chapter (1)

21 - 40 of 69 works

2018

Journal Article

Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases

Woodman, Owen L., Chin, Kai Yee, Thomas, Colleen J., Ng, Dominic C. H. and May, Clive N. (2018). Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases. Current Medicinal Chemistry, 25 (34), 4402-4415. doi: 10.2174/0929867325666180326161730

Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases

2018

Journal Article

Factors that influence adult neurogenesis as potential therapy

Shohayeb, Belal, Diab, Mohamed, Ahmed, Mazen and Ng, Dominic Chi Hiung (2018). Factors that influence adult neurogenesis as potential therapy. Translational Neurodegeneration, 7 (1) 4, 1-19. doi: 10.1186/s40035-018-0109-9

Factors that influence adult neurogenesis as potential therapy

2018

Journal Article

Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2

Chin, Kai Yee, Silva, Lokugan S., Darby, Ian A., Ng, Dominic C. H. and Woodman, Owen L. (2018). Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2. International Journal of Cardiology, 254, 265-271. doi: 10.1016/j.ijcard.2017.11.101

Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2

2017

Journal Article

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

Shohayeb, Belal, Lim, Nicholas Rui, Ho, Uda, Xu, Zhiheng, Dottori, Mirella, Quinn, Leonie and Ng, Dominic Chi Hiung (2017). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Molecular Neurobiology, 55 (7), 5409-5424. doi: 10.1007/s12035-017-0778-x

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

2017

Journal Article

Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2017). Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. Scientific Reports, 7 (1) 5245, 5245. doi: 10.1038/s41598-017-05340-x

Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus

2017

Journal Article

Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth

Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C. H. and Quinn, Leonie M. (2017). Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth. Stem Cell Reports, 9 (1), 32-41. doi: 10.1016/j.stemcr.2017.05.015

Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth

2017

Journal Article

Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration

Fife, C. M., Sagnella, S. M., Teo, W. S., Po'Uha, S. T., Byrne, F. L., Yeap, Y. Y. C., Ng, D. C. H., Davis, T. P., McCarroll, J. A. and Kavallaris, M. (2017). Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Intensive Care Medicine, 36 (4), 501-511. doi: 10.1038/onc.2016.220

Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration

2017

Journal Article

WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells

Alshawaf, Abdulah J., Antonic, Ana, Skafidas, Efstratios, Ng, Dominic Chi-Hung and Dottori, Mirella (2017). WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells. Stem Cells International, 2017 7848932, 7848932-9. doi: 10.1155/2017/7848932

WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells

2016

Journal Article

A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Hoque, Ashfaqul, Hossain, M. Iqbal, Ameen, S. Sadia, Ang, Ching-Seng, Williamson, Nicholas, Ng, Dominic C. H., Chueh, Anderly C., Roulston, Carli and Cheng, Heung-Chin (2016). A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies. Pharmacology and Therapeutics, 160, 159-179. doi: 10.1016/j.pharmthera.2016.02.009

A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

2016

Journal Article

A large dataset of protein dynamics in the mammalian heart proteome

Lau, Edward, Cao, Quan, Ng, Dominic C. M., Bleakley, Brian J., Dincer, T. Umut, Bot, Brian M., Wang, Ding, Liem, David A., Lam, Maggie P. Y., Ge, Junbo and Ping, Peipei (2016). A large dataset of protein dynamics in the mammalian heart proteome. Scientific Data, 3 (1) 160015. doi: 10.1038/sdata.2016.15

A large dataset of protein dynamics in the mammalian heart proteome

2016

Journal Article

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

Lim, Nicholas R., Yeap, Yvonne Y. C., Ang, Ching-Seng, Williamson, Nicholas A., Bogoyevitch, Marie A., Quinn, Leonie M. and Ng, Dominic C. H. (2016). Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation. Cell Cycle, 15 (3), 413-424. doi: 10.1080/15384101.2015.1127472

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

2015

Journal Article

Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol

Thomas, Colleen J., Lim, Nicholas R., Kedikaetswe, Alphious, Yeap, Yvonne Y., Woodman, Owen L., Ng, Dominic C. H. and May, Clive N. (2015). Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol. European Journal of Pharmacology, 758, 53-59. doi: 10.1016/j.ejphar.2015.03.054

Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol

2015

Journal Article

Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma

Birnie, Kimberly A., Yip, Yan Y., Ng, Dominic C. H., Kirschner, Michaela B., Reid, Glen, Prele, Cecilia M., Musk, Arthur W. (Bill), Lee, Y. C. Gary, Thompson, Philip J., Mutsaers, Steven E. and Badrian, Bahareh (2015). Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma. Molecular Cancer Research, 13 (7), 1106-1118. doi: 10.1158/1541-7786.MCR-14-0442

Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma

2015

Journal Article

Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

Bell, James R., Raaijmakers, Antonia J. A., Curl, Claire L., Reichelt, Melissa E., Harding, TristanW., Bei, Aier, Ng, Dominic C. H., Erickson, Jeffrey R., Petroff, Martin Vila, Harrap, Stephen B. and Delbridge, Lea M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

2015

Journal Article

Dual role of Src kinase in governing neuronal survival

Hossaina, M. Iqbal, Hoquel, Ashfaqul, Lessene, Guillaume, Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Ivan H. W., Irtegun, Sevgi, Ng, Dominic C. H., Bogoyevitch, Marie A., Burgess, Antony W., Hill, Andrew F. and Cheng, Heung-Chin (2015). Dual role of Src kinase in governing neuronal survival. Brain Research, 1594, 1-14. doi: 10.1016/j.brainres.2014.10.040

Dual role of Src kinase in governing neuronal survival

2015

Journal Article

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

Lim, Nicholas R., Yeap, Yvonne Y. C., Zhao, Teresa T., Yip, Yan Y., Wong, Shu C., Xu, Dan, Ang, Ching-Seng, Williamson, Nicholas A., Xu, Zhiheng, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2015). Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules. Journal of Cell Science, 128 (3), 527-540. doi: 10.1242/jcs.157537

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

2014

Journal Article

Lysine ubiquitination and acetylation of human cardiac 20S proteasomes

Zong, Nobel, Ping, Peipei, Lau, Edward, Choi, Howard J. H., Ng, Dominic C. M., Meyer, David, Fang, Caiyun, Li, Haomin, Wang, Ding, Zelaya, Ivette M., Yates, John R. and Lam, Maggie P. Y. (2014). Lysine ubiquitination and acetylation of human cardiac 20S proteasomes. Proteomics Clinical Applications, 8 (7-8), 590-594. doi: 10.1002/prca.201400029

Lysine ubiquitination and acetylation of human cardiac 20S proteasomes

2014

Journal Article

Characterization of human plasma proteome dynamics using deuterium oxide

Wang, Ding, Liem, David A., Lau, Edward, Ng, Dominic C. M., Bleakley, Brian J., Cadeiras, Martin, Deng, Mario C., Lam, Maggie P. Y. and Ping, Peipei (2014). Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clinical Applications, 8 (7-8), 610-619. doi: 10.1002/prca.201400038

Characterization of human plasma proteome dynamics using deuterium oxide

2014

Journal Article

Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members

Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members. Biochemical and Biophysical Research Communications, 446 (1), 248-254. doi: 10.1016/j.bbrc.2014.02.101

Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members

2014

Journal Article

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Misheva, Mariya, Kaur, Gurpreet, Ngoei, Kevin R. W., Yeap, Yvonne Y., Ng, Ivan H. W., Wagstaff, Kylie M., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2014). Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. BBA- Molecular Cell Research, 1843 (2), 253-264. doi: 10.1016/j.bbamcr.2013.10.017

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Current funding

  • 2025 - 2026
    Striking a sour note: Revealing ageing-related intracellular acidification as a trigger for ALS pathomechanisms
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2025
    Understanding how the ALS risk factor, GGNBP2, contributes to autophagy
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    How defects in centrosome to microtubule attachment cause microcephaly
    NHMRC Project Grant
    Open grant
  • 2019 - 2023
    Identifying conserved alternative splicing mechanisms in vivo
    NHMRC Project Grant
    Open grant
  • 2017 - 2021
    Trophoblast cell-cell fusion in preeclampsia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Mitotic spindle regulation by novel Aurora A control mechanisms [The Robert Baillie Research Grant]
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Interrogating a novel protein scaffold that coordinates signal transduction and molecular motor function
    ARC Future Fellowships
    Open grant
  • 2015 - 2016
    New insights into mechanisms that coordinate kinase signalling and molecular motors in mitosis: A novel role for the protein scaffold WD-repeat protein 62 (WDR62)
    NHMRC Project Grant
    Open grant

Availability

Associate Professor Dominic Ng is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Characterising a new role for the microcephaly protein WDR62 in cellular purine metabolism

    Principal Advisor

    Other advisors: Associate Professor Sean Millard

  • Doctor Philosophy

    Tuning mitophagy in mitochondrial disease

    Associate Advisor

    Other advisors: Dr Julia Pagan

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Professor Wally Thomas, Dr Melissa Reichelt

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Professor Wally Thomas, Dr Melissa Reichelt

Completed supervision

Enquiries

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