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2024 Journal Article Stress pathway outputs are encoded by pH-dependent clustering of kinase componentsDidan, Yuliia, Ghomlaghi, Milad, Nguyen, Lan K. and Ng, Dominic C. H. (2024). Stress pathway outputs are encoded by pH-dependent clustering of kinase components. Nature Communications, 15 (1) 6614, 1-16. doi: 10.1038/s41467-024-50638-w |
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2021 Journal Article Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesisRashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J., Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C., Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H. and Khanna, Kum Kum (2021). Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis. PLoS Genetics, 17 (10) e1009334, 1-31. doi: 10.1371/journal.pgen.1009334 |
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2020 Journal Article The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical developmentShohayeb, Belal, Ho, Uda, Yeap, Yvonne Y., Parton, Robert G., Millard, Sean S., Xu, Zhiheng, Piper, Michael and Ng, Dominic C. H. (2020). The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics, 29 (2), 248-263. doi: 10.1093/hmg/ddz281 |
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2024 Journal Article Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple ImputationYan, Yu, Sankar, Baradwaj Simha, Mirza, Bilal, Ng, Dominic C. M., Pelletier, Alexander R., Huang, Sarah D., Wang, Wei, Watson, Karol, Wang, Ding and Ping, Peipei (2024). Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation. Journal of Proteome Research, 23 (9), 4151-4162. doi: 10.1021/acs.jproteome.4c00263 |
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2024 Journal Article PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y |
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2024 Journal Article Tissue usage preference and intrinsically disordered region remodeling of alternative splicing derived proteoforms in the heartPandi, Boomathi, Brenman, Stella, Black, Alexander, Ng, Dominic C. M., Lau, Edward and Lam, Maggie P. Y. (2024). Tissue usage preference and intrinsically disordered region remodeling of alternative splicing derived proteoforms in the heart. Journal of Proteome Research, 23 (8), 3161-3173. doi: 10.1021/acs.jproteome.3c00789 |
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2023 Journal Article Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-SYan, Yu, Wang, Dean, Xin, Ruiqi, Soriano, Raine A., Ng, Dominic C. M., Wang, Wei and Ping, Peipei (2023). Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S. Star Protocols, 4 (4) 102682, 1-10. doi: 10.1016/j.xpro.2023.102682 |
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2023 Journal Article MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseasesYan, Yu, Jiang, Jyun-Yu, Fu, Mingzhou, Wang, Ding, Pelletier, Alexander R., Sigdel, Dibaka, Ng, Dominic C. M., Wang, Wei and Ping, Peipei (2023). MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases. Cell Reports Methods, 3 (3) 100430, 1-19. doi: 10.1016/j.crmeth.2023.100430 |
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2022 Journal Article Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron DiseaseDing, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5 |
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2021 Journal Article Cilia, centrosomes and skeletal muscleNg, Dominic C. H., Ho, Uda Y. and Grounds, Miranda D. (2021). Cilia, centrosomes and skeletal muscle. International Journal of Molecular Sciences, 22 (17) 9605, 9605. doi: 10.3390/ijms22179605 |
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2021 Journal Article TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cellsDing, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601 |
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2021 Journal Article WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesisHo, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5 |
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2021 Journal Article Pathophysiological significance of WDR62 and JNK signaling in human diseasesZhi, Yiqiang, Zhou, Xiaokun, Yu, Jurui, Yuan, Ling, Zhang, Hongsheng, Ng, Dominic C. H., Xu, Zhiheng and Xu, Dan (2021). Pathophysiological significance of WDR62 and JNK signaling in human diseases. Frontiers in Cell and Developmental Biology, 9 640753, 640753. doi: 10.3389/fcell.2021.640753 |
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2020 Journal Article Centrosome reduction promotes terminal differentiation of human cardiomyocytesNg, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007 |
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2020 Journal Article The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampusShohayeb, Belal, Ho, Uda Y., Hassan, Halah, Piper, Michael and Ng, Dominic C. H. (2020). The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus. Frontiers in Cell and Developmental Biology, 8 549353, 549353. doi: 10.3389/fcell.2020.549353 |
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2020 Journal Article Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYCShohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M. and Ng, Dominic C.H. (2020). Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. Biochimica et Biophysica Acta - Molecular Cell Research, 1867 (7) 118713, 118713. doi: 10.1016/j.bbamcr.2020.118713 |
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2019 Journal Article Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament associationMoslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association. Biochemical and Biophysical Research Communications, 513 (3), 540-545. doi: 10.1016/j.bbrc.2019.04.005 |
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2019 Journal Article Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filamentsMoslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments. Biochimica et Biophysica Acta - Molecular Cell Research, 1866 (4), 638-649. doi: 10.1016/j.bbamcr.2019.01.003 |
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2019 Journal Article Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell deathHoque, Ashfaqul, Williamson, Nicholas A., Ameen, S. Sadia, Ciccotosto, Giuseppe D., Hossain, M. Iqbal, Oakhill, Jonathan S., Ng, Dominic C. H., Ang, Ching-Seng and Cheng, Heung-Chin (2019). Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death and Disease, 10 (3) 213, 213. doi: 10.1038/s41419-019-1445-0 |
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2018 Journal Article MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesisXu, Dan, Yao, Minghui, Wang, Yaqing, Yuan, Ling, Hoeck, Joerg D., Yu, Jingwen, Liu, Liang, Yeap, Yvonne Y. C., Zhang, Weiya, Zhang, Feng, Feng, Yinghang, Ma, Tiantian, Wang, Yujie, Ng, Dominic C. H., Niu, Xiaoyin, Su, Bing, Behrens, Axel and Xu, Zhiheng (2018). MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology, 16 (12) e2006613, e2006613. doi: 10.1371/journal.pbio.2006613 |
