Associate Professor Dominic Ng
Associate Professor

Dominic Ng

Email: 
Phone: 
+61 7 336 53077

Background

Dr Dominic Ng graduated with a BSc (Hons) and gained his PhD from the University of Western Australia. His doctoral studies, conducted in the laboratory of Assoc. Prof. Marie Bogoyevitch, were focused on cardiomyocyte signalling mechanisms regulating pathological tissue growth (ie cardiac hypertrophy). He continued his research training in Singapore as a post-doctoral research fellow based at the Institute of Molecular and Cell Biology, the flagship institute of Singapore’s science agency (A*STAR) located at the world renowned Biopolis research precinct. During this time, his research interests turned to the complex regulation of the cytoskeleton and their functions in development and disease.

He returned to the Australian medical research community on an NHMRC Peter Doherty Fellowship (2006-2010) followed by a Faculty Trust Roper Fellowship (2011-2012). In this time, Dominic established an independent research program focused on complex signalling regulation of microtubule organization. In 2013, Dominic was appointed as a Senior Research Fellow, supported by an ARC Future Fellowship (2013-2016) at the Department of Biochemistry within the Bio21 Institute, University of Melbourne. In 2015, Dominic relocated his research group to the School of Biomedical Science, University of Queensland and is currently appointed as an ARC Future Fellow and Senior Lecturer.

Availability

Associate Professor Dominic Ng is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cardiovascular medicine and haematology Cardiovascular medicine and haematology not elsewhere classified Cell development, proliferation and death Neurosciences Oncology and carcinogenesis Signal transduction

Qualifications

  • Bachelor of Science, University of Western Australia
  • Doctor of Philosophy, University of Western Australia

Research interests

  • Cell Signalling

    Protein phosphorylation, protein interactions, kinases, STAT transcription factors, microtubule-associated proteins.

  • Molecular Cardiology

    Cardiomyocyte growth, cardiac hypertrophy, cardiac injury, cardioprotection

  • Neural Development

    Neural stem cells, microcephaly genes, neural migration, neural proliferation, neuronal cell death

Search Professor Dominic Ng’s works on UQ eSpace

69 works between 2000 and 2024
All (69) Journal Article (68) Book Chapter (1)

41 - 60 of 69 works

2014

Journal Article

CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress

Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress. Journal of Biological Chemistry, 289 (4), 2157-2169. doi: 10.1074/jbc.M113.470682

CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress

2013

Journal Article

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition

Lim, Nicholas R., Thomas, Colleen J., Silva, Lokugan S., Yeap, Yvonne Y., Yap, Suwan, Bell, James R., Delbridge, Lea M. D., Bogoyevitch, Marie A., Woodman, Owen L., Williams, Spencer J., May, Clive N. and Ng, Dominic C. H. (2013). Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition. Biochemical Journal, 456 (2), 149-161. doi: 10.1042/BJ20121538

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition

2013

Journal Article

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds

Ngoei, Kevin R. W., Ng, Dominic C. H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J. and Bogoyevitch, Marie A. (2013). Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834 (6), 1077-1088. doi: 10.1016/j.bbapap.2013.02.001

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds

2013

Journal Article

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

Hossain, M. Iqbal, Roulston, Carli L., Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Dominic C. H., Dusting, Gregory J., Bjorge, Jeffrey D., Williamson, Nicholas A., Fujita, Donald J., Cheung, Steve N., Chan, Tung O., Hill, Andrew F. and Cheng, Heung-Chin (2013). A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. Journal of Biological Chemistry, 288 (14), 9696-9709. doi: 10.1074/jbc.M112.419713

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

2012

Journal Article

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Bogoyevitch, Marie A., Yeap, Yvonne Y. C., Qu, Zhengdong, Ngoei, Kevin R., Yip, Yan Y., Zhao, Teresa T., Heng, Julian I. and Ng, Dominic C. H. (2012). WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression. Journal of Cell Science, 125 (21), 5096-5109. doi: 10.1242/jcs.107326

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

2012

Journal Article

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, Ivan H. W., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2012). Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochemical Journal, 447 (1), 125-136. doi: 10.1042/BJ20120941

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

2012

Journal Article

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Yasmin M., Polling, Saskia, Chia, Cheryl P. Z., Ng, Ivan H. W., Ormsby, Angelique R., Croft, Nathan P., Purcell, Anthony W., Bogoyevitch, Marie A., Ng, Dominic C. H., Gleeson, Paul A. and Hatters, Danny M. (2012). Tracking protein aggregation and mislocalization in cells with flow cytometry. Nature Methods, 9 (5), 467-470. doi: 10.1038/nmeth.1930

Tracking protein aggregation and mislocalization in cells with flow cytometry

2012

Book Chapter

Stathmin and cancer

Ng, Dominic Chi Hiung and Byrne, Frances (2012). Stathmin and cancer. Cytoskeleton and Human Disease. (pp. 259-284) edited by Maria Kavallaris. New York, NY USA: Humana Press. doi: 10.1007/978-1-61779-788-0_14

Stathmin and cancer

2011

Journal Article

Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure

Waardenberg, Ashley J., Bernardo, Bianca C., Ng, Dominic C. H., Shepherd, Peter R., Cemerlang, Nelly, Sbroggio, Mauro, Wells, Christine A., Dalrymple, Brian P., Brancaccio, Mara, Lin, Ruby C. Y. and McMullen, Julie R. (2011). Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry, 286 (35), 30837-30846. doi: 10.1074/jbc.M111.271684

Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure

2011

Journal Article

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK

Thomas, Colleen J., Ng, Dominic C. H., Patsikatheodorou, Nikolas, Limengka, Yuliardy, Lee, Matthew W. K., Darby, Ian A., Woodman, Owen L. and May, Clive N. (2011). Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK. European Journal of Pharmacology, 658 (2-3), 160-167. doi: 10.1016/j.ejphar.2011.02.041

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK

2011

Journal Article

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Ngoei, Kevin R. W., Catimel, Bruno, Church, Nicole, Lio, Daisy S., Dogovski, Con, Perugini, Matthew A., Watt, Paul M., Cheng, Heung-Chin, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2011). Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide. Biochemical Journal, 434 (3), 399-413. doi: 10.1042/BJ20101244

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

2011

Journal Article

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Meyerowitz, Jodi, Parker, Sarah J., Vella, Laura J., Ng, Dominic C. H., Price, Katherine A., Liddell, Jeffrey R., Caragounis, Aphrodite, Li, Qiao-Xin, Masters, Colin L., Nonaka, Takashi, Hasegawa, Masato, Bogoyevitch, Marie A., Kanninen, Katja M., Crouch, Peter J. and White, Anthony R. (2011). C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress. Molecular Neurodegeneration, 6 (57) 57. doi: 10.1186/1750-1326-6-57

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

2011

Journal Article

Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy

Ng, Dominic C. H., Ng, Ivan H. W., Yeap, Yvonne Y. C., Badrian, Bahareh, Tsoutsman, Tatiana, McMullen, Julie R., Semsarian, Christopher and Bogoyevitch, Marie A. (2011). Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy. Journal of Biological Chemistry, 286 (2), 1576-1587. doi: 10.1074/jbc.M110.128157

Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy

2010

Journal Article

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Yeap, Yvonne Y. C., Ng, Ivan H. W., Badrian, Bahareh, Nguyen, Tuong-Vi, Yip, Yan Y., Dhillon, Amardeep S., Mutsaers, Steven E., Silke, John, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18. Biochemical Journal, 430 (2), 345-354. doi: 10.1042/BJ20100425

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

2010

Journal Article

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

Ng, Dominic C. H., Zhao, Teresa T., Yeap, Yvonne Y. C., Ngoei, Kevin R. and Bogoyevitch, Marie A. (2010). c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress. Journal of Biological Chemistry, 285 (37), 29001-29013. doi: 10.1074/jbc.M110.128454

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

2010

Journal Article

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

Bogoyevitch, Marie A., Ngoei, Kevin R. W., Zhao, Teresa T., Yeap, Yvonne Y. C. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1804 (3), 463-475. doi: 10.1016/j.bbapap.2009.11.002

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

2010

Journal Article

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Ng, Dominic C. H., Lim, Cheh P., Lin, Bao H., Zhang, Tong and Cao, Xinmin (2010). SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. Biochemical Journal, 425 (1), 95-105. doi: 10.1042/BJ20091213

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

2009

Journal Article

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX

Teng, Terk Shin, Lin, Baohong, Manser, Ed, Ng, Dominic Chi Hiung and Cao, Xinmin (2009). Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX. Journal of Cell Science, 122 (22), 4150-4159. doi: 10.1242/jcs.057109

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX

2008

Journal Article

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy

Tsoutsman, Tatiana, Kelly, Matthew, Ng, Dominic C. H., Tan, Ju-En, Tu, Emily, Lam, Lien, Bogoyevitch, Marie A., Seidman, Christine E., Seidman, J. G. and Semsarian, Christopher (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117 (14), 1820-1831. doi: 10.1161/CIRCULATIONAHA.107.755777

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy

2008

Journal Article

Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition

Ng, Dominic C. H., Gebski, Bijanka L., Grounds, Miranda D. and Bogoyevitch, Marie A. (2008). Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. Cell Motility and the Cytoskeleton, 65 (1), 40-58. doi: 10.1002/cm.20242

Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition

Current funding

  • 2025 - 2026
    Striking a sour note: Revealing ageing-related intracellular acidification as a trigger for ALS pathomechanisms
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2025
    Understanding how the ALS risk factor, GGNBP2, contributes to autophagy
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    How defects in centrosome to microtubule attachment cause microcephaly
    NHMRC Project Grant
    Open grant
  • 2019 - 2023
    Identifying conserved alternative splicing mechanisms in vivo
    NHMRC Project Grant
    Open grant
  • 2017 - 2021
    Trophoblast cell-cell fusion in preeclampsia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Mitotic spindle regulation by novel Aurora A control mechanisms [The Robert Baillie Research Grant]
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Interrogating a novel protein scaffold that coordinates signal transduction and molecular motor function
    ARC Future Fellowships
    Open grant
  • 2015 - 2016
    New insights into mechanisms that coordinate kinase signalling and molecular motors in mitosis: A novel role for the protein scaffold WD-repeat protein 62 (WDR62)
    NHMRC Project Grant
    Open grant

Availability

Associate Professor Dominic Ng is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Characterising a new role for the microcephaly protein WDR62 in cellular purine metabolism

    Principal Advisor

    Other advisors: Associate Professor Sean Millard

  • Doctor Philosophy

    Tuning mitophagy in mitochondrial disease

    Associate Advisor

    Other advisors: Dr Julia Pagan

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Professor Wally Thomas, Dr Melissa Reichelt

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Professor Wally Thomas, Dr Melissa Reichelt

Completed supervision

Enquiries

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