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Associate Professor Dominic Ng
Associate Professor

Dominic Ng

Email: 
Phone: 
+61 7 336 53077

Overview

Background

I am an Associate Professor in the School of Biomedical Sciences (SBMS) at The University of Queensland, where I teach physiology and lead research that explores how cells respond to stress, injury and disease. My work aims to better understand the molecular and cellular processes that influence health and disease, with a particular focus on areas relevant to cancer, heart disease, neurological conditions and emerging cell-based therapies.

I completed my doctorate at the University of Western Australia in Biochemistry and Cell Biology, where I studied how heart cells respond to signals that can drive abnormal tissue growth. I then undertook postdoctoral training in Singapore at the Institute of Molecular and Cell Biology, part of A*STAR, where my research expanded into understanding how the cytoskeleton, internal structures of cells, help control development and disease.

After returning to Australia, I was supported by national fellowships from the NHMRC and ARC, which enabled me to establish an internationally connected research program. My research brings together cell biology, imaging, computational approaches and emerging technologies to uncover how cells make critical decisions, including whether to survive or die under stress.

Alongside my research and teaching, I contribute to leadership within SBMS as Director of Research and support major research infrastructure initiatives across the Faculty of Health, Medicine and Behavioural Sciences (HMBS) as Academic Director of Research Infrastructure. I also serve on steering committees for UQ’s Viral Vector Core (VVC) and the Centre for Cardiovascular Health and Research (CCVHR), helping to strengthen the platforms and partnerships that support biomedical discovery and translation.

Availability

Associate Professor Dominic Ng is:
Available for supervision

Qualifications

  • Bachelor of Science, University of Western Australia
  • Doctor of Philosophy, University of Western Australia

Research interests

  • Cell Signalling

    Protein phosphorylation, protein interactions, kinases, STAT transcription factors, microtubule-associated proteins.

  • Molecular Cardiology

    Cardiomyocyte growth, cardiac hypertrophy, cardiac injury, cardioprotection

  • Neural Development

    Neural stem cells, microcephaly genes, neural migration, neural proliferation, neuronal cell death

Research impacts

My research contributes to society by improving understanding of how cells respond to stress, injury and disease, generating knowledge that can inform new approaches to diagnosis, prevention and treatment. By uncovering the molecular mechanisms that influence cell survival, tissue growth and disease progression, my work supports advances in areas of major health burden, including cancer, cardiovascular disease and neurological conditions. Beyond academic discovery, this research helps strengthen Australia’s biomedical innovation pipeline by supporting translational partnerships, enabling platform technologies such as viral vectors and advanced imaging, and training the next generation of researchers with skills relevant to the health, biotechnology and medical research sectors.

Works

Search Professor Dominic Ng’s works on UQ eSpace

70 works between 2000 and 2026

41 - 60 of 70 works

2014

Journal Article

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Misheva, Mariya, Kaur, Gurpreet, Ngoei, Kevin R. W., Yeap, Yvonne Y., Ng, Ivan H. W., Wagstaff, Kylie M., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2014). Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. BBA- Molecular Cell Research, 1843 (2), 253-264. doi: 10.1016/j.bbamcr.2013.10.017

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

2014

Journal Article

CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress

Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress. Journal of Biological Chemistry, 289 (4), 2157-2169. doi: 10.1074/jbc.M113.470682

CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress

2013

Journal Article

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition

Lim, Nicholas R., Thomas, Colleen J., Silva, Lokugan S., Yeap, Yvonne Y., Yap, Suwan, Bell, James R., Delbridge, Lea M. D., Bogoyevitch, Marie A., Woodman, Owen L., Williams, Spencer J., May, Clive N. and Ng, Dominic C. H. (2013). Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition. Biochemical Journal, 456 (2), 149-161. doi: 10.1042/BJ20121538

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition

2013

Journal Article

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds

Ngoei, Kevin R. W., Ng, Dominic C. H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J. and Bogoyevitch, Marie A. (2013). Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834 (6), 1077-1088. doi: 10.1016/j.bbapap.2013.02.001

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds

2013

Journal Article

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

Hossain, M. Iqbal, Roulston, Carli L., Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Dominic C. H., Dusting, Gregory J., Bjorge, Jeffrey D., Williamson, Nicholas A., Fujita, Donald J., Cheung, Steve N., Chan, Tung O., Hill, Andrew F. and Cheng, Heung-Chin (2013). A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. Journal of Biological Chemistry, 288 (14), 9696-9709. doi: 10.1074/jbc.M112.419713

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

2012

Journal Article

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Bogoyevitch, Marie A., Yeap, Yvonne Y. C., Qu, Zhengdong, Ngoei, Kevin R., Yip, Yan Y., Zhao, Teresa T., Heng, Julian I. and Ng, Dominic C. H. (2012). WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression. Journal of Cell Science, 125 (21), 5096-5109. doi: 10.1242/jcs.107326

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

2012

Journal Article

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, Ivan H. W., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2012). Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochemical Journal, 447 (1), 125-136. doi: 10.1042/BJ20120941

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

2012

Journal Article

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Yasmin M., Polling, Saskia, Chia, Cheryl P. Z., Ng, Ivan H. W., Ormsby, Angelique R., Croft, Nathan P., Purcell, Anthony W., Bogoyevitch, Marie A., Ng, Dominic C. H., Gleeson, Paul A. and Hatters, Danny M. (2012). Tracking protein aggregation and mislocalization in cells with flow cytometry. Nature Methods, 9 (5), 467-470. doi: 10.1038/nmeth.1930

Tracking protein aggregation and mislocalization in cells with flow cytometry

2012

Book Chapter

Stathmin and cancer

Ng, Dominic Chi Hiung and Byrne, Frances (2012). Stathmin and cancer. Cytoskeleton and Human Disease. (pp. 259-284) edited by Maria Kavallaris. New York, NY USA: Humana Press. doi: 10.1007/978-1-61779-788-0_14

Stathmin and cancer

2011

Journal Article

Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure

Waardenberg, Ashley J., Bernardo, Bianca C., Ng, Dominic C. H., Shepherd, Peter R., Cemerlang, Nelly, Sbroggio, Mauro, Wells, Christine A., Dalrymple, Brian P., Brancaccio, Mara, Lin, Ruby C. Y. and McMullen, Julie R. (2011). Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry, 286 (35), 30837-30846. doi: 10.1074/jbc.M111.271684

Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure

2011

Journal Article

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK

Thomas, Colleen J., Ng, Dominic C. H., Patsikatheodorou, Nikolas, Limengka, Yuliardy, Lee, Matthew W. K., Darby, Ian A., Woodman, Owen L. and May, Clive N. (2011). Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK. European Journal of Pharmacology, 658 (2-3), 160-167. doi: 10.1016/j.ejphar.2011.02.041

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK

2011

Journal Article

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Ngoei, Kevin R. W., Catimel, Bruno, Church, Nicole, Lio, Daisy S., Dogovski, Con, Perugini, Matthew A., Watt, Paul M., Cheng, Heung-Chin, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2011). Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide. Biochemical Journal, 434 (3), 399-413. doi: 10.1042/BJ20101244

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

2011

Journal Article

Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy

Ng, Dominic C. H., Ng, Ivan H. W., Yeap, Yvonne Y. C., Badrian, Bahareh, Tsoutsman, Tatiana, McMullen, Julie R., Semsarian, Christopher and Bogoyevitch, Marie A. (2011). Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy. Journal of Biological Chemistry, 286 (2), 1576-1587. doi: 10.1074/jbc.M110.128157

Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy

2011

Journal Article

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Meyerowitz, Jodi, Parker, Sarah J., Vella, Laura J., Ng, Dominic C. H., Price, Katherine A., Liddell, Jeffrey R., Caragounis, Aphrodite, Li, Qiao-Xin, Masters, Colin L., Nonaka, Takashi, Hasegawa, Masato, Bogoyevitch, Marie A., Kanninen, Katja M., Crouch, Peter J. and White, Anthony R. (2011). C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress. Molecular Neurodegeneration, 6 (57) 57. doi: 10.1186/1750-1326-6-57

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

2010

Journal Article

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

Ng, Dominic C. H., Zhao, Teresa T., Yeap, Yvonne Y. C., Ngoei, Kevin R. and Bogoyevitch, Marie A. (2010). c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress. Journal of Biological Chemistry, 285 (37), 29001-29013. doi: 10.1074/jbc.M110.128454

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

2010

Journal Article

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Yeap, Yvonne Y. C., Ng, Ivan H. W., Badrian, Bahareh, Nguyen, Tuong-Vi, Yip, Yan Y., Dhillon, Amardeep S., Mutsaers, Steven E., Silke, John, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18. Biochemical Journal, 430 (2), 345-354. doi: 10.1042/BJ20100425

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

2010

Journal Article

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

Bogoyevitch, Marie A., Ngoei, Kevin R. W., Zhao, Teresa T., Yeap, Yvonne Y. C. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1804 (3), 463-475. doi: 10.1016/j.bbapap.2009.11.002

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

2010

Journal Article

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Ng, Dominic C. H., Lim, Cheh P., Lin, Bao H., Zhang, Tong and Cao, Xinmin (2010). SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. Biochemical Journal, 425 (1), 95-105. doi: 10.1042/BJ20091213

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

2009

Journal Article

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX

Teng, Terk Shin, Lin, Baohong, Manser, Ed, Ng, Dominic Chi Hiung and Cao, Xinmin (2009). Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX. Journal of Cell Science, 122 (22), 4150-4159. doi: 10.1242/jcs.057109

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX

2008

Journal Article

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy

Tsoutsman, Tatiana, Kelly, Matthew, Ng, Dominic C. H., Tan, Ju-En, Tu, Emily, Lam, Lien, Bogoyevitch, Marie A., Seidman, Christine E., Seidman, J. G. and Semsarian, Christopher (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117 (14), 1820-1831. doi: 10.1161/CIRCULATIONAHA.107.755777

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy

Funding

Current funding

  • 2026 - 2030
    How pH alters cell responses to kinase signalling
    ARC Discovery Projects
    Open grant

Past funding

  • 2025 - 2026
    Striking a sour note: Revealing ageing-related intracellular acidification as a trigger for ALS pathomechanisms
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2023 - 2025
    Understanding how the ALS risk factor, GGNBP2, contributes to autophagy
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    How defects in centrosome to microtubule attachment cause microcephaly
    NHMRC Project Grant
    Open grant
  • 2019 - 2023
    Identifying conserved alternative splicing mechanisms in vivo
    NHMRC Project Grant
    Open grant
  • 2017 - 2021
    Trophoblast cell-cell fusion in preeclampsia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Mitotic spindle regulation by novel Aurora A control mechanisms [The Robert Baillie Research Grant]
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Interrogating a novel protein scaffold that coordinates signal transduction and molecular motor function
    ARC Future Fellowships
    Open grant
  • 2015 - 2016
    New insights into mechanisms that coordinate kinase signalling and molecular motors in mitosis: A novel role for the protein scaffold WD-repeat protein 62 (WDR62)
    NHMRC Project Grant
    Open grant

Supervision

Availability

Associate Professor Dominic Ng is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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