Overview
Background
Dr Gordon’s research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.
The specific focus of Dr Gordon’s research is to determine the precise molecular signals that control cell adhesion within the vessel wall the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. Dr Gordon aims to use novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.
Dr Gordon received her Bachelor of Science (2005) and PhD (2011) from The University of Adelaide, after which she undertook six years of postdoctoral studies at Yale University in the USA and Uppsala University in Sweden. With the support of an ARC DECRA Fellowship, Dr Gordon relocated to IMB in 2017 to establish her independent research career as an IMB Fellow. In 2019, she was appointed as Group Leader of the Vessel Dynamics Laboratory.
Availability
- Dr Emma Gordon is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Works
Search Professor Emma Gordon’s works on UQ eSpace
2024
Journal Article
Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy
Frampton, Emmanuelle, Som, Priyanka, Hill, Brittany, Yu, Alexander, Naval-Sanchez, Marina, Nefzger, Chistian M., Noordstra, Ivar, Gordon, Emma and Schimmel, Lilian (2024). Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy. The American Journal of Pathology. doi: 10.1016/j.ajpath.2024.09.003
2024
Journal Article
c-Src induced vascular malformations require localised matrix degradation at focal adhesions
Essebier, Patricia, Keyser, Mikaela, Yordanov, Teodor, Hill, Brittany, Yu, Alexander, Noordstra, Ivar, Yap, Alpha S., Stehbens, Samantha J., Lagendijk, Anne K., Schimmel, Lilian and Gordon, Emma J. (2024). c-Src induced vascular malformations require localised matrix degradation at focal adhesions. Journal of Cell Science, 137 (13) jcs262101. doi: 10.1242/jcs.262101
2023
Journal Article
An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion
Noordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011
2023
Journal Article
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release
Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366
2022
Journal Article
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
Jin, Yi, Ding, Yindi, Richards, Mark, Kaakinen, Mika, Giese, Wolfgang, Baumann, Elisabeth, Szymborska, Anna, Rosa, André, Nordling, Sofia, Schimmel, Lilian, Akmeriç, Emir Bora, Pena, Andreia, Nwadozi, Emmanuel, Jamalpour, Maria, Holstein, Katrin, Sáinz-Jaspeado, Miguel, Bernabeu, Miguel O., Welsh, Michael, Gordon, Emma, Franco, Claudio A., Vestweber, Dietmar, Eklund, Lauri, Gerhardt, Holger and Claesson-Welsh, Lena (2022). Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nature Cardiovascular Research, 1 (12), 1156-1173+. doi: 10.1038/s44161-022-00172-z
2021
Journal Article
Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
2021
Journal Article
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration
Arts, Janine J. G., Mahlandt, Eike K., Grönloh, Max, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham C.I., Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A., Postma, Marten, Khuon, Satya, Heddleston, John M., Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, 10 e66074. doi: 10.7554/elife.66074
2021
Journal Article
Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation
Englert, Hanna, Rangaswamy, Chandini, Deppermann, Carsten, Sperhake, Jan-Peter, Krisp, Christoph, Schreier, Danny, Gordon, Emma, Konrath, Sandra, Haddad, Munif, Pula, Giordano, Mailer, Reiner K, Schlüter, Hartmut, Kluge, Stefan, Langer, Florian, Püschel, Klaus, Panousis, Kosta, Stavrou, Evi X, Maas, Coen, Renné, Thomas and Frye, Maike (2021). Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine, 67 103382, 103382. doi: 10.1016/j.ebiom.2021.103382
2021
Journal Article
Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways
Vion, Anne-Clémence, Perovic, Tijana, Petit, Charlie, Hollfinger, Irene, Bartels-Klein, Eireen, Frampton, Emmanuelle, Gordon, Emma, Claesson-Welsh, Lena and Gerhardt, Holger (2021). Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways. Frontiers in Physiology, 11 623769, 623769. doi: 10.3389/fphys.2020.623769
2021
Journal Article
RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in mice
Karunakaran, Denuja, Nguyen, My-Anh, Geoffrion, Michele, Vreeken, Dianne, Lister, Zachary, Cheng, Henry S., Otte, Nicola, Essebier, Patricia, Wyatt, Hailey, Kandiah, Joshua W., Jung, Richard, Alenghat, Francis J., Mompeon, Ana, Lee, Richard, Pan, Calvin, Gordon, Emma, Rasheed, Adil, Lusis, Aldons J., Liu, Peter, Matic, Ljubica Perisic, Hedin, Ulf, Fish, Jason E., Guo, Liang, Kolodgie, Frank, Virmani, Renu, van Gils, Janine M. and Rayner, Katey J. (2021). RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in mice. Circulation, 143 (2) CIRCULATIONAHA.118.038379, 163-177. doi: 10.1161/CIRCULATIONAHA.118.038379
2020
Journal Article
The importance of mechanical forces for in vitro endothelial cell biology
Gordon, Emma, Schimmel, Lilian and Frye, Maike (2020). The importance of mechanical forces for in vitro endothelial cell biology. Frontiers in Physiology, 11 684, 684. doi: 10.3389/fphys.2020.00684
2020
Journal Article
MAFB modulates the maturation of lymphatic vascular networks in mice
Rondon‐Galeano, Maria, Skoczylas, Renae, Bower, Neil I., Simons, Cas, Gordon, Emma, Francois, Mathias, Koltowska, Katarzyna and Hogan, Benjamin M. (2020). MAFB modulates the maturation of lymphatic vascular networks in mice. Developmental Dynamics, 249 (10) dvdy.209, 1201-1216. doi: 10.1002/dvdy.209
2020
Journal Article
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
Smith, Ross O., Ninchoji, Takeshi, Gordon, Emma, André, Helder, Dejana, Elisabetta, Vestweber, Dietmar, Kvanta, Anders and Claesson-Welsh, Lena (2020). Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. eLife, 9 e54056. doi: 10.7554/eLife.54056
2020
Journal Article
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
Schimmel, Lilian, Fukuhara, Daisuke, Richards, Mark, Jin, Yi, Essebier, Patricia, Frampton, Emmanuelle, Hedlund, Marie, Dejana, Elisabetta, Claesson-Welsh, Lena and Gordon, Emma (2020). c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development, 147 (7) 185405, dev.185405. doi: 10.1242/dev.185405
2018
Journal Article
The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall
Schimmel, Lilian and Gordon, Emma (2018). The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Biochemical Society Transactions, 46 (6), 1673-1680. doi: 10.1042/bst20180377
2018
Journal Article
Shear stress and VE-cadherin
Caolo, Vincenza, Peacock, Hanna M., Kasaai, Bahar, Swennen, Geertje, Gordon, Emma, Claesson-Welsh, Lena, Post, Mark J., Verhamme, Peter and Jones, Elizabeth A. V. (2018). Shear stress and VE-cadherin. Arteriosclerosis, Thrombosis, and Vascular Biology, 38 (9), 2174-2183. doi: 10.1161/ATVBAHA.118.310823
2016
Journal Article
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, Michael, Gordon, Emma and Claesson-Welsh, Lena (2016). Mechanisms and regulation of endothelial VEGF receptor signalling. Nature Reviews Molecular Cell Biology, 17 (10), 611-625. doi: 10.1038/nrm.2016.87
2016
Journal Article
The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation
Gordon, Emma J., Fukuhara, Daisuke, Westrom, Simone, Padhan, Narendra, Sjostrom, Elisabet O., van Meeteren, Laurens, He, Liqun, Orsenigo, Fabrizio, Dejana, Elisabetta, Bentley, Katie, Spurkland, Anne and Claesson-Welsh, Lena (2016). The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling, 9 (437) ra72, ra72-ra72. doi: 10.1126/scisignal.aad9256
2016
Journal Article
Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling
Fleetwood, Filippa, Guler, Rezan, Gordon, Emma, Stahl, Stefan, Claesson-Welsh, Lena and Lofblom, John (2016). Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Cellular and Molecular Life Sciences, 73 (8), 1671-1683. doi: 10.1007/s00018-015-2088-7
2016
Journal Article
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Li, Xiujuan, Padhan, Narendra, Sjostrom, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sainz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif and Claesson-Welsh, Lena (2016). VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nature Communications, 7 (1) 11017. doi: 10.1038/ncomms11017
Funding
Current funding
Past funding
Supervision
Availability
- Dr Emma Gordon is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Dr Anne Lagendijk, Dr Lilian Schimmel
-
Doctor Philosophy
Targetting blood vessel dysfunction in disease
Associate Advisor
Other advisors: Dr Samantha Stehbens, Dr Anne Lagendijk
-
Doctor Philosophy
Investigating the role of the blood vasculature in Medulloblastoma progression using zebrafish models
Associate Advisor
Other advisors: Dr Laura Genovesi, Dr Anne Lagendijk
-
Doctor Philosophy
Investigating the vascular dysfunction in COVID-19
Associate Advisor
Other advisors: Dr Keng Chew, Dr Larisa Labzin
-
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Dr Anne Lagendijk, Dr Lilian Schimmel
Completed supervision
-
2022
Master Philosophy
Characterising the role of endothelial c-Src in Oxygen-Induced Retinopathy.
Principal Advisor
Other advisors: Dr Lilian Schimmel
Media
Enquiries
Contact Dr Emma Gordon directly for media enquiries about:
- angiogenesis
- bioengineered organs
- cancer metastasis
- cell adhesion
- dynamic imaging
- scientific imaging
- vascular disease
- vascular eye disease
- vascular permeability
- vessel biology
- zebrafish
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