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2024 Journal Article Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced RetinopathyFrampton, Emmanuelle, Som, Priyanka, Hill, Brittany, Yu, Alexander, Naval-Sanchez, Marina, Nefzger, Chistian M., Noordstra, Ivar, Gordon, Emma and Schimmel, Lilian (2024). Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy. The American Journal of Pathology, 194 (12), 2239-2251. doi: 10.1016/j.ajpath.2024.09.003 |
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2024 Journal Article c-Src induced vascular malformations require localised matrix degradation at focal adhesionsEssebier, Patricia, Keyser, Mikaela, Yordanov, Teodor, Hill, Brittany, Yu, Alexander, Noordstra, Ivar, Yap, Alpha S., Stehbens, Samantha J., Lagendijk, Anne K., Schimmel, Lilian and Gordon, Emma J. (2024). c-Src induced vascular malformations require localised matrix degradation at focal adhesions. Journal of Cell Science, 137 (13) jcs262101. doi: 10.1242/jcs.262101 |
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2023 Journal Article An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotionNoordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011 |
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2023 Journal Article Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion releaseLabzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366 |
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2022 Journal Article Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosisJin, Yi, Ding, Yindi, Richards, Mark, Kaakinen, Mika, Giese, Wolfgang, Baumann, Elisabeth, Szymborska, Anna, Rosa, André, Nordling, Sofia, Schimmel, Lilian, Akmeriç, Emir Bora, Pena, Andreia, Nwadozi, Emmanuel, Jamalpour, Maria, Holstein, Katrin, Sáinz-Jaspeado, Miguel, Bernabeu, Miguel O., Welsh, Michael, Gordon, Emma, Franco, Claudio A., Vestweber, Dietmar, Eklund, Lauri, Gerhardt, Holger and Claesson-Welsh, Lena (2022). Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nature Cardiovascular Research, 1 (12), 1156-1173+. doi: 10.1038/s44161-022-00172-z |
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2021 Journal Article Endothelial cells are not productively infected by SARS‐CoV‐2Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350 |
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2021 Journal Article Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigrationArts, Janine J. G., Mahlandt, Eike K., Grönloh, Max, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham C.I., Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A., Postma, Marten, Khuon, Satya, Heddleston, John M., Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, 10 e66074. doi: 10.7554/elife.66074 |
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2021 Journal Article Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammationEnglert, Hanna, Rangaswamy, Chandini, Deppermann, Carsten, Sperhake, Jan-Peter, Krisp, Christoph, Schreier, Danny, Gordon, Emma, Konrath, Sandra, Haddad, Munif, Pula, Giordano, Mailer, Reiner K, Schlüter, Hartmut, Kluge, Stefan, Langer, Florian, Püschel, Klaus, Panousis, Kosta, Stavrou, Evi X, Maas, Coen, Renné, Thomas and Frye, Maike (2021). Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine, 67 103382, 103382. doi: 10.1016/j.ebiom.2021.103382 |
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2021 Journal Article Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathwaysVion, Anne-Clémence, Perovic, Tijana, Petit, Charlie, Hollfinger, Irene, Bartels-Klein, Eireen, Frampton, Emmanuelle, Gordon, Emma, Claesson-Welsh, Lena and Gerhardt, Holger (2021). Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways. Frontiers in Physiology, 11 623769, 623769. doi: 10.3389/fphys.2020.623769 |
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2021 Journal Article RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in miceKarunakaran, Denuja, Nguyen, My-Anh, Geoffrion, Michele, Vreeken, Dianne, Lister, Zachary, Cheng, Henry S., Otte, Nicola, Essebier, Patricia, Wyatt, Hailey, Kandiah, Joshua W., Jung, Richard, Alenghat, Francis J., Mompeon, Ana, Lee, Richard, Pan, Calvin, Gordon, Emma, Rasheed, Adil, Lusis, Aldons J., Liu, Peter, Matic, Ljubica Perisic, Hedin, Ulf, Fish, Jason E., Guo, Liang, Kolodgie, Frank, Virmani, Renu, van Gils, Janine M. and Rayner, Katey J. (2021). RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in mice. Circulation, 143 (2) CIRCULATIONAHA.118.038379, 163-177. doi: 10.1161/CIRCULATIONAHA.118.038379 |
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2020 Journal Article The importance of mechanical forces for in vitro endothelial cell biologyGordon, Emma, Schimmel, Lilian and Frye, Maike (2020). The importance of mechanical forces for in vitro endothelial cell biology. Frontiers in Physiology, 11 684, 684. doi: 10.3389/fphys.2020.00684 |
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2020 Journal Article MAFB modulates the maturation of lymphatic vascular networks in miceRondon‐Galeano, Maria, Skoczylas, Renae, Bower, Neil I., Simons, Cas, Gordon, Emma, Francois, Mathias, Koltowska, Katarzyna and Hogan, Benjamin M. (2020). MAFB modulates the maturation of lymphatic vascular networks in mice. Developmental Dynamics, 249 (10) dvdy.209, 1201-1216. doi: 10.1002/dvdy.209 |
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2020 Journal Article Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherinSmith, Ross O., Ninchoji, Takeshi, Gordon, Emma, André, Helder, Dejana, Elisabetta, Vestweber, Dietmar, Kvanta, Anders and Claesson-Welsh, Lena (2020). Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. eLife, 9 e54056. doi: 10.7554/eLife.54056 |
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2020 Journal Article c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assemblySchimmel, Lilian, Fukuhara, Daisuke, Richards, Mark, Jin, Yi, Essebier, Patricia, Frampton, Emmanuelle, Hedlund, Marie, Dejana, Elisabetta, Claesson-Welsh, Lena and Gordon, Emma (2020). c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development, 147 (7) 185405, dev.185405. doi: 10.1242/dev.185405 |
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2018 Journal Article The precise molecular signals that control endothelial cell–cell adhesion within the vessel wallSchimmel, Lilian and Gordon, Emma (2018). The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Biochemical Society Transactions, 46 (6), 1673-1680. doi: 10.1042/bst20180377 |
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2018 Journal Article Shear stress and VE-cadherinCaolo, Vincenza, Peacock, Hanna M., Kasaai, Bahar, Swennen, Geertje, Gordon, Emma, Claesson-Welsh, Lena, Post, Mark J., Verhamme, Peter and Jones, Elizabeth A. V. (2018). Shear stress and VE-cadherin. Arteriosclerosis, Thrombosis, and Vascular Biology, 38 (9), 2174-2183. doi: 10.1161/ATVBAHA.118.310823 |
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2016 Journal Article Mechanisms and regulation of endothelial VEGF receptor signallingSimons, Michael, Gordon, Emma and Claesson-Welsh, Lena (2016). Mechanisms and regulation of endothelial VEGF receptor signalling. Nature Reviews Molecular Cell Biology, 17 (10), 611-625. doi: 10.1038/nrm.2016.87 |
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2016 Journal Article The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activationGordon, Emma J., Fukuhara, Daisuke, Westrom, Simone, Padhan, Narendra, Sjostrom, Elisabet O., van Meeteren, Laurens, He, Liqun, Orsenigo, Fabrizio, Dejana, Elisabetta, Bentley, Katie, Spurkland, Anne and Claesson-Welsh, Lena (2016). The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling, 9 (437) ra72, ra72-ra72. doi: 10.1126/scisignal.aad9256 |
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2016 Journal Article Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signalingFleetwood, Filippa, Guler, Rezan, Gordon, Emma, Stahl, Stefan, Claesson-Welsh, Lena and Lofblom, John (2016). Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Cellular and Molecular Life Sciences, 73 (8), 1671-1683. doi: 10.1007/s00018-015-2088-7 |
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2016 Journal Article VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spreadLi, Xiujuan, Padhan, Narendra, Sjostrom, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sainz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif and Claesson-Welsh, Lena (2016). VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nature Communications, 7 (1) 11017. doi: 10.1038/ncomms11017 |
