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Dr Emma Gordon
Dr

Emma Gordon

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Overview

Background

Dr Gordon’s research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.

The specific focus of Dr Gordon’s research is to determine the precise molecular signals that control cell adhesion within the vessel wall the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. Dr Gordon aims to use novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.

Dr Gordon received her Bachelor of Science (2005) and PhD (2011) from The University of Adelaide, after which she undertook six years of postdoctoral studies at Yale University in the USA and Uppsala University in Sweden. With the support of an ARC DECRA Fellowship, Dr Gordon relocated to IMB in 2017 to establish her independent research career as an IMB Fellow. In 2019, she was appointed as Group Leader of the Vessel Dynamics Laboratory.

Availability

Dr Emma Gordon is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Adelaide

Works

Search Professor Emma Gordon’s works on UQ eSpace

29 works between 2008 and 2024

21 - 29 of 29 works

2016

Journal Article

Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling

Fleetwood, Filippa, Guler, Rezan, Gordon, Emma, Stahl, Stefan, Claesson-Welsh, Lena and Lofblom, John (2016). Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Cellular and Molecular Life Sciences, 73 (8), 1671-1683. doi: 10.1007/s00018-015-2088-7

Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling

2016

Journal Article

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

Li, Xiujuan, Padhan, Narendra, Sjostrom, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sainz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif and Claesson-Welsh, Lena (2016). VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nature Communications, 7 (1) 11017. doi: 10.1038/ncomms11017

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

2015

Journal Article

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizan, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne and Gerhardt, Holger (2015). Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nature Communications, 6 (1) 7264. doi: 10.1038/ncomms8264

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

2014

Journal Article

Netrin-1 controls sympathetic arterial innervation

Brunet, Isabelle, Gordon, Emma, Han, Jinah, Cristofaro, Brunella, Broqueres-You, Dong, Liu, Chun, Bouvree, Karine, Zhang, Jiasheng, del Toro, Raquel, Mathivet, Thomas, Larrivee, Bruno, Jagu, Julia, Pibouin-Fragner, Laurence, Pardanaud, Luc, Machado, Maria J. C., Kennedy, Timothy E., Zhuang, Zhen, Simons, Michael, Levy, Bernard I., Tessier-Lavigne, Marc, Grenz, Almut, Eltzschig, Holger and Eichmann, Anne (2014). Netrin-1 controls sympathetic arterial innervation. Journal of Clinical Investigation, 124 (7), 3230-3240. doi: 10.1172/JCI75181

Netrin-1 controls sympathetic arterial innervation

2012

Journal Article

Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis

Harvey, Natasha L. and Gordon, Emma J. (2012). Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vascular Cell, 4 (1) 15, 15. doi: 10.1186/2045-824X-4-15

Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis

2012

Journal Article

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation

Bouvree, Karine, Brunet, Isabelle, del Toro, Raquel, Gordon, Emma, Prahst, Claudia, Cristofaro, Brunella, Mathivet, Thomas, Xu, Yunling, Soueid, Jihane, Fortuna, Vitor, Miura, Nayoki, Aigrot, Marie-Stephane, Maden, Charlotte H., Ruhrberg, Christiana, Thomas, Jean Leon and Eichmann, Anne (2012). Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circulation Research, 111 (4), 437-445. doi: 10.1161/CIRCRESAHA.112.269316

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation

2012

Journal Article

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway

Larrivee, Bruno, Prahst, Claudia, Gordon, Emma, del Toro, Raquel, Mathivet, Thomas, Duarte, Antonio, Simons, Michael and Eichmann, Anne (2012). ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Developmental Cell, 22 (3), 489-500. doi: 10.1016/j.devcel.2012.02.005

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway

2010

Journal Article

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

Gordon, Emma J., Rao, Sujata, Pollard, Jeffrey W., Nutt, Stephen L., Lang, Richard A. and Harvey, Natasha L. (2010). Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development, 137 (22), 3899-3910. doi: 10.1242/dev.050021

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

2008

Journal Article

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels

Gordon, Emma J., Gale, Nicholas W. and Harvey, Natasha L. (2008). Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Developmental Dynamics, 237 (7), 1901-1909. doi: 10.1002/dvdy.21605

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels

Funding

Current funding

  • 2022 - 2025
    COVID-19-induced vascular complications: mechanisms and potential therapies
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2024
    Targeting the mechanosensory properties of vessels to control dysfunction in disease
    National Heart Foundation Future Leader Fellowship
    Open grant
  • 2020 - 2023
    Defining mechanisms behind the formation of hierarchical vascular networks
    ARC Discovery Projects
    Open grant
  • 2019 - 2023
    Mechanisms to promote vascular normalisation and barrier integrity
    NHMRC Project Grant
    Open grant
  • 2018
    Molecular cues guiding cell dynamics during pathological blood vessel sprouting
    UQ Early Career Researcher
    Open grant
  • 2017 - 2020
    Molecular signals guiding dynamic cell movement during blood vessel growth
    ARC Discovery Early Career Researcher Award
    Open grant

Supervision

Availability

Dr Emma Gordon is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Dr Emma Gordon directly for media enquiries about:

  • angiogenesis
  • bioengineered organs
  • cancer metastasis
  • cell adhesion
  • dynamic imaging
  • scientific imaging
  • vascular disease
  • vascular eye disease
  • vascular permeability
  • vessel biology
  • zebrafish

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