
Overview
Background
Dr Gordon’s research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.
The specific focus of Dr Gordon’s research is to determine the precise molecular signals that control cell adhesion within the vessel wall the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. Dr Gordon aims to use novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.
Dr Gordon received her Bachelor of Science (2005) and PhD (2011) from The University of Adelaide, after which she undertook six years of postdoctoral studies at Yale University in the USA and Uppsala University in Sweden. With the support of an ARC DECRA Fellowship, Dr Gordon relocated to IMB in 2017 to establish her independent research career as an IMB Fellow. In 2019, she was appointed as Group Leader of the Vessel Dynamics Laboratory.
Availability
- Dr Emma Gordon is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Works
Search Professor Emma Gordon’s works on UQ eSpace
2016
Journal Article
Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling
Fleetwood, Filippa, Guler, Rezan, Gordon, Emma, Stahl, Stefan, Claesson-Welsh, Lena and Lofblom, John (2016). Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Cellular and Molecular Life Sciences, 73 (8), 1671-1683. doi: 10.1007/s00018-015-2088-7
2016
Journal Article
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Li, Xiujuan, Padhan, Narendra, Sjostrom, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sainz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif and Claesson-Welsh, Lena (2016). VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nature Communications, 7 (1) 11017. doi: 10.1038/ncomms11017
2015
Journal Article
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch
Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizan, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne and Gerhardt, Holger (2015). Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nature Communications, 6 (1) 7264. doi: 10.1038/ncomms8264
2014
Journal Article
Netrin-1 controls sympathetic arterial innervation
Brunet, Isabelle, Gordon, Emma, Han, Jinah, Cristofaro, Brunella, Broqueres-You, Dong, Liu, Chun, Bouvree, Karine, Zhang, Jiasheng, del Toro, Raquel, Mathivet, Thomas, Larrivee, Bruno, Jagu, Julia, Pibouin-Fragner, Laurence, Pardanaud, Luc, Machado, Maria J. C., Kennedy, Timothy E., Zhuang, Zhen, Simons, Michael, Levy, Bernard I., Tessier-Lavigne, Marc, Grenz, Almut, Eltzschig, Holger and Eichmann, Anne (2014). Netrin-1 controls sympathetic arterial innervation. Journal of Clinical Investigation, 124 (7), 3230-3240. doi: 10.1172/JCI75181
2012
Journal Article
Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis
Harvey, Natasha L. and Gordon, Emma J. (2012). Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vascular Cell, 4 (1) 15, 15. doi: 10.1186/2045-824X-4-15
2012
Journal Article
Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation
Bouvree, Karine, Brunet, Isabelle, del Toro, Raquel, Gordon, Emma, Prahst, Claudia, Cristofaro, Brunella, Mathivet, Thomas, Xu, Yunling, Soueid, Jihane, Fortuna, Vitor, Miura, Nayoki, Aigrot, Marie-Stephane, Maden, Charlotte H., Ruhrberg, Christiana, Thomas, Jean Leon and Eichmann, Anne (2012). Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circulation Research, 111 (4), 437-445. doi: 10.1161/CIRCRESAHA.112.269316
2012
Journal Article
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway
Larrivee, Bruno, Prahst, Claudia, Gordon, Emma, del Toro, Raquel, Mathivet, Thomas, Duarte, Antonio, Simons, Michael and Eichmann, Anne (2012). ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Developmental Cell, 22 (3), 489-500. doi: 10.1016/j.devcel.2012.02.005
2010
Journal Article
Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation
Gordon, Emma J., Rao, Sujata, Pollard, Jeffrey W., Nutt, Stephen L., Lang, Richard A. and Harvey, Natasha L. (2010). Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development, 137 (22), 3899-3910. doi: 10.1242/dev.050021
2008
Journal Article
Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels
Gordon, Emma J., Gale, Nicholas W. and Harvey, Natasha L. (2008). Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Developmental Dynamics, 237 (7), 1901-1909. doi: 10.1002/dvdy.21605
Funding
Current funding
Past funding
Supervision
Availability
- Dr Emma Gordon is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Investigating the mechanosensory properties of blood vessels
Associate Advisor
Other advisors: Dr Samantha Stehbens, Associate Professor Anne Lagendijk
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Doctor Philosophy
Investigating the role of the blood vasculature in Medulloblastoma progression using zebrafish models
Associate Advisor
Other advisors: Dr Laura Genovesi, Associate Professor Anne Lagendijk
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Doctor Philosophy
Targetting blood vessel dysfunction in disease
Associate Advisor
Other advisors: Dr Samantha Stehbens, Associate Professor Anne Lagendijk
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Doctor Philosophy
Uncovering dynamic changes in tumour associated vasculature using zebrafish models
Associate Advisor
Other advisors: Dr Laura Genovesi, Associate Professor Anne Lagendijk
-
Doctor Philosophy
Investigating the vascular dysfunction in COVID-19
Associate Advisor
Other advisors: Dr Keng Chew, Dr Larisa Labzin
-
Doctor Philosophy
Investigating the role of the blood vasculature in Medulloblastoma progression using zebrafish models
Associate Advisor
Other advisors: Dr Laura Genovesi, Associate Professor Anne Lagendijk
-
Doctor Philosophy
Targetting blood vessel dysfunction in disease
Associate Advisor
Other advisors: Dr Samantha Stehbens, Associate Professor Anne Lagendijk
-
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Associate Professor Anne Lagendijk, Dr Lilian Schimmel
-
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Associate Professor Anne Lagendijk, Dr Lilian Schimmel
-
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Associate Professor Anne Lagendijk, Dr Lilian Schimmel
Completed supervision
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2022
Master Philosophy
Characterising the role of endothelial c-Src in Oxygen-Induced Retinopathy.
Principal Advisor
Other advisors: Dr Lilian Schimmel
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2025
Doctor Philosophy
The role of c-Src in facilitating endothelial dysfunction in aortic disease
Associate Advisor
Other advisors: Associate Professor Anne Lagendijk, Dr Lilian Schimmel
Media
Enquiries
Contact Dr Emma Gordon directly for media enquiries about:
- angiogenesis
- bioengineered organs
- cancer metastasis
- cell adhesion
- dynamic imaging
- scientific imaging
- vascular disease
- vascular eye disease
- vascular permeability
- vessel biology
- zebrafish
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