Overview
Background
David Cantillo studied chemistry at the University of Extremadura, Spain. In 2011, he obtained his PhD under the supervision of Prof. Jose Luis Jimenez at the same university. His PhD work focused on the experimental and theoretical study of 1,3-dipolar cycloadditions of mesoionic compounds. Then, he moved to the University of Graz as a postdoctoral researcher within the group of Prof. C. Oliver Kappe, where he gained experience in flow chemistry. In 2018, he started his independent academic career at the University of Graz as an Assistant Professor and became an Area Leader at the Research Center Pharmaceutical Engineering GmbH. David has joined the University of Queensland in 2023.
His research group focuses on synthetic organic electrochemistry. In particular, the group explores the use of electrical current to develop novel synthetic methodologies and more sustainable routes for the synthesis of medicines, as well as process scale up using continuous flow technology.
Availability
- Dr David Cantillo is:
- Available for supervision
Qualifications
- Licentiate of Chemistry, Universidad de Extremadura
- Doctoral (Research) of Organic Chemistry, Universidad de Extremadura
Research interests
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Synthetic organic electrochemistry
Development of novel synthetic methods of organic compounds, such as active pharmaceutical ingredients and agrochemicals, using electrolysis instead of chemical reagents. Scale up of electrochemical reactions using flow electrolysis cells to ensure industrial application of electrochemical methods
Research impacts
David has published over 100 papers in scientific journals that have been cited over 5000 times (H-Index=35). His research has been recognized with several awards, including the 2020 Thieme Chemistry Journals Award, the 2024 OPRD award from the ACS and the Inventor Award from UniGraz. David is member of the scientific advisory boards of Axplora and Chimica Oggi.
Works
Search Professor David Cantillo’s works on UQ eSpace
2018
Journal Article
Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat
Znidar, Desiree, Cantillo, David, Inglesby, Phillip, Boyd, Alistair and Kappe, C. Oliver (2018). Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat. Organic Process Research and Development, 22 (5), 633-640. doi: 10.1021/acs.oprd.8b00089
2018
Journal Article
Continuous multistep synthesis of 2-(azidomethyl)oxazoles
Rossa, Thais A., Suveges, Nicolas S., Sa, Marcus M., Cantillo, David and Kappe, C. Oliver (2018). Continuous multistep synthesis of 2-(azidomethyl)oxazoles. Beilstein Journal of Organic Chemistry, 14, 506-514. doi: 10.3762/bjoc.14.36
2017
Other Outputs
Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives
Kappe, C. O., Gutmann, B., Weigl, U., Egli, P., Cox, P. D. and Cantillo, D. (2017). Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives. WO2017185004.
2017
Conference Publication
Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence
Cantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. (2017). Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC United States, 20-24 August 2017. Washington, DC United States: American Chemical Society.
2017
Other Outputs
Process for manufacturing 1,4-benzoxazinones
Wolf, Bernd, Goetz, Roland, Kappe, C. Oliver and Cantillo, David (2017). Process for manufacturing 1,4-benzoxazinones. EP3184515A1.
2017
Journal Article
An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioids
Mata, Alejandro, Cantillo, David and Kappe, C. Oliver (2017). An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioids. European Journal of Organic Chemistry, 2017 (44), 6505-6510. doi: 10.1002/ejoc.201700811
2017
Journal Article
Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide
Cantillo, David, Inglesby, Phillip A., Boyd, Alistair and Kappe, C. Oliver (2017). Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide. Journal of Flow Chemistry, 7 (2), 29-32. doi: 10.1556/1846.2017.00006
2017
Journal Article
Halogenation of organic compounds using continuous flow and microreactor technology
Cantillo, David and Kappe, C. Oliver (2017). Halogenation of organic compounds using continuous flow and microreactor technology. Reaction Chemistry and Engineering, 2 (1), 7-19. doi: 10.1039/c6re00186f
2017
Journal Article
Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode
Gutmann, Bernhard, Cantillo, David, Weigl, Ulrich, Cox, D. Phillip and Kappe, C. Oliver (2017). Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode. European Journal of Organic Chemistry, 2017 (4), 914-927. doi: 10.1002/ejoc.201601453
2017
Journal Article
Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence
Cantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. Oliver (2017). Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence. Organic Process Research and Development, 21 (1), 125-132. doi: 10.1021/acs.oprd.6b00409
2016
Journal Article
Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow
Guerra, Javier, Cantillo, David and Kappe, C. Oliver (2016). Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow. Catalysis Science and Technology, 6 (13), 4695-4699. doi: 10.1039/c6cy00070c
2016
Journal Article
Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process
Nikolaev, Valerij A., Cantillo, David, Kappe, C. Oliver, Medvedev, Jury J., Prakash, G. K. Surya and Supurgibekov, Murat B. (2016). Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process. Chemistry: A European Journal, 22 (1), 174-184. doi: 10.1002/chem.201503448
2016
Journal Article
A laboratory-scale continuous flow chlorine generator for organic synthesis
Strauss, Franz J., Cantillo, David, Guerra, Javier and Kappe, C. Oliver (2016). A laboratory-scale continuous flow chlorine generator for organic synthesis. Reaction Chemistry and Engineering, 1 (5), 472-476. doi: 10.1039/c6re00135a
2016
Journal Article
Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins
Cantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2016). Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins. Organic and Biomolecular Chemistry, 14 (3), 853-857. doi: 10.1039/c5ob02425k
2015
Journal Article
A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective
David Cantillo (2015). A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective. Journal of Flow Chemistry, 5 (4), 195-196. doi: 10.1556/1846.2015.00021
2015
Journal Article
Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides
Cantillo, David, Mateos, Carlos, Rincon, Juan A., de Frutos, Oscar and Oliver Kappe, C. (2015). Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides. Chemistry: A European Journal, 21 (37), 12894-12898. doi: 10.1002/chem.201502357
2015
Journal Article
Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry
Cantillo, David and Kappe, C. Oliver (2015). Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry. Chimica Oggi, 33 (4), 6-10.
2015
Journal Article
Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients
Gutmann, Bernhard, Cantillo, David and Kappe, C. Oliver (2015). Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients. Angewandte Chemie (International Edition), 54 (23), 6688-6728. doi: 10.1002/anie.201409318
2015
Journal Article
Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin
Ullen, Andreas, Nusshold, Christoph, Glasnov, Toma, Saf, Robert, Cantillo, David, Eibinger, Gerald, Reicher, Helga, Fauler, Guenter, Bernhart, Eva, Hallstrom, Seth, Kogelnik, Nora, Zangger, Klaus, Kappe, C. Oliver, Malle, Ernst and Sattler, Wolfgang (2015). Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin. Biochemical Pharmacology, 93 (4), 470-481. doi: 10.1016/j.bcp.2014.12.017
2015
Journal Article
Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies
Greco, Roberto, Goessler, Walter, Cantillo, David and Kappe, C. Oliver (2015). Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies. ACS Catalysis, 5 (2), 1303-1312. doi: 10.1021/cs5020089
Supervision
Availability
- Dr David Cantillo is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
-
Synthetic organic electrochemisty
This project deals with the development of novel methods for the preparation of pharmaceutical intermediates using electrochemistry
Supervision history
Current supervision
-
Doctor Philosophy
Mass-Transfer Control-Enabled Electrochemical Reactions
Principal Advisor
Other advisors: Professor Paul Bernhardt
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Doctor Philosophy
Harvesting fluorine from fluorocarbons: Developing transfer fluorination
Associate Advisor
Other advisors: Associate Professor Rowan Young
Media
Enquiries
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