Overview
Background
David Cantillo studied chemistry at the University of Extremadura, Spain. In 2011, he obtained his PhD under the supervision of Prof. Jose Luis Jimenez at the same university. His PhD work focused on the experimental and theoretical study of 1,3-dipolar cycloadditions of mesoionic compounds. Then, he moved to the University of Graz as a postdoctoral researcher within the group of Prof. C. Oliver Kappe, where he gained experience in flow chemistry. In 2018, he started his independent academic career at the University of Graz as an Assistant Professor and became an Area Leader at the Research Center Pharmaceutical Engineering GmbH. David has joined the University of Queensland in 2023.
His research group focuses on synthetic organic electrochemistry. In particular, the group explores the use of electrical current to develop novel synthetic methodologies and more sustainable routes for the synthesis of medicines, as well as process scale up using continuous flow technology.
Availability
- Dr David Cantillo is:
- Available for supervision
Qualifications
- Licentiate of Chemistry, Universidad de Extremadura
- Doctoral (Research) of Organic Chemistry, Universidad de Extremadura
Research interests
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Synthetic organic electrochemistry
Development of novel synthetic methods of organic compounds, such as active pharmaceutical ingredients and agrochemicals, using electrolysis instead of chemical reagents. Scale up of electrochemical reactions using flow electrolysis cells to ensure industrial application of electrochemical methods
Research impacts
David has published over 90 papers in scientific journals that have been cited over 5000 times (H-Index=32). His research has been recognized with several awards, including the 2020 Thieme Chemistry Journals Award, the 2024 OPRD award from the ACS and the Inventor Award from UniGraz. David is member of the scientific advisory boards of Axplora and Chimica Oggi.
Works
Search Professor David Cantillo’s works on UQ eSpace
2020
Journal Article
Electrochemical N-demethylation of 14-hydroxy morphinans: sustainable access to opioid antagonists
Glotz, Gabriel, Kappe, C. Oliver and Cantillo, David (2020). Electrochemical N-demethylation of 14-hydroxy morphinans: sustainable access to opioid antagonists. Organic Letters, 22 (17), 6891-6896. doi: 10.1021/acs.orglett.0c02424
2020
Journal Article
A continuous flow cell for high‐temperature/high‐pressure electroorganic synthesis
Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2020). A continuous flow cell for high‐temperature/high‐pressure electroorganic synthesis. ChemElectroChem, 7 (13), 2777-2783. doi: 10.1002/celc.202000696
2020
Journal Article
Organophotocatalytic N‐demethylation of oxycodone using molecular oxygen
Chen, Yuesu, Glotz, Gabriel, Cantillo, David and Kappe, C. Oliver (2020). Organophotocatalytic N‐demethylation of oxycodone using molecular oxygen. Chemistry: A European Journal, 26 (13), 2973-2979. doi: 10.1002/chem.201905505
2020
Journal Article
Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist’s guide
Maljuric, Snjezana, Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2020). Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist’s guide. Journal of Flow Chemistry, 10 (1), 181-190. doi: 10.1007/s41981-019-00050-z
2019
Journal Article
Continuous flow synthesis of terminal epoxides from ketones using in situ generated bromomethyl lithium
von Keutz, Timo, Cantillo, David and Kappe, C. Oliver (2019). Continuous flow synthesis of terminal epoxides from ketones using in situ generated bromomethyl lithium. Organic Letters, 21 (24), 10094-10098. doi: 10.1021/acs.orglett.9b04072
2019
Journal Article
Continuous flow synthesis of methyl oximino acetoacetate: accessing greener purification methods with inline liquid–liquid extraction and membrane separation technology
Lebl, René, Murray, Trevor, Adamo, Andrea, Cantillo, David and Kappe, C. Oliver (2019). Continuous flow synthesis of methyl oximino acetoacetate: accessing greener purification methods with inline liquid–liquid extraction and membrane separation technology. ACS Sustainable Chemistry and Engineering, 7 (24), 20088-20096. doi: 10.1021/acssuschemeng.9b05954
2019
Journal Article
Cathodic C–H trifluoromethylation of arenes and heteroarenes enabled by an in situ-generated triflyltriethylammonium complex
Jud, Wolfgang, Maljuric, Snjezana, Kappe, C. Oliver and Cantillo, David (2019). Cathodic C–H trifluoromethylation of arenes and heteroarenes enabled by an in situ-generated triflyltriethylammonium complex. Organic Letters, 21 (19), 7970-7975. doi: 10.1021/acs.orglett.9b02948
2019
Journal Article
Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions
Lebl, Rene, Cantillo, David and Kappe, C. Oliver (2019). Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions. Reaction Chemistry and Engineering, 4 (4), 738-746. doi: 10.1039/c8re00323h
2019
Journal Article
Visible light‐promoted Beckmann rearrangements: separating sequential photochemical and thermal phenomena in a continuous flow reactor
Chen, Yuesu, Cantillo, David and Kappe, C. Oliver (2019). Visible light‐promoted Beckmann rearrangements: separating sequential photochemical and thermal phenomena in a continuous flow reactor. European Journal of Organic Chemistry, 2019 (11), 2163-2171. doi: 10.1002/ejoc.201900231
2019
Journal Article
Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors
von Keutz, Timo, Cantillo, David and Kappe, C. Oliver (2019). Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors. Journal of Flow Chemistry, 9 (1), 27-34. doi: 10.1007/s41981-018-0026-1
2019
Journal Article
Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients
Aguiar, Renata M., Leão, Raquel A. C., Mata, Alejandro, Cantillo, David, Kappe, C. Oliver, Miranda, Leandro S. M. and de Souza, Rodrigo O. M. A. (2019). Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients. Organic and Biomolecular Chemistry, 17 (6), 1552-1557. doi: 10.1039/c8ob03088j
2019
Journal Article
On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media
Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2019). On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media. Organic and Biomolecular Chemistry, 17 (14), 3529-3537. doi: 10.1039/c9ob00456d
2018
Journal Article
Catalyst‐free oxytrifluoromethylation of alkenes through paired electrolysis in organic‐aqueous media
Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2018). Catalyst‐free oxytrifluoromethylation of alkenes through paired electrolysis in organic‐aqueous media. Chemistry: A European Journal, 24 (65), 17234-17238. doi: 10.1002/chem.201804708
2018
Journal Article
Continuous flow photochemical benzylic bromination of a key intermediate in the synthesis of a 2-oxazolidinone
Chen, Yuesu, de Frutos, Oscar, Mateos, Carlos, Rincon, Juan A., Cantillo, David and Kappe, C. Oliver (2018). Continuous flow photochemical benzylic bromination of a key intermediate in the synthesis of a 2-oxazolidinone. Chemphotochem, 2 (10), 906-912. doi: 10.1002/cptc.201800114
2018
Journal Article
Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates
von Keutz, Timo, Strauss, Franz J., Cantillo, David and Kappe, C. Oliver (2018). Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates. Tetrahedron, 74 (25), 3113-3117. doi: 10.1016/j.tet.2017.11.063
2018
Journal Article
Review of Timothy Noël (ed): photochemical processes in continuous flow reactors: from engineering principles to chemical applications
Cantillo, David (2018). Review of Timothy Noël (ed): photochemical processes in continuous flow reactors: from engineering principles to chemical applications. Journal of Flow Chemistry, 8 (2), 107-108. doi: 10.1007/s41981-018-0011-8
2018
Journal Article
Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat
Znidar, Desiree, Cantillo, David, Inglesby, Phillip, Boyd, Alistair and Kappe, C. Oliver (2018). Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat. Organic Process Research and Development, 22 (5), 633-640. doi: 10.1021/acs.oprd.8b00089
2018
Journal Article
Continuous multistep synthesis of 2-(azidomethyl)oxazoles
Rossa, Thais A., Suveges, Nicolas S., Sa, Marcus M., Cantillo, David and Kappe, C. Oliver (2018). Continuous multistep synthesis of 2-(azidomethyl)oxazoles. Beilstein Journal of Organic Chemistry, 14, 506-514. doi: 10.3762/bjoc.14.36
2017
Other Outputs
Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives
Kappe, C. O., Gutmann, B., Weigl, U., Egli, P., Cox, P. D. and Cantillo, D. (2017). Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives. WO2017185004.
2017
Conference Publication
Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence
Cantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. (2017). Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC United States, 20-24 August 2017. Washington, DC United States: American Chemical Society.
Supervision
Availability
- Dr David Cantillo is:
- Available for supervision
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Available projects
-
Synthetic organic electrochemisty
This project deals with the development of novel methods for the preparation of pharmaceutical intermediates using electrochemistry
Media
Enquiries
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