Overview
Background
John-Paul Tung is a Senior Research Fellow at Australian Red Cross Lifeblood (Lifeblood). He leads a program of research focused on the changes that occur in blood in between collection and transfusion, as well as how these changes might impact transfused patients. Particular focuses are on transfusion-related acute lung inujry (TRALI), transfusion-associated circulatory overload (TACO), and extracellular vesicles. He leads a research team of five Senior Research Assistants and three Research Assistants. He also supervises several PhD and Masters students. He holds an Honorary Senior Research Fellow position with the Faculty of Medicine at UQ. He also holds an adjunct Associate Professor position with the University of the Sunshine Coast and an adjunct Senior Lecturer position with QUT. He is also a former Secretary and Council Member of the International Society of Blood Transfusion's Young Professionals Council.
John-Paul completed a Bachelor of Science at UQ in 1999, after which he worked as a Scientist in nucleic acid testing in Brisbane, Melbourne and London. After returning to Brisbane, he commenced work as a Research Scientist with Lifeblood (formerly the Blood Service) in 2007. John-Paul then commenced a PhD with UQ and Prince Charles Hospital's Critical Care Research Group in 2008. His PhD, conferred in 2012, invovled the development of the first large animal model of TRALI using sheep, and resulted in several awards including best paper prizes from the International Society of Blood Transfusion and the Prince Charles Hospital as well as other awards from the Australian and New Zealand Society of Blood Transfusion and the British Blood Transfusion Society.
Availability
- Dr John-Paul Tung is:
- Available for supervision
Research impacts
As well as internal Lifeblood research project funding, John-Paul has been an investigator on over 20 competitive external grants worth over $7.5 million, including from the NHMRC, the ARC, and the Emergency Medicine Foundation. John-Paul has published over 40 papers including in American Journal of Respiratory and Critical Care Medicine (JIF 30.5), Intensive Care Medicine (JIF 17.4), Critical Care (JIF 9.1), and Blood Reviews (JIF 8.3). He has presented at international and national conferences, inculding invited presenations at the International Society of Blood Transfusion Congress, the Royal College of Pathologists Association Pathology Update, and the Brazilian Congress of Hematology, Hemotherapy, and Cellular Therapy. He has supervised over 20 research students including three PhD completions, two Masters completions, and eight Honours completions. He has several on-going academic and clincal collaborations including with the the Royal Brisbane and Women's Hospital, the Prince Charles Hospital, the Australian Defence Force, and the Baker Institute.
Works
Search Professor John-Paul Tung’s works on UQ eSpace
2021
Journal Article
A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
2021
Journal Article
An ovine model of haemorrhagic shock and resuscitation, to assess recovery of tissue oxygen delivery and oxygen debt, and inform patient blood management
Dyer, Wayne B., Tung, John-Paul, Li Bassi, Gianluigi, Wildi, Karin, Jung, Jae-Seung, Colombo, Sebastiano Maria, Rozencwajg, Sacha, Simonova, Gabriela, Chiaretti, Sara, Temple, Fergal T., Ainola, Carmen, Shuker, Tristan, Palmieri, Chiara, Shander, Aryeh, Suen, Jacky Y., Irving, David O. and Fraser, John F. (2021). An ovine model of haemorrhagic shock and resuscitation, to assess recovery of tissue oxygen delivery and oxygen debt, and inform patient blood management. Shock, 56 (6), 1080-1091. doi: 10.1097/SHK.0000000000001805
2021
Conference Publication
Quantification and Characterisation of Nano-Sized Particles in Cryoprecipitate Units
Hwang, Ji Hui, Tung, John-Paul, Flower, Robert L. and Pecheniuk, Natalie M. (2021). Quantification and Characterisation of Nano-Sized Particles in Cryoprecipitate Units. 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. AMSTERDAM: ELSEVIER. doi: 10.1182/blood-2021-147793
2021
Conference Publication
The Impact of Revised Definitions for TACO and TRALI on Hemovigilance Reporting
Yuan, Yin, Dennington, Peta, Daly, James J., Tung, John-Paul and Baidya, Shoma (2021). The Impact of Revised Definitions for TACO and TRALI on Hemovigilance Reporting. 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. AMSTERDAM: ELSEVIER. doi: 10.1182/blood-2021-145294
2021
Conference Publication
Anti-HNA-3a Alloantibodies Can Cause Differential Endothelial Damage through a Direct Neutrophil Activation Pathway
Radenkovic, Filip, Chiaretti, Sara, Burton, Mark, Hassell, Penny, Bui, Xuan, Flower, Robert and Tung, John-Paul (2021). Anti-HNA-3a Alloantibodies Can Cause Differential Endothelial Damage through a Direct Neutrophil Activation Pathway. 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. AMSTERDAM: ELSEVIER. doi: 10.1182/blood-2021-152047
2020
Journal Article
Ovine red cell concentrates for transfusion research – is the storage lesion comparable to human red cell concentrates?
Simonova, Gabriela, Wellburn, Rebecca, Fung, Yoke Lin, Fraser, John F. and Tung, John‐Paul (2020). Ovine red cell concentrates for transfusion research – is the storage lesion comparable to human red cell concentrates?. Vox Sanguinis, 116 (5) vox.13020, 524-532. doi: 10.1111/vox.13020
2020
Journal Article
Development and validation of ELISAs for the quantitation of interleukin (IL)-1β, IL-6, IL-8 and IL-10 in ovine plasma
Bouquet, Mahé, Passmore, Margaret R., See Hoe, Louise E., Tung, John-Paul, Simonova, Gabriela, Boon, Ai-Ching and Fraser, John F. (2020). Development and validation of ELISAs for the quantitation of interleukin (IL)-1β, IL-6, IL-8 and IL-10 in ovine plasma. Journal of Immunological Methods, 486 112835, 112835. doi: 10.1016/j.jim.2020.112835
2020
Conference Publication
Autologous intraoperative cell salvage ameliorates suppression of transfusion-related monocyte and dendritic cell inflammatory responses
Dean, Melinda M., Obeysekera, Maheshi P., Tran, Thu V., Sturgess, David, Wyssusek, Kerstin, Van Zundert, Andrea, Gordon, Louisa G., Da Silva, D., Punnasseril, J., Tung, John-Paul, Flower, Robert L. and Roets, Michelle (2020). Autologous intraoperative cell salvage ameliorates suppression of transfusion-related monocyte and dendritic cell inflammatory responses. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.220.31
2020
Conference Publication
Coronary artery bypass grafting surgery differentially modulates the leucocyte gene expression profile
Perros, Alexis J., Chong, Fenny, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Rooks, Kelly, Faddy, Helen M., Hewlett, Elise, Naidoo, Rishendran, Tung, John-Paul, Fraser, John F., Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee, Flower, Robert L. and Dean, Melinda M. (2020). Coronary artery bypass grafting surgery differentially modulates the leucocyte gene expression profile. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.69.18
2020
Journal Article
Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells
Perros, Alexis J., Esguerra‐Lallen, Arlanna, Rooks, Kelly, Chong, Fenny, Engkilde‐Pedersen, Sanne, Faddy, Helen M., Hewlett, Elise, Naidoo, Rishendran, Tung, John‐Paul, Fraser, John F., Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee, Flower, Robert L. and Dean, Melinda M. (2020). Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells. Journal of Cellular and Molecular Medicine, 24 (8) jcmm.15154, 4791-4803. doi: 10.1111/jcmm.15154
2020
Journal Article
Intraoperative cell salvage as an alternative to allogeneic (donated) blood transfusion: a prospective observational evaluation of the immune response profile
Roets, Michelle, Sturgess, David John, Obeysekera, Maheshi Prabodani, Tran, Thu Vinh, Wyssusek, Kerstin Hildegard, Punnasseril, Jaisil Eldo Jos, da Silva, Diana, van Zundert, Andre, Perros, Alexis Jacqueline, Tung, John Paul, Flower, Robert Lewis Powell and Dean, Melinda Margaret (2020). Intraoperative cell salvage as an alternative to allogeneic (donated) blood transfusion: a prospective observational evaluation of the immune response profile. Cell Transplantation, 29, 096368972096626. doi: 10.1177/0963689720966265
2019
Journal Article
Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk
Ng, Monica Suet Ying, Hay, Karen, Choy, Joleen, Middelburg, Rutger A., Tung, John-Paul and Fraser, John Francis (2019). Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk. Vox Sanguinis, 114 (8) vox.12838, 835-841. doi: 10.1111/vox.12838
2019
Conference Publication
Coronary artery bypass grafting surgery is associated with immunoparalysis of monocytes and dendritic cells
Perros, Alexis J., Esguerra-Lallen, Arlanna, Rooks, Kelly, Chong, Fenny N., Engkilde-Pedersen, Sanne, Faddy, Helen M., Hewlett, Elise, Naidoo, Rishendran, Tung, John-Paul, Fraser, John F., Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O'Brien, Donalee, Flower, Robert L. and Dean, Melinda M. (2019). Coronary artery bypass grafting surgery is associated with immunoparalysis of monocytes and dendritic cells. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.182.69
2019
Journal Article
Non-antibody mediated transfusion-related acute lung injury an enigma
Fung, Yoke Lin and Tung, John-Paul (2019). Non-antibody mediated transfusion-related acute lung injury an enigma. Annals of Blood, 4 (April) 7, 7. doi: 10.21037/aob.2019.03.02
2019
Journal Article
Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock
Passmore, Margaret R., Obonyo, Nchafatso G., Byrne, Liam, Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Fung, Yoke L., Spanevello, Michelle M., Fauzi, Mohd H., Pedersen, Sanne E., Simonova, Gabriela, Anstey, Chris M., Shekar, Kiran, Tung, John-Paul, Maitland, Kathryn and Fraser, John F. (2019). Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock. Thrombosis Research, 176, 39-45. doi: 10.1016/j.thromres.2019.02.015
2019
Journal Article
Endothelialized flow models for blood transfusion research
Ng, Monica S. Y., Suen, Jacky Y., Tung, John-Paul and Fraser, John F. (2019). Endothelialized flow models for blood transfusion research. Haematologica, 104 (3), 428-434. doi: 10.3324/haematol.2018.205203
2019
Journal Article
Pre-clinical study protocol: Blood transfusion in endotoxaemic shock
Obonyo, Nchafatso G., Byrne, Liam, Tung, John-Paul, Simonova, Gabriela, Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Mohd H., Pimenta, Leticia P., Millar, Jonathan E., Fanning, Jonathon P., Van Haren, Frank, Anstey, Chris M., Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2019). Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX, 6, 1124-1132. doi: 10.1016/j.mex.2019.05.005
2018
Journal Article
Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock
Passmore, Margaret R., Byrne, Liam, Obonyo, Nchafatso G., See Hoe, Louise E., Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Bisht, Kavita, Tung, John-Paul, Fauzi, Mohd H., Narula, Monica, Pedersen, Sanne E., Esguerra-Lallen, Arlanna, Simonova, Gabriela, Sultana, Annette, Anstey, Chris M., Shekar, Kiran, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2018). Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock. Respiratory Research, 19 (1) 231, 231. doi: 10.1186/s12931-018-0935-4
2018
Journal Article
Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Pedersen, Sanne, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Van Haren, Frank, Anstey, Christopher M., Cullen, Louise, Tung, John-Paul, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia. American Journal of Respiratory and Critical Care Medicine, 198 (8), 1043-1054. doi: 10.1164/rccm.201801-0064OC
2018
Journal Article
How different animal models help us understand TRALI
Fung, Y. L. and Tung, J. P. (2018). How different animal models help us understand TRALI. ISBT Science Series, 13 (3), 197-205. doi: 10.1111/voxs.12423
Funding
Past funding
Supervision
Availability
- Dr John-Paul Tung is:
- Available for supervision
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Supervision history
Completed supervision
-
2020
Doctor Philosophy
Characterisation of immune responses to standard stored and cryopreserved blood components in sheep in vitro models of transfusion
Principal Advisor
Other advisors: Professor Michael Reade
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2023
Doctor Philosophy
The role of the endothelial glycocalyx in severe trauma
Associate Advisor
Other advisors: Professor Michael Reade
-
2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr Jacky Suen, Professor John Fraser
Media
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