Overview
Background
John-Paul Tung is a Senior Research Fellow at Australian Red Cross Lifeblood (Lifeblood). He leads a program of research focused on the changes that occur in blood in between collection and transfusion, as well as how these changes might impact transfused patients. Particular focuses are on transfusion-related acute lung inujry (TRALI), transfusion-associated circulatory overload (TACO), and extracellular vesicles. He leads a research team of five Senior Research Assistants and three Research Assistants. He also supervises several PhD and Masters students. He holds an Honorary Senior Research Fellow position with the Faculty of Medicine at UQ. He also holds an adjunct Associate Professor position with the University of the Sunshine Coast and an adjunct Senior Lecturer position with QUT. He is also a former Secretary and Council Member of the International Society of Blood Transfusion's Young Professionals Council.
John-Paul completed a Bachelor of Science at UQ in 1999, after which he worked as a Scientist in nucleic acid testing in Brisbane, Melbourne and London. After returning to Brisbane, he commenced work as a Research Scientist with Lifeblood (formerly the Blood Service) in 2007. John-Paul then commenced a PhD with UQ and Prince Charles Hospital's Critical Care Research Group in 2008. His PhD, conferred in 2012, invovled the development of the first large animal model of TRALI using sheep, and resulted in several awards including best paper prizes from the International Society of Blood Transfusion and the Prince Charles Hospital as well as other awards from the Australian and New Zealand Society of Blood Transfusion and the British Blood Transfusion Society.
Availability
- Dr John-Paul Tung is:
- Available for supervision
Research impacts
As well as internal Lifeblood research project funding, John-Paul has been an investigator on over 20 competitive external grants worth over $7.5 million, including from the NHMRC, the ARC, and the Emergency Medicine Foundation. John-Paul has published over 40 papers including in American Journal of Respiratory and Critical Care Medicine (JIF 30.5), Intensive Care Medicine (JIF 17.4), Critical Care (JIF 9.1), and Blood Reviews (JIF 8.3). He has presented at international and national conferences, inculding invited presenations at the International Society of Blood Transfusion Congress, the Royal College of Pathologists Association Pathology Update, and the Brazilian Congress of Hematology, Hemotherapy, and Cellular Therapy. He has supervised over 20 research students including three PhD completions, two Masters completions, and eight Honours completions. He has several on-going academic and clincal collaborations including with the the Royal Brisbane and Women's Hospital, the Prince Charles Hospital, the Australian Defence Force, and the Baker Institute.
Works
Search Professor John-Paul Tung’s works on UQ eSpace
2017
Conference Publication
Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI)
Tung, John-Paul, Simonova, Gabriela, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Sultana, Annette, Hewlett, Elise, Obonyo, Nchafatso, Millar, Jonathan, Flower, Robert and Fraser, John (2017). Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI). Pathology Update 2017, Sydney, NSW Australia, 24-26 February 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2016.12.309
2017
Conference Publication
Modulation of immune responses in patients following cardiac surgery
Perros, Alexis J., Esguerra-Lallen, Arlanna, Rooks, Kelly, Chong, Fenny, Flower, Robert L., Pedersen, Sanne Engkilde, Naidoo, Rishendran, Tung, John-Paul, Fraser, John, Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee and Dean, Melinda M. (2017). Modulation of immune responses in patients following cardiac surgery. Pathology Update 2017, Sydney, NSW Australia, 24-26 February 2017. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1016/j.pathol.2016.12.317
2017
Journal Article
Procoagulant role of microparticles in routine storage of packed red blood cells: potential risk for prothrombotic post-transfusion complications
Aung, Htet Htet, Tung, John-Paul, Dean, Melinda M., Flower, Robert L. and Pecheniuk, Natalie M. (2017). Procoagulant role of microparticles in routine storage of packed red blood cells: potential risk for prothrombotic post-transfusion complications. Pathology, 49 (1), 62-69. doi: 10.1016/j.pathol.2016.10.001
2016
Journal Article
Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support
Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Dunster, Kimble R., Diab, Sara D., Tung, John-Paul, Minchinton, Robyn M., McDonald, Charles I., Anstey, Chris M., Shekar, Kiran and Fraser, John F. (2016). Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support. AJP - Lung Cellular and Molecular Physiology, 311 (6), L1202-L1212. doi: 10.1152/ajplung.00296.2016
2016
Conference Publication
A Histologic Approach to Qualify Lung Tissue Damage in a Sheep Model of Transfusion-Related Lung Injury: Role of Red Blood Cell Storage Duration and Heat Treatment
Roche, Elise, Passmore, Margaret, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Bierman, Wesley, Fraser, John and Tung, John-Paul (2016). A Histologic Approach to Qualify Lung Tissue Damage in a Sheep Model of Transfusion-Related Lung Injury: Role of Red Blood Cell Storage Duration and Heat Treatment. 2016 American Society of Clincial Pathology (ASCP) Annual Meeting, Las Vegas, NV United States, 14 -16 September 2016. Cary, NC United States: Oxford University Press.
2016
Conference Publication
The potential of inflammatory responses to contribute to the development of transfusion-related acute lung injury (TRALI)
Sultana, A., Meka, D., Dean, M. M., Simonova, G., Christensen, A-M, Flower, R. L. and Tung, J-P (2016). The potential of inflammatory responses to contribute to the development of transfusion-related acute lung injury (TRALI). International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.
2015
Journal Article
Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review
Ng, Monica Suet Ying, Ng, Angela Suet Yeung, Chan, Jessica, Tung, John-Paul and Fraser, John Francis (2015). Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review. Intensive Care Medicine, 41 (12), 2087-2097. doi: 10.1007/s00134-015-4078-5
2015
Journal Article
Hepatitis C virus genotype 4 in England: diversity and demographic associations
Ngui, Siew-Lin, Brant, Lisa, Markov, Peter V., Tung, John-Paul, Pybus, Oliver G., Teo, Chong-Gee and Ramsay, Mary E. (2015). Hepatitis C virus genotype 4 in England: diversity and demographic associations. Journal of Medical Virology, 87 (3), 417-423. doi: 10.1002/jmv.24069
2014
Journal Article
Letter: the need for a definitive clinical trial of cryopreserved red blood cells
Milford, Elissa M., Tung, John Paul and Reade, Michael C. (2014). Letter: the need for a definitive clinical trial of cryopreserved red blood cells. Journal of Trauma and Acute Care Surgery, 77 (6), 1004-1004. doi: 10.1097/TA.0000000000000463
2014
Conference Publication
Potential Role of Bioactive Lipids in the Development of Non-Antibody Mediated Transfusion-Related Acute Lung Injury (TRALI)
Tung, John-Paul, Meka, Denisa, Sultana, Annette J., Simonova, Gabriela, Christensen, Anne-Marie, Flower, Robert L. and Dean, Melinda M. (2014). Potential Role of Bioactive Lipids in the Development of Non-Antibody Mediated Transfusion-Related Acute Lung Injury (TRALI). WASHINGTON: AMER SOC HEMATOLOGY.
2014
Journal Article
Neutrophil antibodies are clinically important
Fung, Y. L., Tung, J. P. and Minchinton, R. M. (2014). Neutrophil antibodies are clinically important. ISBT Science Series, 9 (1), 253-257. doi: 10.1111/voxs.12062
2014
Journal Article
An age-of-blood transfusion trial in the trauma setting is crucial and animal models may help inform trial design
Milford, Elissa M., Reade, Michael C., Colone, Lieutenant, Shekar, Kiran, Tung, John-Paul and Fraser, John F. (2014). An age-of-blood transfusion trial in the trauma setting is crucial and animal models may help inform trial design. Critical Care and Resuscitation, 16 (2), 149-150.
2014
Journal Article
Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
Chemonges, Saul, Shekar, Kiran, Tung, John-Paul, Dunster, Kimble R., Diab, Sara, Platts, David, Watts, Ryan P., Gregory, Shaun D., Foley, Samuel, Simonova, Gabriela, McDonald, Charles, Hayes, Rylan, Bellpart, Judith, Timms, Daniel, Chew, Michelle, Fung, Yoke L., Toon, Michael, Maybauer, Marc O. and Fraser, John F. (2014). Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. BioMed Research International, 2014 (468309) 468309, 1-17. doi: 10.1155/2014/468309
2014
Journal Article
Proteogenomics of selective susceptibility to endotoxin using circulating acute phase biomarkers and bioassay development in sheep: a review
Chemonges, Saul, Tung, John-Paul and Fraser, John F. (2014). Proteogenomics of selective susceptibility to endotoxin using circulating acute phase biomarkers and bioassay development in sheep: a review. Proteome Science, 12 12, 1-12. doi: 10.1186/1477-5956-12-12
2014
Journal Article
A comprehensive ovine model of blood transfusion
Simonova, G., Tung, J. P., Fraser, J. F., Do, H. L., Staib, A., Chew, M. S., Dunster, K. R., Glenister, K. M., Jackson, D. E. and Fung, Y. L. (2014). A comprehensive ovine model of blood transfusion. Vox Sanguinis, 106 (2), 153-160. doi: 10.1111/vox.12076
2013
Journal Article
Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage
Fung, Y. L., Tung, J. P., Foley, S. R., Simonova, G., Thom, O., Staib, A., Collier, J., Dunster, K. R., Solano, C., Shekar, K., Chew, M. S. and Fraser, J. F. (2013). Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage. Vox Sanguinis, 105 (2), 150-158. doi: 10.1111/vox.12032
2013
Conference Publication
The Ovine Packed Red Blood Cell Storage Lesion: Characterisation and Comparison to That of Human Packed Red Blood Cells
Simonova, G., Fung, Y. L., Glenister, K. M., Fraser, J. F. and Tung, J-P (2013). The Ovine Packed Red Blood Cell Storage Lesion: Characterisation and Comparison to That of Human Packed Red Blood Cells. HOBOKEN: WILEY-BLACKWELL.
2012
Other Outputs
Development of an ovine model of transfusion-related acute lung injury (TRALI)
Tung, John-Paul (2012). Development of an ovine model of transfusion-related acute lung injury (TRALI). PhD Thesis, School of Medicine, The University of Queensland.
2012
Journal Article
Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
Tung, John-Paul, Fraser, John F., Nataatmadja, Maria, Colebourne, Kathryn I., Barnett, Adrian G., Glenister, Kristen M., Zhou, Anna Y., Wood, Peter, Silliman, Christopher C. and Fung, Yoke L. (2012). Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Critical Care, 16 (1) R19, R19.1-R19.14. doi: 10.1186/cc11178
2011
Journal Article
A novel in vivo ovine model of transfusion-related acute lung injury (TRALI)
Tung, J. P., Fung, Y. L., Nataatmadja, M., Colebourne, K. I., Esmaeel, H. M., Wilson, K., Barnett, A. G., Wood, P., Silliman, C. C. and Fraser, J. F. (2011). A novel in vivo ovine model of transfusion-related acute lung injury (TRALI). Vox Sanguinis, 100 (2), 219-230. doi: 10.1111/j.1423-0410.2010.01381.x
Funding
Past funding
Supervision
Availability
- Dr John-Paul Tung is:
- Available for supervision
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Supervision history
Completed supervision
-
2020
Doctor Philosophy
Characterisation of immune responses to standard stored and cryopreserved blood components in sheep in vitro models of transfusion
Principal Advisor
Other advisors: Professor Michael Reade
-
2023
Doctor Philosophy
The role of the endothelial glycocalyx in severe trauma
Associate Advisor
Other advisors: Professor Michael Reade
-
2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr Jacky Suen, Professor John Fraser
Media
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