Overview
Background
Dr Keane is a haematologist at Princess Alexandra Hospital and runs the Lymphoma Research Lab at the UQDI in Brisbane. His main research interest is focused on the interface between the tumour microenvironment and the malignant lymphoma cell, with a goal to build an understanding of lymphoma from an immunological and biomarkers perspective. To bridge developments between the clinic and bench-top, the laboratory has a strong emphasis on patient material, which it obtains from international and national clinical collaborators, much being from investigator-led clinical trials.
Lymphomas studied include more common lymphomas such as Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma and Follicular Lymphoma but his lab has a particular focus on rare lymphomas such as primary central nervous system lymphoma and lymphomas that develop in patients who are immunocompromised.
Dr. Keane has been instrumental in translating work from his lab into multiple immune based clinical trials currently being run across Australia, many in rare and hard to treat lymphomas, where patients have limited treatments available.
The goals of the lab are to directly improve outcomes for all lymphoma patients by performing innovative translational science that not only generates new knowledge and brings new treatments to Australian patients but helps to train the next generation of lymphoma researchers in Australia.
Availability
- Associate Professor Colm Keane is:
- Available for supervision
Qualifications
- Masters (Coursework) of Business Administration, Griffith University
- Doctor of Philosophy, Griffith University
Research interests
-
Tumour Immunology
-
DLBCL
-
Primary CNS Lymphoma
-
Hodgkin Lymphoma
-
Viral Associated Lymphomas
Works
Search Professor Colm Keane’s works on UQ eSpace
2012
Conference Publication
Serum CD163 and TARC in Combination As Disease Response Biomarkers in Classical Hodgkin Lymphoma
Gandhi, Maher K., Vari, Frank, Crooks, Pauline, Keane, Colm, Nourse, Jamie P., Seymour, Louise A., Ritchie, David, Gottlieb, David, Gill, Devinder and Jones, Kimberley (2012). Serum CD163 and TARC in Combination As Disease Response Biomarkers in Classical Hodgkin Lymphoma. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta GA, United States, 8-11 December 2012. Washington, DC United States: American Society of Hematology.
2011
Journal Article
Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8 T-cell epitopes
Nguyen-Van, Do, Keane, Colm, Han, Erica, Jones, Kimberley, Nourse, Jamie P., Vari, Frank, Ross, Nathan, Crooks, Pauline, Ramuz, Olivier, Green, Michael, Griffith, Lyn, Trappe, Ralf, Grigg, Andrew, Mollee, Peter and Gandhi, Maher K. (2011). Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8 T-cell epitopes. American Journal of Blood Research, 1 (2), 146-159.
2011
Journal Article
Treatment of acute promyelocytic leukaemia in the Jehovah's Witness population
Keane, Colm, Mollee, Peter, Marlton, Paula and Gill, Devinder (2011). Treatment of acute promyelocytic leukaemia in the Jehovah's Witness population. Annals of Hematology, 90 (3), 359-360. doi: 10.1007/s00277-010-1023-0
2011
Conference Publication
Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL
Gandhi, MK, Hertzberg, MS, Han, E, Seymour, JF, Hicks, R, Gill, DS, Keane, C, Crooks, P, Radford, K and Vari, F (2011). Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 10-13, 2011. WASHINGTON: AMER SOC HEMATOLOGY.
2011
Conference Publication
Tissue microarray in DLBCL patients receiving CHOP-R chemo-immunotherapy shows survival benefit for coexpression of LMO2/BCL6 and poor outcome for EBER-ISH positive patients
Keane, C., Shen, L., Nourse, J., Han, E., Jones, K. and Gandhi, M. (2011). Tissue microarray in DLBCL patients receiving CHOP-R chemo-immunotherapy shows survival benefit for coexpression of LMO2/BCL6 and poor outcome for EBER-ISH positive patients. 11th International Conference on Malignant Lymphoma, Lugano, Switzerland, 15-18 June 2011. Oxford, United Kingdom: Oxford University Press.
2011
Conference Publication
Tissue Microarray in DLBCL Patients receiving R-CHOP Chemo-Immunotherapy Shows Survival Benefit for Coexpression of LMO2/BCL6
Keane, C, Shen, L, Han, E, Nourse, JP, Lea, R, Mollee, P, Gill, DS and Gandhi, MK (2011). Tissue Microarray in DLBCL Patients receiving R-CHOP Chemo-Immunotherapy Shows Survival Benefit for Coexpression of LMO2/BCL6. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 10-13, 2011. WASHINGTON: AMER SOC HEMATOLOGY.
2010
Conference Publication
Ebv-Positive Dlbcl of the Elderly Is a Distinct Clinico-Biological Entity with Poor Outcome in Chop-R Treated Patients
Gandhi, M., Keane, C., Nourse, J., Jones, K., Ross, N., Han, E. and Nguyen-Van, D. (2010). Ebv-Positive Dlbcl of the Elderly Is a Distinct Clinico-Biological Entity with Poor Outcome in Chop-R Treated Patients. 15th Annual Meeting of the European-Hematology-Association, Barcelona Spain, June 10-13, 2010. Pavia, Italy: Fondazione Ferrata Storti.
2009
Journal Article
Myeloid and lymphoid neoplasm with FGFR1 abnormality
Keane, Colm, Henden, Andrea, Mills, Tony and Wood, Peter (2009). Myeloid and lymphoid neoplasm with FGFR1 abnormality. British Journal of Haematology, 145 (4), 440-440. doi: 10.1111/j.1365-2141.2008.07480.x
2009
Journal Article
Catastrophic tumour lysis syndrome following single dose of imatinib
Keane, Colm, Henden, Andrea and Bird, Robert (2009). Catastrophic tumour lysis syndrome following single dose of imatinib. European Journal of Haematology, 82 (3), 244-245. doi: 10.1111/j.1600-0609.2008.01186.x
2009
Journal Article
Aspergillus flavus sinusitis in ALL
Keane, Colm, Colreavy, Michael, Lynch, Maureen and O'Gorman, Peter (2009). Aspergillus flavus sinusitis in ALL. American Journal of Hematology, 84 (2), 123-123. doi: 10.1002/ajh.21167
2008
Journal Article
Neutrophil phagocytosis of Klebsiella pneumoniae
Keane, Colm, Prout, Barry and Bird, Robert (2008). Neutrophil phagocytosis of Klebsiella pneumoniae. British Journal of Haematology, 142 (5), 682-682. doi: 10.1111/j.1365-2141.2008.07213.x
2008
Journal Article
Multi-organ involvement with crystal-storing histiocytosis
Keane, C. and Gill, D. (2008). Multi-organ involvement with crystal-storing histiocytosis. British Journal of Haematology, 141 (6), 750-750. doi: 10.1111/j.1365-2141.2008.07131.x
2006
Conference Publication
Thalidomide and dexamethasone in newly diagnosed multiple myeloma
McHugh, Johnny, O'Ceallaigh, Cathal, Keane, Colm, Otridge, Brian W. and O'Gorman, Peter (2006). Thalidomide and dexamethasone in newly diagnosed multiple myeloma. 48th Annual Meeting of the American Society of Hematology, Orlando, FL, United States, 9-12 December 2006. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V108.11.5120.5120
2006
Journal Article
The Hyper-CVAD chemotherapy regimen has an adverse long-term impact on the ability to mobilize peripheral blood stem cells, which can be readily circumvented by using the early cycles for mobilization
Keane, Colm, Gibbs, Simon, Seymour, John F., Mills, Anthony K ., Grimmett, Karen, Van Kuilenberg, Rosita, Russell, Saal, Gill, Devinder, Prince, H. Miles, Marlton, Paula and Mollee, Peter (2006). The Hyper-CVAD chemotherapy regimen has an adverse long-term impact on the ability to mobilize peripheral blood stem cells, which can be readily circumvented by using the early cycles for mobilization. Hematological Oncology, 24 (3), 159-163. doi: 10.1002/hon.784
2005
Conference Publication
Thalidomide and dexamethasone in newly diagnosed multiple myeloma
McHugh, Johnny, Keane, Colm, Otridge, Brian W., Thornton, Patrick and O'Gorman, Peter (2005). Thalidomide and dexamethasone in newly diagnosed multiple myeloma. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA, United States, 10-13 December 2005. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V106.11.5185.5185
2004
Conference Publication
Optimal timing of peripheral blood stem cell mobilisation in patients with hematological malignancies treated with the hyper-CVAD chemotherapy regimen
Mills, AK, Gibbs, S, Keane, C, Mollee, P, Grimmett, K, Van Kuilenburg, R, Saal, R, Gill, D, Prince, HM, Seymour, JF and Marlton, P (2004). Optimal timing of peripheral blood stem cell mobilisation in patients with hematological malignancies treated with the hyper-CVAD chemotherapy regimen. 46th Annual Meeting of the American-Society-of-Hematology, San Diego Ca, Dec 04-07, 2004. WASHINGTON: AMER SOC HEMATOLOGY.
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Colm Keane is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Immuno-genetic biomarkers of response in a prospective study of immune checkpoint therapy in primary CNS lymphoma
Principal Advisor
Other advisors: Dr Arutha Kulasinghe, Dr Zachary Hawula
-
Doctor Philosophy
Investigating the mechanisms of immune evasion in relapsed/refractory DLBCL
Principal Advisor
Other advisors: Dr Zachary Hawula
-
Doctor Philosophy
Investigation of immune responses to novel and standard therapies in DLBCL
Principal Advisor
Other advisors: Dr Joshua Tobin, Associate Professor Fernando Guimaraes
-
Master Philosophy
Amyloidosis Monitoring and Outcomes in an Australian Tertiary Centre
Associate Advisor
-
Doctor Philosophy
Reversing tumour necrosis factor-mediated immunosuppression to boost immunity against experimental CD19+ blood cancers
Associate Advisor
Other advisors: Dr Allie Lam, Associate Professor Fernando Guimaraes
-
Doctor Philosophy
Impact of genetics upon the tumour microenvironment in Follicular Lymphoma
Associate Advisor
Other advisors: Dr Joshua Tobin, Dr Soi Law, Professor Maher Gandhi
Completed supervision
-
2022
Doctor Philosophy
A Comprehensive Study of Intratumoural T-cells in Follicular Lymphoma
Associate Advisor
Other advisors: Dr Soi Law, Professor Maher Gandhi
-
2021
Doctor Philosophy
Clinical and Prognostic Tools to Improve Frontline Management Strategies in Follicular Lymphoma
Associate Advisor
Other advisors: Professor Maher Gandhi
-
2020
Doctor Philosophy
The impact of deficient antigen presentation on the tumour microenvironment of diffuse large B cell lymphoma
Associate Advisor
Other advisors: Professor Maher Gandhi
-
2019
Doctor Philosophy
A LABORATORY STUDY OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA
Associate Advisor
Other advisors: Professor Maher Gandhi
Media
Enquiries
For media enquiries about Associate Professor Colm Keane's areas of expertise, story ideas and help finding experts, contact our Media team: