Overview
Availability
- Dr Allie Lam is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Allie Lam’s works on UQ eSpace
2025
Journal Article
Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR
Lam, Pui Yeng, Omer, Natacha, Wong, Josh K. M., Tu, Cui, Alim, Louisa, Rossi, Gustavo R., Victorova, Maria, Tompkins, Hannah, Lin, Cheng-Yu, Mehdi, Ahmed M., Choo, Amos, Elliott, Melissa R., Coleborn, Elaina, Sun, Jane, Mercer, Timothy, Vittorio, Orazio, Dobson, Lachlan J., Mclellan, Alexander D., Brooks, Andrew, Tuong, Zewen Kelvin, Cheetham, Seth W., Nicholls, Wayne and Souza-Fonseca-Guimaraes, Fernando (2025). Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR. Clinical and Translational Medicine, 15 (1) e70140, 1-21. doi: 10.1002/ctm2.70140
2024
Journal Article
Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation
McCulloch, Timothy R., Rossi, Gustavo R., Alim, Louisa, Lam, Pui Yeng, Wong, Joshua K. M., Coleborn, Elaina, Kumari, Snehlata, Keane, Colm, Kueh, Andrew J., Herold, Marco J., Wilhelm, Christoph, Knolle, Percy A., Kane, Lawrence, Wells, Timothy J. and Souza-Fonseca-Guimaraes, Fernando (2024). Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation. Nature Communications, 15 (1) 9871, 1-16. doi: 10.1038/s41467-024-54232-y
2024
Journal Article
A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy
Rossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820
2024
Journal Article
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy
McCulloch, Timothy R., Rossi, Gustavo R., Miranda‐Hernandez, Socorro, Valencia‐Hernandez, Ana Maria, Alim, Louisa, Belle, Clemence J., Krause, Andrew, Zacchi, Lucia F., Lam, Pui Yeng, Nakamura, Kyohei, Kupz, Andreas, Wells, Timothy J. and Souza‐Fonseca‐Guimaraes, Fernando (2024). The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy. Immunology and Cell Biology, 102 (8), 721-733. doi: 10.1111/imcb.12794
2024
Journal Article
Highlight of 2023: Unlocking the therapeutic potential of <scp>natural killer</scp> cells—advances in adaptive functions, cellular engineering and immunotherapy
Lam, Pui Yeng and Souza‐Fonseca‐Guimaraes, Fernando (2024). Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapy. Immunology & Cell Biology, 102 (6), 444-447. doi: 10.1111/imcb.12769
2023
Journal Article
Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues
Pham, Duy, Tan, Xiao, Balderson, Brad, Xu, Jun, Grice, Laura F., Yoon, Sohye, Willis, Emily F., Tran, Minh, Lam, Pui Yeng, Raghubar, Arti, Kalita-de Croft, Priyakshi, Lakhani, Sunil, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan H. (2023). Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues. Nature Communications, 14 (1) 7739, 1-25. doi: 10.1038/s41467-023-43120-6
2023
Book Chapter
Spatial transcriptomics in kidney tissue
Raghubar, Arti M., Crawford, Joanna, Jones, Kahli, Lam, Pui Y., Andersen, Stacey B., Matigian, Nicholas A., Ng, Monica S Y, Healy, Helen, Kassianos, Andrew J. and Mallett, Andrew J. (2023). Spatial transcriptomics in kidney tissue. Kidney research: experimental protocols. (pp. 233-282) edited by Tim D. Hewitson, Nigel D. Toussaint and Edward R. Smith. New York, NY USA: Humana New York. doi: 10.1007/978-1-0716-3179-9_17
2023
Conference Publication
Differential regulation of natural killer cells by tumor necrosis factor receptors 1 and 2
McCulloch, Timothy R., Rossi, Gustavo Rodrigues, Lam, Allie, Wong, Joshua, Kane, Lawrence P., Herold, Marco, Wells, Timothy and Souza-Fonseca-Guimaraes, Fernando (2023). Differential regulation of natural killer cells by tumor necrosis factor receptors 1 and 2. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.72.28
2022
Journal Article
A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages
Tran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873
2022
Journal Article
Spatially resolved transcriptomes of mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments
Raghubar, Arti M., Pham, Duy T., Tan, Xiao, Grice, Laura F., Crawford, Joanna, Lam, Pui Yeng, Andersen, Stacey B., Yoon, Sohye, Teoh, Siok Min, Matigian, Nicholas A., Stewart, Anne, Francis, Leo, Ng, Monica S. Y., Healy, Helen G., Combes, Alexander N., Kassianos, Andrew J., Nguyen, Quan and Mallett, Andrew J. (2022). Spatially resolved transcriptomes of mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments. Frontiers in Medicine, 9 873923, 873923. doi: 10.3389/fmed.2022.873923
2020
Journal Article
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment
Kobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602
2020
Conference Publication
Spatial Transcriptomics (ST): Integrating Molecular Profiles with Histomorphology in Kidney Tissue Sections
Raghubar, Arti M., Pham, Duy T., Tan, Xiao, Grice, Laura F., Lam, Pui Yeng, Crawford, Joanna, Andersen, Stacey, Yoon, Sohye, Holland, Samuel E., Francis, Leo, Combes, Alexander N., Kassianos, Andrew J., Healy, Helen G., Nguyen, Quan and Mallett, Andrew J. (2020). Spatial Transcriptomics (ST): Integrating Molecular Profiles with Histomorphology in Kidney Tissue Sections. Kidney Week, Online, 19-25 October 2020. Washington, DC United States: American Society of Nephrology. doi: 10.1681/asn.20203110s112b
2020
Journal Article
stLearn integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues
Pham, Duy, Tan, Xiao, Xu, Jun, Grice, Laura F., Lam, Pui Yeng, Raghubar, Arti, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan (2020). stLearn integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues. Biorxiv, 1-18. doi: 10.1101/2020.05.31.125658v1
2019
Other Outputs
Harnessing the immunomodulatory effects of NKT cells for cancer immunotherapy using a Clec9a-targeted nanoemulsion delivery system
Lam, Pui Yeng (Allie) (2019). Harnessing the immunomodulatory effects of NKT cells for cancer immunotherapy using a Clec9a-targeted nanoemulsion delivery system. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2019.797
2019
Journal Article
NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion
Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650
2018
Journal Article
Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia
Kerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952
2018
Journal Article
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article
Achuthan, Adrian, Aslam, Ahmad S. M., Nguyen, Quyen, Lam, Pui-Yeng, Fleetwood, Andrew J., Frye, Ashlee T., Louis, Cynthia, Lee, Ming-Chin, Smith, Julia E., Cook, Andrew D., Olshansky, Moshe, Turner, Stephen J. and Hamilton, John A. (2018). Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article. Cell Death and Disease, 9 (3) 267, 1-13. doi: 10.1038/s41419-018-0332-4
2018
Journal Article
B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity
McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599
2017
Journal Article
Invariant natural killer T cell in immune regulation of blood cancers: harnessing their potential in immunotherapies
Lam, Pui Yeng, Nissen, Michael D. and Mattarollo, Stephen R. (2017). Invariant natural killer T cell in immune regulation of blood cancers: harnessing their potential in immunotherapies. Frontiers in Immunology, 8 (OCT) 1355, 1355. doi: 10.3389/fimmu.2017.01355
2016
Journal Article
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation
Achuthan, Adrian, Cook, Andrew D., Lee, Ming-Chin, Saleh, Reem, Khiew, Hsu-Wei, Chang, Melody W.N., Louis, Cynthia, Fleetwood, Andrew J., Lacey, Derek C., Christensen, Anne D., Frye, Ashlee T., Lam, Pui Yeng, Kusano, Hitoshi, Nomura, Koji, Steiner, Nancy, Förster, Irmgard, Nutt, Stephen L., Olshansky, Moshe, Turner, Stephen J. and Hamilton, John A. (2016). Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. Journal of Clinical Investigation, 126 (9), 3453-3466. doi: 10.1172/JCI87828
Funding
Current funding
Past funding
Supervision
Availability
- Dr Allie Lam is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of natural killer cells with enhanced tumoricidal functions using CRISPR homology-directed repair-mediated gene editing
Associate Advisor
Other advisors: Professor Gabrielle Belz, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Maximising the success of cancer immunotherapy by preventing extracellular vesicle hijacking of the immune system
Associate Advisor
Other advisors: Associate Professor Joy Wolfram
-
Doctor Philosophy
Reversing tumour necrosis factor-mediated immunosuppression to boost immunity against experimental CD19+ blood cancers
Associate Advisor
Other advisors: Associate Professor Colm Keane, Associate Professor Fernando Guimaraes
Media
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