Overview
Background
Dr Keane is a haematologist at Princess Alexandra Hospital and runs the Lymphoma Research Lab at the UQDI in Brisbane. His main research interest is focused on the interface between the tumour microenvironment and the malignant lymphoma cell, with a goal to build an understanding of lymphoma from an immunological and biomarkers perspective. To bridge developments between the clinic and bench-top, the laboratory has a strong emphasis on patient material, which it obtains from international and national clinical collaborators, much being from investigator-led clinical trials.
Lymphomas studied include more common lymphomas such as Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma and Follicular Lymphoma but his lab has a particular focus on rare lymphomas such as primary central nervous system lymphoma and lymphomas that develop in patients who are immunocompromised.
Dr. Keane has been instrumental in translating work from his lab into multiple immune based clinical trials currently being run across Australia, many in rare and hard to treat lymphomas, where patients have limited treatments available.
The goals of the lab are to directly improve outcomes for all lymphoma patients by performing innovative translational science that not only generates new knowledge and brings new treatments to Australian patients but helps to train the next generation of lymphoma researchers in Australia.
Availability
- Associate Professor Colm Keane is:
- Available for supervision
Qualifications
- Masters (Coursework) of Business Administration, Griffith University
- Doctor of Philosophy, Griffith University
Research interests
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Tumour Immunology
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DLBCL
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Primary CNS Lymphoma
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Hodgkin Lymphoma
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Viral Associated Lymphomas
Works
Search Professor Colm Keane’s works on UQ eSpace
2019
Journal Article
Progression of disease within 24 months in follicular lymphoma is associated with reduced intratumoral immune infiltration
Tobin, Joshua W. D., Keane, Colm, Gunawardana, Jay, Mollee, Peter, Birch, Simone, Hoang, Thanh, Lee, Justina, Li, Li, Huang, Li, Murigneux, Valentine, Fink, J. Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu, Kridel, Robert, Weigert, Oliver, Haebe, Sarah, Jurinovic, Vindi, Klapper, Wolfram, Steidl, Christian, Sehn, Laurie H., Law, Soi-Cheng, Wykes, Michelle N. and Gandhi, Maher K. (2019). Progression of disease within 24 months in follicular lymphoma is associated with reduced intratumoral immune infiltration. Journal of Clinical Oncology, 37 (34), 3300-3309. doi: 10.1200/JCO.18.02365
2019
Conference Publication
EBV+ CNS lymphomas have a distinctive tumor microenvironment and genetic profile, which is amenable to combination 3rd party EBV-specific CTL and Ibrutinib therapy
Gandhi, M.K., Hoang, T., Tobin, J.W., Law, S.C., Talaulikar, D., Jain, S., Vari, F., Murigneux, V., Fink, L., Gunawardana, J., Gould, C., Oey, H., Delecluse, S., Trappe, R.U., Merida de Long, L., Sabdia, M.B., Bhagat, G., Hapgood, G., Blyth, E., Clancy, L., Casey, J., Wight, J., Hawkes, E. and Keane, C. (2019). EBV+ CNS lymphomas have a distinctive tumor microenvironment and genetic profile, which is amenable to combination 3rd party EBV-specific CTL and Ibrutinib therapy. 15th International Conference on Malignant Lymphoma, Lugano, Switzerland, 18–22 June 2019. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/hon.91_2629
2019
Journal Article
Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions
Lees, Charlotte, Keane, Colm, Gandhi, Maher K. and Gunawardana, Jay (2019). Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions. British Journal of Haematology, 185 (1), 25-41. doi: 10.1111/bjh.15778
2019
Journal Article
Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies
Law, Soi Cheng, Haigh, Oscar L., Walpole, Carina M., Keane, Colm, Miles, John, Gandhi, Maher K., Radford, Kristen J. and Steptoe, Raymond J. (2019). Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies. Journal of Immunological Methods, 465, 72-76. doi: 10.1016/j.jim.2018.12.002
2019
Conference Publication
B2M Gene Expression Reflects an Immunologically Active Tumor Microenvironment in DLBCL
Gould, Clare, Keane, Colm, Murigneux, Valentine, Oey, Harald, Ellis, Jonathan, Birch, Simone, Gunawardana, Jay, Talaulikar, Dipti, Hertzberg, Mark S., Jones, Kimberley and Gandhi, Maher K. (2019). B2M Gene Expression Reflects an Immunologically Active Tumor Microenvironment in DLBCL. ASH Annual Meeting, Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-126537
2019
Journal Article
Designing optimal prognostic models for diffuse large B-cell lymphoma
Keane, Colm and Yoon Cheah, Chan (2019). Designing optimal prognostic models for diffuse large B-cell lymphoma. Leukemia and Lymphoma, 60 (8), 1-3. doi: 10.1080/10428194.2019.1599117
2018
Conference Publication
A critical role for intratumoral and circulating LAG3 in classical Hodgkin Lymphoma: analysis from the Rathl prospective phase III international clinical trial
Abro, Emad Uddin, Law, Soi C., Keane, Colm, Birch, Simone, Sabdia, Muhammed Bilal, Tobin, Joshua W. D., Johnson, Peter, Trotman, Judith, Berkahn, Leanne, Fulham, Michael, Anderson, Richard A., Saunderson, Anne L., Gunawardana, Jay, Cross, Donna, Hernandez, Annette, Halliday, Sarah-Jane, Bird, Robert, Law, W. P., Gill, Devinder and Gandhi, Maher K. (2018). A critical role for intratumoral and circulating LAG3 in classical Hodgkin Lymphoma: analysis from the Rathl prospective phase III international clinical trial. 60th ASH Annual Meeting, San Diego, CA United States, 1-4 December 2020. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-112008
2018
Journal Article
Circulating cell-free miR-494 and miR-21 are disease response biomarkers associated with interim-positron emission tomography response in patients with diffuse large b-cell lymphoma
Cui, Qingyan, Vari, Frank, Cristino, Alexandre S., Salomon, Carlos, Rice, Gregory E., Sabdia, Muhammed B., Guanzon, Dominic, Palma, Carlos, Mathew, Marina, Talaulikar, Dipti, Jain, Sanjiv, Han, Erica, Hertzberg, Mark S., Gould, Clare, Crooks, Pauline, Thillaiyampalam, Gayathri, Keane, Colm and Gandhi, Maher K. (2018). Circulating cell-free miR-494 and miR-21 are disease response biomarkers associated with interim-positron emission tomography response in patients with diffuse large b-cell lymphoma. Oncotarget, 9 (78), 34644-34657. doi: 10.18632/oncotarget.26141
2018
Journal Article
A high LDH to absolute lymphocyte count ratio in patients with DLBCL predicts for a poor intratumoral immune response and inferior survival
Keane, Colm, Tobin, Joshua, Talaulikar, Dipti, Green, Michael, Crooks, Pauline, Jain, Sanjiv and Gandhi, Maher (2018). A high LDH to absolute lymphocyte count ratio in patients with DLBCL predicts for a poor intratumoral immune response and inferior survival. OncoTarget, 9 (34), 23620-23627. doi: 10.18632/oncotarget.25306
2018
Journal Article
Immune evasion via PD-1/PD-L1 on NK-cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL
Vari, Frank, Arpon, David, Keane, Colm, Hertzberg, Mark S, Talaulikar, Dipti, Jain, Sanjiv, Cui, Qingyan, Han, Erica, Tobin, Josh, Bird, Robert, Cross, Donna, Hernandez, Annette, Gould, Clare, Birch, Simone and Gandhi, Maher K (2018). Immune evasion via PD-1/PD-L1 on NK-cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL. Blood, 131 (16), 1809-1819. doi: 10.1182/blood-2017-07-796342
2018
Conference Publication
The Tumor Microenvironment of Nodular Lymphocyte Predominant Hodgkin Lymphoma Is a Unique Immunobiological Entity Distinct from Classical Hodgkin Lymphoma
Gunawardana, Jay, Bednarska, Karolina, Law, Soi C., Lee, Justina, Sabdia, Muhammed Bilal, Tobin, Joshua W. D., Birch, Simone, Keane, Colm and Gandhi, Maher K. (2018). The Tumor Microenvironment of Nodular Lymphocyte Predominant Hodgkin Lymphoma Is a Unique Immunobiological Entity Distinct from Classical Hodgkin Lymphoma. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego CA, United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-115836
2018
Journal Article
B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity
McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599
2018
Conference Publication
The Tumour Microenvironment as an Independent Prognostic Biomarker in Follicular Lymphoma
Tobin, J., Keane, C., Mollee, P., Birch, S., Gould, C., Gunawardana, J., Hoang, T., Savarimuthu, S., Ma, T., Li, L., Murigneux, V. , Fink, L., Matigian, N. and Gandhi, M. K. (2018). The Tumour Microenvironment as an Independent Prognostic Biomarker in Follicular Lymphoma. RACP Congress 2018, Disruption for Healthy Futures, Sydney, NSW Australia, 14–16 May 2018. Hoboken, NJ United States: Wiley. doi: 10.1111/imj.2_13826
2018
Conference Publication
Elevated LAG-3 111,xpression in the Tumor Microenvironement of Patients with DLBCL Is Associated with a Non-GCB Phenotype and Poor Prognosis
Keane, Colm, Law, Soi C., Gould, Clare, Francis, Santiyagu, Abro, Emad Uddin, Tobin, Joshua W. D., Birch, Simone, Gifford, Grace, Gabreilli, Sara, Stevenson, William S., Talaulikar, Dipti, Gill, Anthony, Jain, Sanjiv, Cross, Donna, Hernadez, Annette, Halliday, Sarah-Jane, Bird, Robert, Hertzberg, Mark and Gandhi, Maher K. (2018). Elevated LAG-3 111,xpression in the Tumor Microenvironement of Patients with DLBCL Is Associated with a Non-GCB Phenotype and Poor Prognosis. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 1-4 December 2018. Washington, DC, Untied States: American Society of Hematology. doi: 10.1182/blood-2018-99-112830
2017
Conference Publication
The tumor microenvironment is independently prognostic of conventional and clinicogenetic risk models in follicular lymphoma
Tobin, Joshua W. D., Keane, Colm, Mollee, Peter, Birch, Simone, Gould, Clare, Gunawardana, Jay, Hoang, Thanh , Ma, Ti, Abro, Emad Uddin, Shanavas, Mohamed, Yoo, Hyung, Li, Li, Scuffham, Paul, Murigneux, Valentine, Fink, Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu and Gandhi, Maher K. (2017). The tumor microenvironment is independently prognostic of conventional and clinicogenetic risk models in follicular lymphoma. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, 9-12 December 2017. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V130.Suppl_1.728.728
2017
Journal Article
Stem cell-based therapies for sepsis
Keane, Colm, Jerkic, Mirjana and Laffey, John G. (2017). Stem cell-based therapies for sepsis. Anesthesiology, 127 (6), 1017-1034. doi: 10.1097/ALN.0000000000001882
2017
Journal Article
The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma
Keane, Colm, Gould, Clare, Jones, Kimberley, Hamm, David, Talaulikar, Dipti, Ellis, Jonathan, Vari, Frank, Birch, Simone, Han, Erica, Wood, Peter, Le-Cao, Kim-Anh, Green, Michael R., Crooks, Pauline, Jain, Sanjiv, Tobin, Josh, Steptoe, Raymond J. and Gandhi, Maher K. (2017). The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma. Clinical Cancer Research, 23 (7), 1820-1828. doi: 10.1158/1078-0432.CCR-16-1576
2017
Conference Publication
The T-Cell Receptor Repertoire Predicts Interim-PET in Patients with DLBCL Treated with R-CHOP: An Observational Study from a Prospective Clinical Trial
Shanavas, Mohamed, Hertzberg, Mark, Hicks, Rodney J., Seymour, John F., Tobin, Joshua W. D., Mathews, Marina, Francis, Santiyagu, Vari, Frank, Gandhi, Maher K. and Keane, Colm (2017). The T-Cell Receptor Repertoire Predicts Interim-PET in Patients with DLBCL Treated with R-CHOP: An Observational Study from a Prospective Clinical Trial. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, 9-12 December 2017. Washington, DC United States: American Society of Hematology.
2017
Conference Publication
The Effect of Immune Checkpoint Inhibitors in Patients with Concomitant Advanced Melanoma and Chronic Lymphocytic Leukaemia
Tobin, Joshua W. D., Royle, Jane, Mason, Robert, Michael, Millward, Lydia, Warburton, Sandhu, Shahneen, Haydon, Andrew, Long, Georgina, Carlino, Matteo, Smith, Jessica L., Dearden, Helen, Mollee, Peter, Gill, Devinder, Mapp, Sally, Atkinson, Victoria and Keane, Colm (2017). The Effect of Immune Checkpoint Inhibitors in Patients with Concomitant Advanced Melanoma and Chronic Lymphocytic Leukaemia. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, 9-12 December 2017. Washington, DC United States: American Society of Hematology.
2017
Conference Publication
The impact of EBV upon the tumor microenvironment and mutational profile of primary CNS lymphoma in PTLD
Gandhi, Maher K., Keane, Colm, Tobin, Joshua W. D., Talaulikar, Dipti, Jain, Sanjiv, Vari, Frank, Kruze, Lutz, Murigneux, Valentine, Fink, Lynn, Gunawardana, Jithendra, Gould, Clare, Oey, Harold, Fink, Susanne, Trappe, Ralf Ulrich, Mathews, Marina, Francis, Santiyagu and Hoang, Thanh (2017). The impact of EBV upon the tumor microenvironment and mutational profile of primary CNS lymphoma in PTLD. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 9-12 December 2017. Washington, DC, United States: American Society of Hematology.
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Colm Keane is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Investigating the mechanisms of immune evasion in relapsed/refractory DLBCL
Principal Advisor
Other advisors: Dr Zachary Hawula
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Doctor Philosophy
Investigation of immune responses to novel and standard therapies in DLBCL
Principal Advisor
Other advisors: Dr Joshua Tobin, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Immuno-genetic biomarkers of response in a prospective study of immune checkpoint therapy in primary CNS lymphoma
Principal Advisor
Other advisors: Dr Arutha Kulasinghe, Dr Zachary Hawula
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Doctor Philosophy
Impact of genetics upon the tumour microenvironment in Follicular Lymphoma
Associate Advisor
Other advisors: Dr Joshua Tobin, Dr Soi Law, Professor Maher Gandhi
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Master Philosophy
Amyloidosis Monitoring and Outcomes in an Australian Tertiary Centre
Associate Advisor
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Doctor Philosophy
Reversing tumour necrosis factor-mediated immunosuppression to boost immunity against experimental CD19+ blood cancers
Associate Advisor
Other advisors: Dr Allie Lam, Associate Professor Fernando Guimaraes
Completed supervision
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2022
Doctor Philosophy
A Comprehensive Study of Intratumoural T-cells in Follicular Lymphoma
Associate Advisor
Other advisors: Dr Soi Law, Professor Maher Gandhi
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2021
Doctor Philosophy
Clinical and Prognostic Tools to Improve Frontline Management Strategies in Follicular Lymphoma
Associate Advisor
Other advisors: Professor Maher Gandhi
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2020
Doctor Philosophy
The impact of deficient antigen presentation on the tumour microenvironment of diffuse large B cell lymphoma
Associate Advisor
Other advisors: Professor Maher Gandhi
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2019
Doctor Philosophy
A LABORATORY STUDY OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA
Associate Advisor
Other advisors: Professor Maher Gandhi
Media
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