Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2019
Conference Publication
Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model
Hoe, L. See, Shuker, T., Bartnikowski, N., Passmore, M., Bouquet, M., Obonyo, N., Engkilde-Pedersen, S., McDonald, C., Wells, M., Boon, A., Hyslop, K., James, L., Wildi, K., Cullen, L., Bassi, G. Li, Suen, J., McGiffin, D. and Fraser, J. (2019). Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model. 67th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 13th Annual Australia and New Zealand Endovascular Therapies Meeting, Adelaide, Australia, 8-11 August 2019. chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2019.06.074
2019
Journal Article
Pre-clinical study protocol: Blood transfusion in endotoxaemic shock
Obonyo, Nchafatso G., Byrne, Liam, Tung, John-Paul, Simonova, Gabriela, Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Mohd H., Pimenta, Leticia P., Millar, Jonathan E., Fanning, Jonathon P., Van Haren, Frank, Anstey, Chris M., Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2019). Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX, 6, 1124-1132. doi: 10.1016/j.mex.2019.05.005
2018
Conference Publication
Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation
Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation. American Heart Association's 2018 Scientific Sessions, Chicago, IL United States, 10-12 November 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/circ.138.suppl_1.17116
2018
Journal Article
Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction
Pickering, John W., Young, Joanna M., George, Peter M., Watson, Antony S., Aldous, Sally J., Troughton, Richard W., Pemberton, Christopher J., Richards, A. Mark, Cullen, Louise A. and Than, Martin P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3 (11), 1108-1112. doi: 10.1001/jamacardio.2018.3368
2018
Journal Article
Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Pedersen, Sanne, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Van Haren, Frank, Anstey, Christopher M., Cullen, Louise, Tung, John-Paul, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia. American Journal of Respiratory and Critical Care Medicine, 198 (8), 1043-1054. doi: 10.1164/rccm.201801-0064OC
2018
Journal Article
Prospective validation of prognostic and diagnostic syncope scores in the emergency department
du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Isenrich, Rahel, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Bustamante Mandrión, José, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Mueller, Christian, Reichlin, Tobias, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut ... For the BASEL IX Investigators (2018). Prospective validation of prognostic and diagnostic syncope scores in the emergency department. International Journal of Cardiology, 269, 114-121. doi: 10.1016/j.ijcard.2018.06.088
2018
Journal Article
Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope
du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut ... BASEL IX Investigators (2018). Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope. EP Europace, 21 (3), 511-521. doi: 10.1093/europace/euy186
2018
Journal Article
Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department
Kavsak, Peter A., Neumann, Johannes T., Cullen, Louise, Than, Martin, Shortt, Colleen, Greenslade, Jaimi H., Pickering, John W., Ojeda, Francisco, Ma, Jinhui, Clayton, Natasha, Sherbino, Jonathan, Hill, Stephen A., McQueen, Matthew, Westermann, Dirk, Sörensen, Nils A., Parsonage, William A., Griffith, Lauren, Mehta, Shamir R., Devereaux, P.J., Richards, Mark, Troughton, Richard, Pemberton, Chris, Aldous, Sally, Blankenberg, Stefan and Worster, Andrew (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. Canadian Medical Association Journal, 190 (33), E974-E984. doi: 10.1503/cmaj.180144
2018
Conference Publication
Impact of routine implementation of high sensitivity troponin in a state-wide health service
Khan, E., Chuang, A., Halabi, A., Tiver, K., Horsfall, M., Briffa, T., Sun, B., Cullen, L., French, J. and Chew, D. (2018). Impact of routine implementation of high sensitivity troponin in a state-wide health service. European Society of Cardiology Congress, Munich, Germany, 25-29 August 2018. Oxford, United Kingdom: Oxford University Press.
2018
Conference Publication
Sex-specific symptoms in the early diagnosis of syncope
De Lavallaz, J. Du Fay, Badertscher, P., Nestelberger, T., Miro, O., Twerenbold, R., Cullen, L., Than, M., Martin-Sanchez, F. J., Keller, D., Kuehne, M., Reichlin, T. and Mueller, C. (2018). Sex-specific symptoms in the early diagnosis of syncope. European-Society-of-Cardiology Congress, Munich Germany, Aug 25-29, 2018. OXFORD: OXFORD UNIV PRESS.
2018
Journal Article
Deliberate clinical inertia: using meta-cognition to improve decision-making
Keijzers, Gerben, Fatovich, Daniel M., Egerton-Warburton, Diana, Cullen, Louise, Scott, Ian A., Glasziou, Paul and Croskerry, Pat (2018). Deliberate clinical inertia: using meta-cognition to improve decision-making. Emergency Medicine Australasia, 30 (4), 585-590. doi: 10.1111/1742-6723.13126
2018
Journal Article
Re: Medical student enquiries on the art of clinical inertia
Keijzers, Gerben, Cullen, Louise, Egerton-Warburton, Diana and Fatovich, Daniel M (2018). Re: Medical student enquiries on the art of clinical inertia. EMA - Emergency Medicine Australasia, 30 (3), 435-436. doi: 10.1111/1742-6723.12980
2018
Journal Article
‘What the hell is water?’ How to use deliberate clinical inertia in common emergency department situations
Egerton‐Warburton, Diana, Cullen, Louise, Keijzers, Gerben and Fatovich, Daniel M. (2018). ‘What the hell is water?’ How to use deliberate clinical inertia in common emergency department situations. Emergency Medicine Australasia, 30 (3), 426-430. doi: 10.1111/1742-6723.12950
2018
Journal Article
Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: an observational study
Than, Martin P., Aldous, Sally J., Troughton, Richard W., Pemberton, Christopher J., Richards, A. Mark, Frampton, Christopher M. A., Florkowski, Christopher M., George, Peter M., Bailey, Samantha, Young, Joanna M., Cullen, Louise, Greenslade, Jaimi H., Parsonage, William A., Everett, Brendan M., Peacock, W. Frank, Jaffe, Allan S. and Pickering, John W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: an observational study. Clinical Chemistry, 64 (7), 1044-1053. doi: 10.1373/clinchem.2017.285700
2018
Journal Article
The assessment and management of chest pain in primary care: 'a focus on acute coronary syndrome'
Thomsett, Richard and Cullen, Louise (2018). The assessment and management of chest pain in primary care: 'a focus on acute coronary syndrome'. Australian Journal of General Practice, 47 (5), 246-251. doi: 10.31128/AFP-08-17-4304
2018
Journal Article
A critical evaluation of the Beckman Coulter Access hsTnI: analytical performance, reference interval and concordance
Pretorius, Carel J., Tate, Jillian R., Wilgen, Urs, Cullen, Louise and Ungerer, Jacobus P. J. (2018). A critical evaluation of the Beckman Coulter Access hsTnI: analytical performance, reference interval and concordance. Clinical Biochemistry, 55, 49-55. doi: 10.1016/j.clinbiochem.2018.03.003
2018
Journal Article
Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction
van der Linden, Noreen, Wildi, Karin, Twerenbold, Raphael, Pickering, John W, Than, Martin, Cullen, Louise, Greenslade, Jaimi, Parsonage, William, Nestelberger, Thomas, Boeddinghaus, Jasper, Badertscher, Patrick, Rubini Giménez, Maria, Klinkenberg, Lieke J J, Bekers, Otto, Schöni, Aline, Keller, Dagmar I, Sabti, Zaid, Puelacher, Christian, Cupa, Janosch, Schumacher, Lukas, Kozhuharov, Nikola, Grimm, Karin, Shrestha, Samyut, Flores, Dayana, Freese, Michael, Stelzig, Claudia, Strebel, Ivo, Miró, Òscar, Rentsch, Katharina ... Mueller, Christian (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138 (10), CIRCULATIONAHA.117.032003-999. doi: 10.1161/CIRCULATIONAHA.117.032003
2018
Journal Article
Don't just do something, stand there! The value and art of deliberate clinical inertia
Keijzers, Gerben, Cullen, Louise, Egerton-Warburton, Diana and Fatovich, Daniel M (2018). Don't just do something, stand there! The value and art of deliberate clinical inertia. Emergency medicine Australasia : EMA, 30 (2), 273-278. doi: 10.1111/1742-6723.12922
2018
Journal Article
Characteristics and occurrence of type 2 myocardial infarction in emergency department patients: a prospective study
Greenslade, Jaimi H., Adikari, Thushani, Mueller, Christian, Sandoval, Yader, Nestelberger, Thomas, Parsonage, William, Hawkins, Tracey and Cullen, Louise (2018). Characteristics and occurrence of type 2 myocardial infarction in emergency department patients: a prospective study. Emergency Medicine Journal : EMJ, 35 (3), 169-175. doi: 10.1136/emermed-2017-206869
2018
Journal Article
Evaluating rapid rule-out of acute myocardial infarction by use of a high-sensitivity cardiac troponin I assay at presentation
Greenslade, Jaimi, Cho, Elizabeth, Van Hise, Christopher, Hawkins, Tracey, Parsonage, William, Ungerer, Jacobus, Tate, Jillian, Pretorius, Carel, Than, Martin and Cullen, Louise (2018). Evaluating rapid rule-out of acute myocardial infarction by use of a high-sensitivity cardiac troponin I assay at presentation. Clinical Chemistry, 64 (5), 820-829. doi: 10.1373/clinchem.2017.283887
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study
Principal Advisor
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Doctor Philosophy
Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study
Principal Advisor
Completed supervision
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2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
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2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
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