Professor Louise Cullen
Professor

Louise Cullen

Email: 

Background

Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.

As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.

More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.

Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.

Pre-Eminent Staff Specialist, Department of Emergency Medicine

Prof, Queensland University of Technology

A/Prof, University of Queensland

Royal Brisbane and Women’s Hospital

Brisbane, Queensland 4029, AUSTRALIA.

Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.

Email: louise.cullen@health.qld.gov.au

Twitter: @louiseacullen

Qualifications: MBBS (Hon) FACEM PhD

Availability

Professor Louise Cullen is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Clinical sciences Health Sciences

Research impacts

Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.

Search Professor Louise Cullen’s works on UQ eSpace

268 works between 2004 and 2025
All (268) Journal Article (232) Conference Publication (36)

1 - 20 of 268 works

2025

Journal Article

Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments

Hickling, Siobhan, Sanfilippo, Frank M, Cullen, Louise, Chew, Derek P, Hillis, Graham S, Fatovich, Daniel M, Karnon, Jonathon, Rankin, Jamie, Nedkoff, Lee, Scanlan, Samuel, Hickman, Peter E, Stapleton, Stuart, Knuiman, Matthew, Parsonage, William, Mitra, Biswadev, Schneider, Hans G, Wilkes, Garry, Robinson, Teagan and Briffa, Tom (2025). Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments. Heart 324959, heartjnl-2024. doi: 10.1136/heartjnl-2024-324959

Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments

2025

Journal Article

Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction

Lambrakis, Kristina, Khan, Ehsan, Liao, Zhibin, Gerlach, Joey, Nelson, Adam J., Goodman, Shaun G., Briffa, Tom, Cullen, Louise, Verjans, Johan and Chew, Derek P. (2025). Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction. Heart Lung and Circulation. doi: 10.1016/j.hlc.2024.11.023

Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction

2024

Journal Article

Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study

Toprak, Betül, Solleder, Hugo, Di Carluccio, Eleonora, Greenslade, Jaimi H, Parsonage, William A, Schulz, Karen, Cullen, Louise, Apple, Fred S, Ziegler, Andreas, Blankenberg, Stefan, Stephensen, Laura, Brownlee, Emily, McCormick, Ellyse, Fincher, Gavin, Hall, Emma J., Hancock, Rebecca, Gaikwad, Niranjan, Gangathimmaiah, Vinay, Hamilton-Craig, Christian, Hobbins-King, Andrew, Keijzers, Gerben, Bayat, Maryam Khorramshahi, Mahmoodi, Ehsan, Perez, Siegfried, Ranasinghe, Isuru, Staib, Andrew, Zournazi, Anna and Than, Martin (2024). Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study. The Lancet Digital Health, 6 (10), e729-e738. doi: 10.1016/s2589-7500(24)00191-2

Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study

2024

Journal Article

Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h

Cullen, Louise, Greenslade, Jaimi, Parsonage, William, Stephensen, Laura, Smith, Stephen W, Sandoval, Yader, Ranasinghe, Isuru, Gaikwad, Niranjan, Khorramshahi Bayat, Maryam, Mahmoodi, Ehsan, Schulz, Karen, Than, Martin, Apple, Fred S, Brownlee, Emily, Fincher, Gavin, Hall, Emma, Hancock, Rebecca, Gangathimmaiah, Vinay, Hamilton-Craig, Christian, Hobbins-King, Andrew, Keijzers, Gerben, McCormick, Ellyse, Perez, Siegfried, Staib, Andrew, Zournazi, Anna, Than, Martin and the SAMIE and SEIGE investigators (2024). Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h. European Heart Journal, 45 (28), 2508-2515. doi: 10.1093/eurheartj/ehae343

Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h

2024

Journal Article

Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative

Pickering, John W., Devlin, Gerard, Body, Richard, Aldous, Sally, Jaffe, Allan S., Apple, Fred S., Mills, Nicholas, Troughton, Richard W., Kavsak, Peter, Peacock, W. Frank, Cullen, Louise, Müller, Christian, Lord, Sarah J., Joyce, Laura, Frampton, Chris, Lacey, Cameron James, Richards, Arthur M., Pitama, Suzanne and Than, Martin (2024). Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative. BMJ Open, 14 (6) e083752, 1-11. doi: 10.1136/bmjopen-2023-083752

Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative

2024

Journal Article

Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome

Khan, Ehsan, Lambrakis, Kristina, Liao, Zhibin, Gerlach, Joey, Briffa, Tom, Cullen, Louise, Nelson, Adam J., Verjans, Johan and Chew, Derek P. (2024). Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome. JACC: Advances, 3 (9) 101011, 101011. doi: 10.1016/j.jacadv.2024.101011

Machine-Learning for Phenotyping and Prognostication of Myocardial Infarction and Injury in Suspected Acute Coronary Syndrome

2024

Journal Article

Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure

Lee, Kuan Ken, Doudesis, Dimitrios, Mair, Johannes, Mills, Nicholas L, Lindahl, Bertil, Boeddinghaus, Jasper, Cullen, Louise, Daniels, Lori, Hammarsten, Ola, Huber, Kurt, Giannitsis, Evangelos, Jaffe, Allan S, Kimenai, Dorien M, Krychtiuk, Konstantin, Möckel, Martin, Mueller, Christian, Thielmann, Matthias, Thygesen, Kristian, Mair, Johannes, Mills, Nicholas L and the Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care (2024). Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure. European Heart Journal: Acute Cardiovascular Care, 13 (6) zuae064, 515-516. doi: 10.1093/ehjacc/zuae064

Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure

2024

Journal Article

How to use natriuretic peptides in non-cardiac surgery

Duceppe, Emmanuelle, Mills, Nicholas L, Mueller, Christian, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian, Thielmann, Matthias, Jaffe, Allan S and Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care (2024). How to use natriuretic peptides in non-cardiac surgery. European Heart Journal: Acute Cardiovascular Care, 13 (4), 380-382. doi: 10.1093/ehjacc/zuae038

How to use natriuretic peptides in non-cardiac surgery

2024

Journal Article

Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay

Pickering, John W, Young, Joanna M, George, Peter M, Watson, Antony S, Aldous, Sally J, Verryt, Toby, Troughton, Richard W, Pemberton, Christopher J, Richards, A Mark, Cullen, Louise A, Apple, Fred S and Than, Martin P (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. The Journal of Applied Laboratory Medicine, 9 (3), 526-539. doi: 10.1093/jalm/jfae001

Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay

2024

Journal Article

Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial

Altinger, Gemma, Sharma, Sweekriti, Maher, Chris G, Cullen, Louise, McCaffery, Kirsten, Linder, Jeffrey A, Buchbinder, Rachelle, Harris, Ian A, Coiera, Enrico, Li, Qiang, Howard, Kirsten, Coggins, Andrew, Middleton, Paul M, Gunja, Naren, Ferguson, Ian, Chan, Trevor, Tambree, Karen, Varshney, Ajay and Traeger, Adrian C (2024). Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial. BMJ Open, 14 (3) e079870, 1-12. doi: 10.1136/bmjopen-2023-079870

Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial

2024

Journal Article

Lower limits for reporting high-sensitivity cardiac troponin assays and impact of analytical performance on patient misclassification

Aakre, Kristin M., Apple, Fred S., Mills, Nicolas L., Meex, Steven J.R., Collinson, Paul O., on behalf of the International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB), Hammarsten, Ola, Jaffe, Allan S., Omland, Torbjørn, Cullen, Louise (International Federation of Clinical Chemistry (IFCC) Committee on Clinical Applications of Cardiac Biomarkers (C-CB) member) and Sandoval, Yader (2024). Lower limits for reporting high-sensitivity cardiac troponin assays and impact of analytical performance on patient misclassification. Clinical Chemistry, 70 (3), 497-505. doi: 10.1093/clinchem/hvad185

Lower limits for reporting high-sensitivity cardiac troponin assays and impact of analytical performance on patient misclassification

2024

Journal Article

External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction

Cullen, Louise, Greenslade, Jaimi H., Stephensen, Laura, Ranasinghe, Isuru, Gaikwad, Niranjan, Khorramshahi Bayat, Maryam, Mahmoodi, Ehsan, Than, Martin, Apple, Fred, Parsonage, William and SAMIE study group 2022 (2024). External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction. Emergency Medicine Journal, 41 (5), 313-319. doi: 10.1136/emermed-2023-213539

External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction

2024

Journal Article

Biomarkers for diagnosis and prognostication of acute aortic syndromes

Morello, Fulvio, Nazerian, Peiman, Lupia, Enrico, Castelli, Matteo, Mills, Nicholas L, Mueller, Christian, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian, Thielmann, Matthias, Jaffe, Allan S. and the Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care (2024). Biomarkers for diagnosis and prognostication of acute aortic syndromes. European Heart Journal: Acute Cardiovascular Care, 13 (2), 254-256. doi: 10.1093/ehjacc/zuae011

Biomarkers for diagnosis and prognostication of acute aortic syndromes

2023

Journal Article

Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design

Thulin, Ingrid Viola Lavesson, Jordalen, Silje Marie Farestveit, Lekven, Ole Christian, Krishnapillai, Jeyaseelan, Steiro, Ole Thomas, Collinson, Paul, Apple, Fred, Cullen, Louise, Norekval, Tone M., Wisloff, Torbjorn, Vikenes, Kjell, Omland, Torbjorn, Bjorneklett, Rune O. and Aakre, Kristin Moberg (2023). Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design. Scandinavian Cardiovascular Journal, 57 (1) 2272585, 1-7. doi: 10.1080/14017431.2023.2272585

Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design

2023

Journal Article

Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: interactions between low troponin concentrations and participant sex within two randomized clinical trials

Lambrakis, Kristina, Khan, Ehsan, van den Merkhof, Anke, Papendick, Cynthia, Chuang, Anthony, Zhai, Yuze, Eng-Frost, Joanne, Rocheleau, Simon, Lehman, Sam J., Blyth, Andrew, Briffa, Tom, Quinn, Stephen, French, John K., Cullen, Louise and Chew, Derek P. (2023). Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: interactions between low troponin concentrations and participant sex within two randomized clinical trials. International Journal of Cardiology, 393 131396, 1-8. doi: 10.1016/j.ijcard.2023.131396

Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: interactions between low troponin concentrations and participant sex within two randomized clinical trials

2023

Journal Article

Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access hsTnI high-sensitivity cardiac troponin I assay

Meek, Robert, Cullen, Louise, Lu, Zhong, Nasis, Arthur, Kuhn, Lisa and Sorace, Laurence (2023). Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access hsTnI high-sensitivity cardiac troponin I assay. EMA - Emergency Medicine Australasia, 35 (6), 1005-1012. doi: 10.1111/1742-6723.14282

Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access hsTnI high-sensitivity cardiac troponin I assay

2023

Journal Article

Cardiac troponin T and I: back to basics

Mingels, Alma M., Mills, Nicholas L., Mueller, Christian, Jaffe, Allan, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian, Thielmann, Matthias and Study Group on Biomarkers of the ESC Association for Acute CardioVascular Care (2023). Cardiac troponin T and I: back to basics. European Heart Journal: Acute Cardiovascular Care, 12 (9), 631-632. doi: 10.1093/ehjacc/zuad084

Cardiac troponin T and I: back to basics

2023

Journal Article

Improving difficult peripheral intravenous access requires thought, training and technology (DART3): a stepped-wedge, cluster randomised controlled trial protocol

Schults, Jessica A., Marsh, Nicole, Ullman, Amanda J., Kleidon, Tricia M., Ware, Robert S., Byrnes, Joshua, Young, Emily, Hall, Lisa, Keijzers, Gerben, Cullen, Louise, Calleja, Pauline, McTaggart, Steven, Peters, Nathan, Watkins, Stuart, Corley, Amanda, Brown, Christine, Lin, Zhen, Williamson, Frances, Burgess, Luke, Macfarlane, Fiona, Cooke, Marie, Battley, Callan and Rickard, Claire M. (2023). Improving difficult peripheral intravenous access requires thought, training and technology (DART3): a stepped-wedge, cluster randomised controlled trial protocol. BMC Health Services Research, 23 (1) 587, 1-12. doi: 10.1186/s12913-023-09499-0

Improving difficult peripheral intravenous access requires thought, training and technology (DART3): a stepped-wedge, cluster randomised controlled trial protocol

2023

Journal Article

Healthcare cost burden of acute chest pain presentations

Dawson, Luke, Nehme, Emily, Nehme, Ziad, Zomer, Ella, Bloom, Jason, Cox, Shelley, Anderson, David, Stephenson, Michael, Lefkovits, Jeffrey, Taylor, Andrew, Kaye, David, Cullen, Louise, Smith, Karen and Stub, Dion (2023). Healthcare cost burden of acute chest pain presentations. Emergency Medicine Journal, 40 (6) emermed-2022-212674, 1-7. doi: 10.1136/emermed-2022-212674

Healthcare cost burden of acute chest pain presentations

2023

Journal Article

Clinical characteristics of Aboriginal and Torres Strait Islander emergency department patients with suspected acute coronary syndrome

Stephensen, Laura, Greenslade, Jaimi, Starmer, Katrina, Starmer, Greg, Stone, Richard, Bonnin, Robert, Brazzale, Anthony, Drahm‐Butler, Tileah, Campbell, Virginia, Davis, Tania, Mowatt, Elizabeth, Brown, Nathan, Proctor, Karlie, Ashover, Sarah, Milburn, Tanya, McCormack, Louise, Graves, Nicholas, Gatton, Michelle, Mahoney, Ray, Parsonage, William and Cullen, Louise (2023). Clinical characteristics of Aboriginal and Torres Strait Islander emergency department patients with suspected acute coronary syndrome. Emergency Medicine Australasia, 35 (3), 442-449. doi: 10.1111/1742-6723.14138

Clinical characteristics of Aboriginal and Torres Strait Islander emergency department patients with suspected acute coronary syndrome

Current funding

  • 2022 - 2025
    NUDG-ED: Trial of behavioural 'nudging' interventions to reduce unnecessary care for low back pain in the Emergency Department (NHMRC CTCS Externally administered by USyd)
    University of Sydney
    Open grant
  • 2021 - 2025
    Difficult peripheral intravenous catheter insertion: Australian considerations for sustainable implementation of ultrasound guided procedures
    NHMRC Partnership Projects
    Open grant

Past funding

  • 2021 - 2024
    Development of a first-in-class therapeutic for protecting the ischemic heart
    NHMRC Development Grant
    Open grant
  • 2017 - 2020
    Improving Rapid Decision-Making in the Face of Uncertainty: A randomised trial of a 1-hour troponin protocol in suspected acute coronary syndromes (NHMRC Project Grant led by Flinders University)
    Flinders University
    Open grant
  • 2017 - 2020
    Is highly-sensitive troponin testing advancing clinical practice, improving outcomes and cost-effective in the investigation and manageme..(NHMRC Project Grant led by University of Western Australia)
    University of Western Australia
    Open grant
  • 2015 - 2020
    Centre of Research Excellence in Cardiovascular Outcomes Improvement (NHMRC CRE administered by Curtin University)
    Curtin University of Technology
    Open grant
  • 2011 - 2016
    Study 3: A decision analytic cost-effectiveness model for chest pain pathways
    QEMRF Project Grants Scheme
    Open grant
  • 2011 - 2016
    Rapid assessment of cardiac chest pain: the Australian and New Zealand Assessment of chest Pain Rule (ANZAP rule): A prospective validation study
    QEMRF Program Grants Scheme
    Open grant
  • 2010 - 2012
    Controlling Laboratory Test Ordering in Emergency Departments
    QEMRF Emergency Medicine Staff Specialist Research Grants Scheme
    Open grant
  • 2010 - 2011
    Factors influencing triage allocation for patients with acute myocardial infarction
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2009 - 2010
    Accelerated pathway in the assessment of suspected acute coronary syndrome in the Emergency Department
    QEMRF Emergency Medicine Staff Specialist Research Grants Scheme
    Open grant

Availability

Professor Louise Cullen is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study

    Principal Advisor

  • Doctor Philosophy

    Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study

    Principal Advisor

Completed supervision

Enquiries

For media enquiries about Professor Louise Cullen's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au