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2025 Journal Article Cost-effectiveness of the transition from conventional to high-sensitivity troponin assay for the investigation and management of suspected acute coronary syndrome in the emergency departmentPincombe, Aubyn, Gray, Jodi, Hickling, Siobhan, Sanfilippo, Frank, Briffa, Tom, Cullen, Louise, Chew, Derek, Hillis, Graham, Fatovich, Daniel, Rankin, Jamie, Nedkoff, Lee, Scanlan, Samuel, Hickman, Peter E., Stapleton, Stuart, Parsonage, William, Mitra, Biswadev, Schneider, Hans G., Wilkes, Garry, Robinson, Teagan and Karnon, Jonathan (2025). Cost-effectiveness of the transition from conventional to high-sensitivity troponin assay for the investigation and management of suspected acute coronary syndrome in the emergency department. American Heart Journal, 287, 107-118. doi: 10.1016/j.ahj.2025.03.022 |
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2025 Conference Publication Costs and Healthcare Utilisation for Aboriginal and Torres Strait Islander People With Suspected Acute Coronary SyndromeStephensen, L., Mahoney, R., Cullen, L. and Parsonage, W. (2025). Costs and Healthcare Utilisation for Aboriginal and Torres Strait Islander People With Suspected Acute Coronary Syndrome. Cardiac Society of Australia and New Zealand 4th Indigenous Cardiovascular Health Conference 2025, Sydney, NSW Australia, 17–19 June 2025. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2025.05.069 |
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2025 Journal Article Implementing best practice for peripheral intravenous cannula use in Australian emergency departments: a stepped-wedge cluster-controlled trial and health economic analysis protocolEgerton-Warburton, Diana, Kuhn, Lisa, Enticott, Joanne, Yang, Sundy Ni-Yen, Buntine, Paul, Callander, Emily, Cullen, Louise, Fatovich, Daniel, Hullick, Carolyn, Heiss, Leah, Keijzers, Gerben, Le, Long Khanh-Dao, Mihalopoulos, Cathrine, Morphet, Julia, O’Reilly, Gerard, Pokhrel, Bibesh, Rickard, Claire, Tran, Viet, Cameron, Peter and Teede, Helena J (2025). Implementing best practice for peripheral intravenous cannula use in Australian emergency departments: a stepped-wedge cluster-controlled trial and health economic analysis protocol. BMJ Open, 15 (6) e096962, e096962-6. doi: 10.1136/bmjopen-2024-096962 |
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2025 Conference Publication Listening to See: Co-Designing the Powerful Pictures Model of Care With Aboriginal and Torres Strait Islander Communities and Health ServicesGoodman, A., Allen, M., McKivett, A., Thorne, T., Stephenson, L., Cullen, L., Parsonage, W. and Mahoney, R. (2025). Listening to See: Co-Designing the Powerful Pictures Model of Care With Aboriginal and Torres Strait Islander Communities and Health Services. Cardiac Society of Australia and New Zealand 4th Indigenous Cardiovascular Health Conference 2025, Sydney, NSW Australia, 17–19 June 2025. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2025.05.012 |
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2025 Journal Article Potential length of stay reductions from emergency department use of a point-of-care high-sensitivity cardiac troponin assay: Pilot findings from Australia's first cardiac emergency departmentMeek, Robert, Hayden, Georgina, Lu, Zhong X., Damianopoulos, Adam, Cullen, Louise, Kumarakurusingham, Evan, Pathirana, Pavith, Than, Martin, Pickering, John W., Doery, James, Duong, Alex and Egerton-Warburton, Diana (2025). Potential length of stay reductions from emergency department use of a point-of-care high-sensitivity cardiac troponin assay: Pilot findings from Australia's first cardiac emergency department. Emergency Medicine Australasia, 37 (2) e70041, e70041. doi: 10.1111/1742-6723.70041 |
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2025 Journal Article Evidence-based medicine and the cardiac troponin 99th percentile for the diagnosis of acute myocardial infarctionHickman, Peter E, Potter, Julia M, Cullen, Louise, Eggers, Kai M, Than, Martin, Pickering, John W, Parsonage, William and Doust, Jenny (2025). Evidence-based medicine and the cardiac troponin 99th percentile for the diagnosis of acute myocardial infarction. European Heart Journal: Acute Cardiovascular Care, 14 (3), 183-188. doi: 10.1093/ehjacc/zuaf007 |
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2025 Journal Article Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artficial intelligence. (RAPIDx AI) – a cluster randomised study designKhan, Ehsan, Lambrakis, Kristina, Briffa, Tom, Cullen, Louise A, Karnon, Jonathon, Papendick, Cynthia, Quinn, Stephen, Tideman, Phil, Hengel, Anton Van Den, Verjans, Johan and Chew, Derek P (2025). Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artficial intelligence. (RAPIDx AI) – a cluster randomised study design. American Heart Journal, 285, 106-118. doi: 10.1016/j.ahj.2025.02.016 |
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2025 Journal Article Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departmentsHickling, Siobhan, Sanfilippo, Frank M, Cullen, Louise, Chew, Derek P, Hillis, Graham S, Fatovich, Daniel M, Karnon, Jonathon, Rankin, Jamie, Nedkoff, Lee, Scanlan, Samuel, Hickman, Peter E, Stapleton, Stuart, Knuiman, Matthew, Parsonage, William, Mitra, Biswadev, Schneider, Hans G, Wilkes, Garry, Robinson, Teagan and Briffa, Tom (2025). Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments. Heart, 111 (10) 324959, heartjnl-2024. doi: 10.1136/heartjnl-2024-324959 |
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2025 Journal Article Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial InfarctionLambrakis, Kristina, Khan, Ehsan, Liao, Zhibin, Gerlach, Joey, Nelson, Adam J., Goodman, Shaun G., Briffa, Tom, Cullen, Louise, Verjans, Johan and Chew, Derek P. (2025). Prognostic Implications of Machine Learning Algorithm–Supported Diagnostic Classification of Myocardial Injury Using the Fourth Universal Definition of Myocardial Infarction. Heart Lung and Circulation, 34 (5), 497-505. doi: 10.1016/j.hlc.2024.11.023 |
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2025 Journal Article Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled TrialThulin, Viola I.L., Jordalen, Silje M.F., Myrmel, Gard M.S., Lekven, Ole Christian, Krishnapillai, Jeyaseelan, Steiro, Ole Thomas, Body, Richard, Collinson, Paul, Apple, Fred S., Cullen, Louise, Norekvål, Tone M., Wisløff, Torbjørn, Vikenes, Kjell, Bjørneklett, Rune O., Omland, Torbjørn and Aakre, Kristin M. (2025). Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial. Annals of Emergency Medicine. doi: 10.1016/j.annemergmed.2025.03.005 |
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2024 Journal Article Machine-learning for phenotyping and prognostication of myocardial infarction and injury in suspected acute coronary syndromeKhan, Ehsan, Lambrakis, Kristina, Liao, Zhibin, Gerlach, Joey, Briffa, Tom, Cullen, Louise, Nelson, Adam J., Verjans, Johan and Chew, Derek P. (2024). Machine-learning for phenotyping and prognostication of myocardial infarction and injury in suspected acute coronary syndrome. JACC: Advances, 3 (9) 101011, 101011. doi: 10.1016/j.jacadv.2024.101011 |
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2024 Journal Article Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective studyToprak, Betül, Solleder, Hugo, Di Carluccio, Eleonora, Greenslade, Jaimi H., Parsonage, William A., Schulz, Karen, Cullen, Louise, Apple, Fred S., Ziegler, Andreas, Stephensen, Laura, Blankenberg, Stefan, on behalf of the Artificial Intelligence in Suspected Myocardial Infarction Study (ARTEMIS) group, Brownlee, Emily, McCormick, Ellyse, Fincher, Gavin, Hall, Emma J., Hancock, Rebecca, Gaikwad, Niranjan, Gangathimmaiah, Vinay, Hamilton-Craig, Christian, Keijzers, Gerben, Hobbins-King, Andrew, Bayat, Maryam Khorramshahi, Mahmoodi, Ehsan, Perez, Siegfried, Ranasinghe, Isuru, Staib, Andrew, Zournazi, Anna and Than, Martin (2024). Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study. The Lancet Digital Health, 6 (10), e729-e738. doi: 10.1016/s2589-7500(24)00191-2 |
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2024 Journal Article Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 hCullen, Louise, Greenslade, Jaimi, Parsonage, William, Stephensen, Laura, Smith, Stephen W, Sandoval, Yader, Ranasinghe, Isuru, Gaikwad, Niranjan, Khorramshahi Bayat, Maryam, Mahmoodi, Ehsan, Schulz, Karen, Than, Martin, Apple, Fred S, Brownlee, Emily, Fincher, Gavin, Hall, Emma, Hancock, Rebecca, Gangathimmaiah, Vinay, Hamilton-Craig, Christian, Hobbins-King, Andrew, Keijzers, Gerben, McCormick, Ellyse, Perez, Siegfried, Staib, Andrew, Zournazi, Anna, Than, Martin and the SAMIE and SEIGE investigators (2024). Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h. European Heart Journal, 45 (28), 2508-2515. doi: 10.1093/eurheartj/ehae343 |
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2024 Journal Article Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiativePickering, John W., Devlin, Gerard, Body, Richard, Aldous, Sally, Jaffe, Allan S., Apple, Fred S., Mills, Nicholas, Troughton, Richard W., Kavsak, Peter, Peacock, W. Frank, Cullen, Louise, Müller, Christian, Lord, Sarah J., Joyce, Laura, Frampton, Chris, Lacey, Cameron James, Richards, Arthur M., Pitama, Suzanne and Than, Martin (2024). Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative. BMJ Open, 14 (6) e083752, 1-11. doi: 10.1136/bmjopen-2023-083752 |
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2024 Journal Article Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failureLee, Kuan Ken, Doudesis, Dimitrios, Mair, Johannes, Mills, Nicholas L, Lindahl, Bertil, Boeddinghaus, Jasper, Cullen, Louise, Daniels, Lori, Hammarsten, Ola, Huber, Kurt, Giannitsis, Evangelos, Jaffe, Allan S, Kimenai, Dorien M, Krychtiuk, Konstantin, Möckel, Martin, Mueller, Christian, Thielmann, Matthias, Thygesen, Kristian, Mair, Johannes, Mills, Nicholas L and the Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care (2024). Clinical decision support using machine learning and natriuretic peptides for the diagnosis of acute heart failure. European Heart Journal: Acute Cardiovascular Care, 13 (6) zuae064, 515-516. doi: 10.1093/ehjacc/zuae064 |
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2024 Journal Article How to use natriuretic peptides in non-cardiac surgeryDuceppe, Emmanuelle, Mills, Nicholas L, Mueller, Christian, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian, Thielmann, Matthias, Jaffe, Allan S and Study Group on Biomarkers of the ESC Association for Acute Cardiovascular Care (2024). How to use natriuretic peptides in non-cardiac surgery. European Heart Journal: Acute Cardiovascular Care, 13 (4), 380-382. doi: 10.1093/ehjacc/zuae038 |
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2024 Journal Article Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assayPickering, John W, Young, Joanna M, George, Peter M, Watson, Antony S, Aldous, Sally J, Verryt, Toby, Troughton, Richard W, Pemberton, Christopher J, Richards, A Mark, Cullen, Louise A, Apple, Fred S and Than, Martin P (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. The Journal of Applied Laboratory Medicine, 9 (3), 526-539. doi: 10.1093/jalm/jfae001 |
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2024 Journal Article Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trialAltinger, Gemma, Sharma, Sweekriti, Maher, Chris G, Cullen, Louise, McCaffery, Kirsten, Linder, Jeffrey A, Buchbinder, Rachelle, Harris, Ian A, Coiera, Enrico, Li, Qiang, Howard, Kirsten, Coggins, Andrew, Middleton, Paul M, Gunja, Naren, Ferguson, Ian, Chan, Trevor, Tambree, Karen, Varshney, Ajay and Traeger, Adrian C (2024). Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial. BMJ Open, 14 (3) e079870, 1-12. doi: 10.1136/bmjopen-2023-079870 |
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2024 Journal Article Lower limits for reporting high-sensitivity cardiac troponin assays and impact of analytical performance on patient misclassificationAakre, Kristin M., Apple, Fred S., Mills, Nicolas L., Meex, Steven J.R., Collinson, Paul O., on behalf of the International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB), Hammarsten, Ola, Jaffe, Allan S., Omland, Torbjørn, Cullen, Louise (International Federation of Clinical Chemistry (IFCC) Committee on Clinical Applications of Cardiac Biomarkers (C-CB) member) and Sandoval, Yader (2024). Lower limits for reporting high-sensitivity cardiac troponin assays and impact of analytical performance on patient misclassification. Clinical Chemistry, 70 (3), 497-505. doi: 10.1093/clinchem/hvad185 |
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2024 Journal Article External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarctionCullen, Louise, Greenslade, Jaimi H., Stephensen, Laura, Ranasinghe, Isuru, Gaikwad, Niranjan, Khorramshahi Bayat, Maryam, Mahmoodi, Ehsan, Than, Martin, Apple, Fred, Parsonage, William and SAMIE study group 2022 (2024). External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction. Emergency Medicine Journal, 41 (5), 313-319. doi: 10.1136/emermed-2023-213539 |
