Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2023
Journal Article
High-sensitivity cardiac troponin in stable atherosclerotic vascular disease
Morrow, David A., Mills, Nicholas L., Mueller, Christian, Jaffe, Allan, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian and Thielmann, Matthias (2023). High-sensitivity cardiac troponin in stable atherosclerotic vascular disease. European Heart Journal: Acute Cardiovascular Care, 12 (6), 396-398. doi: 10.1093/ehjacc/zuad054
2023
Journal Article
Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations
Doudesis, Dimitrios, Lee, Kuan Ken, Boeddinghaus, Jasper, Bularga, Anda, Ferry, Amy V., Tuck, Chris, Lowry, Matthew T. H., Lopez-Ayala, Pedro, Nestelberger, Thomas, Koechlin, Luca, Bernabeu, Miguel O., Neubeck, Lis, Anand, Atul, Schulz, Karen, Apple, Fred S., Parsonage, William, Greenslade, Jaimi H., Cullen, Louise, Pickering, John W., Than, Martin P., Gray, Alasdair, Mueller, Christian, Mills, Nicholas L., Richards, A. Mark, Pemberton, Chris, Troughton, Richard W., Aldous, Sally J., Brown, Anthony F. T., Dalton, Emily ... CoDE-ACS Investigators (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29 (5), 1201-1210. doi: 10.1038/s41591-023-02325-4
2023
Journal Article
Personalized diagnosis in suspected myocardial infarction
Neumann, Johannes Tobias, Twerenbold, Raphael, Ojeda, Francisco, Aldous, Sally J., Allen, Brandon R., Apple, Fred S., Babel, Hugo, Christenson, Robert H., Cullen, Louise, Di Carluccio, Eleonora, Doudesis, Dimitrios, Ekelund, Ulf, Giannitsis, Evangelos, Greenslade, Jaimi, Inoue, Kenji, Jernberg, Tomas, Kavsak, Peter, Keller, Till, Lee, Kuan Ken, Lindahl, Bertil, Lorenz, Thiess, Mahler, Simon A., Mills, Nicholas L., Mokhtari, Arash, Parsonage, William, Pickering, John W., Pemberton, Christopher J., Reich, Christoph, Richards, A. Mark ... Zournazi, Anna (2023). Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology, 112 (9), 1288-1301. doi: 10.1007/s00392-023-02206-3
2023
Journal Article
Rapid rule-out of myocardial infarction using a single high-sensitivity cardiac troponin I measurement strategy at presentation to the emergency department: The SAFETY Study
Fabre-Estremera, Blanca, Smith, Stephen W., Sandoval, Yader, Schulz, Karen, Okeson, Brynn, Cullen, Louise and Apple, Fred S. (2023). Rapid rule-out of myocardial infarction using a single high-sensitivity cardiac troponin I measurement strategy at presentation to the emergency department: The SAFETY Study. Clinical Chemistry, 69 (6), 627-636. doi: 10.1093/clinchem/hvad033
2023
Journal Article
Snapshot of suspected acute coronary syndrome assessment processes in the emergency department: A national cross‐sectional survey
Brownlee, Emily, Greenslade, Jaimi H, Kelly, Anne‐Maree, Meek, Robert A, Parsonage, William A and Cullen, Louise (2023). Snapshot of suspected acute coronary syndrome assessment processes in the emergency department: A national cross‐sectional survey. Emergency Medicine Australasia, 35 (2), 261-268. doi: 10.1111/1742-6723.14115
2023
Journal Article
Sex differences in epidemiology, care, and outcomes in patients with acute chest pain
Dawson, Luke P., Nehme, Emily, Nehme, Ziad, Davis, Esther, Bloom, Jason, Cox, Shelley, Nelson, Adam J., Okyere, Daniel, Anderson, David, Stephenson, Michael, Lefkovits, Jeffrey, Taylor, Andrew J., Nicholls, Stephen J., Cullen, Louise, Kaye, David, Smith, Karen and Stub, Dion (2023). Sex differences in epidemiology, care, and outcomes in patients with acute chest pain. Journal of the American College of Cardiology, 81 (10), 933-945. doi: 10.1016/j.jacc.2022.12.025
2023
Journal Article
Acute cardiovascular care in the Emergency Department and beyond: a call for interdisciplinary collaboration in clinical research
Platz, Elke, Morrow, David A, Verbrugge, Frederik H, Vranckx, Pascal and Cullen, Louise (2023). Acute cardiovascular care in the Emergency Department and beyond: a call for interdisciplinary collaboration in clinical research. European Heart Journal. Acute Cardiovascular Care, 12 (2), 77-79. doi: 10.1093/ehjacc/zuac170
2023
Journal Article
Chest pain management using prehospital point-of-care troponin and paramedic risk assessment
Dawson, Luke P., Nehme, Emily, Nehme, Ziad, Zomer, Ella, Bloom, Jason, Cox, Shelley, Anderson, David, Stephenson, Michael, Ball, Jocasta, Zhou, Jennifer, Lefkovits, Jeffrey, Taylor, Andrew J., Horrigan, Mark, Chew, Derek P., Kaye, David, Cullen, Louise, Mihalopoulos, Cathrine, Smith, Karen and Stub, Dion (2023). Chest pain management using prehospital point-of-care troponin and paramedic risk assessment. JAMA Internal Medicine, 183 (3), 203-211. doi: 10.1001/jamainternmed.2022.6409
2022
Journal Article
Single high-sensitivity point of care whole blood cardiac troponin I measurement to rule out acute myocardial infarction at low risk
Apple, Fred S., Smith, Stephen W., Greenslade, Jaimi H., Sandoval, Yader, Parsonage, William, Ranasinghe, Isuru, Gaikwad, Niranjan J, Schulz, Karen, Stephensen, Laura, Schmidt, Christian W., Okeson, Brynn and Cullen, Louise (2022). Single high-sensitivity point of care whole blood cardiac troponin I measurement to rule out acute myocardial infarction at low risk. Circulation, 146 (25), 1918-1929. doi: 10.1161/circulationaha.122.061148
2022
Journal Article
Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain
Eggers, Kai M., Hammarsten, Ola, Aldous, Sally J., Cullen, Louise, Greenslade, Jaimi H., Lindahl, Bertil, Parsonage, William A., Pemberton, Christopher J., Pickering, John W., Richards, A. Mark, Troughton, Richard W. and Than, Martin P. (2022). Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain. PLoS One, 17 (11) e0276645, 1-14. doi: 10.1371/journal.pone.0276645
2022
Journal Article
Cardiac biomarkers in the field of cardio-oncology
Cardinale, Daniela, Mills, Nicholas L., Mueller, Christian, Jaffe, Allan, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian and Thielmann, Matthias (2022). Cardiac biomarkers in the field of cardio-oncology. European Heart Journal: Acute Cardiovascular Care, 11 (11), E1-E2. doi: 10.1093/ehjacc/zuac126
2022
Journal Article
The retirement of CKMB
Jaffe, Allan S., Mills, Nicholas L., Mueller, Christian, Giannitsis, Evangelos, Daniels, Lori, Huber, Kurt, Mair, Johannes, Cullen, Louise, Hammarsten, Ola, Möckel, Martin, Krychtiuk, Konstantin, Thygesen, Kristian and Study Group on Biomarkers of the ESC Association for Acute CardioVascular Care (2022). The retirement of CKMB. European Heart Journal: Acute Cardiovascular Care, 11 (10), 784-785. doi: 10.1093/ehjacc/zuac113
2022
Conference Publication
Machine learning to optimise use of cardiac troponin in the diagnosis of acute myocardial infarction
Doudesis, D., Lee, K. K., Bularga, A., Ferry, A. V., Tuck, C., Anand, A., Boeddinghaus, J., Mueller, C., Greenslade, J. H., Pickering, J. W., Than, M. P., Cullen, L. and Mills, N. L. (2022). Machine learning to optimise use of cardiac troponin in the diagnosis of acute myocardial infarction. ESC Congress 2022, Barcelona, Spain, 26-29 August 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/eurheartj/ehac544.1349
2022
Journal Article
Performance of the American Heart Association/American College of Cardiology/Heart Rhythm Society versus European Society of Cardiology guideline criteria for hospital admission of patients with syncope
du Fay de Lavallaz, Jeanne, Zimmermann, Tobias, Badertscher, Patrick, Lopez-Ayala, Pedro, Nestelberger, Thomas, Miró, Òscar, Salgado, Emilio, Zaytseva, Xenia, Gafner, Michele Sara, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Sigal, Alan, Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Strebel, Ivo, Schuler, Sereina, Manka, Robert, Bilici, Murat, Lohrmann, Jens, Kühne, Michael, Breidthardt, Tobias, Clark, Carol L. ... Storrow, Alan B. (2022). Performance of the American Heart Association/American College of Cardiology/Heart Rhythm Society versus European Society of Cardiology guideline criteria for hospital admission of patients with syncope. Heart Rhythm, 19 (10), 1712-1722. doi: 10.1016/j.hrthm.2022.05.024
2022
Journal Article
How is cardiac troponin released from cardiomyocytes?
Hammarsten, Ola, Wernbom, Mathias, Mills, Nicholas L., Mueller, Christian, Giannitsis, Evangelos, Jaffe, Allan S., Huber, Kurt, Mair, Johannes, Cullen, Louise, Möckel, Martin, Krychtiuk, Konstantin and Thygesen, Kristian (2022). How is cardiac troponin released from cardiomyocytes?. European Heart Journal: Acute Cardiovascular Care, 11 (9), 718-720. doi: 10.1093/ehjacc/zuac091
2022
Journal Article
Diagnoses and trends in use of imaging for low back pain in four Australian emergency departments between 2012 and 2019
Blokzijl, Johan, Lee, Hopin, Cullen, Louise, Coggins, Andrew, Golding, Michael, Gillett, Mark, Middleton, Paul M, Ferreira, Giovanni E, Machado, Gustavo C, Maher, Christopher G and Traeger, Adrian C (2022). Diagnoses and trends in use of imaging for low back pain in four Australian emergency departments between 2012 and 2019. Emergency Medicine Australasia, 34 (4), 539-546. doi: 10.1111/1742-6723.13928
2022
Journal Article
Clinical utility of D-dimer for rule-out or rule-in of venous thromboembolism in syncope
Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Mueller, Christian, Zimmermann, Tobias, Lopez-Ayala, Pedro, Nestelberger, Thomas, Gualandro, Danielle M., Miró, Òscar, Keller, Dagmar I., Martin-Sanchez, F. Javier, Bürgler, Franz, Than, Martin, Widmer, Velina, Christ, Michael, Cullen, Louise, Di Somma, Salvatore, Peacock, W. Frank, Geigy, Nicolas, Kühne, Michael, Freese, Michael, Salgado, Emilio, Martinez-Nadal, Gemma, Inostroza, Carolina Isabel Fuenzalida, Costabel, Juan Pablo, Mandrión, José Bustamante, Poepping, Imke, Rentsch, Katharina, von Eckardstein, Arnold ... Lohrmann, Jens (2022). Clinical utility of D-dimer for rule-out or rule-in of venous thromboembolism in syncope. Journal of Cardiovascular Translational Research, 16 (2), 427-429. doi: 10.1007/s12265-022-10306-0
2022
Journal Article
Chest pain workup in the presence of atrial fibrillation: impacts on troponin testing, myocardial infarction diagnoses, and long-term prognosis
Lancini, Daniel, Greenslade, Jaimi, Martin, Paul, Prasad, Sandhir, Atherton, John, Parsonage, William, Aldous, Sally, Than, Martin and Cullen, Louise (2022). Chest pain workup in the presence of atrial fibrillation: impacts on troponin testing, myocardial infarction diagnoses, and long-term prognosis. European Heart Journal. Acute Cardiovascular Care, 11 (10), 772-781. doi: 10.1093/ehjacc/zuac090
2022
Conference Publication
Effect of a waiting room communication strategy on imaging rates and awareness of public health messages for low back pain in the emergency department
Sharma, Sweekriti, Traeger, Adrian, Tcharkhedian, Elise, Middleton, Paul, Cullen, Louise and Maher, Chris G. (2022). Effect of a waiting room communication strategy on imaging rates and awareness of public health messages for low back pain in the emergency department. OXFORD: OXFORD UNIV PRESS.
2022
Journal Article
Emergency department assessment of suspected acute coronary syndrome using the IMPACT pathway in Aboriginal and Torres Strait Islander people
Cullen, Louise, Stephensen, Laura, Greenslade, Jaimi, Starmer, Katrina, Starmer, Greg, Stone, Richard, Bonnin, Robert, Brazzale, Anthony, Drahm-Butler, Tileah, Campbell, Virginia, Davis, Tania, Mowatt, Elizabeth, Brown, Nathan J., Proctor, Karlie, Ashover, Sarah, Milburn, Tanya, McCormack, Louise, Graves, Nicholas and Parsonage, William (2022). Emergency department assessment of suspected acute coronary syndrome using the IMPACT pathway in Aboriginal and Torres Strait Islander people. Heart Lung and Circulation, 31 (7), 1029-1036. doi: 10.1016/j.hlc.2022.02.010
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study
Principal Advisor
-
Doctor Philosophy
Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study
Principal Advisor
Completed supervision
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2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
-
2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
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