Dr Nicole Warrington
Dr

Nicole Warrington

Email: 
Phone: 
+61 7 344 37347

Background

Dr Nicole Warrington is a NHMRC Emerging Leadership Fellow at the University of Queensland Institute for Molecular Bioscience. She has a strong background in statistical genetics and has been actively working towards understanding the genetic determinants of early life growth. Dr Warrington studied a Bachelor of Science at Victoria University in Wellington, New Zealand, majoring in Mathematical Statistics and Psychology. She then completed an honours degree at The University of Western Australia, where she developed a keen interest for genetics, and was subsequently awarded an Australian Postgraduate Award to complete her PhD in statistical genetics and life-course epidemiology. During her PhD she spent time at the University of Toronto to gain experience in statistical modelling methods for longitudinal growth trajectories and conducted the first genome-wide association study of longitudinal growth trajectories over childhood. After completing her PhD, Dr Warrington started at the University of Queensland and focused on using genetics to inform about the relationship between birth weight and cardio-metabolic diseases in later life. She pioneered a new statistical method to partition genetic effects on birth weight into maternal and fetal components, and combined this method with a causal modelling approach, Mendelian randomization. This method was instrumental in demonstrating the relationship between birth weight and adult hypertension is driven by genetic effects, over-turning 30 years of research into the effects of intrauterine programming. More recently, her research focus has broadened to determine whether rapid weight growth across early life, including fetal development, childhood and adolescence, causally increases risk of cardio-metabolic disease and in doing so, hopes to identify optimal times across the life-course where interventions could reduce the incidence of cardio-metabolic diseases.

Availability

Dr Nicole Warrington is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Biostatistics Foetal development and medicine Gene mapping Genetics Mathematical Sciences Statistics

Qualifications

  • Doctor of Philosophy, University of Western Australia

Research interests

  • Developmental origins of health and disease

    The development of obesity often occurs in early life and tends to persist into adulthood. Unfavourable growth in early life is also associated with adverse cardio-metabolic outcomes in later life, such as type two diabetes and heart disease. Understanding the mechanisms underlying this relationship is a vital step in combating these lifestyle diseases and evaluating the likely success of early interventions. This research aims to address the following questions: (a) What maternal characteristics modify the early life environment and cause rapid early life weight growth in her offspring? (b) Is there a time period in early life where rapid weight growth causes increased risk of cardio-metabolic disease in later life, independent of adult obesity? Dr Warrington is a leading member of the Early Growth Genetics (EGG) consortium, which brings together studies from around the world with growth related phenotypes and genetic data in order to conduct large-scale genetic research. The EGG consortium have conducted several large genome-wide association studies of growth phenotypes, which are published in high impact journals including Nature and Nature Genetics. The results from these genome-wide association studies are then used to perform causal modelling to help disentangle the relationship between childhood growth and later life cardio-metabolic disease risk.

Search Professor Nicole Warrington’s works on UQ eSpace

120 works between 2007 and 2024
All (120) Journal Article (103) Book Chapter (1) Conference Publication (13) Other Outputs (3)

81 - 100 of 120 works

2013

Journal Article

Common variation contributes to the genetic architecture of social communication traits

St Pourcain, Beate, Whitehouse, Andrew J. O., Ang, Wei Q., Warrington, Nicole M., Glessner, Joseph T., Wang, Kai, Timpson, Nicholas J., Evans, David M., Kemp, John P., Ring,Susan M., McArdle, Wendy L., Golding, Jean, Hakonarson, Hakon, Pennell, Craig E. and Smith, George Davey (2013). Common variation contributes to the genetic architecture of social communication traits. Molecular Autism, 4 (1) 34, 34.1-34.12. doi: 10.1186/2040-2392-4-34

Common variation contributes to the genetic architecture of social communication traits

2012

Journal Article

Genome-wide meta-analysis of common variant differences between men and women

Boraska, Vesna, Jeroncic, Ana, Colonna, Vincenza, Southam, Lorraine, Nyholt, Dale R., Rayner, Nigel William, Perry, John R. B., Toniolo, Daniela, Albrecht, Eva, Ang, Wei, Bandinelli, Stefania, Barbalic, Maja, Barroso, Ines, Beckmann, Jacques S., Biffar, Reiner, Boomsma, Dorret, Campbell, Harry, Corre, Tanguy, Erdmann, Jeanette, Esko, Tonu, Fischer, Krista, Franceschini, Nora, Frayling, Timothy M., Girotto, Giorgia, Gonzalez, Juan R., Harris, Tamara B., Heath, Andrew C., Heid, Iris M., Hoffmann, Wolfgang ... Zeggini, Eleftheria (2012). Genome-wide meta-analysis of common variant differences between men and women. Human Molecular Genetics, 21 (21) dds304, 4805-4815. doi: 10.1093/hmg/dds304

Genome-wide meta-analysis of common variant differences between men and women

2012

Journal Article

Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood

Rye, Marie S., Warrington, Nicole M., Scaman, Elizabeth S. H., Vijayasekaran, Shyan, Coates, Harvey L., Anderson, Denise, Pennell, Craig E., Blackwell, Jenefer M. and Jamieson, Sarra E. (2012). Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood. PLoS One, 7 (10) e48215, e48215.1-e48215.12. doi: 10.1371/journal.pone.0048215

Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood

2012

Journal Article

Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J. ... Middeldorp, Christel (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532-538. doi: 10.1038/ng.2238

Common variants at 12q15 and 12q24 are associated with infant head circumference

2012

Journal Article

A genome-wide association meta-analysis identifies new childhood obesity loci

Bradfield, Jonathan P., Taal, H. Rob, Timpson, Nicholas J., Scherag, André, Lecoeur, Cecile, Warrington, Nicole M., Hypponen, Elina, Holst, Claus, Valcarcel, Beatriz, Thiering, Elisabeth, Salem, Rany M., Schumacher, Fredrick R., Cousminer, Diana L., Sleiman, Patrick M. A., Zhao, Jianhua, Berkowitz, Robert I., Vimaleswaran, Karani S., Jarick, Ivonne, Pennell, Craig E., Evans, David M., St Pourcain, Beate, Berry, Diane J., Mook-Kanamori, Dennis O., Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, André G., van Duijn, Cornelia M., van der Valk, Ralf J. P., de Jongste, Johan C. ... Grant, Struan F. A. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526-531. doi: 10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

2012

Journal Article

Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

Louise, Sandra, Warrington, Nicole M., McCaskie, Pamela A., Oddy, Wendy H., Zubrick, Stephen R., Hands, Beth, Mori, Trevor A., Briollais, Laurent, Silburn, Sven, Palmer, Lyle J., Mattes, Eugen and Beilin, Lawrence J. (2012). Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study. Preventive Medicine, 54 (5), 345-350. doi: 10.1016/j.ypmed.2012.03.004

Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

2012

Journal Article

Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts

Boraska, Vesna, Day-Williams, Aaron, Franklin, Christopher S., Elliott, Katherine S., Panoutsopoulou, Kalliope, Tachmazidou, Ioanna, Albrecht, Eva, Bandinelli, Stefania, Beilin, Lawrence J., Bochud, Murielle, Cadby, Gemma, Ernst, Florian, Evans, David M., Hayward, Caroline, Hicks, Andrew A., Huffman, Jennifer, Huth, Cornelia, James, Alan L., Klopp, Norman, Kolcic, Ivana, Kutalik, Zoltan, Lawlor, Debbie A., Musk, Arthur W., Pehlic, Marina, Pennell, Craig E., Perry, John R. B., Peters, Annette, Polasek, Ozren, St Pourcain, Beate ... Zeggini, Eleftheria (2012). Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts. Plos One, 7 (3) e31369, e31369.1-e31369.10. doi: 10.1371/journal.pone.0031369

Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts

2012

Journal Article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Paternoster, Lavinia, Standl, Marie, Chen, Chi-Mei, Ramasamy, Adaikalavan, Bonnelykke, Klaus, Duijts, Liesbeth, Ferreira, Manuel A., Alves, Alexessander C., Thyssen, Jacob P., Albrecht, Eva, Baurecht, Hansjorg, Feenstra, Bjarke, Sleiman, Patrick M. A., Hysi, Piro, Warrington, Nicole M., Curjuric, Ivan, Myhre, Ronny, Curtin, John A., Groen-Blokhuis, Maria M., Kerkhof, Marjan, Saaf, Annika, Franke, Andre, Ellinghaus, David, Folster-Holst, Regina, Dermitzakis, Emmanouil, Montgomery, Stephen B., Prokisch, Holger, Heim, Katharina, Hartikainen, Anna-Lisa ... EArly Genetics Lifecourse Epidemiology (EAGLE) Consortium (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44 (2), 187-192. doi: 10.1038/ng.1017

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

2012

Journal Article

Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: An effect that is reversed in the offspring of smoking mothers

Marsh, J. A., Pennell, C. E., Warrington, N. M., Mook-Kanamori, D., Briollais, L., Lye, S. J., Beilin, L. J., Steegers, E., Hofman, A., Jaddoe, V. W. V., Newnham, J.P. and Palmer, L. J. (2012). Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: An effect that is reversed in the offspring of smoking mothers. Journal of Developmental Origins of Health and Disease, 3 (1), 10-20. doi: 10.1017/S2040174411000638

Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: An effect that is reversed in the offspring of smoking mothers

2012

Journal Article

Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations

Middelberg, Rita P., Benyamin, Beben, de Moor, Marleen H. M., Warrington, Nicole M., Gordon, Scott, Henders, Anjali K., Medland, Sarah E., Nyholt, Dale R., de Geus, Eco J. C., Hottenga, Jouke J., Willemsen, Gonneke, Beilin, Lawrence J., Mori, Trevor A., Wright, Margaret J., Heath, Andrew C., Madden, Pamela A. F., Boomsma, Dorret I., Pennell, Craig E., Montgomery, Grant W., Martin, Nicholas G. and Whitfield, John B. (2012). Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations. Human Molecular Genetics, 21 (2) ddr478, 446-455. doi: 10.1093/hmg/ddr478

Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations

2012

Journal Article

Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents

Skouen, J. S., Smith, A. J., Warrington, N. M., O'Sullivan, P. B., McKenzie, L., Pennell, C. E. and Straker, L. M. (2012). Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents. European Journal of Pain (United Kingdom), 16 (9), 1232-1242. doi: 10.1002/j.1532-2149.2012.00131.x

Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents

2012

Journal Article

Associations between aggressive behaviour scores and cardiovascular risk factors in childhood

Louise, S., Warrington, N. M., McCaskie, P. A., Oddy, W. H., Zubrick, S. R., Hands, B., Mori, T. A., Briollais, L., Silburn, S., Palmer, L. J., Mattes, E. and Beilin, L. J. (2012). Associations between aggressive behaviour scores and cardiovascular risk factors in childhood. Pediatric Obesity, 7 (4), 319-328. doi: 10.1111/j.2047-6310.2012.00047.x

Associations between aggressive behaviour scores and cardiovascular risk factors in childhood

2012

Journal Article

Role of the TCF4 gene intronic variant in normal variation of corneal endothelium

MacKey, David A., Warrington, Nicole M., Hewitt, Alex W., Oates, Sandra K., Yazar, Seyhan, Soloshenko, Alla, Crawford, Geoffrey J., Mountain, Jenny A. and Pennell, Craig E. (2012). Role of the TCF4 gene intronic variant in normal variation of corneal endothelium. Cornea, 31 (2), 162-166. doi: 10.1097/ICO.0b013e318226155f

Role of the TCF4 gene intronic variant in normal variation of corneal endothelium

2012

Journal Article

The impact of breastfeeding on FTO-related BMI growth trajectories: An application to the Raine pregnancy cohort study

Abarin, Taraneh, wu, Yan Yan, Warrington, Nicole, Lye, Stephen, Pennell, Craig and Briollais, Laurent (2012). The impact of breastfeeding on FTO-related BMI growth trajectories: An application to the Raine pregnancy cohort study. International Journal of Epidemiology, 41 (6) dys171, 1650-1660. doi: 10.1093/ije/dys171

The impact of breastfeeding on FTO-related BMI growth trajectories: An application to the Raine pregnancy cohort study

2011

Journal Article

Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data

Webster,Rebecca J., Carter, Kim W., Warrington, Nicole M., Loh, Angeline M., Zaloumis, Sophie, Kuijpers, Taco W., Palmer, Lyle J. and Burgner, David P. (2011). Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data. PLoS One, 6 (11) e28004, e28004.1-e28004.11. doi: 10.1371/journal.pone.0028004

Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data

2011

Journal Article

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Artigas, M.S., Loth, D.W., Wain, L.V., Gharib, S.A., Obeidat, M., Tang, W.B., Zhai, G.J., Zhao, J.H., Smith, A.V., Huffman, J.E., Albrecht, E., Jackson, C.M., Evans, D.M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L.M., Johnson, T., Aldrich, M.C., Aspelund, T., Barroso, I., Campbell, H., Cassano, P.A., Couper, D.J., Eiriksdottir, G., Franceschini, N., Garcia, M., Gieger, C., Gislason, G.K. ... GIANT Consortium (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43 (11), 1082-1090. doi: 10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

2011

Journal Article

Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals

Kilpelainen T.O., Den Hoed M., Ong K.K., Grontved A., Brage S., Jameson K., Cooper C., Khaw K.-T., Ekelund U., Wareham N.J., Loos R.J.F., Freathy R.M., Mook-Kanamori D.O., Sovio U., Prokopenko I., Timpson N.J., Berry D.J., Warrington N.M., Widen E., Hottenga J.J., Kaakinen M., Lange L.A., Bradfield J.P., Kerkhof M., Marsh J.A., Magi R., Chen C.-M., Lyon H.N., Kirin M. ... McCarthy M.I. (2011). Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851-860. doi: 10.3945/ajcn.110.000828

Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals

2011

Journal Article

Association of genetic loci with glucose levels in childhood and adolescence: A meta-analysis of over 6,000 children

Barker, Adam, Sharp, Stephen J., Timpson, Nicholas J., Bouatia-Naji, Nabila, Warrington, Nicole M., Kanoni, Stavroula, Beilin, Lawrence J., Brage, Soren, Deloukas, Panos, Evans, David M., Grontved, Anders, Hassanali, Neelam, Lawlor, Deborah A., Lecoeur, Cecile, Loos, Ruth J.F., Lye, Stephen J., McCarthy, Mark I., Mori, Trevor A., Ndiaye, Ndeye Coumba, Newnham, John P., Ntalla, Ioanna, Pennell, Craig E., St Pourcain, Beate, Prokopenko, Inga, Ring, Susan M., Sattar, Naveed, Visvikis-Siest, Sophie, Dedoussis, George V., Palmer, Lyle J. ... Langenberg, Claudia (2011). Association of genetic loci with glucose levels in childhood and adolescence: A meta-analysis of over 6,000 children. Diabetes, 60 (6), 1805-1812. doi: 10.2337/db10-1575

Association of genetic loci with glucose levels in childhood and adolescence: A meta-analysis of over 6,000 children

2011

Journal Article

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC) and Warrington, N. (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ, 342 (7794) d548, d548.1-d548.8. doi: 10.1136/bmj.d548

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

2011

Journal Article

Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters

Mook-Kanamori, Dennis O., Marsh, Julie A., Warrington, Nicole M., Taal, H. Rob, Newnham, John P., Beilin, Lawrie J., Lye, Stephen J., Palmer, Lyle J., Hofman, Albert, Steegers, Eric A. P., Pennell, Craig E. and Jaddoe, Vincent W. V. (2011). Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters. Journal of Clinical Endocrinology and Metabolism, 96 (5), E810-E815. doi: 10.1210/jc.2010-2316

Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters

Current funding

  • 2022 - 2027
    Using genetics to identify optimal times to intervene on early life growth and reduce future risk of cardio-metabolic disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2019 - 2022
    Identifying maternal and fetal genetic determinants of infant birthweight and their relationship to offspring cardiometabolic risk
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Investigating the Genetic Correlation Underlying the Developmental Origins of Health and Disease
    NHMRC Early Career Fellowships
    Open grant
  • 2015
    Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2015
    Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life.
    UQ Early Career Researcher
    Open grant

Availability

Dr Nicole Warrington is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health

    Principal Advisor

    Other advisors: Honorary Professor Jake Gratten, Professor David Evans

  • Doctor Philosophy

    Investigating the time and tissue dependent genetic architecture of complex traits

    Associate Advisor

    Other advisors: Professor Loic Yengo

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Associate Advisor

    Other advisors: Dr John Kemp

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Associate Advisor

    Other advisors: Dr John Kemp

  • Doctor Philosophy

    Investigating the time and tissue dependent genetic architecture of complex traits

    Associate Advisor

    Other advisors: Professor Loic Yengo

  • Doctor Philosophy

    Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease

    Associate Advisor

    Other advisors: Professor David Evans

  • Doctor Philosophy

    Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis

    Associate Advisor

    Other advisors: Dr John Kemp

Completed supervision

Enquiries

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