Dr Nicole Warrington
Dr

Nicole Warrington

Email: 
Phone: 
+61 7 344 37347

Background

Dr Nicole Warrington is a NHMRC Emerging Leadership Fellow at the University of Queensland Institute for Molecular Bioscience. She has a strong background in statistical genetics and has been actively working towards understanding the genetic determinants of early life growth. Dr Warrington studied a Bachelor of Science at Victoria University in Wellington, New Zealand, majoring in Mathematical Statistics and Psychology. She then completed an honours degree at The University of Western Australia, where she developed a keen interest for genetics, and was subsequently awarded an Australian Postgraduate Award to complete her PhD in statistical genetics and life-course epidemiology. During her PhD she spent time at the University of Toronto to gain experience in statistical modelling methods for longitudinal growth trajectories and conducted the first genome-wide association study of longitudinal growth trajectories over childhood. After completing her PhD, Dr Warrington started at the University of Queensland and focused on using genetics to inform about the relationship between birth weight and cardio-metabolic diseases in later life. She pioneered a new statistical method to partition genetic effects on birth weight into maternal and fetal components, and combined this method with a causal modelling approach, Mendelian randomization. This method was instrumental in demonstrating the relationship between birth weight and adult hypertension is driven by genetic effects, over-turning 30 years of research into the effects of intrauterine programming. More recently, her research focus has broadened to determine whether rapid weight growth across early life, including fetal development, childhood and adolescence, causally increases risk of cardio-metabolic disease and in doing so, hopes to identify optimal times across the life-course where interventions could reduce the incidence of cardio-metabolic diseases.

Availability

Dr Nicole Warrington is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Biostatistics Foetal development and medicine Gene mapping Genetics Mathematical Sciences Statistics

Qualifications

  • Doctor of Philosophy, University of Western Australia

Research interests

  • Developmental origins of health and disease

    The development of obesity often occurs in early life and tends to persist into adulthood. Unfavourable growth in early life is also associated with adverse cardio-metabolic outcomes in later life, such as type two diabetes and heart disease. Understanding the mechanisms underlying this relationship is a vital step in combating these lifestyle diseases and evaluating the likely success of early interventions. This research aims to address the following questions: (a) What maternal characteristics modify the early life environment and cause rapid early life weight growth in her offspring? (b) Is there a time period in early life where rapid weight growth causes increased risk of cardio-metabolic disease in later life, independent of adult obesity? Dr Warrington is a leading member of the Early Growth Genetics (EGG) consortium, which brings together studies from around the world with growth related phenotypes and genetic data in order to conduct large-scale genetic research. The EGG consortium have conducted several large genome-wide association studies of growth phenotypes, which are published in high impact journals including Nature and Nature Genetics. The results from these genome-wide association studies are then used to perform causal modelling to help disentangle the relationship between childhood growth and later life cardio-metabolic disease risk.

Search Professor Nicole Warrington’s works on UQ eSpace

117 works between 2007 and 2024
All (117) Journal Article (103) Book Chapter (1) Conference Publication (13)

101 - 117 of 117 works

2010

Journal Article

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C. Y., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J. J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., McArdle, P. F., Smith, A. V., Stolk, L., Van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K. E. ... GIANT Consortium (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42 (12), 1077-1085. doi: 10.1038/ng.714

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

2010

Journal Article

The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

Webster, Rebecca J., Warrington, Nicole M., Beilby, John P., Frayling, Timothy M. and Palmer, Lyle J. (2010). The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. BMC Medical Genetics, 11 (1) 140. doi: 10.1186/1471-2350-11-140

The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

2010

Journal Article

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1

Warrington, Nicole M., Gianino, Scott M., Jackson, Erin, Goldhoff, Patricia, Garbow, Joel R., Piwnica-Worms, David, Gutmann, David H. and Rubin, Joshua B. (2010). Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Research, 70 (14), 5717-5727. doi: 10.1158/0008-5472.CAN-09-3769

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1

2010

Journal Article

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

Burgess, S., Thompson, S. G., Andrews, G., Samani, N. J., Hall, A., Whincup, P., Morris, R., Lawlor, D. A., Davey Smith, G., Timpson, N., Ebrahim, S., Ben-Shlomo, Y., Brown, M., Ricketts, S., Sandhu, M., Reiner, A., Psaty, B., Lange, L., Cushman, M., Hung, J., Thompson, P., Beilby, J., Warrington, N., Palmer, L. J., Nordestgaard, B. G., Tybjaerg-Hansen, A., Zacho, J., Wu, C., Lowe, G. ... Whittaker, J. (2010). Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Statistics in Medicine, 29 (12), 1298-1311. doi: 10.1002/sim.3843

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

2010

Journal Article

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, Rachel M., Mook-Kanamor, Dennis O., Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J., Berry, Diane J., Warrington, Nicole M., Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A., Bradfield, Jonathan P., Kerkhof, Marjan, Marsh, Julie A., Magi, Reedik, Chen, Chih-Mei, Lyon, Helen N., Kirin, Mirna, Adair, Linda S., Aulchenko, Yurii S., Bennett, Amanda J., Borja, Judith B., Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan ..J. M., Cousminer, Diana L., De Geus, Eco J. C., Deloukas, Panos, Elliott, Paul ... McCarthy, Mark I. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430-435. doi: 10.1038/ng.567

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

2010

Journal Article

Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

Golledge, Jonathan, Biros, Erik, Cooper, Matthew, Warrington, Nicole, Palmer, Lyle J. and Norman, Paul E. (2010). Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm. Atherosclerosis, 209 (2), 487-491. doi: 10.1016/j.atherosclerosis.2009.09.027

Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

2010

Journal Article

Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients

Tan, Joo-Huang, Price, Patricia, Gut, Ivo, Stacey, Michael C., Warrington, Nicole M. and Wallace, Hilary J. (2010). Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. Human Immunology, 71 (12), 1214-1219. doi: 10.1016/j.humimm.2010.09.001

Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients

2009

Journal Article

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

Ferreira, MAR, Hottenga, JJ, Warrington, NM, Medland, SE, Willemsen, G, Lawrence, RW, Gordon, S, de Geus, EJC, Henders, AK, Smit, JH, Campbell, MJ, Wallace, L, Evans, DM, Wright, MJ, Nyholt, DR, James, AL, Beilby, JP, Penninx, BW, Palmer, LJ, Frazer, IH, Montgomery, GW, Martin, NG and Boomsma, DI (2009). Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume. AMERICAN JOURNAL OF HUMAN GENETICS, 85 (5), 745-749. doi: 10.1016/j.ajhg.2009.10.005

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

2009

Journal Article

Analyses of associations with asthma in four asthma population samples from Canada and Australia

Daley, Denise, Lemire, Mathieu, Akhabir, Loubna, Chan-Yeung, Moira, He, Jian Qing, McDonald, Treena, Sandford, Andrew, Stefanowicz, Dorota, Tripp, Ben, Zamar, David, Bosse, Yohan, Ferretti, Vincent, Montpetit, Alexandre, Tessier, Marie-Catherine, Becker, Allan, Kozyrskyj, Anita L., Beilby, John, McCaskie, Pamela A., Musk, Bill, Warrington, Nicole, James, Alan, Laprise, Catherine, Palmer, Lyle J., Pare, Peter D. and Hudson, Thomas J. (2009). Analyses of associations with asthma in four asthma population samples from Canada and Australia. Human Genetics, 125 (4), 445-459. doi: 10.1007/s00439-009-0643-8

Analyses of associations with asthma in four asthma population samples from Canada and Australia

2009

Journal Article

The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populations

McClenaghan, J., Warrington, N. M., Jamrozik, E. F., Hui, J., Beilby, J. P., Hansen, J., De Klerk, N. H., James, A. L., Musk, A. W. and Palmer, L. J. (2009). The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populations. Thorax, 64 (7), 620-625. doi: 10.1136/thx.2008.108985

The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populations

2009

Journal Article

The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

Webster, R. J., Warrington, N. M., Weedon, M. N., Hattersley, A. T., McCaskie, P. A., Beilby, J. P., Palmer, L. J. and Frayling, T. M. (2009). The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia, 52 (1), 106-114. doi: 10.1007/s00125-008-1175-9

The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

2009

Journal Article

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Gudbjartsson, Daniel F., Bjornsdottir, Unnur S., Halapi, Eve, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M., Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M., James, Alan, Palmer, Lyle J., Koppelman, Gerard H., Heinzmann, Andrea, Krueger, Marcus, Boezen, H. Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M. ... Stefansson, Kari (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41 (3), 342-347. doi: 10.1038/ng.323

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

2009

Journal Article

Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm

Smallwood, L., Warrington, N., Allcock, R., van Bockxmeer, F., Palmer, L. J., Iacopetta, B., Golledge, J. and Norman, P. E. (2009). Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery, 38 (2), 169-171. doi: 10.1016/j.ejvs.2009.04.019

Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm

2008

Journal Article

The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants

Lawlor, Debbie A., Harbord, Roger M., Timpson, Nic J., Lowe, Gordon D. O., Rumley, Ann, Gaunt, Tom R., Baker, Ian, Yarnell, John W. G., Kivimäki, Mika, Kumari, Meena, Norman, Paul E., Jamrozik, Konrad, Hankey, Graeme J., Almeida, Osvaldo P., Flicker, Leon, Warrington, Nicole, Marmot, Michael G., Ben-Shlomo, Yoav, Palmer, Lyle J., Day, Ian N. M., Ebrahim, Shah and Smith, George Davey (2008). The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One, 3 (8) e3011, e3011.1-e3011.14. doi: 10.1371/journal.pone.0003011

The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants

2008

Journal Article

Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm

Smallwood, L., Allcock, R., van Bockxmeer, F., Warrington, N., Palmer, L. J., Iacopetta, B. and Norman, P. E. (2008). Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery, 35 (1), 31-36. doi: 10.1016/j.ejvs.2007.08.021

Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm

2008

Journal Article

Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

Smallwood, L., Allcock, R., Van Bockxmeer, F., Warrington, N., Palmer, L. J., Iacopetta, B., Golledge, J. and Norman, P. E. (2008). Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm. British Journal of Surgery, 95 (10), 1239-1244. doi: 10.1002/bjs.6345

Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

2007

Journal Article

Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1

Warrington, Nicole M., Woerner, B. Mark, Daginakatte, Girish C., Dasgupta, Biplab, Perry, Arie, Gutmann, David H. and Rubin, Joshua B. (2007). Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1. Cancer Research, 67 (18), 8588-8595. doi: 10.1158/0008-5472.CAN-06-2220

Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1

Current funding

  • 2022 - 2027
    Using genetics to identify optimal times to intervene on early life growth and reduce future risk of cardio-metabolic disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2019 - 2022
    Identifying maternal and fetal genetic determinants of infant birthweight and their relationship to offspring cardiometabolic risk
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Investigating the Genetic Correlation Underlying the Developmental Origins of Health and Disease
    NHMRC Early Career Fellowships
    Open grant
  • 2015
    Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2015
    Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life.
    UQ Early Career Researcher
    Open grant

Availability

Dr Nicole Warrington is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health

    Principal Advisor

    Other advisors: Honorary Professor Jake Gratten, Professor David Evans

  • Doctor Philosophy

    Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease

    Associate Advisor

    Other advisors: Professor David Evans

  • Doctor Philosophy

    Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis

    Associate Advisor

    Other advisors: Dr John Kemp

  • Doctor Philosophy

    Investigating the time and tissue dependent genetic architecture of complex traits

    Associate Advisor

    Other advisors: Professor Loic Yengo

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Associate Advisor

    Other advisors: Dr John Kemp

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Associate Advisor

    Other advisors: Dr John Kemp

  • Doctor Philosophy

    Investigating the time and tissue dependent genetic architecture of complex traits

    Associate Advisor

    Other advisors: Professor Loic Yengo

Completed supervision

Enquiries

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