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2011 Journal Article Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimersKaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2011). Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Molecular Pharmaceutics, 8 (2), 338-349. doi: 10.1021/mp1001872 |
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2009 Journal Article PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in ratsKaminskas, Lisa M., Kota, Jagannath, McLeod, Victoria M., Kelly, Brian D., Karellas, Peter and Porter, Christopher J. H. (2009). PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats. Journal of Controlled Release, 140 (2), 108-116. doi: 10.1016/j.jconrel.2009.08.005 |
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2009 Journal Article Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimersKaminskas, L. M., Wu, Z., Barlow, N., Krippner, G. Y., Boyd, B. J. and Porter, C. J. H. (2009). Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers. Journal of Pharmaceutical Sciences, 98 (10), 3871-3875. doi: 10.1002/jps.21692 |
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2009 Journal Article Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimersKaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Boyd, Ben J., Krippner, Guy Y., Williams, Elizabeth D. and Porter, Christopher J. H. (2009). Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers. Molecular Pharmaceutics, 6 (4), 1190-1204. doi: 10.1021/mp900049a |
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2008 Journal Article The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimersKaminskas, Lisa M., Boyd, Ben J., Karellas, Peter, Krippner, Guy Y., Lessene, Romina, Kelly, Brian and Porter, Chrisiopher J. H. (2008). The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimers. Molecular Pharmaceutics, 5 (3), 449-463. doi: 10.1021/mp7001208 |
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2008 Journal Article Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injuryBurcham, P. C., Kaminskas, L. M., Tan, D. and Pyke, S. M. (2008). Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury. Mini-Reviews in Medicinal Chemistry, 8 (4), 319-330. doi: 10.2174/138955708783955953 |
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2007 Journal Article Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and dispositionKaminskas, Lisa M., Boyd, Ben J., Karellas, Peter, Henderson, Scott A., Giannis, Michael P., Krippner, Guy Y. and Porter, Christopher J. H. (2007). Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition. Molecular Pharmaceutics, 4 (6), 949-961. doi: 10.1021/mp070047s |
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2007 Journal Article Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugsKaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2007). Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs. Rapid Communications in Mass Spectrometry, 21 (7), 1155-1164. doi: 10.1002/rcm.2945 |
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2006 Journal Article Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to ratsBoyd, Ben J., Kaminskas, Lisa M., Karellas, Peter, Krippner, Guy, Lessene, Romina and Porter, Christopher J. H. (2006). Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Molecular Pharmaceutics, 3 (5), 614-627. doi: 10.1021/mp060032e |
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2005 Journal Article Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytesKaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2005). Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes. Chemical Research in Toxicology, 18 (11), 1627-1633. doi: 10.1021/tx0502387 |
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2004 Journal Article Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehydeKaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2004). Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Organic and Biomolecular Chemistry, 2 (18), 2578-2584. doi: 10.1039/b408796h |
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2004 Journal Article Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in miceKaminskas, Lisa M., Pyke, Simon M. and Burcham, Philip C. (2004). Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. Journal of Pharmacology and Experimental Therapeutics, 310 (3), 1003-1010. doi: 10.1124/jpet.104.067330 |
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2004 Journal Article Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated ToxicityBurcham, Philip C., Fontaine, Frank R., Kaminskas, Lisa M., Petersen, Dennis R. and Pyke, Simon M. (2004). Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity. Molecular Pharmacology, 65 (3), 655-664. doi: 10.1124/mol.65.3.655 |
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2002 Journal Article Aldehyde-Sequestering Drugs: Tools for Studying Protein Damage by Lipid Peroxidation ProductsBurcham, Philip C., Kaminskas, Lisa M., Fontaine, Frank R., Petersen, Dennis R. and Pyke, Simon M. (2002). Aldehyde-Sequestering Drugs: Tools for Studying Protein Damage by Lipid Peroxidation Products. Toxicology, 181-182, 229-236. doi: 10.1016/S0300-483X(02)00287-1 |
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2002 Journal Article The contribution of the metabolitep-hydroxyamphetamine to the central actions ofp-methoxyamphetamineKaminskas, Lisa M., Irvine, Rodney J., Callaghan, Paul D., White, Jason M. and Kirkbride, Paul (2002). The contribution of the metabolitep-hydroxyamphetamine to the central actions ofp-methoxyamphetamine. Psychopharmacology, 160 (2), 155-160. doi: 10.1007/s00213-001-0984-z |
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2000 Journal Article Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctionsGamble, Jennifer R., Drew, Jenny, Trezise, Libby, Underwood, Anne, Parsons, Michelle, Kasminkas, Lisa, Rudge, John, Yancopoulos, George and Vadas, Mathew A. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation research, 87 (7), 603-607. doi: 10.1161/01.res.87.7.603 |
