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2020 Journal Article The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in ratsMarasini, Nirmal, Fu, Changkui, Fletcher, Nicholas L., Subasic, Christopher, Er, Gerald, Mardon, Karine, Thurecht, Kristofer J., Whittaker, Andrew K. and Kaminskas, Lisa M. (2020). The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in rats. Nanomaterials, 10 (12) 2452, 1-16. doi: 10.3390/nano10122452 |
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2020 Journal Article The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to ratsHaque, Shadabul, Pouton, Colin W., McIntosh, Michelle P., Ascher, David B, Keizer, David W, Whittaker, Michael R. and Kaminskas, Lisa M. (2020). The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats. Nanomedicine: Nanotechnology, Biology, and Medicine, 30 102291, 102291. doi: 10.1016/j.nano.2020.102291 |
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2020 Journal Article Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposureKuilamu, Esther, Subasic, Christopher, Cowin, Gary J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2020). Cetuximab exhibits sex differences in lymphatic exposure after intravenous administration in rats in the absence of differences in plasma exposure. Pharmaceutical Research, 37 (11) 224, 1-12. doi: 10.1007/s11095-020-02945-2 |
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2020 Journal Article Lymph-directed immunotherapy – harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancerFeeney, Orlagh M., Gracia, Gracia, Brundel, Daniel H. S., Trevaskis, Natalie L., Cao, Enyuan, Kaminskas, Lisa M. and Porter, Christopher J. H. (2020). Lymph-directed immunotherapy – harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer. Advanced Drug Delivery Reviews, 160, 115-135. doi: 10.1016/j.addr.2020.10.002 |
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2019 Journal Article Aerosol pirfenidone pharmacokinetics after inhaled delivery in sheep: a viable approach to treating idiopathic pulmonary fibrosisKaminskas, Lisa M, Landersdorfer, Cornelia B, Bischof, Robert J, Leong, Nathania, Ibrahim, Jibriil, Davies, Andrew N, Pham, Stephen, Beck, Steven, Montgomery, A. Bruce and Surber, Mark W (2019). Aerosol pirfenidone pharmacokinetics after inhaled delivery in sheep: a viable approach to treating idiopathic pulmonary fibrosis. Pharmaceutical Research, 37 (1) 3, 3. doi: 10.1007/s11095-019-2732-2 |
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2019 Journal Article dendPoint: a web resource for dendrimer pharmacokinetics investigation and predictionKaminskas, Lisa M., Pires, Douglas E. V. and Ascher, David B. (2019). dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction. Scientific Reports, 9 (1) 15465, 15465. doi: 10.1038/s41598-019-51789-3 |
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2019 Journal Article Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to ratsHaque, Shadabul, Feeney, Orlagh, Meeusen, Els, Boyd, Ben J., McIntosh, Michelle P., Pouton, Colin W., Whittaker, Michael and Kaminskas, Lisa M. (2019). Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats. Journal of Controlled Release, 307, 32-43. doi: 10.1016/j.jconrel.2019.05.043 |
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2019 Journal Article Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastasesWang, Lili, Subasic, Christopher, Minchin, Rodney F. and Kaminskas, Lisa M. (2019). Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases. Nanomedicine, 14 (12), 1605-1621. doi: 10.2217/nnm-2018-0478 |
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2019 Journal Article A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in ratsKaminskas, Lisa M., Williams, Charlotte C., Leong, Nathania J., Chan, Linda J., Butcher, Neville J., Feeney, Orlagh M., Porter, Christopher J.H., Tyssen, David, Tachedjian, Gilda and Ascher, David B. (2019). A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats. European Journal of Pharmaceutics and Biopharmaceutics, 137, 218-226. doi: 10.1016/j.ejpb.2019.03.008 |
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2019 Journal Article Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?Marasini, Nirmal and Kaminskas, Lisa M. (2019). Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?. Drug development and Industrial Pharmacy, 45 (6), 1-13. doi: 10.1080/03639045.2019.1583758 |
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2019 Conference Publication Pharmacokinetics and Safety of Pirfenidone Following Inhaled Delivery to Sheep: A Viable Approach to Treating Idiopathic Pulmonary FibrosisSurber, M., Kaminskas, L., Landersdorfer, C., Bischof, R., Beck, S., Pham, S., Jain, A., Halvarsson, A., Hug, M. and Montgomery, A. (2019). Pharmacokinetics and Safety of Pirfenidone Following Inhaled Delivery to Sheep: A Viable Approach to Treating Idiopathic Pulmonary Fibrosis. International Conference of the American-Thoracic-Society, Dallas Tx, May 17-22, 2019. NEW YORK: AMER THORACIC SOC. doi: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5422 |
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2018 Journal Article Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticlesYu, Sul Hwa, Patra, Malay, Ferrari, Stefano, Ramirez Garcia, Paulina, Veldhuis, Nicholas A., Kaminskas, Lisa M., Graham, Bim, Quinn, John F., Whittaker, Michael R., Gasser, Gilles and Davis, Thomas P. (2018). Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles. Journal of Materials Chemistry B, 6 (47), 7805-7810. doi: 10.1039/c8tb02464b |
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2018 Journal Article Reducing dendrimer generation and PEG chain length increases drug release and promotes anti-cancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a cathepsin-cleavable peptide linkerMehta, Dharmini, Leong, Nathania, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J.H. and Kaminskas, Lisa M. (2018). Reducing dendrimer generation and PEG chain length increases drug release and promotes anti-cancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a cathepsin-cleavable peptide linker. Molecular Pharmaceutics, 15 (10) acs.molpharmaceut.8b00581, 4568-4576. doi: 10.1021/acs.molpharmaceut.8b00581 |
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2018 Journal Article Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in ratsLeong, Nathania J., Mehta, Dharmini, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2018). Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats. Journal of Pharmaceutical Sciences, 107 (9), 2509-2513. doi: 10.1016/j.xphs.2018.05.013 |
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2018 Journal Article A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in ratsHaque, Shadabul, Whittaker, Michael, McIntosh, Michelle P., Pouton, Colin W, Phipps, Simon and Kaminskas, Lisa M. (2018). A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats. European Journal of Pharmaceutics and Biopharmaceutics , 125, 1-12. doi: 10.1016/j.ejpb.2018.01.001 |
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2018 Journal Article Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesenteryYadav, Preeti, McLeod, Victoria M., Nowell, Cameron J., Selby, Laura I., Johnston, Angus P. R., Kaminskas, Lisa M. and Trevaskis, Natalie L. (2018). Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery. Journal of Controlled Release , 272, 17-28. doi: 10.1016/j.jconrel.2017.12.031 |
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2018 Book Chapter Prediction and optimization of pharmacokinetic and toxicity properties of the ligandPires, Douglas E. V., Kaminskas, Lisa M. and Ascher, David B. (2018). Prediction and optimization of pharmacokinetic and toxicity properties of the ligand. Computational Drug Discovery and Design. (pp. 271-284) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-7756-7_14 |
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2018 Journal Article The applications of 3D printing in pulmonary drug delivery and treatment of respiratory disordersHaque, Shadabul, Md, Shadab, Whittaker, Michael and Kaminskas, Lisa M. (2018). The applications of 3D printing in pulmonary drug delivery and treatment of respiratory disorders. Current Pharmaceutical Design, 24 (42), 5072-5080. doi: 10.2174/1381612825666181206123414 |
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2018 Journal Article Suggested procedures for the reproducible synthesis of poly(d,l-lactide-co-glycolide) nanoparticles using the emulsification solvent diffusion platformHaque, Shadabul, Boyd, Ben J., McIntosh, Michelle P., Pouton, Colin W., Kaminskas, Lisa M. and Whittaker, Michael (2018). Suggested procedures for the reproducible synthesis of poly(d,l-lactide-co-glycolide) nanoparticles using the emulsification solvent diffusion platform. Current Nanoscience, 14 (5), 448-453. doi: 10.2174/1573413714666180313130235 |
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2017 Journal Article Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection siteRyan G.M., McLeod V.M., Mehta D., Kelly B.D., Stanislawski P.C., Owen D.J., Kaminskas L.M. and Porter C.J.H. (2017). Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (8), 2485-2494. doi: 10.1016/j.nano.2017.08.003 |
