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2017 Journal Article Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection siteRyan G.M., McLeod V.M., Mehta D., Kelly B.D., Stanislawski P.C., Owen D.J., Kaminskas L.M. and Porter C.J.H. (2017). Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (8), 2485-2494. doi: 10.1016/j.nano.2017.08.003 |
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2017 Journal Article Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetrationDong, Yao-Da, Tchung, Estefania, Nowell, Cameron, Kaga, Sadik, Leong, Nathania, Mehta, Dharmini, Kaminskas, Lisa M. and Boyd, Ben J. (2017). Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration. Journal of Liposome Research, 29 (1), 1-9. doi: 10.1080/08982104.2017.1391285 |
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2017 Journal Article Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimersHaque, Shadabul, McLeod, Victoria M., Jones, Seth, Fung, Sandy, Whittaker, Michael, McIntosh, Michelle, Pouton, Colin, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2017). Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics, 119, 408-418. doi: 10.1016/j.ejpb.2017.07.005 |
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2017 Journal Article Influence of size and shape on the biodistribution of nanoparticles prepared by polymerization-induced self-assemblyKaga, Sadik, Truong, Nghia P., Esser, Lars, Senyschyn, Danielle, Sanyal, Amitav, Sanyal, Rana, Quinn, John F., Davis, Thomas P., Kaminskas, Lisa M. and Whittaker, Michael R. (2017). Influence of size and shape on the biodistribution of nanoparticles prepared by polymerization-induced self-assembly. Biomacromolecules, 18 (12), 3963-3970. doi: 10.1021/acs.biomac.7b00995 |
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2017 Journal Article An evaluation of optimal PEGylation strategies for maximizing the lymphatic exposure and antiviral activity of interferon after subcutaneous administrationChan, Linda J., Feeney, Orlagh M., Leong, Nathania J., McLeod, Victoria M., Porter, Christopher J.H., Williams, Charlotte C. and Kaminskas, Lisa M. (2017). An evaluation of optimal PEGylation strategies for maximizing the lymphatic exposure and antiviral activity of interferon after subcutaneous administration. Biomacromolecules, 18 (9), 2866-2875. doi: 10.1021/acs.biomac.7b00794 |
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2017 Journal Article Polymer-drug conjugates as inhalable drug delivery systems: A reviewMarasini, Nirmal, Haque, Shadabul and Kaminskas, Lisa M. (2017). Polymer-drug conjugates as inhalable drug delivery systems: A review. Current Opinion in Colloid & Interface Science, 31, 18-29. doi: 10.1016/j.cocis.2017.06.003 |
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2016 Journal Article Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challengesHaque, Shadabul, Whittaker, Michael R., McIntosh, Michelle P., Pouton, Colin W. and Kaminskas, Lisa M. (2016). Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges. Nanomedicine: Nanotechnology, Biology, and Medicine, 12 (6), 1703-1724. doi: 10.1016/j.nano.2016.03.002 |
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2016 Journal Article Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after InstillationKuehl, Christopher, Zhang, Ti, Kaminskas, Lisa M., Porter, Christopher J. H., Davies, Neal M., Forrest, Laird and Berkland, Cory (2016). Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after Instillation. Molecular Pharmaceutics, 13 (6), 1904-1914. doi: 10.1021/acs.molpharmaceut.6b00069 |
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2016 Journal Article Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological ActivityChan, Linda J., Ascher, David B., Yadav, Rajbharan, Bulitta, Jürgen B., Williams, Charlotte C., Porter, Christopher J. H., Landersdorfer, Cornelia B. and Kaminskas, Lisa M. (2016). Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity. Molecular Pharmaceutics, 13 (4), 1229-1241. doi: 10.1021/acs.molpharmaceut.5b00749 |
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2016 Journal Article A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheepRyan, Gemma M., Bischof, Robert J., Enkhbaatar, Perenlei, McLeod, Victoria M., Chan, Linda J., Jones, Seth A., Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2016). A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharmaceutical Research, 33 (2), 510-525. doi: 10.1007/s11095-015-1806-z |
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2016 Journal Article The pharmacokinetics and biodistribution of a 64 kDa PolyPEG star polymer after subcutaneous and pulmonary administration to ratsKhor, Song Yang, Hu, Jinming, McLeod, Victoria M., Quinn, John F., Porter, Christopher J. H., Whittaker, Michael R., Kaminskas, Lisa M. and Davis, Thomas P. (2016). The pharmacokinetics and biodistribution of a 64 kDa PolyPEG star polymer after subcutaneous and pulmonary administration to rats. Journal of Pharmaceutical Sciences, 105 (1), 293-300. doi: 10.1016/j.xphs.2015.11.038 |
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2016 Journal Article Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisationSou, Tomás, Forbes, Robert T., Gray, Jason, Prankerd, Richard J., Kaminskas, Lisa M., McIntosh, Michelle P. and Morton, David A.V. (2016). Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation. Powder Technology, 287, 248-255. doi: 10.1016/j.powtec.2015.10.008 |
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2016 Book Chapter Impact of physicochemical properties on dendrimer pharmacokinetics and biodistributionFeeney, Orlagh, Caliph, Suzanne M., Porter, Christopher J.H. and Kaminskas, Lisa M. (2016). Impact of physicochemical properties on dendrimer pharmacokinetics and biodistribution. Dendrimers in nanomedicine. (pp. 311-351) edited by Delphine Felder-Flesch. Singapore: Pan Stanford Publishing. doi: 10.1201/9781315364513-9 |
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2015 Journal Article PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude miceLandersdorfer, Cornelia B., Caliph, Suzanne M., Shackleford, David M., Ascher, David B. and Kaminskas, Lisa M. (2015). PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice. Journal of Pharmaceutical Sciences, 104 (5), 1848-1855. doi: 10.1002/jps.24412 |
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2015 Journal Article Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymersKhor, Song Yang, Hu, Jinming, McLeod, Victoria M., Quinn, John F., Williamson, Mark, Porter, Christopher J. H., Whittaker, Michael R., Kaminskas, Lisa M. and Davis, Thomas P. (2015). Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers. Nanomedicine: Nanotechnology, Biology and Medicine, 11 (8), 2099-2108. doi: 10.1016/j.nano.2015.08.001 |
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2015 Journal Article From sewer to saviour-targeting the lymphatic system to promote drug exposure and activityTrevaskis, Natalie L., Kaminskas, Lisa M. and Porter, Christopher J. H. (2015). From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity. Nature Reviews Drug Discovery, 14 (11), 781-803. doi: 10.1038/nrd4608 |
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2015 Journal Article Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary administrationSou, Tomás, Morton, David A.V., Williamson, Mark, Meeusen, Els N., Kaminskas, Lisa M. and McIntosh, Michelle P. (2015). Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary administration. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28 (5), 361-371. doi: 10.1089/jamp.2014.1176 |
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2015 Journal Article Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administrationMcleod, Victoria M., Chan, Linda J., Ryan, Gemma M., Porter, Christopher J. H. and Kaminskas, Lisa M. (2015). Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration. Journal of Pharmaceutical Sciences, 104 (4), 1421-1430. doi: 10.1002/jps.24353 |
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2015 Journal Article Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in ratsKaminskas, Lisa M., McLeod, Victoria M., Ascher, David B., Ryan, Gemma M., Jones, Seth, Haynes, John M., Trevaskis, Natalie L., Chan, Linda J., Sloan, Erica K., Finnin, Benjamin A., Williamson, Mark, Velkov, Tony, Williams, Elizabeth D., Kelly, Brian D., Owen, David J. and Porter, Christopher J. H. (2015). Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular Pharmaceutics, 12 (2), 432-443. doi: 10.1021/mp500531e |
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2015 Journal Article PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administrationChan, Linda J., Bulitta, Jürgen B., Ascher, David B., Haynes, John Michael, McLeod, Victoria M., Porter, Christopher J. H., Williams, Charlotte C. and Kaminskas, Lisa M. (2015). PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration. Molecular Pharmaceutics, 12 (3), 794-809. doi: 10.1021/mp5006189 |
