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2024

Journal Article

Hydrogenated Soy Phosphatidylcholine Liposomes Stimulate Differential Expression of Chemokines And Cytokines by Rat Alveolar Macrophages In Vitro

Ibrahim, Jibriil P., Dao, Nam, Haque, Shadabul, Phipps, Simon, Whittaker, Michael R. and Kaminskas, Lisa M. (2024). Hydrogenated Soy Phosphatidylcholine Liposomes Stimulate Differential Expression of Chemokines And Cytokines by Rat Alveolar Macrophages In Vitro. Journal of Pharmaceutical Sciences, 113 (5), 1395-1400. doi: 10.1016/j.xphs.2024.03.001

Hydrogenated Soy Phosphatidylcholine Liposomes Stimulate Differential Expression of Chemokines And Cytokines by Rat Alveolar Macrophages In Vitro

2024

Journal Article

A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs

Subasic, Christopher N., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2024). A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs. Nanomedicine: Nanotechnology, Biology and Medicine, 56 102733, 1-8. doi: 10.1016/j.nano.2024.102733

A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs

2024

Journal Article

Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms

Kaminskas, Lisa M., Butcher, Neville J., Subasic, Christopher N., Kothapalli, Ashok, Haque, Shadabul, Grace, James L., Morsdorf, Alexander, Blanchfield, Joanne T., Whittaker, Andrew K., Quinn, John F. and Whittaker, Michael R. (2024). Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms. Expert Opinion On Drug Delivery, 21 (1), 151-167. doi: 10.1080/17425247.2024.2305116

Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms

2024

Journal Article

Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity

Ediriweera, Gayathri R., Butcher, Neville J., Kothapalli, Ashok, Zhao, Jiacheng, Blanchfield, Joanne T., Subasic, Christopher N., Grace, James L., Fu, Changkui, Tan, Xiao, Quinn, John F., Ascher, David B., Whittaker, Michael R., Whittaker, Andrew K. and Kaminskas, Lisa M. (2024). Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity. Biomaterials Science, 12 (11), 2978-2992. doi: 10.1039/d3bm02020g

Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity

2023

Journal Article

Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats

Subasic, Christopher N., Butcher, Neville J., Simpson, Fiona, Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (9), 4468-4477. doi: 10.1021/acs.molpharmaceut.3c00102

Dose-dependent effect of phenothiazines as dynamin II inhibitors on the uptake of PEGylated liposomes by endocytic cells and in vivo pharmacokinetics of PEGylated liposomal doxorubicin in rats

2023

Journal Article

Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration

Ibrahim, Jibriil P., Butcher, Neville J., Kothapalli, Ashok, Subasic, Christopher N., Blanchfield, Joanne T., Whittaker, Andrew K., Whittaker, Michael R and Kaminskas, Lisa M. (2023). Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration. Expert Opinion on Drug Delivery, 20 (8), 1145-1155. doi: 10.1080/17425247.2023.2244881

Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration

2023

Conference Publication

Fermentation metabolites of 14C-labelled aromatic amino acid, tyrosine, detected in the brain in a pig model

Murray, Margaret, Gibbon, Anne, Kaminskas, Lisa, Selby-Pham, Sophie, Williamson, Gary and Bennett, Louise (2023). Fermentation metabolites of 14C-labelled aromatic amino acid, tyrosine, detected in the brain in a pig model. IUNS 22nd International Congress of Nutrition, Tokyo, Japan, 14 - 19 September 2021. Basel, Switzerland: S. Karger.

Fermentation metabolites of 14C-labelled aromatic amino acid, tyrosine, detected in the brain in a pig model

2023

Journal Article

Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats

Subasic, Christopher N., Butcher, Neville J., Minchin, Rodney F. and Kaminskas, Lisa M. (2023). Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats. Molecular Pharmaceutics, 20 (7), 3494-3504. doi: 10.1021/acs.molpharmaceut.3c00104

Dose-dependent production of anti-PEG IgM after intramuscular PEGylated-hydrogenated soy phosphatidylcholine liposomes, but not lipid nanoparticle formulations of DNA, correlates with the plasma clearance of PEGylated liposomal doxorubicin in rats

2023

Journal Article

Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model

Murray, Margaret, Barlow, Christopher K., Blundell, Scott, Buecking, Mark, Gibbon, Anne, Goeckener, Bernd, Kaminskas, Lisa M., Leitner, Patricia, Selby-Pham, Sophie, Sinclair, Andrew, Waktola, Habtewold D., Williamson, Gary and Bennett, Louise E. (2023). Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model. Frontiers in Nutrition, 10 1127729, 1-14. doi: 10.3389/fnut.2023.1127729

Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model

2022

Book Chapter

Using graph-based signatures to guide rational antibody engineering

Ascher, David B., Kaminskas, Lisa M., Myung, Yoochan and Pires, Douglas E. V. (2022). Using graph-based signatures to guide rational antibody engineering. Computer-aided antibody design. (pp. 375-397) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-2609-2_21

Using graph-based signatures to guide rational antibody engineering

2022

Journal Article

Liposomes are poorly absorbed via lung lymph after inhaled administration in sheep

Ibrahim, Jibriil P., Haque, Shadabul, Bischof, Robert J., Whittaker, Andrew K., Whittaker, Michael R. and Kaminskas, Lisa M. (2022). Liposomes are poorly absorbed via lung lymph after inhaled administration in sheep. Frontiers in Pharmacology, 13 880448, 1-9. doi: 10.3389/fphar.2022.880448

Liposomes are poorly absorbed via lung lymph after inhaled administration in sheep

2022

Journal Article

Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis

Marasini, Nirmal, Er, Gerald, Fu, Changkui, Subasic, Christopher N., Ibrahim, Jibriil, Skwarczynski, Mariusz, Toth, Istvan, Whittaker, Andrew K. and Kaminskas, Lisa M. (2022). Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis. Acta Biomaterialia, 142, 298-307. doi: 10.1016/j.actbio.2022.01.054

Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis

2021

Journal Article

Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins

Subasic, Christopher N., Ardana, Aditya, Chan, Linda J., Huang, Fei, Scoble, Judith A., Butcher, Neville J., Meagher, Laurence, Chiefari, John, Kaminskas, Lisa M. and Williams, Charlotte C. (2021). Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins. International Journal of Pharmaceutics, 608 121075, 121075. doi: 10.1016/j.ijpharm.2021.121075

Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins

2021

Journal Article

The pharmacokinetics of PEGylated liposomal doxorubicin are not significantly affected by sex in rats or humans, but may be affected by immune dysfunction

Subasic, Christopher N., Kuilamu, Esther, Cowin, Gary, Minchin, Rodney F. and Kaminskas, Lisa M. (2021). The pharmacokinetics of PEGylated liposomal doxorubicin are not significantly affected by sex in rats or humans, but may be affected by immune dysfunction. Journal of Controlled Release, 337, 71-80. doi: 10.1016/j.jconrel.2021.07.006

The pharmacokinetics of PEGylated liposomal doxorubicin are not significantly affected by sex in rats or humans, but may be affected by immune dysfunction

2021

Journal Article

Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells

Dao, Nam V., Ercole, Francesca, Li, Yuhuan, Davis, Thomas P., Kaminskas, Lisa M., Sloan, Erica K., Quinn, John F. and Whittaker, Michael R. (2021). Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells. Journal of Materials Chemistry B, 9 (37), 7805-7820. doi: 10.1039/d1tb00812a

Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells

2021

Journal Article

Recent advances in nano/microparticle-based oral vaccines

Li, Mengdie, Kaminskas, Lisa M. and Marasini, Nirmal (2021). Recent advances in nano/microparticle-based oral vaccines. Journal of Pharmaceutical Investigation, 51 (4), 1-14. doi: 10.1007/s40005-021-00537-9

Recent advances in nano/microparticle-based oral vaccines

2021

Journal Article

Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration

Brundel, Daniel H.S., Feeney, Orlagh M., Nowell, Cameron J., Suys, Estelle J.A., Gracia, Gracia, Kaminskas, Lisa M., McIntosh, Michelle M., Kang, David W. and Porter, Christopher J.H. (2021). Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration. Nanomedicine, 16 (4), 275-292. doi: 10.2217/nnm-2020-0433

Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration

2021

Journal Article

Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model

Dao, Nam V., Ercole, Francesca, Urquhart, Matthew C., Kaminskas, Lisa M., Nowell, Cameron J., Davis, Thomas P., Sloan, Erica K., Whittaker, Michael R. and Quinn, John F. (2021). Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model. Biomaterials Science, 9 (3), 835-846. doi: 10.1039/d0bm01544j

Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model

2021

Journal Article

Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin

Wang, Lili, Butcher, Neville J, Minchin, Rodney F and Kaminskas, Lisa M (2021). Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin. Journal of Pharmaceutical Sciences, 110 (8), 3099-3101. doi: 10.1016/j.xphs.2021.05.009

Monocytes do not contribute to sex differences seen in the pharmacokinetics of pegylated liposomal doxorubicin

2020

Journal Article

Trisulfide-bearing PEG brush polymers donate hydrogen sulfide and ameliorate cellular oxidative stress

Dao, Nam V., Ercole, Francesca, Kaminskas, Lisa M., Davis, Thomas P., Sloan, Erica K., Whittaker, Michael R. and Quinn, John F. (2020). Trisulfide-bearing PEG brush polymers donate hydrogen sulfide and ameliorate cellular oxidative stress. Biomacromolecules, 21 (12), 5292-5305. doi: 10.1021/acs.biomac.0c01347

Trisulfide-bearing PEG brush polymers donate hydrogen sulfide and ameliorate cellular oxidative stress