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2019 Journal Article Cholesterol crystals induce coagulation activation through complement-dependent expression of monocytic tissue factorGravastrand, Caroline S., Steinkjer, Bjørg, Halvorsen, Bente, Landsem, Anne, Skjelland, Mona, Jacobsen, Eva Astrid, Woodruff, Trent M., Lambris, John D., Mollnes, Tom E., Brekke, Ole-Lars, Espevik, Terje and Rokstad, Anne Mari A. (2019). Cholesterol crystals induce coagulation activation through complement-dependent expression of monocytic tissue factor. Journal of Immunology, 203 (4), 853-863. doi: 10.4049/jimmunol.1900503 |
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Featured 2019 Journal Article Revisiting the role of the innate immune complement system in ALSParker, Sandra E., Hanton, Angela M., Stefanou, Stephen N., Noakes, Peter G., Woodruff, Trent M. and Lee, John D. (2019). Revisiting the role of the innate immune complement system in ALS. Neurobiology of Disease, 127, 223-232. doi: 10.1016/j.nbd.2019.03.003 |
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2019 Journal Article Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibodyGulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls, Robin R., Woodruff, Trent M., Song, Wen-Chao, Schuurman, Janine, Rice, Peter A. and Ram, Sanjay (2019). Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody. PLoS Biology, 17 (6) e3000323, e3000323. doi: 10.1371/journal.pbio.3000323 |
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2019 Journal Article The complement receptor C5aR2: a powerful modulator of innate and adaptive immunityLi, Xaria X., Lee, John D., Kemper, Claudia and Woodruff, Trent M. (2019). The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity. Journal of Immunology, 202 (12), 3339-3348. doi: 10.4049/jimmunol.1900371 |
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2019 Journal Article Gut microbiota in ALS: possible role in pathogenesis?McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026 |
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2019 Journal Article Deletion of biliverdin reductase A in myeloid cells promotes chemokine expression and chemotaxis in part via a complement C5a–C5aR1 pathwayBisht, Kavita, Canesin, Giacomo, Cheytan, Tasneem, Li, Mailin, Nemeth, Zsuzsanna, Csizmadia, Eva, Woodruff, Trent M., Stec, David E., Bulmer, Andrew C., Otterbein, Leo E. and Wegiel, Barbara (2019). Deletion of biliverdin reductase A in myeloid cells promotes chemokine expression and chemotaxis in part via a complement C5a–C5aR1 pathway. The Journal of Immunology, 202 (10), ji1701443-2990. doi: 10.4049/jimmunol.1701443 |
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2019 Journal Article Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254 |
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2019 Journal Article Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1Pandey, Shubhi, Li, Xaria X., Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Chaturvedi, Madhu, Ghosh, Eshan, Woodruff, Trent M. and Shukla, Arun K. (2019). Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1. Journal of Biological Chemistry, 294 (24), jbc.RA119.007485-9429. doi: 10.1074/jbc.ra119.007485 |
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2019 Journal Article Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4Landsem, A., Fure, H., Krey Ludviksen, J., Christiansen, D., Lau, C., Mathisen, M., Bergseth, G., Nymo, S., Lappegård, K. T., Woodruff, T. M., Espevik, T., Mollnes, T. E. and Brekke, O. L. (2019). Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4. Clinical and Experimental Immunology, 196 (1), 97-110. doi: 10.1111/cei.13240 |
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2019 Journal Article Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Liu, Ning, Levin, Samantha C., Ottosson, Lars, Andersson, Ulf, Harris, Helena E. and Woodruff, Trent M. (2019). Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 16 (1) 45, 45. doi: 10.1186/s12974-019-1435-2 |
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2018 Journal Article C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliteransVerghese, Divya A., Chun, Nicholas, Paz, Katelyn, Fribourg, Miguel, Woodruff, Trent M., Flynn, Ryan, Hu, Yuan, Xiong, Huabao, Zhang, Weijia, Yi, Zhengzi, Du, Jing, Blazar, Bruce R. and Heeger, Peter S. (2018). C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans. JCI Insight, 3 (24). doi: 10.1172/jci.insight.124646 |
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2018 Journal Article Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signallingSchofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1 |
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2018 Journal Article Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performanceCoulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271 |
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2018 Journal Article New tricks for an ancient system: physiological and pathological roles of complement in the CNSTenner, Andrea J., Stevens, Beth and Woodruff, Trent M. (2018). New tricks for an ancient system: physiological and pathological roles of complement in the CNS. Molecular Immunology, 102, 3-13. doi: 10.1016/j.molimm.2018.06.264 |
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2018 Journal Article Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosisLee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2 |
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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitisMichailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y |
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2018 Journal Article T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survivalA. Verghese, Divya, Demir, Markus, Chun, Nicholas, Fribourg, Miguel, Cravedi, Paolo, Llaudo, Ines, Woodruff, Trent M., Yadav, Pragya, Lira, Sergio A., Medof, M. Edward and Heeger, Peter S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survival. Journal of Immunology, 200 (6), 2186-2198. doi: 10.4049/jimmunol.1701638 |
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2018 Journal Article Complement in stem cells and developmentHawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna and Woodruff, Trent M (2018). Complement in stem cells and development. Seminars in Immunology, 37 (C), 74-84. doi: 10.1016/j.smim.2018.02.009 |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
