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2024

Conference Publication

C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment

Ahmari, Niousha, Perrino, Melissa, Pundavela, Jay, Szabo, Sara, Woodruff, Trent, Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment. American Society for Pharmacology and Experimental Therapeutics. doi: 10.1124/jpet.249.988670

C5aR-antagonism alone or in combination with MEK inhibition durably alters the plexiform neurofibroma tumor micro-environment

2023

Conference Publication

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

Merle, Nicolas S., Freeley, Simon, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Kolev, Martin, Niyonzima, Nathalie, Morgensen, Trine Hyrup, Woodruff, Trent M., Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollness, Tom Eirik, Christiansen, Mette, West, Erin E. and Kemper, Claudia (2023). T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.64.15

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

2023

Conference Publication

Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic mice

Snelson, M., Tan, S. M., Kumar, V., Woodruff, T. and Coughlan, M. T. (2023). Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic mice. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA, Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001921

Dietary resistant starch alters gut microbiota, microbially produced metabolites and albuminuria in diabetic mice

2022

Conference Publication

Immunoregulatory role for complement receptors in murine breast cancer

Rolfe, Barbara, Sonderegger, Stefan, McGirr, Crystal and Woodruff, Trent (2022). Immunoregulatory role for complement receptors in murine breast cancer. 28th Virtual International Complement Workshop (ICW) of the International-Complement-Society (ICS), Virtual, 6-10 December 2021. Oxford, United Kingdom: Elsevier.

Immunoregulatory role for complement receptors in murine breast cancer

2022

Conference Publication

Identification of potent small peptides targeting human C3a receptor

Deerain, Nick, Kumar, Vinod, Clark, Richard and Woodruff, Trent (2022). Identification of potent small peptides targeting human C3a receptor. ICW – 2021 Virtual Workshop of the International Complement Society (ICS), Virtual, 7-10 December 2021. Oxford, United Kingdom: Elsevier.

Identification of potent small peptides targeting human C3a receptor

2021

Conference Publication

Stimulating the Activity of NEP and ACE2: A Unique Approach to Prevent Dementia

Tran, Shirley, Woodruff, Trent, Kumar, Vinod, Smith, A. Ian, Rajapakse, Niwanthi and Kuruppu, Sanjaya (2021). Stimulating the Activity of NEP and ACE2: A Unique Approach to Prevent Dementia. Experimental Biology Meeting EB 2021, Online, 27–30 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2021.35.s1.01628

Stimulating the Activity of NEP and ACE2: A Unique Approach to Prevent Dementia

2020

Conference Publication

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

West, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Mogensen, Trine Hyrup, Woodruff, Trent M., Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollnes, Tom Eirik, Christiansen, Mette and Kemper, Claudia (2020). T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.150.23

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

2020

Conference Publication

Increased complement component 5a signalling drives severe asthma pathogenesis

Kim, R., Brown, A., Carroll, O., Hsu, A., Baines, K., Pathinayake, P., Kemper, C., Woodruff, T., Adcock,, Gibson, P., Wark, P., Horvat, J. and Hansbro, P. (2020). Increased complement component 5a signalling drives severe asthma pathogenesis. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health and Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777

Increased complement component 5a signalling drives severe asthma pathogenesis

2019

Conference Publication

Deciphering key roles for complement peptide receptors in brain development

Woodruff, T., Hawksworth, O., Lee, J. and Coulthard, L. (2019). Deciphering key roles for complement peptide receptors in brain development. Joint Meeting of the International Society for Neurochemistry and American Society for Neurochemistry (ISN-ASN), Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Deciphering key roles for complement peptide receptors in brain development

2019

Conference Publication

Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma

Nabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley.

Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma

2019

Conference Publication

Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming

Coughlan, M. T., Tan, S., Ziemann, M., Snelson, M., El-Osta, A., MacIsaac, R. J., Meikle, P. J., Forbes, J. M., Cooper, M. E., Ekinci, E. I. and Woodruff, T. M. (2019). Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming. 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona Spain, 16-20 September 2019. Heidelberg, Germany: Springer.

Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming

2019

Conference Publication

Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra Envenomation

Silva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent, da-Silva-Reis, Edimara, Lambris, John and Tambourgi, Denise (2019). Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra Envenomation. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier .

Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra Envenomation

2019

Conference Publication

Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole blood

Quang Huy Quach,, Johnson, Christina, Lau, Corinna, Woodruff, Trent M., Pischke, Soren E., Mollnes, Tom Eirik and Nilsson, Per H. (2019). Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole blood. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier .

Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole blood

2019

Conference Publication

Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody

Beurskens, Frank, de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane, Shaughnessy, Jutamas, Taylors, Ronald, Botto, Marina, He, Xianbao, Ingalls, Robin, Woodruff, Trent, Song, Wen-Chao, Schuurman, Janine, Rice, Peter and Ram, Sanjay (2019). Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom: Elsevier .

Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody

2018

Conference Publication

The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease

Muenstermann, Marcel, Herrmann, Johannes, Strobel, Lea, Woodruff, Trent, Klos, Andreas, Wetsel, Rick, Gerard, Craig, Koehl, Joerg and Johswich, Kay Ole (2018). The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.109

The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease

2018

Conference Publication

Complement activation contributes to the pathogenesis of African cobra envenomation

Silva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent and Tambourgi, Denise (2018). Complement activation contributes to the pathogenesis of African cobra envenomation. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.220

Complement activation contributes to the pathogenesis of African cobra envenomation

2018

Conference Publication

Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patients

Ong, Voon, Arbore, Giuseppina, Costantini, Benedetta, Abrahams, David, Denton, Christopher, Placais, Leo, Mitchell, Lynne, Ellis, Richard, Heck, Susanne, Woodruff, Trent, Kordasti, Shahram, Kemper, Claudia and Hourcade, Dennis (2018). Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patients. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.098

Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patients

2018

Conference Publication

C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation

Gordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, Sep 16-20, 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.247

C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation

2018

Conference Publication

Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation

West, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Peter N. and Kemper, Claudia (2018). Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, 16-20 September 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.246

Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation

2017

Conference Publication

Targeting the C5a-C5aR1 signalling axis in diabetic kidney disease

Coughlan, M. T., Tan, S. M., Ekinci, E. I., Snelson, M., Penfold, S. A., Higgins, G. C., Lindblom, R. S., Sourris, K. C., Thallas-Bonke, V., Jerums, G., Skene, A., Power, D. A., MacIsaac, R. J., Cooper, M. E. and Woodruff, T. M. (2017). Targeting the C5a-C5aR1 signalling axis in diabetic kidney disease. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK: SPRINGER.

Targeting the C5a-C5aR1 signalling axis in diabetic kidney disease