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2018 Journal Article Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosisLee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2 |
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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitisMichailidou, Iliana, Jongejan, Aldo, Vreijling, Jeroen P., Georgakopoulou, Theodosia, de Wissel, Marit B., Wolterman, Ruud A., Ruizendaal, Patrick, Klar-Mohamad, Ngaisah, Grootemaat, Anita E., Picavet, Daisy I., Kumar, Vinod, van Kooten, Cees, Woodruff, Trent M., Morgan, B. Paul, van der Wel, Nicole N., Ramaglia, Valeria, Fluiter, Kees and Baas, Frank (2018). Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications, 6 (1) 36, 36. doi: 10.1186/s40478-018-0536-y |
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2018 Journal Article T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survivalA. Verghese, Divya, Demir, Markus, Chun, Nicholas, Fribourg, Miguel, Cravedi, Paolo, Llaudo, Ines, Woodruff, Trent M., Yadav, Pragya, Lira, Sergio A., Medof, M. Edward and Heeger, Peter S. (2018). T cell expression of C5a receptor 2 augments murine regulatory T cell (T) generation and T-dependent cardiac allograft survival. Journal of Immunology, 200 (6), 2186-2198. doi: 10.4049/jimmunol.1701638 |
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2018 Journal Article Complement in stem cells and developmentHawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna and Woodruff, Trent M (2018). Complement in stem cells and development. Seminars in Immunology, 37 (C), 74-84. doi: 10.1016/j.smim.2018.02.009 |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
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2018 Journal Article Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulationSkjeflo, E. W., Christiansen, D., Fure, H., Ludviksen, J. K., Woodruff, T. M., Espevik, Terje, Nielsen, E. W., Brekke, O. L. and Mollnes, T. E. (2018). Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation. Journal of Thrombosis and Haemostasis, 16 (5), 905-918. doi: 10.1111/jth.13979 |
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2018 Journal Article Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced painMorgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016 |
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2018 Journal Article Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease TreatmentHerrmann, Johannes B., Muenstermann, Marcel, Strobel, Lea, Schubert-Unkmeir, Alexandra, Woodruff, Trent M., Gray-Owen, Scott D., Klos, Andreas and Johswich, Kay O. (2018). Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. mBio, 9 (1) e01755-17, 1-17. doi: 10.1128/mBio.01755-17 |
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2017 Journal Article C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritisDick, Jonathan, Gan, Poh-Yi, Ford, Sharon L., Odobasic, Dragana, Alikhan, Maliha A., Loosen, Sven H., Hall, Pam, Westhorpe, Clare L., Li, Anqi, Ooi, Joshua D., Woodruff, Trent M., Mackay, Charles R., Kitching, A Richard, Hickey, Michael J. and Holdsworth, Stephen R. (2017). C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis. Kidney International, 93 (3), 615-625. doi: 10.1016/j.kint.2017.09.018 |
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2017 Journal Article The concise guide to pharmacology 2017/18: OverviewAlexander, Stephen P. H., Kelly, Eamonn, Marrion, Neil V., Peters, John A., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Buneman, O. Peter, Cidlowski, John A., Christopoulos, Arthur, Davenport, Anthony P., Fabbro, Doriano, Spedding, Michael, Striessnig, Jorg, Davies, Jamie A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K., Arumugam, T., V, Attali, B., Back, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M. ... Woodruff, Trent (2017). The concise guide to pharmacology 2017/18: Overview. British Journal of Pharmacology, 174, S1-S16. doi: 10.1111/bph.13882/full |
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2017 Journal Article Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouseKarsten, Christian M., Wiese, Anna V., Mey, Fabian, Figge, Julia, Woodruff, Trent M., Reuter, Tom, Scurtu, Olga, Kordowski, Anna, Almeida, Larissa N., Briukhovetska, Daria, Quell, Katharina M., Sun, Jing, Ender, Fanny, Schmudde, Inken, Vollbrandt, Tillman, Laumonnier, Yves and Köhl, Jörg (2017). Monitoring C5AR2 expression using a floxed tdtomato-C5AR2 knock-in mouse. Journal of Immunology, 199 (9), 3234-3248. doi: 10.4049/jimmunol.1700710 |
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2017 Journal Article New concepts on the therapeutic control of complement anaphylatoxin receptorsHawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
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2017 Journal Article The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microgliaDeora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017). The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 (4), 1-7. doi: 10.1007/s11481-017-9754-5 |
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2017 Journal Article Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous mannerGorelik, Anna, Sapir, Tamar, Woodruff, Trent M. and Reiner, Orly (2017). Serping1/C1 inhibitor affects cortical development in a cell autonomous and non-cell autonomous manner. Frontiers in Cellular Neuroscience, 11 169. doi: 10.3389/fncel.2017.00169 |
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2017 Journal Article Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosisWang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M. and Noakes, Peter G. (2017). Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Skeletal Muscle, 7 (1) 10, 10. doi: 10.1186/s13395-017-0128-8 |
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2017 Journal Article Developmental activities of the complement pathway in migrating neuronsGorelik, Anna , Sapir, Tamar , Haffner-Krausz, Rebecca , Olender, Tsviya , Woodruff, Trent M. and Reiner, Orly (2017). Developmental activities of the complement pathway in migrating neurons. Nature Communications, 8 (1) 15096, 15096 .1-15096 .12. doi: 10.1038/ncomms15096 |
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2017 Journal Article The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injuryBiggins, Patrick, Brennan, Faith, Taylor, Stephen, Woodruff, Trent and Ruitenberg, Marc (2017). The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injury. Journal of Neurotrauma, 34 (12), 2075-2085. doi: 10.1089/neu.2016.4701 |
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2017 Journal Article Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanismJain, U., Midgen, C. A., Woodruff, T. M., Schwaeble, W. J., Stover, C. M. and Stadnyk, A. W. (2017). Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism. Clinical and Experimental Immunology, 188 (1), 36-44. doi: 10.1111/cei.12922 |
