|
2024 Journal Article Complement(ing) long-COVID thromboinflammation and pathogenesisLee, John D. and Woodruff, Trent M. (2024). Complement(ing) long-COVID thromboinflammation and pathogenesis. Trends in Immunology, 45 (6), 397-399. doi: 10.1016/j.it.2024.04.001 |
|
2024 Journal Article Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsisKhan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768 |
|
2024 Journal Article Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killingLi, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5) e2314627121, 1-10. doi: 10.1073/pnas.2314627121 |
|
2023 Journal Article Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activationLi, Xaria X. and Woodruff, Trent M. (2023). Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation. STAR Protocols, 4 (4) 102758, 102758. doi: 10.1016/j.xpro.2023.102758 |
|
2023 Journal Article Complement in human disease: approved and up-and-coming therapeuticsWest, Erin E., Woodruff, Trent, Fremeaux-Bacchi, Veronique and Kemper, Claudia (2023). Complement in human disease: approved and up-and-coming therapeutics. The Lancet, 403 (10424), 392-405. doi: 10.1016/s0140-6736(23)01524-6 |
|
2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
|
2023 Journal Article Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptorsYadav, Manish K., Maharana, Jagannath, Yadav, Ravi, Saha, Shirsha, Sarma, Parishmita, Soni, Chahat, Singh, Vinay, Saha, Sayantan, Ganguly, Manisankar, Li, Xaria X., Mohapatra, Samanwita, Mishra, Sudha, Khant, Htet A., Chami, Mohamed, Woodruff, Trent M., Banerjee, Ramanuj, Shukla, Arun K. and Gati, Cornelius (2023). Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186 (22), 4956-4973.e21. doi: 10.1016/j.cell.2023.09.020 |
|
2023 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2023). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23) e168277, 1-19. doi: 10.1172/jci168277 |
|
2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
|
2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
|
2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
|
2022 Journal Article Complement drives circuit modulation in the adult brainParker, Sandra E., Bellingham, Mark C. and Woodruff, Trent M. (2022). Complement drives circuit modulation in the adult brain. Progress in Neurobiology, 214 102282, 102282. doi: 10.1016/j.pneurobio.2022.102282 |
|
2021 Journal Article Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammationNiyonzima, Nathalie, Rahman, Jubayer, Kunz, Natalia, West, Erin E., Freiwald, Tilo, Desai, Jigar V., Merle, Nicolas S., Gidon, Alexandre, Sporsheim, Bjørnar, Lionakis, Michail S., Evensen, Kristin, Lindberg, Beate, Skagen, Karolina, Skjelland, Mona, Singh, Parul, Haug, Markus, Ruseva, Marieta M., Kolev, Martin, Bibby, Jack, Marshall, Olivia, O’Brien, Brett, Deeks, Nigel, Afzali, Behdad, Clark, Richard J., Woodruff, Trent M., Pryor, Milton, Yang, Zhi-Hong, Remaley, Alan T., Mollnes, Tom E. ... Kemper, Claudia (2021). Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation. Science Immunology, 6 (66) eabf2489, eabf2489. doi: 10.1126/sciimmunol.abf2489 |
|
2021 Journal Article In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacyCui, Cedric S., Kumar, Vinod, Gorman, Declan M., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy. ACS Pharmacology and Translational Science, 5 (1) acsptsci.1c00227, 41-51. doi: 10.1021/acsptsci.1c00227 |
|
2021 Journal Article Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptorsPandey, Shubhi, Kumari, Punita, Baidya, Mithu, Kise, Ryoji, Cao, Yubo, Dwivedi-Agnihotri, Hemlata, Banerjee, Ramanuj, Li, Xaria X., Cui, Cedric S., Lee, John D., Kawakami, Kouki, Maharana, Jagannath, Ranjan, Ashutosh, Chaturvedi, Madhu, Jhingan, Gagan Deep, Laporte, Stéphane A., Woodruff, Trent M., Inoue, Asuka and Shukla, Arun K. (2021). Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell, 81 (22), 4605-4621.e11. doi: 10.1016/j.molcel.2021.09.007 |
|
2021 Journal Article Processed foods drive intestinal barrier permeability and microvascular diseasesSnelson, Matthew, Tan, Sih Min, Clarke, Rachel E., De Pasquale, Cassandra, Thallas-Bonke, Vicki, Nguyen, Tuong-Vi, Penfold, Sally A., Harcourt, Brooke E., Sourris, Karly C., Lindblom, Runa S., Ziemann, Mark, Steer, David, El-Osta, Assam, Davies, Michael J., Donnellan, Leigh, Deo, Permal, Kellow, Nicole J., Cooper, Mark E., Woodruff, Trent M., Mackay, Charles R., Forbes, Josephine M. and Coughlan, Melinda T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7 (14) eabe4841, 1-16. doi: 10.1126/sciadv.abe4841 |
|
2020 Journal Article Absence of the C5a receptor C5aR2 worsens ischemic tissue injury by increasing C5aR1-mediated neutrophil infiltrationWu, Mike C. L., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2020). Absence of the C5a receptor C5aR2 worsens ischemic tissue injury by increasing C5aR1-mediated neutrophil infiltration. The Journal of Immunology, 205 (10), 1-6. doi: 10.4049/jimmunol.2000778 |
|
2020 Journal Article Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptorSchofield, Zoe, Wu, Mike C. L., Hansbro, Philip M., Cooper, Matthew A. and Woodruff, Trent M. (2020). Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor. The FASEB Journal, 34 (8), 10418-10430. doi: 10.1096/fj.202000960R |
|
2020 Journal Article Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and functionLi, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology, 180 114156, 114156. doi: 10.1016/j.bcp.2020.114156 |
|
2020 Journal Article C5aR2 activation broadly modulates the signaling and function of primary human macrophagesLi, Xaria X., Clark, Richard J. and Woodruff, Trent M. (2020). C5aR2 activation broadly modulates the signaling and function of primary human macrophages. Journal of Immunology, 205 (4), 1-11. doi: 10.4049/jimmunol.2000407 |
