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2020 Journal Article A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease modelsKumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119 |
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2020 Journal Article COVID-19: Complement, coagulation, and collateral damageLo, Martin W., Kemper, Claudia and Woodruff, Trent M. (2020). COVID-19: Complement, coagulation, and collateral damage. The Journal of Immunology, 205 (6), ji2000644-1495. doi: 10.4049/jimmunol.2000644 |
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2020 Journal Article Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral SclerosisLee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9 |
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2020 Journal Article Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitationHan, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291 |
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2020 Journal Article Emerging insights into the structure and function of complement C5a receptorsPandey, Shubhi, Maharana, Jagannath, Li, Xaria X., Woodruff, Trent M. and Shukla, Arun K. (2020). Emerging insights into the structure and function of complement C5a receptors. Trends in Biochemical Sciences, 45 (8), 693-705. doi: 10.1016/j.tibs.2020.04.004 |
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2020 Journal Article The peripheral immune system and amyotrophic lateral sclerosisMcCombe, Pamela A., Lee, John D., Woodruff, Trent M. and Henderson, Robert D. (2020). The peripheral immune system and amyotrophic lateral sclerosis. Frontiers in Neurology, 11 279, 279. doi: 10.3389/fneur.2020.00279 |
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Featured 2020 Journal Article The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosisMcDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781 |
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2020 Journal Article Complement: bridging the innate and adaptive immune systems in sterile inflammationLo, Martin W. and Woodruff, Trent M. (2020). Complement: bridging the innate and adaptive immune systems in sterile inflammation. Journal of Leukocyte Biology, 108 (1) JLB.3MIR0220-270R, 339-351. doi: 10.1002/jlb.3mir0220-270r |
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2020 Journal Article Low-fouling fluoropolymers for bioconjugation and in vivo trackingFu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12), 4729-4735. doi: 10.1002/anie.201914119 |
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2020 Journal Article Editorial: The Role of Complement in TumorsRolfe, Barbara E., Pio, Ruben, Woodruff, Trent M., Markiewski, Maciej M. and Manthey, Helga D. (2020). Editorial: The Role of Complement in Tumors. Frontiers in Immunology, 11 139, 139. doi: 10.3389/fimmu.2020.00139 |
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2020 Journal Article Low‐fouling fluoropolymers for bioconjugation and in vivo trackingFu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2020 Journal Article Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735 |
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2020 Journal Article Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosisArbore, Giuseppina, Ong, Voon H., Costantini, Benedetta, Denton, Christopher P., Abraham, David, Placais, Leo, Blighe, Kevin, Mitchell, Lynne, Ellis, Richard, Heck, Susanne, Nocerino, Paola, Woodruff, Trent M., Kordasti, Shahram, Kemper, Claudia and Hourcade, Dennis E. (2020). Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis. Cellular & Molecular Immunology, 17 (9), 1010-1013. doi: 10.1038/s41423-019-0360-8 |
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2019 Journal Article Commentary: Beyond C4: analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls by Holland, J. F., Cosgrove, D., Whitton, L., Harold, D., Corvin, A., Gill, M., et al. (2019). Genes Brain Behav. 18:e12602Coulthard, Liam G. and Woodruff, Trent M. (2019). Commentary: Beyond C4: analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls by Holland, J. F., Cosgrove, D., Whitton, L., Harold, D., Corvin, A., Gill, M., et al. (2019). Genes Brain Behav. 18:e12602. Frontiers in Immunology, 10 2853, 2853. doi: 10.3389/fimmu.2019.02853 |
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2019 Journal Article The Concise Guide to Pharmacology 2019/20: G protein‐coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair, Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria P., Alexander, Wayne, Al-hosaini, Khaled, Bäck, Magnus, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P., Catt, Kevin J. ... Yao, Chengcan (2019). The Concise Guide to Pharmacology 2019/20: G protein‐coupled receptors. British Journal of Pharmacology, 176 (S1), S21-S141. doi: 10.1111/bph.14748 |
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2019 Journal Article Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agilityTan, Sih Min, Ziemann, Mark, Thallas-Bonke, Vicki, Snelson, Matthew, Kumar, Vinod, Laskowski, Adrienne, Nguyen, Tuong-Vi, Huynh, Kevin, Clarke, Michele V., Libianto, Renata, Baker, Scott T., Skene, Alison, Power, David A., MacIsaac, Richard J., Henstridge, Darren C., Wetsel, Rick A., El-Osta, Assam, Meikle, Peter J., Wilson, Scott G., Forbes, Josephine M., Cooper, Mark E., Ekinci, Elif I., Woodruff, Trent M. and Coughlan, Melinda T. (2019). Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility. Diabetes, 69 (1), 83-98. doi: 10.2337/db19-0043 |
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Featured 2019 Journal Article Complement dysregulation in the central nervous system during development and diseaseLee, John D., Coulthard, Liam G. and Woodruff, Trent M. (2019). Complement dysregulation in the central nervous system during development and disease. Seminars in Immunology, 45 101340, 101340. doi: 10.1016/j.smim.2019.101340 |
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2019 Journal Article Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology DatabaseCianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2019). Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). doi: 10.2218/gtopdb/f5/2019.4 |
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2019 Journal Article Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14Skjeflo, E. W., Christiansen, D., Landsem, A., Stenvik, J., Woodruff, T. M., Espevik, T., Nielsen, E. W. and Mollnes, T. E. (2019). Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14. Molecular Immunology, 112, 131-139. doi: 10.1016/j.molimm.2019.03.014 |
